scholarly journals Age- and Sex-Specific Reference Intervals for Myocardial Enzyme Activity in Healthy Chinese Han Population Aged 1∼<18 years

2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Wenjia Guo ◽  
Qi Zhou ◽  
Yanan Jia ◽  
Jiancheng Xu
Keyword(s):  
Enzyme Activity ◽  
Children And Adolescents ◽  
Reference Intervals ◽  
Integrated System ◽  
Chinese Han Population ◽  
Specific Reference ◽  
Chinese Han ◽  
Han Population ◽  
Healthy Chinese ◽  
Age And Sex

Age- and sex-specific reference intervals (RIs) for myocardial enzyme activity of children and adolescents are not available in China. Our study aimed to establish age- and gender-related RIs for AST, LDH, CK, and CKMB activity in healthy Chinese Han population aged 1∼<18 years. Healthy Han children and adolescents (n = 6322, 1∼<18 years old) were assessed from completed questionnaires and defined criteria from communities and schools in 5 administrative districts of Jilin Province from September 2017 to December 2018. Measurements of AST, LDH, CK, and CKMB activity were performed on the VITROS 5600 Integrated System. Percentiles of enzyme activity were completed by LMS. RIs were established by Medcalc according to the EP28-A3c guidelines issued by the Clinical and Laboratory Standards Institute. AST declined rapidly during 1∼<6 years and had been subsided during 11∼<18 years, though LDH decreased at a steady rate. CK activity stabilized while CKMB showed a downward trend. Sex differences started after age 12 when males presented higher results. There were significant differences comparing with domestic and other countries’ experiments which applied similar methodologies. Enzymes were associated with age and sex, while age had greater impact. We established age- and sex-specific RIs of serum AST, LDH, CK, and CKMB activities for Chinese children and adolescents using the VITROS 5600 Integrated System for the first time. These data will lay the groundwork for the next horizon in pediatric RIs as well as improve test result interpretation for pediatric illness.

An Association Study on the Polymorphisms of Dopaminergic Genes with Working Memory in a Healthy Chinese Han Population

2012 ◽  
Vol 32 (6) ◽  
pp. 1011-1019 ◽  
Author(s):  
Pingyuan Gong ◽  
Hang Zhang ◽  
Wanyu Chi ◽  
Wanhua Ge ◽  
Kejin Zhang ◽  
...  
Keyword(s):  
Working Memory ◽  
Association Study ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Healthy Chinese ◽  
Dopaminergic Genes

scholarly journals Reference Intervals of Serum Sodium, Potassium, and Chlorine in Chinese Han Population and Comparison of Two ISE Methods

2014 ◽  
Vol 29 (3) ◽  
pp. 226-234 ◽  
Author(s):  
Keke Jia ◽  
Chuanbao Zhang ◽  
Xianzhang Huang ◽  
Lanlan Wang ◽  
Xiaoke Hao ◽  
...  
Keyword(s):  
Serum Sodium ◽  
Reference Intervals ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Sodium Potassium ◽  
Han Population

scholarly journals Better pulmonary function is associated with greater handgrip strength in a healthy Chinese Han population

2020 ◽  
Author(s):  
Liangmei Chen ◽  
Xiaomin Liu ◽  
Qian Wang ◽  
Linpei Jia ◽  
Kangkang Song ◽  
...  
Keyword(s):  
Linear Regression ◽  
Pulmonary Function ◽  
Vital Capacity ◽  
Handgrip Strength ◽  
Multivariate Linear Regression ◽  
Chinese Han Population ◽  
Categorical Variables ◽  
Chinese Han ◽  
Han Population ◽  
Healthy Chinese

Abstract Background: Handgrip strength (HGS) has been widely studied in clinical and epidemiological settings, but the relationship between HGS and pulmonary function is still controversial. This study analyzed pulmonary function and HGS stratified by sex and age in a healthy Chinese Han population, as well as the associations between HGS and pulmonary function parameters. Methods: HGS was measured by a Jamar dynamometer and pulmonary function was tested using a portable spirometer. Frequencies and variables are presented as percentages and means ± standard deviations, respectively. Chi-square tests were used for comparisons of categorical variables, and Student’s t-tests or Mann–Whitney U-tests were used for continuous variables. Pearson correlation and multivariate linear regression models were employed to explore the relationships between HGS and parameters of pulmonary function. The statistical significance was set at p <0.01. Results: Cross-sectional data were available for 1519 subjects (59.0% females, 57.9±13.1 years old). Males had higher average HGS than females (40.2 vs 25.0 kg, p <0.01 ), as well as better pulmonary function. Both HGS and pulmonary function parameters were significantly inversely correlated with age (r=-0.30, p < 0.01). Maximum value of vital capacity, forced expiratory volume in 3 second and forced vital capacity were strongly correlated with HGS among the pulmonary function indices (r=0.72, 0.70 and 0.69, respectively, p <0.001). In multivariate linear regression analysis, HGS and height were positively correlated, while age and pulse pressure were negatively correlated with HGS. Conclusions: Both pulmonary function and HGS were inversely correlated with age, and better pulmonary function was associated with greater handgrip strength.

