scholarly journals Mannose-Binding Lectin Gene Polymorphism and Its Association with Susceptibility to Recurrent Vulvovaginal Candidiasis

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Noha M. Hammad ◽  
Nissreen E. El Badawy ◽  
Ashraf M. Nasr ◽  
Hamed A. Ghramh ◽  
Laila M. Al Kady
Keyword(s):  
Serum Level ◽  
Immune Defense ◽  
Vulvovaginal Candidiasis ◽  
Mannose Binding Lectin ◽  
Variant Allele ◽  
Recurrent Vulvovaginal Candidiasis ◽  
Mannose Binding ◽  
Exon 1 ◽  
Childbearing Women ◽  
Binding Lectin

Recurrent vulvovaginal candidiasis (RVVC) is a common illness influencing childbearing women worldwide. Most women suffering from RVVC develop infection without specified risk factors. Mannose-binding lectin (MBL) is an important component of innate immune defense against Candida infection. Innate immunity gene mutations and polymorphisms have been suggested to play a role in susceptibility to RVVC. This study aimed to investigate the association between MBL 2 gene exon 1 codon 54 polymorphism and susceptibility to RVVC in childbearing women. Whole blood and serum samples were obtained from 59 RVVC cases and 59 controls. MBL serum level was measured by enzyme-linked immune-sorbent assay (ELISA). MBL2 exon 1 codon 54 polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). It was shown that MBL serum level was nonsignificantly different between RVVC cases and controls. The risk of RVVC was 3 times higher in those carrying MBL2 exon 1 codon 54 variant allele (B). It could be concluded that the carrying of MBL2 exon 1 codon 54 variant allele (B) was shown to be a risk factor for RVVC in childbearing women.

Is mannose-binding lectin serum concentration a reliable predictor for recurrent vulvovaginal candidiasis?

Mycoses ◽  
2018 ◽  
Vol 62 (2) ◽  
pp. 106-111 ◽  
Author(s):  
Mona Ghazanfari ◽  
Mehraban Falahati ◽  
Azam Fattahi ◽  
Fatemeh Bazrafshan ◽  
Sanam Nami ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Vulvovaginal Candidiasis ◽  
Mannose Binding Lectin ◽  
Recurrent Vulvovaginal Candidiasis ◽  
Reliable Predictor ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Association of the polymorphism Exon 1 (A/O) region of the mannose-binding lectin gene and periportal fibrosis regression in schistosomiasis after specific treatment

2021 ◽  
Vol 54 ◽  
Author(s):  
Saulo Gomes de Oliveira ◽  
Ilana Brito Ferraz de Souza ◽  
Taynan da Silva Constantino ◽  
Paula Carolina Valença Silva ◽  
Elker Lene Santos de Lima ◽  
...  
Keyword(s):  
Specific Treatment ◽  
Mannose Binding Lectin ◽  
Lectin Gene ◽  
Periportal Fibrosis ◽  
Mannose Binding ◽  
Exon 1 ◽  
Fibrosis Regression ◽  
Binding Lectin

Evaluation of mannose-binding lectin serum level in prediction of neonatal sepsis

2015 ◽  
Vol 32 (2) ◽  
pp. 126
Author(s):  
IbrahimM Mohamed ◽  
El-SayedA Amer ◽  
OssamaS El-Shaer
Keyword(s):  
Serum Level ◽  
Neonatal Sepsis ◽  
Mannose Binding Lectin ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Genetic association between mannose-binding lectin polymorphisms and viral hepatitis: a meta-analysis

2019 ◽  
Vol 77 (7) ◽  
Author(s):  
Chunhua Qie ◽  
Yamin Liu ◽  
Ping Ma ◽  
Hongzhang Wu
Keyword(s):  
Viral Hepatitis ◽  
Genetic Association ◽  
Association Studies ◽  
Meta Analysis ◽  
Mannose Binding Lectin ◽  
Dominant Model ◽  
Subgroup Analyses ◽  
Mannose Binding ◽  
Exon 1 ◽  
Binding Lectin

ABSTRACT Some previous genetic association studies have tried to investigate potential associations between mannose-binding lectin (MBL) polymorphisms and viral hepatitis. However, the results of those studies were not consistent. Therefore, we performed the current meta-analysis to explore associations between MBL polymorphisms and viral hepatitis in a large pooled population. A systematic literature research of PubMed, Web of Science, Embase and CNKI was performed to identify eligible studies for pooled analyses. We used Review Manager version 5.3.3 to conduct statistical analyses. In total, 27 studies were included for analysis (4840 cases and 5729 controls). The pooled analyses showed that MBL promoter (-211C/G, dominant model: P = 0.0002, I2 = 40%; over-dominant model: P = 0.0001, I2 = 22%) and exon 1 (codon 52, 54 and 57, dominant model: P = 0.04, I2 = 49%; allele model: P = 0.01, I2 = 48%) polymorphisms were both significantly associated with viral hepatitis in the overall population. Further subgroup analyses revealed similarly significant findings for MBL promoter polymorphism in HBV and HCV, but no positive results were detected in subgroup analyses for MBL exon 1 polymorphism. These results suggested that MBL promoter and exon 1 polymorphisms could be used to identify individuals at higher susceptibility to HBV and HCV.

Sign in / Sign up

Export Citation Format

Share Document