scholarly journals Traditional Chinese Medicine for Refractory Nephrotic Syndrome: Strategies and Promising Treatments

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Xiao-Qin Wang ◽  
Lan Wang ◽  
Yuan-Chao Tu ◽  
Yuan Clare Zhang
Keyword(s):  
Nephrotic Syndrome ◽  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Kidney Diseases ◽  
Immunosuppressive Agents ◽  
Complementary Therapy ◽  
Great Promise ◽  
Serious Adverse Events ◽  
Refractory Nephrotic Syndrome

Refractory nephrotic syndrome (RNS) is an immune-related kidney disease with poor clinical outcomes. Standard treatments include corticosteroids as the initial therapy and other immunosuppressants as second-line options. A substantial proportion of patients with RNS are resistant to or dependent on immunosuppressive drugs and often experience unremitting edema and proteinuria, cycles of remission and relapse, and/or serious adverse events due to long-term immunosuppression. Traditional Chinese medicine has a long history of treating complicated kidney diseases and holds great potential for providing effective treatments for RNS. This review describes the Chinese medical theories relating to the pathogenesis of RNS and discusses the strategies and treatment options using Chinese herbal medicine. Available preclinical and clinical evidence strongly supports the integration of traditional Chinese medicine and Western medicine for improving the outcome of RNS. Herbal medicine such as Astragalus membranaceus, Stephania tetrandra S. Moore, and Tripterygium wilfordii Hook F can serve as the alternative therapy when patients fail to respond to immunosuppression or as the complementary therapy to improve therapeutic efficacy and reduce side effects of immunosuppressive agents. Wuzhi capsules (Schisandra sphenanthera extract) with tacrolimus and tetrandrine with corticosteroids are two herb-drug combinations that have shown great promise and warrant further studies.

Comparison of second-line immunosuppressants for childhood refractory nephrotic syndrome: a systematic review and network meta-analysis

2016 ◽  
Vol 65 (1) ◽  
pp. 65-71 ◽  
Author(s):  
Hai-Dong Fu ◽  
Gu-Ling Qian ◽  
Zheng-yang Jiang
Keyword(s):  
Nephrotic Syndrome ◽  
Mycophenolate Mofetil ◽  
Meta Analysis ◽  
Immunosuppressive Agents ◽  
Second Line ◽  
Childhood Nephrotic Syndrome ◽  
Randomized Controlled ◽  
Search Terms ◽  
October 17 ◽  
Refractory Nephrotic Syndrome

Although, most patients respond initially to therapy for nephrotic syndrome, about 70% of patients have a relapse. Currently, there is no consensus about the most appropriate second-line agent in children who continue to suffer a relapse. This network meta-analysis was designed to compare the efficacy and safety of the commonly used immunosuppressive agents in second-line therapeutic agents (ie, cyclophosphamide, cyclosporine, tacrolimus and mycophenolate mofetil) for refractory childhood nephrotic syndrome. MEDLINE, Cochrane, EMBASE and Google Scholar databases were searched until October 17, 2015 using the following search terms: cyclophosphamide, cyclosporine, tacrolimus, mycophenolate mofetil and childhood nephrotic syndrome. Randomized controlled trials, prospective 2-arm studies and cohort studies were included. 7 studies with 391 patients were included. Bayesian network meta-analysis found that treatment with mycophenolate mofetil had the greatest odds of relapse compared with tacrolimus (pooled OR=49.72, 95% credibility interval (CrI) 1.65 to 2483.32), cyclophosphamide (pooled OR=72.05, 95% CrI 1.44 to 13633.33) and cyclosporine (pooled OR=11.42, 95% CrI 1.03 to 131.60). Rank probability analysis found cyclophosphamide was the best treatment with the lowest relapse rate as compared with other treatments (rank probability=0.58), and tacrolimus was ranked as the second best (rank probability=0.38). Our findings support the use of cyclophosphamide and tacrolimus in treating children with relapsing nephrotic syndrome.

Traditional Medicinal Systems

2020 ◽  
pp. 1-24
Author(s):  
Aashaq Hussain Bhat ◽  
Shahla Nigar
Keyword(s):  
Chinese Medicine ◽  
Side Effects ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Medicinal Plants ◽  
Secondary Metabolites ◽  
Modern Science ◽  
Blood Purification ◽  
Traditional Use ◽  
Korean Medicine

