scholarly journals Hangekobokuto (Banxia-houpo-tang), a Kampo Medicine that Treats Functional Dyspepsia

2009 ◽  
Vol 6 (3) ◽  
pp. 375-378 ◽  
Author(s):  
Tetsuro Oikawa ◽  
Go Ito ◽  
Takayuki Hoshino ◽  
Hidehiko Koyama ◽  
Toshihiko Hanawa
Keyword(s):  
Abdominal Pain ◽  
Herbal Medicine ◽  
Functional Dyspepsia ◽  
Healthy Subjects ◽  
Gastrointestinal Symptoms ◽  
Abdominal Bloating ◽  
Chinese Herbal ◽  
Therapeutic Drugs ◽  
Gas Volume ◽  
Volume Score

Although abdominal bloating is one of the most bothersome symptoms experienced by patients with functional dyspepsia (FD), therapeutic drugs to relieve abdominal bloating have not been established. We investigated the Kampo (Chinese herbal) medicine, Hangekobokuto (Banxia-houpo-tang, HKT) for patients with FD from the standpoint of bowel gas retention. The bowel gas volume calculated from a plain abdominal radiogram (gas volume score, GVS) in FD patients was significantly higher than that in healthy subjects. Two week administration of HKT in the FD patients showed a significant decrease of GVS. Furthermore, gastrointestinal symptoms, especially symptoms of abdominal pain, indigestion and constipation, all of which are closely related to abdominal bloating, improved significantly in FD patients after the administration of HKT. These results suggest that HKT improves abdominal bloating accompanied by the reduction of bowel gas in FD patients.

scholarly journals An Herbal Medicine, Yukgunja-Tang is more Effective in a Type of Functional Dyspepsia Categorized by Facial Shape Diagnosis: A Placebo-Controlled, Double-Blind, Randomized Trial

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Seok-Jae Ko ◽  
Jae-Woo Park ◽  
Jae-hyung Lee ◽  
Jung-eun Lee ◽  
Na-yeon Ha ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Functional Dyspepsia ◽  
Three Dimensional ◽  
Gastrointestinal Symptoms ◽  
Diagnostic System ◽  
Gastrointestinal Disorder ◽  
Symptom Scale ◽  
Double Blind ◽  
Facial Shape ◽  
Superior Effect

Introduction. Functional dyspepsia (FD) is a functional gastrointestinal disorder characterized by persistent upper dyspeptic symptoms without organic lesions. There is no standard therapy for FD. Yukgunja-tang (YGJT) is an herbal medicine used for treating upper gastrointestinal symptoms in Asia. Studies on the effect of YGJT on FD have been conducted. However, the results were inconsistent. In Hyungsang medicine, traditional Korean medicine, FD patients are classified into bladder body (BB) or gallbladder body (GB) subtypes by the shape and angle of their faces. Each subtype may have different characteristics, physiology, and pathology of the same disease. YGJT is more effective for patients with BB subtype. The three-dimensional facial shape diagnostic system (3-FSDS) was shown to be effective in diagnosing BB or GB subtypes. This study aimed to investigate the effect of YGJT on FD patients classified using the 3-FSDS. Materials and Methods. The current study was a placebo-controlled, double-blinded, randomized, two-center trial. Eligible patients were diagnosed with either BB or GB FD subtype using the 3-FSDS. Ninety-six participants (48 BB and 48 GB subtypes) were randomly allocated to treatment or control groups in a 2:1 ratio. YGJT or placebo was administered for eight weeks. The primary outcome was assessed using the total dyspepsia symptom scale (TDS), while the secondary outcomes were assessed using the single dyspepsia symptom scale (SDS), proportion of responders, visual analog scale, Nepean dyspepsia index, functional dyspepsia-related quality of life, and spleen qi deficiency questionnaire. Results and Discussion. The result of TDS showed the superior effect of YGJT on BB over GB subtype. The subgroup analysis of TDS and SDS scores showed the superior effect of YGJT over placebo. Other outcome variables did not show any significant differences between groups. Conclusion. YGJT may be considered for FD patients diagnosed with BB subtype using 3-FSDS.

scholarly journals Chinese Herbal Medicine for Functional Abdominal Pain Syndrome: From Clinical Findings to Basic Understandings

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Tao Liu ◽  
Ning Wang ◽  
Li Zhang ◽  
Linda Zhong
Keyword(s):  
Abdominal Pain ◽  
Chinese Medicine ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Functional Gastrointestinal Disorders ◽  
Pain Syndrome ◽  
Solid Base ◽  
Functional Abdominal Pain ◽  
Chinese Herbal ◽  
Functional Abdominal Pain Syndrome

