scholarly journals Synthesis, Structure, DNA Interaction, and SOD Activity of Three Nickel(II) Complexes Containing L-Phenylalanine Schiff Base and 1,10-Phenanthroline

2018 ◽  
Vol 2018 ◽  
pp. 1-16 ◽  
Author(s):  
Peiran Zhao ◽  
Shanshan Zhai ◽  
Jianfang Dong ◽  
Lei Gao ◽  
Xinru Liu ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Interaction ◽  
Scavenging Activity ◽  
X Ray Diffraction ◽  
Sod Activity ◽  
X Ray ◽  
Light Reduction ◽  
Superoxide Scavenging Activity ◽  
Intercalative Mode ◽  
Ct Dna

Three hexacoordinated octahedral nickel(II) complexes, [Ni(sal-L-phe)(phen)(CH3OH)]⋅CH3OH (1), [Ni(naph-L-phe)(phen)(CH3OH)] (2), and [Ni(o-van-L-phe)(phen)(CH3OH)]⋅5CH3OH (3) (sal-L-phe = a Schiff base derived from salicylaldehyde and L-phenylalanine, naph-L-phe = a Schiff base derived from 2-hydroxy-1-naphthaldehyde and L-phenylalanine, o-van-L-phe = a Schiff base derived from o-vanillin and L-phenylalanine, and phen = 1,10-phenanthroline), have been synthesized and characterized by elemental analysis, IR spectra, and single-crystal X-ray diffraction. The interactions of these complexes with CT-DNA were studied by UV-Vis absorption spectroscopy, fluorescence spectroscopy, circular dichroism spectroscopy, and viscosity measurements. The binding constant (Kb) values of 1.82 × 104 M−1 for 1, 1.96 × 104 M−1 for 2, and 2.02 × 104 M−1 for 3 suggest that each of these complexes could bind with DNA in a moderate intercalative mode. Complex 3 exhibited a stronger interaction with CT-DNA than complexes 1 and 2. In addition, the superoxide scavenging activity of these complexes was investigated by the nitrotetrazolium blue chloride (NBT) light reduction method, and the results showed that they exhibited a significant superoxide scavenging activity with the IC50 values of 4.4 × 10−5 M for complex 1, 5.6 × 10−5 M for complex 2, and 3.1 × 10−5 M for complex 3, respectively.

New Copper Compounds with Antiplatelet Aggregation Activity

2019 ◽  
Vol 15 (8) ◽  
pp. 850-862
Author(s):  
Mirthala Flores-García ◽  
Juan Manuel Fernández-G. ◽  
Cristina Busqueta-Griera ◽  
Elizabeth Gómez ◽  
Simón Hernández-Ortega ◽  
...  
Keyword(s):  
Schiff Base ◽  
Solid State ◽  
Thrombotic Event ◽  
X Ray Diffraction ◽  
Nmr Studies ◽  
Schiff Base Ligands ◽  
X Ray ◽  
Antiplatelet Aggregation ◽  
Aggregation Activity ◽  
L1 And L2

Background: Ischemic heart disease, cerebrovascular accident, and venous thromboembolism have the presence of a thrombotic event in common and represent the most common causes of death within the population. Objective: Since Schiff base copper(II) complexes are able to interact with polyphosphates (PolyP), a procoagulant and potentially prothrombotic platelet agent, we investigated the antiplatelet aggregating properties of two novel tridentate Schiff base ligands and their corresponding copper( II) complexes. Methods: The Schiff base ligands (L1) and (L2), as well as their corresponding copper(II) complexes (C1) and (C2), were synthesized and characterized by chemical analysis, X-ray diffraction, mass spectrometry, and UV-Visible, IR and far IR spectroscopy. In addition, EPR studies were carried out for (C1) and (C2), while (L1) and (L2) were further analyzed by 1H and 13C NMR. Tests for antiplatelet aggregation activities of all of the four compounds were conducted. Results: X-ray diffraction studies show that (L1) and (L2) exist in the enol-imine tautomeric form with a strong intramolecular hydrogen bond. NMR studies show that both ligands are found as enol-imine tautomers in CDCl3 solution. In the solid state, the geometry around the copper(II) ion in both (C1) and (C2) is square planar. EPR spectra suggest that the geometry of the complexes is similar to that observed in the solid state by X-ray crystallography. Compound (C2) exhibited the strongest antiplatelet aggregation activity. Conclusion: Schiff base copper(II) complexes, which are attracting increasing interest, could represent a new approach to treat thrombosis by blocking the activity of PolyP with a potential anticoagulant activity and, most importantly, demonstrating no adverse bleeding events.

