scholarly journals LC-MS/MS Analysis and Hepatoprotective Activity of Artichoke (Cynara scolymusL.) Leaves Extract against High Fat Diet-Induced Obesity in Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-12 ◽  
Author(s):  
Maryem Ben Salem ◽  
Kamilia Ksouda ◽  
Raouia Dhouibi ◽  
Slim Charfi ◽  
Mouna Turki ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Ethanol Extract ◽  
Hepatoprotective Activity ◽  
Hepatic Tissue ◽  
High Fat ◽  
Cynara Scolymus ◽  
Antioxidative Effects

Cynara scolymusL. (Artichoke) has been used for the treatment of metabolic disorders. The purpose of the present study was to investigate the hepatoprotective effect ofCynara scolymusleaves extract against a high fat diet (HFD) induced rats. This study investigated the most abundant phenolic compounds richCynara scolymusleaves extract and it is antihypercholesterolemic and antioxidative effectsin vivo. The hypercaloric high fat diet (HFD) was treated with 200 mg/kg and 400 mg/kg of ethanol extract (EEA) from leaves ofCynaraand atorvastatin (ATOR) (10 mg/kg/day) during an 8-week period. Lipid profile was measured and oxidative stress systematic in hepatic tissue was determined. Our data revealed that HFD-induced hepatic dysfunction manifested by significant abnormal levels of AST, ALT, ALP, LDH, and OCT was accompanied by increasing levels of oxidative stress biomarker (ROS, MDA, and AOPP) while decreasing in antioxidant status. Coadministration of EEA significantly reduced serum lipid profile and hepatic disorders which was confirmed to be histological by reducing the fatty liver deposition in hepatic lobule. These findings suggest thatCynaraleaves exert antiobesity and antioxidant liver effects in HFD-induced obese rats.

scholarly journals The effect of high-fat diet and 13-cis retinoic acid application on lipid profile, glycemic response and oxidative stress in female Lewis rats

PLoS ONE ◽  
2020 ◽  
Vol 15 (9) ◽  
pp. e0238600
Author(s):  
Ivana Ilić ◽  
Nada Oršolić ◽  
Edi Rođak ◽  
Dyana Odeh ◽  
Marko Lovrić ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Retinoic Acid ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Glycemic Response ◽  
High Fat ◽  
Lewis Rats ◽  
And Oxidative Stress

Citrus flavanones prevent systemic inflammation and ameliorate oxidative stress in C57BL/6J mice fed high-fat diet

2016 ◽  
Vol 7 (6) ◽  
pp. 2675-2681 ◽  
Author(s):  
Paula S. Ferreira ◽  
Luis C. Spolidorio ◽  
John A. Manthey ◽  
Thais B. Cesar
Keyword(s):  
Oxidative Stress ◽  
Systemic Inflammation ◽  
High Fat Diet ◽  
High Fat ◽  
Anti Inflammatory

In vivoantioxidant and anti-inflammatory effects of citrus flavanones.

scholarly journals EXPLORATION OF IN VIVO ANTIOXIDANT ACTIVITY OF 50% ETHANOLIC EXTRACT OF SESAMUM INDICUM L. SEED AGAINST HIGH FAT DIET INDUCED RATS

2019 ◽  
pp. 55-61
Author(s):  
ZAFAR JAVED KHAN ◽  
NAEEM AHMAD KHAN
Keyword(s):  
Oxidative Stress ◽  
Antioxidant Activity ◽  
Body Weight ◽  
High Fat Diet ◽  
Ethanolic Extract ◽  
Sesamum Indicum ◽  
Control Group ◽  
High Fat ◽  
Lipid Peroxidase

Objective: The aim of the present study was to investigate the in vivo antioxidant potential of 50% ethanolic extract of Sesamum indicum against high-fat diet-induced rats. Methods: Animals were treated with plant extract for 30 d, and a high-fat diet was given to all groups except plain control, throughout, out the study. And alpha-tocopherol acetate (Vit, E) was used as standard. Pre-treatment with 16 mg/100 gm of body weight of 50% ethanolic extract of Sesamum indicum improved the Superoxide dismutase, catalase, glutathione, and lipid peroxidation levels significantly as compared to control group. Results: The present studies revealed that Sesamum indicum has significant in vivo antioxidant activity and can be used to protect tissue from oxidative stress. The result showed that the activities of SOD, catalase, lipid peroxidase, and glutathione, in the group treated with high-fat diet declined significantly than that of normal group. Conclusion: 50% ethanolic extract of in the dose of Sesamum indicum 16 mg/100 gm of body weight, has improved the SOD, catalase, glutathione, and lipid peroxidase levels significantly, which were comparable with high-fat-diet-induced rats. Based on this study we conclude that the 50% ethanolic extract of Sesamum indicum possesses in vivo antioxidant activity and can be employed in protecting tissue from oxidative stress.

scholarly journals Effect of Acute Ingestion of Green Tea Extract and Lemon Juice on Oxidative Stress and Lipid Profile in Pigs Fed a High-Fat Diet

Antioxidants ◽  
2019 ◽  
Vol 8 (6) ◽  
pp. 195 ◽  
Author(s):  
Xi Fang ◽  
Michael Azain ◽  
Kristi Crowe-White ◽  
Jennifer Mumaw ◽  
Janet A. Grimes ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Single Dose ◽  
Lipid Profile ◽  
Green Tea ◽  
High Fat Diet ◽  
Lemon Juice ◽  
Green Tea Extract ◽  
High Fat ◽  
Tea Extract