Functional abdominal pain syndrome (FAPS) is one of the less common functional gastrointestinal disorders. Conventional therapy has unsatisfactory response to it so people turn to Chinese medicine for help. Currently, we reviewed the whole picture of Chinese herbal medicine (CHM) clinical and basic application in the treatment of FAPS, especially the traditional Chinese medicine (TCM) syndrome, the single herb, and Chinese medicine formulae, thus to provide a solid base to further develop evidence-based study for this common gastrointestinal complaint in the future. We developed the search strategy and set the inclusion and exclusion criteria for article search. From the included articles, we totally retrieved 586 records according to our searching criteria, of which 16 were duplicate records and 291 were excluded for reasons of irrelevance. The full text of 279 articles was retrieved for detailed assessment, of which 123 were excluded for various reasons. The number one used single herb is Radix Ginseng. The most common syndrome wasliver qi depression. The most frequently used classic formula was Si-Mo-Tang. This reflected the true situation of clinical practice of Chinese medicine practitioners and could be further systematically synthesized as key points of the therapeutic research for FAPS.

scholarly journals IDDF2021-ABS-0052 Chinese herbal medicine for functional dyspepsia: network meta-analysis of placebo-controlled randomised trials

2021 ◽  
Author(s):  
Leonard Ho ◽  
Claire Chenwen Zhong ◽  
Charlene Hoi Lam Wong ◽  
Justin Che Yuen Wu ◽  
Karina Kar-Han Chan ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Functional Dyspepsia ◽  
Chinese Herbal Medicine ◽  
Meta Analysis ◽  
Randomised Trials ◽  
Chinese Herbal

scholarly journals Chinese herbal medicine for functional dyspepsia: systematic review of systematic reviews

2019 ◽  
Vol 6 ◽  
pp. S69
Author(s):  
Vincent Chi Ho Chung ◽  
Michael H.K. Chu ◽  
Irene Xin Yin Wu ◽  
Robin Sze Tak Ho ◽  
Charlene Hoi Lam Wong ◽  
...  
Keyword(s):  
Systematic Review ◽  
Herbal Medicine ◽  
Functional Dyspepsia ◽  
Systematic Reviews ◽  
Chinese Herbal Medicine ◽  
Chinese Herbal

scholarly journals Chinese Herbal Medicine for Irritable Bowel Syndrome: A Meta-Analysis and Trial Sequential Analysis of Randomized Controlled Trials

2021 ◽  
Vol 12 ◽  
Author(s):  
Hui Zheng ◽  
Song Jin ◽  
Yin-Li Shen ◽  
Wen-Yan Peng ◽  
Kun Ye ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Abdominal Pain ◽  
Herbal Medicine ◽  
Sequential Analysis ◽  
Primary Outcome ◽  
Meta Analysis ◽  
Trial Sequential Analysis ◽  
Controlled Trials ◽  
Chinese Herbal ◽  
Irritable Bowel

Purpose: Chinese herbal medicine (CHM) is an important complementary and alternative therapy for the management of irritable bowel syndrome (IBS). Previous meta-analyses suggested that CHM is effective for IBS; nonetheless, its effectiveness is inconclusive owing to repeated significance testing. We aimed to examine the efficacy and safety of CHM for IBS through a meta-analysis and trial sequential analysis (TSA).Methods: We searched OVID Medline, Embase, Cochrane Central Register of Controlled Trials, and Web of Science from January 1, 1980, to September 20, 2020. The primary outcome was adequate relief of global IBS symptoms. The secondary outcomes included relief of abdominal pain and treatment-related adverse events. The relative ratio (RR) and required information size (RIS) were calculated for each outcome.Results: Ten trials recruiting 2,501 participants were included. Seven (70%) trials were at low risk of bias (RoB). Compared with placebo, CHM was associated with a significantly higher proportion of adequate relief of global IBS symptoms [RR 1.76 (95% confidence interval (95%CI), 1.33–2.33); I2 = 81.1%; p < 0.001]. The RIS was 1,083 for the primary outcome, and the accrued information size was 1,716. The analysis of the relief of abdominal pain (three trials with 916 participants) showed similar results compared with placebo [RR 1.85 (95%CI, 1.59–2.14); I2 = 0%; p < 0.001; RIS = 197 participants]. CHM was associated with a higher proportion of adverse events compared with placebo [RR 1.51 (95%CI, 1.14–2); I2 = 0%; p = 0.004].Conclusion: CHM was effective in relieving IBS symptoms but caused a higher adverse event rate than placebo. TSA analysis confirmed the findings with sufficient information size.

