scholarly journals An Herbal Medicine, Yukgunja-Tang is more Effective in a Type of Functional Dyspepsia Categorized by Facial Shape Diagnosis: A Placebo-Controlled, Double-Blind, Randomized Trial

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Seok-Jae Ko ◽  
Jae-Woo Park ◽  
Jae-hyung Lee ◽  
Jung-eun Lee ◽  
Na-yeon Ha ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Functional Dyspepsia ◽  
Three Dimensional ◽  
Gastrointestinal Symptoms ◽  
Diagnostic System ◽  
Gastrointestinal Disorder ◽  
Symptom Scale ◽  
Double Blind ◽  
Facial Shape ◽  
Superior Effect

Introduction. Functional dyspepsia (FD) is a functional gastrointestinal disorder characterized by persistent upper dyspeptic symptoms without organic lesions. There is no standard therapy for FD. Yukgunja-tang (YGJT) is an herbal medicine used for treating upper gastrointestinal symptoms in Asia. Studies on the effect of YGJT on FD have been conducted. However, the results were inconsistent. In Hyungsang medicine, traditional Korean medicine, FD patients are classified into bladder body (BB) or gallbladder body (GB) subtypes by the shape and angle of their faces. Each subtype may have different characteristics, physiology, and pathology of the same disease. YGJT is more effective for patients with BB subtype. The three-dimensional facial shape diagnostic system (3-FSDS) was shown to be effective in diagnosing BB or GB subtypes. This study aimed to investigate the effect of YGJT on FD patients classified using the 3-FSDS. Materials and Methods. The current study was a placebo-controlled, double-blinded, randomized, two-center trial. Eligible patients were diagnosed with either BB or GB FD subtype using the 3-FSDS. Ninety-six participants (48 BB and 48 GB subtypes) were randomly allocated to treatment or control groups in a 2:1 ratio. YGJT or placebo was administered for eight weeks. The primary outcome was assessed using the total dyspepsia symptom scale (TDS), while the secondary outcomes were assessed using the single dyspepsia symptom scale (SDS), proportion of responders, visual analog scale, Nepean dyspepsia index, functional dyspepsia-related quality of life, and spleen qi deficiency questionnaire. Results and Discussion. The result of TDS showed the superior effect of YGJT on BB over GB subtype. The subgroup analysis of TDS and SDS scores showed the superior effect of YGJT over placebo. Other outcome variables did not show any significant differences between groups. Conclusion. YGJT may be considered for FD patients diagnosed with BB subtype using 3-FSDS.

scholarly journals Effects of a Herbal Medicine, Yukgunja-Tang, on Functional Dyspepsia Patients Classified by 3-Dimensional Facial Measurement: A Study Protocol for Placebo-Controlled, Double-Blind, Randomized Trial

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Juyeon Kim ◽  
Jae-Woo Park ◽  
Seok-Jae Ko ◽  
Soo-Hyung Jeon ◽  
Jong-Won Kim ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Clinical Practice ◽  
Herbal Medicine ◽  
Functional Dyspepsia ◽  
Symptom Scale ◽  
Double Blind ◽  
Korean Medicine ◽  
3 Dimensional ◽  
Objective Evidence