Green tea and its catechins have been shown to ameliorate high fat diet-induced oxidative stress and hyperlipidemia. However, low bioavailability of catechins limits their therapeutic potential. Lemon juice (LJ) has been suggested to enhance the bioavailability of catechins in vitro. This study investigated the antioxidative and hypolipidemic efficacy of a single dose of green tea extract (GTE) or GTE plus LJ (GTE + LJ) in high-fat diet fed pigs. Sixteen pigs ingested a single dose of GTE (190 mg/kg/day) or GTE + LJ (0.75 mL/kg/day) mixed with low-fat (LF; 5% fat) or high-fat (HF; 22% fat) diets and blood samples were collected for 24 h. Plasma catechin level peaked at two hours, and gradually returned to baseline after six hours following the intake. The addition of LJ significantly increased plasma catechin level. The diet containing GTE did not lower plasma cholesterol and triacylglycerol (TG) concentrations, superoxide dismutase (SOD) and catalase activity, or malondialdehyde concentration in 24 h in HF-fed pigs. Addition of a single dose of LJ, however, significantly decreased plasma TG level in LF groups but did not cause further changes on any other markers compared to the GTE alone. Our findings indicate limited effect of a single meal containing GTE on plasma antioxidant enzymes, lipid profile, and lipid peroxidation in pigs and no significant synergistic/additive action of adding LJ to GTE within 24 h in pigs. A study with a longer treatment period is warranted to further understand the potential role of GTE in reducing HF diet-induced oxidative stress and the possible synergistic role of LJ.

scholarly journals Nigella sativaRelieves the Altered Insulin Receptor Signaling in Streptozotocin-Induced Diabetic Rats Fed with a High-Fat Diet

2016 ◽  
Vol 2016 ◽  
pp. 1-16 ◽  
Author(s):  
Mahmoud Balbaa ◽  
Marwa El-Zeftawy ◽  
Doaa Ghareeb ◽  
Nabil Taha ◽  
Abdel Wahab Mandour
Keyword(s):  
Oxidative Stress ◽  
Gene Expression ◽  
Blood Glucose ◽  
Insulin Receptor ◽  
Lipid Profile ◽  
High Fat Diet ◽  
Diabetic Rats ◽  
High Fat ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

The black cumin (Nigella sativa) “NS” or the black seeds have many pharmacological activities such as antioxidant, anticarcinogenic, antihypertensive, and antidiabetic properties. In this work, streptozotocin-induced diabetic rats fed with a high-fat diet were treated daily with NS oil (NSO) in order to study the effect on the blood glucose, lipid profile, oxidative stress parameters, and the gene expression of some insulin receptor-induced signaling molecules. This treatment was combined also with some drugs (metformin and glimepiride) and the insulin receptor inhibitor I-OMe-AG538. The administration of NSO significantly induced the gene expression of insulin receptor compared to rats that did not receive NSO. Also, it upregulated the expression of insulin-like growth factor-1 and phosphoinositide-3 kinase, whereas the expression of ADAM-17 was downregulated. The expression of ADAM-17 is corroborated by the analysis of TIMP-3 content. In addition, the NSO significantly reduced blood glucose level, components of the lipid profile, oxidative stress parameters, serum insulin/insulin receptor ratio, and the tumor necrosis factor-α, confirming that NSO has an antidiabetic activity. Thus, the daily NSO treatment in our rat model indicates that NSO has a potential in the management of diabetes as well as improvement of insulin-induced signaling.

scholarly journals Anti-Obesity Effect of Extract from Nelumbo Nucifera L., Morus Alba L., and Raphanus Sativus Mixture in 3T3-L1 Adipocytes and C57BL/6J Obese Mice

Foods ◽  
2019 ◽  
Vol 8 (5) ◽  
pp. 170 ◽  
Author(s):  
Wan-Sup Sim ◽  
Sun-Il Choi ◽  
Bong-Yeon Cho ◽  
Seung-Hyun Choi ◽  
Xionggao Han ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Raphanus Sativus ◽  
Ethanol Extract ◽  
Morus Alba ◽  
Nelumbo Nucifera ◽  
Total Phenolic ◽  
Control Group ◽  
High Fat

The antioxidant and anti-adipogenic activities of a mixture of Nelumbo nucifera L., Morus alba L., and Raphanus sativus were investigated and their anti-obesity activities were established in vitro and in vivo. Among the 26 different mixtures of extraction solvent and mixture ratios, ethanol extract mixture no. 1 (EM01) showed the highest antioxidant (α,α-Diphenyl-β-picrylhydrazyl, total phenolic contents) and anti-adipogenic (Oil-Red O staining) activities. EM01 inhibited lipid accumulation in 3T3-L1 adipocytes compared to quercetin-3-O-glucuronide. Furthermore, body, liver, and adipose tissue weights decreased in the high-fat diet (HFD)-EM01 group compared to in the high-fat diet control group (HFD-CTL). EM01 lowered blood glucose levels elevated by the HFD. Lipid profiles were improved following EM01 treatment. Serum adiponectin significantly increased, while leptin, insulin growth factor-1, non-esterified fatty acid, and glucose significantly decreased in the HFD-EM01 group. Adipogenesis and lipogenesis-related genes were suppressed, while fat oxidation-related genes increased following EM01 administration. Thus, EM01 may be a natural anti-obesity agent.

Sign in / Sign up

Export Citation Format

Share Document