scholarly journals Chinese herbal medicine for postpartum constipation: a protocol of systematic review and meta-analysis

BMJ Open ◽  
2019 ◽  
Vol 9 (1) ◽  
pp. e023941 ◽  
Author(s):  
Jingbo Zhai ◽  
Yan Li ◽  
Jingyi Lin ◽  
Shuo Dong ◽  
Jinhua Si ◽  
...  
Keyword(s):  
Systematic Review ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Meta Analysis ◽  
Random Effect Model ◽  
Gastrointestinal Symptoms ◽  
Publication Date ◽  
Cochrane Central Register ◽  
Chinese Herbal ◽  
Effect Model

IntroductionConstipation is one of the most common gastrointestinal symptoms in postpartum mothers. The choice of treatments for postpartum constipation remains a challenging clinical problem. Chinese herbal medicine has become increasingly popular as an alternative therapy for constipation. This systematic review aims to evaluate the efficacy and safety of Chinese herbal medicine for postpartum constipation.Methods and analysisWe will search PubMed (1946 to present), EMBASE (1974 to present), Cochrane Central Register of Controlled Trials (all years), Web of Science (1900 to present), Chinese Biomedical Literatures Database (1978 to present), China National Knowledge Infrastructure (1979 to present) and WANFANG data (1998 to present) to identify any eligible study. No restriction will be put on the language, publication date or status of the study. The primary outcome will be the spontaneous bowel movement. Secondary outcomes will be stool consistency, quality of life, transit time, relief of constipation symptoms and adverse events. We will perform the meta-analysis when more than one trial examines the same intervention and outcomes with comparable methods in similar populations. If the heterogeneity is not significant statistically (p>0.10 or I2<50%), the fixed-effect model will be built to estimate the overall intervention effects. Otherwise, the random-effect model will be used to provide more conservative results.Ethics and disseminationNo ethical issues are foreseen because no primary data will be collected. The results will be published in a peer-reviewed scientific journal.PROSPERO registration numberCRD42018093741

scholarly journals Chinese herbal medicine for functional dyspepsia: systematic review of systematic reviews

2018 ◽  
Vol 11 ◽  
pp. 175628481878557 ◽  
Author(s):  
Michael H. K. Chu ◽  
Irene X. Y. Wu ◽  
Robin S. T. Ho ◽  
Charlene H. L. Wong ◽  
Anthony L. Zhang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Herbal Medicine ◽  
Functional Dyspepsia ◽  
Proton Pump Inhibitors ◽  
Proton Pump ◽  
Chinese Herbal Medicine ◽  
Meta Analysis ◽  
Chinese Herbal ◽  
Dyspeptic Symptoms ◽  
Meta Analyses

Background: Pharmacotherapy, including prokinetics and proton pump inhibitors for functional dyspepsia (FD) have limited effectiveness, and their safety has been recently questioned. Chinese herbal medicine (CHM) could be considered as an alternative. A systematic review (SR) of SRs was performed to evaluate the potential effectiveness and safety of CHM. Method: We conducted a comprehensive literature search for SRs with meta-analyses in eight international and Chinese databases. Pooled effect estimation from each meta-analysis was extracted. The AMSTAR instrument was used to assess the methodological quality of the included SRs. Results: A total of 14 SRs of mediocre quality assessing various CHMs, alone or in combination with conventional pharmacotherapy, were included. Meta-analyses showed that CHM was more effective than prokinetic agents for the alleviation of global dyspeptic symptoms. Three specific CHM formulae appeared to show superior results in the alleviation of global dyspeptic symptoms, including Si Ni San, modified Xiao Yao San and Xiang Sha Liu Jun Zi decoction. No significant difference in the occurrence of adverse events in using CHM or pharmacotherapy was reported. Conclusion: CHM can be considered as an alternative for the treatment of FD symptoms when prokinetic agents and proton pump inhibitors are contraindicated. Future trial design should focus on measuring changes in individual dyspeptic symptoms and differentiate the effectiveness of different CHM for postprandial distress syndrome and epigastric pain syndrome. A network meta-analysis approach should be used to explore the most promising CHM formula for FD treatment in the future.

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