scholarly journals Better pulmonary function is associated with greater handgrip strength in a healthy Chinese Han population

2020 ◽  
Author(s):  
Liangmei Chen ◽  
Xiaomin Liu ◽  
Qian Wang ◽  
Linpei Jia ◽  
Kangkang Song ◽  
...  
Keyword(s):  
Linear Regression ◽  
Pulmonary Function ◽  
Vital Capacity ◽  
Handgrip Strength ◽  
Correlation Coefficients ◽  
Multivariate Linear Regression ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
Healthy Chinese

Abstract Background: Handgrip strength (HGS) has been widely studied in clinical and epidemiological settings, but the relationship between HGS and pulmonary function is still controversial. This study analysed pulmonary function and HGS stratified by sex and age in a healthy Chinese Han population, as well as the associations between HGS and pulmonary function parameters. Methods: HGS was measured by a Jamar dynamometer and pulmonary function was tested using a portable spirometer. Frequencies and variables are presented as percentages and means ± standard deviations, respectively. Chi-square tests were used for comparisons of categorical variables, and Student’s t-tests or Mann–Whitney U-tests were used for continuous variables. Pearson's correlation coefficients were used to analyse the normally distributed variables, and Spearman correlation coefficients were used to analyse the non-normally distributed variables. Multivariate linear regression models were employed to explore the relationships between HGS and parameters of pulmonary function. The statistical significance was set at p <0.01. Results: Cross-sectional data were available for 1519 subjects (59.0% females, 57.9±13.1 years old). Males had higher average HGS than females (40.2 vs. 25.0 kg, p <0.01 ), as well as better pulmonary function. Both HGS and pulmonary function parameters were significantly inversely correlated with age (r ≤ -0.30, p < 0.01). The maximum value of vital capacity (VC max), forced expiratory volume in 3 second (FEV3) and forced vital capacity (FVC) were strongly correlated with HGS among the pulmonary function indices (r=0.72, 0.70 and 0.69, respectively, p <0.001). In the multivariate linear regression analysis, HGS and height were positively correlated, while age and pulse pressure were negatively correlated with HGS. In males, the FVC, VC max and FEV3 increased by 0.02L, 0.023L and 0.03L in per 1 kg increase in HGS, respectively. The HGS coefficients for females were smaller than those for males. Conclusions: Both pulmonary function and HGS were inversely correlated with age, and better pulmonary function was associated with greater handgrip strength.

scholarly journals ZSCAN25 and CYP2E1 polymorphisms is risk factors for ischemic stroke in a Chinese Han population: a case control study

2020 ◽  
Author(s):  
Haozheng Yuan ◽  
Pei Fan ◽  
Li Yao ◽  
Yuying Lv ◽  
Haidong Wei ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Odds Ratio ◽  
Case Control Study ◽  
Case Control ◽  
Chinese Han Population ◽  
Chinese Han ◽  
Han Population ◽  
The Relationship ◽  
Control Study ◽  
Age And Sex

Abstract Background We aimed to explore the relationship between ZSCAN25 and CYP2E1 polymorphisms and Ischemic stroke (IS) susceptibility among a Chinese Han population. Methods We enrolled 477 patients with IS and 480 age- and sex- matched health controls. Genotyping of the ZSCAN25 rs10242455, CYP2E1 rs2070672 and rs2515641 were performed by Agena MassARRAY platform. Odds ratio (OR) and 95% confidence interval (CI) were calculated by logistic regression analysis. Results Rs10242455 (OR = 0.56, 95% CI: 0.34–0.93, p = 0.024) was associated with a reduced IS susceptibility, while rs2070672 (OR = 1.40, 95% CI: 1.12–1.75, p = 0.003) and rs2515641 (OR = 1.29, 95% CI: 1.01–1.64, p = 0.041) with an increased IS occurrence. Rs2070672 was observed to correlate with IS risk (OR = 4.06, p = 0.038) at age > 64 years, and rs10242455 (OR = 0.45, p = 0.021) and rs2070672 (OR = 3.28, p = 0.024) affected IS risk in males. In addition, rs10242455 (OR = 1.72, p = 0.014) was significantly associated with hypertension in IS patients. Conclusion Our study firstly found that rs10242455 in ZSCAN25, rs2070672 and rs2515641 in CYP2E1 were associated with the occurrence of IS in a Chinese Han population.