Synthesis of an Unprecedented H-stitched Binuclear Crystal Structure Based on Selective Fluorescence Recognition of Zn2+ in Newly Synthesized Schiff Base Ligand with DFT and Imaging Application in Living Cells

2021 ◽  
Author(s):  
SOUMYA SUNDAR MATI ◽  
Dr. SAUGATA KONAR ◽  
BOBY SAMAI
Keyword(s):  
Crystal Structure ◽  
Schiff Base ◽  
Elemental Analysis ◽  
Schiff Base Ligand ◽  
Binuclear Complex ◽  
Living Cells ◽  
X Ray Diffraction ◽  
Schiff Base Ligands ◽  
X Ray ◽  
Imaging Application

A zinc coordinated rare binuclear complex was synthesised and characterized by elemental analysis and single-crystal X-ray diffraction. Two mononuclear units formed by two Schiff base ligands 2-((2-(pyrimidin-2-yl)hydrazono)methyl)phenol (PHP) coordinated with...

Cyclometalated Pt(ii) complexes with a bidentate Schiff-base ligand displaying unexpected cis/trans isomerism: synthesis, structures and electronic properties

2017 ◽  
Vol 46 (37) ◽  
pp. 12500-12506 ◽  
Author(s):  
A. Poma ◽  
A. Forni ◽  
C. Baldoli ◽  
P. R. Mussini ◽  
A. Bossi
Keyword(s):  
Schiff Base ◽  
Electronic Properties ◽  
Computational Methods ◽  
Schiff Base Ligand ◽  
X Ray Diffraction ◽  
X Ray ◽  
Bidentate Schiff Base Ligand

Unexpected cis/trans isomerism in a bis-cyclometalated Pt(ii) complex is investigated by NMR, X-ray diffraction, optical, electrochemical and computational methods and rationalized.

Syntheses and crystal structures of guanidine hydrochlorides with two Schiff base functions as efficient colorimetric and selective sensors for fluoride

2018 ◽  
Vol 73 (8) ◽  
pp. 601-609 ◽  
Author(s):  
Bei Wang ◽  
Pei-Zhi Zhang ◽  
Xin Chen ◽  
Ai-Quan Jia ◽  
Qian-Feng Zhang
Keyword(s):  
Optical Properties ◽  
Schiff Base ◽  
Molecular Structures ◽  
X Ray Diffraction ◽  
Guanidinium Chloride ◽  
Visible Absorption ◽  
X Ray ◽  
Color Changes ◽  
Base Functions ◽  
Magnetic Resonances

AbstractA series of guanidinium chloride derivatives have been synthesized by condensation of 1,3-diaminoguanidine monohydrochloride with heteroaromatic formaldehydes in good yields. All compounds were characterized by nuclear magnetic resonances and infrared spectroscopies, and the molecular structures of four compounds were determined by single crystal X-ray diffraction. The optical properties of these guanidinium chloride derivatives with fluoride anions were investigated, showing selective color changes from colorless to yellow or orange, red-shifted in the ultraviolet/visible absorption spectra.

scholarly journals Synthesis and structural peculiarities of gallium Complexes with novel paullone derivatives

2008 ◽  
Vol 6 (3) ◽  
pp. 340-346 ◽  
Author(s):  
Werner Ginzinger ◽  
Vladimir Arion ◽  
Gerald Giester ◽  
Markus Galanski ◽  
Bernhard Keppler
Keyword(s):  
Schiff Base ◽  
Tridentate Ligand ◽  
X Ray Diffraction ◽  
X Ray ◽  
Gallium Chloride ◽  
Structural Peculiarities ◽  
Gallium Complex ◽  
Gallium Complexes

Abstract9-Bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6-ylhydrazine was reacted with 2-acetylpyridine to give a Schiff base as a potential tridentate ligand. The reaction of this ligand with gallium chloride afforded complexes of 1:1 and 2:1 stoichiometry. The results of X-ray diffraction studies of the ligand and both gallium complexes are reported and compared with the data for a related gallium complex with a Schiff base obtained from 9-bromo-7,12-dihydroindolo[3,2-d][1]benzazepin-6-ylhydrazine and 2-hydroxybenzaldehyde.

Synthesis, Characterization and X-Ray Crystal Structure of the New Schiff Base and Anticandidal Evaluation

2019 ◽  
Vol 41 (6) ◽  
pp. 1090-1090
Author(s):  
Mehmet Poyraz Mehmet Poyraz ◽  
Musa Sari Musa Sari ◽  
Halil Berber Halil Berber ◽  
Nursenem Karaca and Fatih Demirci Nursenem Karaca and Fatih Demirci
Keyword(s):  
Schiff Base ◽  
Spectroscopic Techniques ◽  
X Ray Diffraction ◽  
X Ray ◽  
Microdilution Method ◽  
Broth Microdilution Method ◽  
Ft Ir ◽  
Anticandidal Activity ◽  
Crystal Structural

A new Schiff base, namely 2-methoxy-6-((2-(4 nitrophenyl) hydrazineylidene) methyl)phenol was synthesized and characterized by melting points, elemental analysis, thermogravimetric analysis and spectroscopic techniques (FT-IR, 1H-NMR and UV-VIS spectra). The chemical structure of compound was further confirmed by single crystal structural X-ray diffraction. The Schiff base is crystallized in the triclinic space group P-1. In the crystal, molecules are linked by O-H…O hydrogen bonds between the hydroxy “-O-” atom and the methoxy “-O-” atom. Furthermore, the synthesized Schiff base was tested for the in vitro anticandidal activities using CLSI broth microdilution method against human pathogenic Candida albicans, C. parapsilosis and C. krusei standard strains. In the anticandidal activity test results, the new Schiff base was found to be effective at 1 mg/mL - 0.25 mg/mL concentrations. (The last line omitted) (The sentence marked in red will be deleted)

scholarly journals Tetranuclear Cu(ii)-chiral complexes: synthesis, characterization and biological activity