Introduction. Functional dyspepsia (FD), a common upper gastrointestinal disease, is difficult to manage because of the limitations of current conventional treatments. Yukgunja-tang (YGJT) is widely used to treat FD in clinical practice in Korea, Japan, and China. However, YGJT significantly improves few symptoms of FD. In Korean medicine, FD is a well-known functional gastric disease that shows difference in the effect of herbal medicine depending on constitution or type of Korean medicine diagnosis. This study aims to investigate the efficacy of YGJT on FD patients classified by 3-dimensional facial measurement using a 3-dimensional facial shape diagnostic system (3-FSDS).Methods. A placebo-controlled, double-blind, randomized, two-center trial will be performed to evaluate the efficacy of YGJT on FD patients. Eligible subjects will be initially classified as two types by 3-dimensional facial measurement using the 3-FSDS. Ninety-six subjects (48 subjects per each type) will be enrolled. These subjects will be randomly allocated into treatment or control groups in a 2 : 1 ratio. YGJT or placebo will be administered to each group during the 8-week treatment period. The primary outcome is total dyspepsia symptom scale, and the secondary outcomes include single dyspepsia symptom scale, proportion of responders with adequate symptom relief, visual analog scale, Nepean dyspepsia index-Korean version, functional dyspepsia-related quality of life, and spleen qi deficiency questionnaire.Discussion. This is the first randomized controlled trial to assess the efficacy of the YGJT on FD patients classified by 3-dimensional facial measurement. We will compare the treatment effect of the YGJT on FD patients classified as two types using the 3-FSDS. The results of this trial will help the FD patients improve the symptoms and quality of life effectively and provide objective evidence for prescribing the YGJT to FD patients in clinical practice.Trial Registration. This trial is registered with Clinical Research Information Service Identifier:KCT0001920, 15 May, 2016.

A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of the Japanese Herbal Medicine Rikkunshito for Patients with Functional Dyspepsia: The Dream Study

2017 ◽  
Vol 152 (5) ◽  
pp. S120-S121 ◽  
Author(s):  
Yasuhisa Sakata ◽  
Kazunari Tominaga ◽  
Hiroaki Kusunoki ◽  
Takeo Odaka ◽  
Kouichi Sakurai ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Herbal Medicine ◽  
Functional Dyspepsia ◽  
Double Blind ◽  
Double Blind Clinical Trial ◽  
Japanese Herbal Medicine

scholarly journals Lactobacillus probiotics for treating functional dyspepsia in children

2016 ◽  
Vol 56 (1) ◽  
pp. 37 ◽  
Author(s):  
Tuty Ahyani ◽  
Supriatmo Supriatmo ◽  
Melda Deliana ◽  
Ade Rachmat Yudiyanto ◽  
Atan Baas Sinuhaji
Keyword(s):  
Placebo Group ◽  
Functional Dyspepsia ◽  
Controlled Trial ◽  
Gastrointestinal Disorder ◽  
Pain Severity ◽  
Double Blind ◽  
Definitive Evidence ◽  
Reduced Frequency ◽  
Pain Duration ◽  
Rome Iii

Background Functional dyspepsia is a common gastrointestinal disorder in school-aged children, though, there is no reliable treatment. Probiotics are live microorganisms administered in adequate amounts to confer beneficial health effects on the host. Although definitive evidence is lacking, several studies have found probiotics to be effective for relieving symptoms of dyspepsia, particularly abdominal pain and bloating.Objective To determine the efficacy of lactobacillus probiotics for treating functional dyspepsia in children.Method A double-blind, randomized controlled trial was done from April to June 2012 in five schools in the Pakpak Bharat Regency, North Sumatera. A total of 116 children who fulfilled the Rome III criteria for functional dyspepsia were randomized into 2 groups to receive either lactobacillus probiotics or placebo for 2 weeks. All patients received a diary to record symptoms and frequency of pain daily. The primary outcome for treatment was defined to be no pain at the end of the intervention.Results The probiotics and placebo groups were not significantly different in recovery from functional dyspepsia (29.3% vs. 13.8%, respectively; P=0.432). However, compared to the placebo group, the probiotics group had significantly reduced frequency of pain (P=0.0001), but no significant differences in pain severity (P=0.08) or pain duration (P 0.091).Conclusion There are no significant differences in recovery from functional dyspepsia, pain severity, or pain duration between the probiotics and placebo groups. However, the probiotics group has significantly reduced frequency of pain compared to that of the placebo group.

scholarly journals Efficacy of Modified Ban Xia Xie Xin Decoction on Functional Dyspepsia of Cold and Heat in Complexity Syndrome: A Randomized Controlled Trial