Medicinal plants are a great source of medicine for treating various human ailments. Traditional use of herbal medicine, which was developed within an ethnic group before the development and spread of modern science, is the very basis and an integral part of various cultures. Different medicinal systems throughout the globe are still operational and use natural herbs for treating diseases. Traditional Chinese Medicine (TCM), Ayurveda, Kampo, Traditional Korean Medicine (TKM), and Unani are some commonly found traditional medicinal systems in use today. They are used directly, or their secondary metabolites are used as anti-bacterial, antifungal, immunomodulators, anti-hair fall, and multiple other purposes. However, their blood purification properties prevent blood from toxicity. Hundreds of medicinal plants are used in Ayurveda for blood purification, particularly plants which are astringent or bitter (pungent or sharp tastes). In addition, medicinal herbs do not have side effects.

scholarly journals Evaluating Traditional Chinese Medicine and Herbal Products for the Treatment of Gestational Diabetes Mellitus

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Yang Xin Zi Xu ◽  
Shengyan Xi ◽  
Xiaoyan Qian
Keyword(s):  
Diabetes Mellitus ◽  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Gestational Diabetes ◽  
Gestational Diabetes Mellitus ◽  
Symptom Relief ◽  
Care Providers ◽  
Herbal Products ◽  
Health Maintenance

Gestational diabetes mellitus is the most common metabolic disorder during pregnancy with health consequences for both lives during and after pregnancy. Studies found that many pregnant women turn to complementary and alternative medicine for health maintenance or symptom relief, such as herbal medicine and acupuncture from traditional Chinese medicine. With the growing popularity of traditional Chinese medicine, we conducted a systemic search in PubMed, Web of Science, and Embase databases on research studies that investigated traditional Chinese medicine during pregnancy. The resultant hits were further searched in relation to all diabetes mellitus. In total, we found three major herbal medicine/herbal products that were associated with glycemic control in gestational diabetes, including Zuo Gui Wan, red raspberry leaves, and Orthosiphon stamineus. We further reviewed them and their relatives in relation to type 2 diabetes mellitus and found more evidence of metabolic benefits. None of the herbal medicine and products examined reported toxicity in the experimental models. Overall, treatments of gestational diabetes by western or alternative interventions are grossly understudied. It is critical to have a standardized protocol when evaluating efficacy of herbal medicine and produce quality results for women and their health-care providers to make informed treatment decisions.

Complementary therapy of traditional Chinese medicine for blood sugar control in a patient with type 1 diabetes

2017 ◽  
Vol 30 ◽  
pp. 10-13 ◽  
Author(s):  
Ming-Huei Cheng ◽  
Ching-Liang Hsieh ◽  
Chih-Yu Wang ◽  
Chin-Chuan Tsai ◽  
Che-Chang Kuo
Keyword(s):  
Type 1 Diabetes ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Blood Sugar ◽  
Complementary Therapy

Acupuncture plus Herbal Medicine for Alzheimer’s Disease: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 45 (07) ◽  
pp. 1327-1344 ◽  
Author(s):  
Simin Zhou ◽  
Lanlan Dong ◽  
Yuan He ◽  
Hong Xiao
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Chinese Medicine ◽  
Herbal Medicine ◽  
Traditional Chinese Medicine ◽  
Chinese Herbal Medicine ◽  
Meta Analysis ◽  
World Population ◽  
Chinese Herbal ◽  
Significant Difference

Alzheimer’s disease (AD) is associated with the unprecedented aging tendency in our world population and has become a significant health issue. The use of Traditional Chinese Medicine to treat AD has been increasing in recent years. The objective of this meta-analysis is to evaluate the effectiveness of combining acupuncture with herbal medicine to treat AD. Randomized controlled trials (RCTs) of acupuncture plus herbals versus treatment with western drugs for AD were retrieved from 11 databases. The data were extracted by two authors; dichotomous data were expressed as odds ratio (ORs) and 95% confidence intervals (CIs), while continuous data were calculated by mean differences (MDs) with 95% CIs. Although the combined analysis of the score of Activity of Daily Life (ADL) scale MD was [Formula: see text]3.59 (95% CI [Formula: see text]7.18–0.01, [Formula: see text]), which indicates there was no statistically significant difference between the two treatments at reducing the ADL scale score, the pooled results of 12 trials indicated that acupuncture plus Chinese herbal medicine was better than western drugs at improving the effectiveness rate (OR 2.24, 95% CI 1.40–3.56), the combined evidence of 11 articles showed that acupuncture plus Chinese herbal medicine was more effective than western drugs at improving the scores for the Mini Mental State Examination (MMSE) scale (2.10, 95% CI 0.69–3.51, [Formula: see text]) and the traditional Chinese medicine symptom (MD 5.07, 95% CI 3.90–6.25, [Formula: see text]). From the current research results, acupuncture plus herbal medicine may have advantages over western drugs for treating AD. Nevertheless, well-designed RCTs with a larger sample size are required in the future.

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