scholarly journals Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a cross-sectional study

BMJ Open ◽  
2019 ◽  
Vol 9 (8) ◽  
pp. e030201
Author(s):  
Junjie Liu ◽  
Yanpeng Dai ◽  
Enwu Yuan ◽  
Yushan Li ◽  
Quanxian Wang ◽  
...  
Keyword(s):  
Children And Adolescents ◽  
Density Lipoprotein ◽  
Reference Intervals ◽  
Chinese Children ◽  
Lipoprotein Cholesterol ◽  
Specific Reference ◽  
Healthy Chinese ◽  
And Gender ◽  
Gender Specific ◽  
Chinese Children And Adolescents

AimsEthnic, demographic, lifestyle, genetic and environmental factors influence lipids and apolipoproteins. The aim of this study was to establish age-specific and gender-specific reference intervals for non-fasting lipids and apolipoproteins in healthy Chinese children and adolescents.MethodsThis study followed the Clinical and Laboratory Standards Institute EP28-A3c guidelines. Non-fasting samples were collected from 7260 healthy Chinese children and adolescents, and they were analysed using the Olympus AU5400 analyser for: triglycerides, total cholesterol (TC), high-density lipoprotein cholesterol, low-density lipoprotein cholesterol (LDL-C), apolipoprotein A1 and apolipoprotein B (ApoB). The age-related and gender-related reference intervals were partitioned using the Harris-Boyd method. The non-parametric method was used to establish the lower limit (2.5th percentile) and the upper limit (97.5th percentile) for the reference intervals. The 90% CIs for the lower and upper limits were also calculated.ResultsBased on the Harris-Boyd method, gender partitions were required for TC, LDL-C and ApoB. Age differences were observed for all analytes. Paediatric reference intervals were established for non-fasting lipids and apolipoproteins based on a large population of healthy children and adolescents.ConclusionsPreviously used reference intervals did not take age and gender into account. These age-specific and gender-specific reference intervals established in this study may contribute to improved management and assessment of paediatric diseases.

scholarly journals CALIPER Hematology Reference Standards (II)

2020 ◽  
Vol 154 (3) ◽  
pp. 342-352 ◽  
Author(s):  
Victoria Higgins ◽  
Houman Tahmasebi ◽  
Mary Kathryn Bohn ◽  
Alexandra Hall ◽  
Khosrow Adeli
Keyword(s):  
Children And Adolescents ◽  
Hemoglobin Concentration ◽  
Reference Intervals ◽  
Reference Standards ◽  
Reference Database ◽  
Specific Reference ◽  
Mean Corpuscular Hemoglobin ◽  
Healthy Children ◽  
Cell Percentage ◽  
Age And Sex

Abstract Objectives The objective of this study was to establish comprehensive age- and sex-specific reference intervals for hematologic parameters in the CALIPER cohort of healthy children and adolescents. Methods A total of 536 healthy children and adolescents (birth to 21 years) were recruited with informed consent, and whole blood samples were analyzed for 27 hematologic parameters on the Beckman Coulter DxH 520 system. Age- and sex-specific pediatric reference standards were established. Reference values obtained on the DxH 520 were also compared with data obtained on a larger laboratory-based instrument (DxH 900). Results Most hematologic parameters showed significant age- and/or sex-specific changes during growth and development. Of the 27 hematologic parameters, all except four (mean corpuscular hemoglobin concentration, basophil percentage, low hemoglobin density, immature cell percentage) required age partitioning, and eight required sex partitioning. Conclusions This study establishes a robust pediatric hematology reference database that will assist in more accurate test result interpretation. Our data clearly demonstrate significant variation in hematologic parameter concentrations in children and adolescents, necessitating the use of pediatric-specific reference standards.

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