2013 ◽  
Vol 2013 ◽  
pp. 1-8 ◽  
Author(s):  
Luqing Zhao ◽  
Shengsheng Zhang ◽  
Zhengfang Wang ◽  
Chuijie Wang ◽  
Suiping Huang ◽  
...  
Keyword(s):  
Functional Dyspepsia ◽  
Controlled Trial ◽  
Symptomatic Improvement ◽  
Clinical Trial Registry ◽  
Symptom Scale ◽  
Double Blind ◽  
Randomized Controlled ◽  
Chinese Herbal ◽  
Symptom Scores ◽  
Boiled Water

Background. Chinese herbal medicine (CHM) has been used in China and elsewhere to treat patients with functional dyspepsia (FD). However, controlled studies supporting the efficacy of such treatment are lacking.Objective. To assess the efficacy and safety of modified Ban xia xie xin decoction in patients with FD of cold and heat in complexity syndrome.Methods. We performed a randomized, double-blind, placebo-controlled trial involving patients from five centers. Patients with FD of cold and heat in complexity syndrome(n=101)were randomly assigned to groups given either CHM modified Ban Xia Xie Xin decoction or placebo in a 2 : 1 ratio. Herbal or placebo granules were dissolved in 300 mL of boiled water cooled to 70°C. Patients in both groups were administered 150 mL (50°C) twice daily. The trial included a 4-week treatment period and a 4-week followup period. The primary outcomes were dyspepsia symptom scores, measured by the total dyspepsia symptom scale and the single dyspepsia symptom scale at weeks 0, 1, 2, 3, 4, and 8.Results. Compared with patients in the placebo group, patients in the CHM group showed significant improvements according to the total and single dyspepsia symptom scores obtained from patients(P<0.01)and investigators(P<0.01).Conclusions. CHM modified Ban Xia Xie Xin decoction appears to offer symptomatic improvement in patients with FD of cold and heat in complexity syndrome.Trial Registration. Chinese Clinical Trial Registry (ChiCTR): ChiCTR-TRC-10001074.

scholarly journals Efficacy and Safety of the Cudrania tricuspidata Extract on Functional Dyspepsia: A Randomized Double-Blind Placebo-Controlled Multicenter Study

2021 ◽  
Vol 10 (22) ◽  
pp. 5323
Author(s):  
Jinyoung Shin ◽  
Tae-Hoon Oh ◽  
Joo-Yun Kim ◽  
Jae-Jung Shim ◽  
Jung-Lyoul Lee
Keyword(s):  
Functional Dyspepsia ◽  
Rating Scale ◽  
Gastrointestinal Symptoms ◽  
Controlled Study ◽  
Caffeine Intake ◽  
Control Group ◽  
Double Blind ◽  
Cudrania Tricuspidata ◽  
Double Blind Placebo ◽  
Folk Remedy

Cudrania tricuspidata is a folk remedy used to treat inflammation in patients with tumors or liver damage. This study investigated the efficacy of Cudrania tricuspidata extract (CTE) for relieving the symptoms of functional dyspepsia. In an 8-week, randomized, double-blind, placebo-controlled study, 100 adults with any condition featured in the Rome IV criteria and a Gastrointestinal Symptoms Scale (GIS) score ≥4 were randomly allocated to take either a placebo (maltodextrin) or a 50 mg CTE tablet, which equally included celluloses, magnesium stearate, and silicon dioxide, twice daily, 20 January 2020, and 3 August 2020. Among the 83 participants finally analyzed, the CTE group was associated with a significant reduction in the gastrointestinal symptom rating scale (day 0: 8.0 ± 5.2, day 28: 4.7 ± 3.9, and day 56: 2.3 ± 2.4, p < 0.001, respectively) in comparison with the control group (day 0: 8.1 ± 4.7, day 28: 7.8 ± 5.7, and day 56: 7.5 ± 6.6, p > 0.05) after adjusting for smoking, drinking, eating habits, stress levels, and caffeine intake. The CTE group resulted in significant improvements of GIS, Nepean Dyspepsia Index (Korean version), and functional dyspepsia-related quality of life over time. There were no different adverse events (p = 0.523). These findings suggest that CTE is safe and efficacious for alleviating gastrointestinal symptoms in patients with functional dyspepsia.