RSC Advances ◽  
2019 ◽  
Vol 9 (42) ◽  
pp. 24087-24091 ◽  
Author(s):  
Krisana Peewasan ◽  
Marcel P. Merkel ◽  
Kristof Zarschler ◽  
Holger Stephan ◽  
Christopher E. Anson ◽  
...  
Keyword(s):  
Biological Activity ◽  
Schiff Base ◽  
Single Crystal ◽  
Cd Spectroscopy ◽  
Schiff Base Complexes ◽  
X Ray Diffraction ◽  
Chiral Complexes ◽  
Enantiomerically Pure ◽  
X Ray

A pair of tetranuclear chiral Cu(ii)-Schiff-base complexes were synthesized using enantiomerically pure (S)-H2L and (R)-H2L ligands. These were characterised using single-crystal X-ray diffraction and CD spectroscopy and their biological activity tested.

scholarly journals Aroylhydrazone Schiff Base Derived Cu(II) and V(V) Complexes: Efficient Catalysts towards Neat Microwave-Assisted Oxidation of Alcohols

2020 ◽  
Vol 21 (8) ◽  
pp. 2832
Author(s):  
Manas Sutradhar ◽  
Tannistha Roy Barman ◽  
Armando J. L. Pombeiro ◽  
Luísa M. D. R. S. Martins
Keyword(s):  
Schiff Base ◽  
Aliphatic Alcohol ◽  
Cinnamyl Alcohol ◽  
X Ray Diffraction ◽  
Reaction Conditions ◽  
Benzyl Alcohols ◽  
X Ray ◽  
Microwave Assisted ◽  
Tert Butyl Hydroperoxide ◽  
Oxidation Of Alcohols

A new hexa-nuclear Cu(II) complex [Cu3(μ2-1κNO2,2κNO2-L)(μ-Cl)2(Cl)(MeOH)(DMF)2]2 (1), where H4L = N′1,N′2-bis(2-hydroxybenzylidene)oxalohydrazide, was synthesized and fully characterized by IR spectroscopy, ESI-MS, elemental analysis, and single crystal X-ray diffraction. Complex 1 and the dinuclear oxidovanadium(V) one [{VO(OEt)(EtOH)}2(1κNO2,2κNO2-L)]·2H2O (2) were used as catalyst precursors for the neat oxidation of primary (cinnamyl alcohol) and secondary (1-phenyl ethanol, benzhydrol) benzyl alcohols and of the secondary aliphatic alcohol cyclohexanol, under microwave irradiation using tert-butyl hydroperoxide (TBHP) as oxidant. Oxidations proceed via radical mechanisms. The copper(II) compound 1 exhibited higher catalytic activity than the vanadium(V) complex 2 for all the tested alcohol substrates. The highest conversion was found for 1-phenylethanol, yielding 95.3% of acetophenone in the presence of 1 and in solvent and promoter-free conditions. This new Cu(II) complex was found to exhibit higher activity under milder reaction conditions than the reported aroylhydrazone Cu(II) analogues.

Syntheses, Structures, Thermal and Photoluminescence Properties of Two Zn(II) and Cd(II) Coordination Polymers Constructed from Taurine-derived Schiff Base and 4,4’-Bipyridine Ligands

2012 ◽  
Vol 67 (8) ◽  
pp. 774-782 ◽  
Author(s):  
Wei-Ting Guo ◽  
Zhi-Min Miao ◽  
Yun-Long Wang
Keyword(s):  
Schiff Base ◽  
Coordination Polymers ◽  
Tridentate Ligand ◽  
Supramolecular Architecture ◽  
Photoluminescence Properties ◽  
X Ray Diffraction ◽  
Monodentate Ligand ◽  
Metal Centers ◽  
X Ray ◽  
Ethanesulfonic Acid

Two chain-like coordination polymers, namely, {[Zn(saes)(4,4'-bipy)(H2O)]·H2O}n (1) and {[Cd (Hsaes)2(4,4'-bipy)(H2O)2]·2H2O}n (2), where H2saes=2-(2-hydroxybenzylideneamino)ethanesulfonic acid and 4,4'-bipy=4,4'-bipyridine, have been synthesized and characterized by singlecrystal X-ray diffraction, IR spectroscopy, elemental, thermogravimetric and photoluminescence analysis. X-Ray diffraction analyses indicate that 1and 2display octahedral metal centers with N3O3 and N2O4 donor sets, respectively. The Schiff base serves as a common N,O'-tridentate ligand in 1, and as a unique O-monodentate ligand in 2. In the crystal, both 1and 2form a 3D supramolecular architecture by O-H···O, C-H···O interactions or π···π stacking. The thermal and solid-state photoluminescence properties of both complexes have been investigated

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