Is mannose-binding lectin serum concentration a reliable predictor for recurrent vulvovaginal candidiasis?

Mycoses ◽  
2018 ◽  
Vol 62 (2) ◽  
pp. 106-111 ◽  
Author(s):  
Mona Ghazanfari ◽  
Mehraban Falahati ◽  
Azam Fattahi ◽  
Fatemeh Bazrafshan ◽  
Sanam Nami ◽  
...  
Keyword(s):  
Serum Concentration ◽  
Vulvovaginal Candidiasis ◽  
Mannose Binding Lectin ◽  
Recurrent Vulvovaginal Candidiasis ◽  
Reliable Predictor ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Mannose-Binding Lectin Gene Polymorphism and Its Association with Susceptibility to Recurrent Vulvovaginal Candidiasis

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Noha M. Hammad ◽  
Nissreen E. El Badawy ◽  
Ashraf M. Nasr ◽  
Hamed A. Ghramh ◽  
Laila M. Al Kady
Keyword(s):  
Serum Level ◽  
Immune Defense ◽  
Vulvovaginal Candidiasis ◽  
Mannose Binding Lectin ◽  
Variant Allele ◽  
Recurrent Vulvovaginal Candidiasis ◽  
Mannose Binding ◽  
Exon 1 ◽  
Childbearing Women ◽  
Binding Lectin

Recurrent vulvovaginal candidiasis (RVVC) is a common illness influencing childbearing women worldwide. Most women suffering from RVVC develop infection without specified risk factors. Mannose-binding lectin (MBL) is an important component of innate immune defense against Candida infection. Innate immunity gene mutations and polymorphisms have been suggested to play a role in susceptibility to RVVC. This study aimed to investigate the association between MBL 2 gene exon 1 codon 54 polymorphism and susceptibility to RVVC in childbearing women. Whole blood and serum samples were obtained from 59 RVVC cases and 59 controls. MBL serum level was measured by enzyme-linked immune-sorbent assay (ELISA). MBL2 exon 1 codon 54 polymorphism was determined by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). It was shown that MBL serum level was nonsignificantly different between RVVC cases and controls. The risk of RVVC was 3 times higher in those carrying MBL2 exon 1 codon 54 variant allele (B). It could be concluded that the carrying of MBL2 exon 1 codon 54 variant allele (B) was shown to be a risk factor for RVVC in childbearing women.

scholarly journals Prospective, case-controlled study evaluating serum concentration of sirtuin-1 and mannose-binding lectin in patients with and without periodontal and coronary artery disease

2020 ◽  
Vol 11 ◽  
pp. 204062232091962
Author(s):  
Pérola Michelle Vasconcelos Caribé ◽  
Cristina Cunha Villar ◽  
Guiseppe Alexandre Romito ◽  
Júlio Yoshio Takada ◽  
Ana Paula Pacanaro ◽  
...  
Keyword(s):  
Coronary Artery Disease ◽  
Coronary Artery ◽  
Serum Concentration ◽  
Mannose Binding Lectin ◽  
Sirtuin 1 ◽  
Controlled Study ◽  
Enzyme Linked Immunosorbent Assay ◽  
Mannose Binding ◽  
Artery Disease ◽  
Binding Lectin

Background: Atherosclerosis and periodontal disease (PD) are inflammatory diseases that have been shown in studies to have a direct association. Mannose-binding lectin (MBL) is an immune system protein that binds to periodontal pathogens favoring phagocytosis. Conversely, increased serum sirtuin-1 (SIRT1) concentration reduces the inflammatory process. Methods: This was a prospective, case-controlled study that analyzed serum concentration of biomarkers in patients with or without coronary artery disease (CAD) and PD. A total of 78 patients were evaluated: 20 healthy individuals, 18 patients with CAD, 20 patients with PD, and 20 patients with both PD and CAD. Clinical and laboratory characteristics were analyzed before and after nonsurgical treatment of PD and also at two equivalent times in patients without PD. Serum MBL and SIRT1 concentration were analyzed by enzyme-linked immunosorbent assay. Results: A negative correlation was observed between changes in serum concentration of MBL and SIRT1 ( r = −0.30; p = 0.006). Comparison between pre- and post-treatment of PD showed a reduction in MBL levels (886.27 ± 906.72 versus 689.94 ± 808.36; p = 0.002) and an increase in SIRT1 values (0.80 ± 1.01 versus 1.49 ± 1.55; p = 0.005) in patients with PD and without CAD. The same result was observed in patients with PD and CAD for MBL and SIRT1, respectively, of 1312.43 ± 898.21 versus 1032.90 ± 602.52 ( p = 0.010) and 1.32 ± 1.0 versus 1.82 ± 1.75 ( p = 0.044). Conclusion: PD treatment reduced MBL serum concentration and increased SIRT1 serum concentration in patients with and without CAD.

Mannose-Binding Lectin Gene Polymorphism, Vulvovaginal Candidiasis, and Bacterial Vaginosis

2007 ◽  
Vol 109 (5) ◽  
pp. 1123-1128 ◽  
Author(s):  
Paulo C. Giraldo ◽  
Oksana Babula ◽  
Ana Katherine S. Gonçalves ◽  
Iara M. Linhares ◽  
Rose Luce Amaral ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Bacterial Vaginosis ◽  
Vulvovaginal Candidiasis ◽  
Mannose Binding Lectin ◽  
Lectin Gene ◽  
Mannose Binding ◽  
Binding Lectin

scholarly journals Mannose-Binding Lectin Codon 54 Gene Polymorphism and Vulvovaginal Candidiasis: A Systematic Review and Meta-Analysis

2014 ◽  
Vol 2014 ◽  
pp. 1-7 ◽  
Author(s):  
Bojan Nedovic ◽  
Brunella Posteraro ◽  
Emanuele Leoncini ◽  
Alberto Ruggeri ◽  
Rosarita Amore ◽  
...  
Keyword(s):  
Systematic Review ◽  
Web Of Science ◽  
Meta Analysis ◽  
Vulvovaginal Candidiasis ◽  
Mannose Binding Lectin ◽  
Innate Immune ◽  
Host Susceptibility ◽  
Wild Type ◽  
Mannose Binding ◽  
Binding Lectin

Mannose-binding lectin (MBL) plays a key role in the human innate immune response. It has been shown that polymorphisms in theMBL2gene, particularly at codon 54 (variant alleleB; wild-type allele designated asA), impact upon host susceptibility toCandidainfection. This systematic review and meta-analysis were performed to assess the association betweenMBL2codon 54 genotype and vulvovaginal candidiasis (VVC) or recurrent VVC (RVVC). Studies were searched in MEDLINE, SCOPUS, and ISI Web of Science until April 2013. Five studies including 704 women (386 cases and 318 controls) were part of the meta-analysis, and pooled ORs were calculated using the random effects model. For subjects with RVVC, ORs ofABversusAAand ofBBversusAAwere 4.84 (95% CI 2.10–11.15;Pfor heterogeneity=0.013;I2=68.6%) and 12.68 (95% CI 3.74–42.92;Pfor heterogeneity=0.932,I2=0.0%), respectively. For subjects with VVC, OR ofABversusAAwas 2.57 (95% CI 1.29–5.12;Pfor heterogeneity=0.897;I2=0.0%). This analysis indicates that heterozygosity for theMBL2alleleBincreases significantly the risk for both diseases, suggesting that MBL may influence the women’s innate immunity in response toCandida.

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