scholarly journals Natural Killer Response and Lipo-Metabolic Profile in Adults with Low HDL-Cholesterol and Mild Hypercholesterolemia: Beneficial Effects of Artichoke Leaf Extract Supplementation

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
M. Rondanelli ◽  
A. M. Castellazzi ◽  
A. Riva ◽  
P. Allegrini ◽  
M. A. Faliva ◽  
...  
Keyword(s):  
Natural Killer ◽  
Metabolic Profile ◽  
Leaf Extract ◽  
Killer Cell ◽  
Hdl Cholesterol ◽  
Model Assessment ◽  
Hierarchical Generalized Linear Model ◽  
Beneficial Effects ◽  
Low Hdl ◽  
Artichoke Leaf Extract

The aim of the present study is to evaluate the effects of 60-day artichoke leaf extract (ALE) supplementation (250mg, twice daily) on cytokines levels, natural killer cell (NK) response, and lipo-metabolic profile (HDL, LDL, and total-cholesterol, triglycerides (TG), ApoB, ApoA, lipid accumulation product (LAP), glucose, insulin, and homeostasis model assessment of insulin resistance (HOMA-IR)) in twenty adults (9/11 males/females, age=49.10 ± 13.74 years, and BMI=33.12 ± 5.14 kg/m2) with low HDL-C and mild hypercholesterolemia. Hierarchical generalized linear model, adjusted for sex, BMI, and age, has been used to evaluate pre-post treatment changes. A significant increase for HDL-C (β=0.14, p=0.0008) and MCP-1 (β=144.77, p=0.004) and a significant decrease for ApoB/ApoA (β=-0.07, p=0.03), total-C/HDL-C ratio (β=-0.58, p<0.001), and NK response at stimulus low (β=0.43, p=0.04), medium (β=0.40, p<0.001), and high (β=0.42, p=0.001) have been found. These results support the benefits of ALE supplementation on metabolic profile.

Niacin as antidyslipidemic drug

2015 ◽  
Vol 93 (12) ◽  
pp. 1043-1054 ◽  
Author(s):  
Ulrich Julius
Keyword(s):  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Vitamin B3 ◽  
End Points ◽  
Lipoprotein A ◽  
Beneficial Effects ◽  
Lipid Disorders ◽  
Cholesterol Levels ◽  
Low Hdl ◽  
Review Reports

Niacin is an important vitamin (B3) that can be used in gram doses to positively modify pathogenetically relevant lipid disorders: elevated LDL cholesterol, elevated non-HDL cholesterol, elevated triglycerides, elevated lipoprotein(a), and reduced HDL cholesterol. This review reports the latest published findings with respect to niacin’s mechanisms of action on these lipids and its anti-inflammatory and anti-atherosclerotic effects. In the pre-statin era, niacin was shown to have beneficial effects on cardiovascular end-points; but in recent years, two major studies performed in patients whose LDL cholesterol levels had been optimized by a statin therapy did not demonstrate an additional significant effect on these end-points in the groups where niacin was administered. Both studies have several drawbacks that suggest that they are not representative for other patients. Thus, niacin still plays a role either as an additive to a statin or as a substitute for a statin in statin-intolerant patients. Moreover, patients with elevated triglyceride and low HDL cholesterol levels and patients with elevated lipoprotein(a) concentrations will possibly benefit from niacin, although currently the study evidence for these indications is rather poor. Niacin may be useful for compliant patients, however possible side effects (flushing, liver damage) and contraindications should be taken into consideration.

scholarly journals Study of potential cardioprotective effects ofGanoderma lucidum(Lingzhi): results of a controlled human intervention trial

2011 ◽  
Vol 107 (7) ◽  
pp. 1017-1027 ◽  
Author(s):  
Tanya T. W. Chu ◽  
Iris F. F. Benzie ◽  
Christopher W. K. Lam ◽  
Benny S. P. Fok ◽  
Kenneth K. C. Lee ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Antioxidant Status ◽  
Animal Studies ◽  
Lymphocyte Subsets ◽  
Plasma Lipids ◽  
Hdl Cholesterol ◽  
Complete Analysis ◽  
Model Assessment ◽  
Double Blind ◽  
Beneficial Effects

Previous studies have suggested that Lingzhi (Ganoderma lucidum) has antioxidant effects and possibly beneficial effects on blood pressure, plasma lipids and glucose, but these have not been confirmed in subjects with mild hypertension or hyperlipidaemia. The objective of the present study was to assess the cardiovascular, metabolic, antioxidant and immunomodulatory responses to therapy with Lingzhi in patients with borderline elevations of blood pressure and/or cholesterol in a controlled cross-over trial. A total of twenty-six patients received 1·44 g Lingzhi daily or matching placebo for 12 weeks in a randomised, double-blind, cross-over study with placebo-controlled run-in and cross-over periods. Body weight, blood pressure, metabolic parameters, urine catecholamines and cortisol, antioxidant status and lymphocyte subsets were measured after each period. Lingzhi was well tolerated and data from twenty-three evaluable subjects showed no changes in BMI or blood pressure when treated with Lingzhi or placebo. Plasma insulin and homeostasis model assessment-insulin resistance were lower after treatment with Lingzhi than after placebo. TAG decreased and HDL-cholesterol increased with Lingzhi but not with placebo in the first treatment period, but significant carry-over effects prevented complete analysis of these parameters. Urine catecholamines and cortisol, plasma antioxidant status and blood lymphocyte subsets showed no significant differences across treatments. Results indicate that Lingzhi might have mild antidiabetic effects and potentially improve the dyslipidaemia of diabetes, as shown previously in some animal studies. Further studies are desirable in patients with hyperglycaemia.