Clinical and Psychological Assessment on Xinwei Decoction for Treating Functional Dyspepsia Accompanied with Depression and Anxiety

2005 ◽  
Vol 33 (02) ◽  
pp. 249-257 ◽  
Author(s):  
Lei Zhao ◽  
Ai-Ping Gan
Keyword(s):  
Herbal Medicine ◽  
Functional Dyspepsia ◽  
Depression Scale ◽  
The Other ◽  
Hamilton Depression Scale ◽  
Depression And Anxiety ◽  
Symptom Scale ◽  
Traditional Chinese Herbal Medicine ◽  
Before And After ◽  
Hamilton Anxiety Scale

The purpose of this study is to explore the psychological efficacy of Xinwei Decoction, a traditional Chinese herbal medicine, to treat functional dyspepsia (FD) accompanied with depression and anxiety. Seventy-three subjects, divided into three groups, had been given herbal medicine (Xinwei Decoction), prokinetic agent (Domperidone) and placebo, respectively for 8 weeks. Before and after treatment, all subjects were examined with FD symptom scale, Hamilton Depression Scale (HAMD) and Hamilton Anxiety Scale (HAMA). As a result, the total scores of the three groups in FD symptom scale, HAMD and HAMA after treatment decreased in different levels, with the decrease in the herbal group more significant than the other two groups ( p <0.01), indicating the efficacy of the herbal medicine. The total effective rates of the herbal, Domperidone and placebo groups were 90%, 67% and 31%, respectively, which indicated significant effect differences between Xinwei Decoction and Domperidone ( p <0.05) and between Xinwei Decoction and placebo ( p <0.01), showing that the efficacy of herbal therapy was superior to that of the other two therapies. Furthermore, there was no one in the Domperidone and placebo groups being cured of depression and anxiety, while the curing rate in the herbal group was about 70%, indicating the efficacy of herbal medicine in comparison to that of Domperidone and placebo for anti-depression and anti-anxiety. The result demonstrated that Xinwei Decoction could not only alleviate FD symptoms but also relieve depression and anxiety.

scholarly journals Hangekobokuto (Banxia-houpo-tang), a Kampo Medicine that Treats Functional Dyspepsia

2009 ◽  
Vol 6 (3) ◽  
pp. 375-378 ◽  
Author(s):  
Tetsuro Oikawa ◽  
Go Ito ◽  
Takayuki Hoshino ◽  
Hidehiko Koyama ◽  
Toshihiko Hanawa
Keyword(s):  
Abdominal Pain ◽  
Herbal Medicine ◽  
Functional Dyspepsia ◽  
Healthy Subjects ◽  
Gastrointestinal Symptoms ◽  
Abdominal Bloating ◽  
Chinese Herbal ◽  
Therapeutic Drugs ◽  
Gas Volume ◽  
Volume Score

Although abdominal bloating is one of the most bothersome symptoms experienced by patients with functional dyspepsia (FD), therapeutic drugs to relieve abdominal bloating have not been established. We investigated the Kampo (Chinese herbal) medicine, Hangekobokuto (Banxia-houpo-tang, HKT) for patients with FD from the standpoint of bowel gas retention. The bowel gas volume calculated from a plain abdominal radiogram (gas volume score, GVS) in FD patients was significantly higher than that in healthy subjects. Two week administration of HKT in the FD patients showed a significant decrease of GVS. Furthermore, gastrointestinal symptoms, especially symptoms of abdominal pain, indigestion and constipation, all of which are closely related to abdominal bloating, improved significantly in FD patients after the administration of HKT. These results suggest that HKT improves abdominal bloating accompanied by the reduction of bowel gas in FD patients.

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