Dual activity of serum lipoprotein-associated phospholipase A2 yielding positive and inverse associations with cardiometabolic risk

2011 ◽  
Vol 49 (8) ◽  
Author(s):  
Altan Onat ◽  
Gülay Hergenç ◽  
Günay Can ◽  
Murat Uğur ◽  
Filiz Nartop
Keyword(s):  
Cardiometabolic Risk ◽  
Inverse Correlation ◽  
Hdl Cholesterol ◽  
Serum Lipoprotein ◽  
Model Assessment ◽  
Apolipoprotein C ◽  
Homeostatic Model Assessment ◽  
Low Hdl ◽  
Homeostatic Model ◽  
High Triglyceride

AbstractThe clinical relevance of serum lipoprotein-associated phospholipase AIn 736 Turkish adults, serum total Lp-PLASignificant inverse correlation existed with high triglyceride/low HDL cholesterol dyslipidemia, waist girth, apolipoprotein C-III, homeostatic model assessment, and linear inverse associations in women with lipoprotein (a) and fibrinogen, suggesting that Lp-PLASerum total Lp-PLA

scholarly journals Dietary calcium intake is associated with adiposity, metabolic profile, inflammatory state and blood pressure, but not with erythrocyte intracellular calcium and endothelial function in healthy pre-menopausal women

2013 ◽  
Vol 110 (6) ◽  
pp. 1079-1088 ◽  
Author(s):  
Thaís da Silva Ferreira ◽  
Márcia Regina Simas Gonçalves Torres ◽  
Antonio Felipe Sanjuliani
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Endothelial Function ◽  
Dietary Intake ◽  
Metabolic Profile ◽  
Hdl Cholesterol ◽  
Dietary Calcium Intake ◽  
Model Assessment ◽  
Menopausal Women ◽  
Inflammatory State

Recent studies have suggested that dietary Ca may have beneficial effects on adiposity, insulin resistance, dyslipidaemia and blood pressure (BP). One potential mechanism underlying these benefits involves modifications in intracellular Ca concentration ([Ca2+]i). The present study aimed to evaluate the associations of dietary Ca with adiposity, erythrocyte [Ca2+]i, metabolic profile, BP, inflammatory state and endothelial function in healthy pre-menopausal women. In the present cross-sectional study, seventy-six women aged 18–50 years were submitted to the evaluation of dietary intake, anthropometric parameters, body composition, erythrocyte [Ca2+]i, biochemical variables, endothelial function and BP. A FFQ was used to assess usual dietary intake. Endothelial function was evaluated by serum concentrations of adhesion molecules and by the peripheral arterial tonometry (PAT) method, using Endo-PAT 2000®. Participants were allocated into two groups according to Ca intake: low-Ca group (LCG;n32; < 600 mg/d) and high-Ca group (HCG;n44; ≥ 600 mg/d). Women in the LCG compared with those in the HCG exhibited, after adjustments for potential confounders, higher values of BMI, waist circumference, waist:height ratio, percentage of body fat, insulin, homeostasis model assessment of insulin resistance, leptin, diastolic and mean BP; and lower levels of HDL-cholesterol, adiponectin and vascular cell adhesion molecule 1. Endothelial function assessed by PAT and [Ca2+]iwas similar in both groups. Subjects in the HCG had lower OR for prevalent overweight, obesity, abdominal obesity, insulin resistance, HDL-cholesterol < 600 mg/l and systolic BP >120 mmHg. The findings of the present study suggest that high Ca intake is inversely associated with some cardiovascular risk factors.

scholarly journals Metabolic and Anti-Inflammatory Protective Properties of Human Enriched Serum Following Artichoke Leaf Extract Absorption: Results from an Innovative Ex Vivo Clinical Trial

Nutrients ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 2653
Author(s):  
Fabien Wauquier ◽  
Line Boutin-Wittrant ◽  
Aurélien Viret ◽  
Laure Guilhaudis ◽  
Hassan Oulyadi ◽  
...  
Keyword(s):  
Chronic Diseases ◽  
Leaf Extract ◽  
Ex Vivo ◽  
Clinical Approach ◽  
Protective Properties ◽  
Cellular Behavior ◽  
Beneficial Effects ◽  
Socio Economic Impact ◽  
Nutritional Strategies ◽  
Artichoke Leaf Extract

The aging of our population is accompanied by an increased prevalence of chronic diseases. Among those, liver, joint and adipose tissue-related pathologies have a major socio-economic impact. They share common origins as they result from a dysregulation of the inflammatory and metabolic status. Plant-derived nutrients and especially polyphenols, exert a large range of beneficial effects in the prevention of chronic diseases but require clinically validated approaches for optimized care management. In this study, we designed an innovative clinical approach considering the metabolites produced by the digestive tract following the ingestion of an artichoke leaf extract. Human serum, enriched with metabolites deriving from the extract, was collected and incubated with human hepatocytes, human primary chondrocytes and adipocytes to determine the biological activity of the extract. Changes in cellular behavior demonstrated that the artichoke leaf extract protects hepatocytes from lipotoxic stress, prevents adipocytes differentiation and hyperplasia, and exerts chondroprotective properties in an inflammatory context. These data validate the beneficial health properties of an artichoke leaf extract at the clinical level and provide both insights and further evidence that plant-derived nutrients and especially polyphenols from artichoke may represent a relevant alternative for nutritional strategies addressing chronic disease issues.

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