scholarly journals Yellow Nail Syndrome with Bilateral Pleural Plaques and Diffuse Pleural Thickening: A Mimic of Asbestos Related Disease

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Adam Dallmann ◽  
Richard L. Attanoos
Keyword(s):  
Asbestos Exposure ◽  
Electron Microscopic ◽  
Yellow Nail Syndrome ◽  
Pleural Thickening ◽  
Pleural Plaques ◽  
Pulmonary Manifestations ◽  
Diffuse Pleural Thickening ◽  
Mineral Fibre ◽  
Asbestos Related Disease ◽  
Fibre Analysis

Yellow nail syndrome is a rare acquired condition of unknown aetiology associated with distinct nail discolouration/xanthonychia, pulmonary manifestations, and lymphoedema. Pleural plaques and diffuse pleural thickening are typically, although not exclusively, recognised as markers of prior commercial asbestos exposure. The presence of such biomarkers may assist an asbestos personal injury evaluation. A postmortem examination performed on a 72-year-old man with known long-standing yellow nail syndrome identified pleural plaques and diffuse pleural thickening. An evaluation of the occupational history identified no known asbestos exposure. Electron microscopic mineral fibre analysis detected no asbestos fibres. To the best of our knowledge, this is the only case of yellow nail syndrome in which these benign pleural changes are reported ex asbestos. Alternate causes for such pleural pathology were absent. There is merit in physicians and pathologists having an awareness of these new manifestations when considering claimed asbestos related changes during life and at postmortem.

Asbestosis

Chest Imaging ◽  
2019 ◽  
pp. 383-386
Author(s):  
Joseph T. Azok
Keyword(s):  
Lung Cancer ◽  
Asbestos Exposure ◽  
Chest Ct ◽  
Pleural Effusions ◽  
Pleural Thickening ◽  
Asbestos Fibers ◽  
Related Disease ◽  
Pleural Plaques ◽  
Increased Risk ◽  
Asbestos Related Disease

Asbestosis is a fibrotic pneumoconiosis resulting from the inhalation of asbestos fibers, most commonly from occupational exposure. Chest radiographs and high-resolution chest CT can detect asbestos-related disease. Pleural abnormalities include pleural plaques, pleural effusions, pleural thickening, and mesothelioma. Pleural plaques serve as a marker of asbestos exposure and are the most common imaging abnormality found in patients exposed to asbestos. Parenchymal-induced lung disease includes pulmonary fibrosis, known as asbestosis, rounded atelectasis, and lung cancer. Asbestos exposure leads to an increased risk of both lung cancer and especially mesothelioma, which is rare in the absence of asbestos exposure.

Pleural Thickening and Calcification

Chest Imaging ◽  
2019 ◽  
pp. 175-179
Author(s):  
Christopher M. Walker
Keyword(s):  
Asbestos Exposure ◽  
Malignant Degeneration ◽  
Pleural Thickening ◽  
Pleural Plaque ◽  
Imaging Appearance ◽  
Pleural Plaques ◽  
Diffuse Pleural Thickening ◽  
Costophrenic Angle ◽  
Common Manifestation ◽  
Over Time

Pleural thickening and calcification discusses the radiographic and computed tomography (CT) manifestations of benign pleural thickening and pleural calcification. Benign pleural thickening must be differentiated from malignant pleural thickening and their differentiating characteristics will be discussed. Pleural plaque is the most common manifestation of asbestos exposure and carries no risk of malignant degeneration. The most common imaging appearance is bilateral sharply demarcated, multifocal areas of discontinuous pleural thickening that often calcifies over time. Pleural plaques spare the apical and costophrenic sulcus pleura and has a predilection for the diaphragmatic pleura. Diffuse pleural thickening is associated with hemothorax, empyema, connective tissue disorders, and asbestos exposure. It is generally unilateral, causes blunting of the costophrenic angle, spans multiple rib interspaces, and is irregular in shape. When diffuse pleural thickening calcifies and is associated with volume loss in the affected lung, it is termed fibrothorax.

scholarly journals Asbestosis, pleural plaques and diffuse pleural thickening: three distinct benign responses to asbestos exposure

1998 ◽  
Vol 11 (5) ◽  
pp. 1021-1027 ◽  
Author(s):  
P.A. Gevenois ◽  
V. De Maertelaer ◽  
A. Madani ◽  
C. Winant ◽  
G. Sergent ◽  
...  
Keyword(s):  
Asbestos Exposure ◽  
Pleural Thickening ◽  
Pleural Plaques ◽  
Diffuse Pleural Thickening

Introduction to Pleural Disease

Chest Imaging ◽  
2019 ◽  
pp. 155-158
Author(s):  
Christopher M. Walker
Keyword(s):  
Pleural Effusion ◽  
Asbestos Exposure ◽  
Pleural Space ◽  
Pulmonary Vasculature ◽  
Pleural Disease ◽  
Pleural Thickening ◽  
Pleural Plaques ◽  
Pleural Surface ◽  
Pleural Neoplasm ◽  
Ct Features

The chapter titled introduction to pleural disease discusses the imaging and clinical features of diseases of the pleura. The pleural space is a potential space located between the visceral and parietal pleural surfaces. Pleural effusion and pneumothorax are the most common manifestations of pleural disease and are caused by a wide variety of disease processes. Pleural thickening may be related to benign or malignant processes. Bilateral discontinuous nodular pleural thickening is characteristic of pleural plaques. Pleural thickening with calcification may also be seen in fibrothorax. Malignant pleural disease may manifest with pleural effusion, pleural nodules or masses, or a combination of the two. There are several CT features suggestive of malignant pleural thickening including circumferential pleural thickening, pleural nodules or masses, involvement of the mediastinal pleural surface, and pleural thickening measuring greater than 1 cm in thickness. Metastatic disease is the most common pleural neoplasm. Mesothelioma is uncommon but remains the most common primary pleural malignancy and is almost always seen in patients with previous asbestos exposure. Pleural abnormalities must be differentiated from pulmonary processes. Pleural masses may exhibit obtuse angles with the adjacent pleural surfaces, displace rather than engulf adjacent pulmonary vasculature, and may exhibit the incomplete border sign.

Occupational lung disease

2018 ◽  
Author(s):  
Paul Cullinan ◽  
Joanna Szram
Keyword(s):  
Occupational Asthma ◽  
Toxic Exposure ◽  
Allergic Alveolitis ◽  
Lung Cancers ◽  
Pleural Diseases ◽  
Pleural Thickening ◽  
Occupational Lung Disease ◽  
Pleural Plaques ◽  
Diffuse Pleural Thickening ◽  
The Many

Some occupational lung diseases are defined by their clinical or pathological nature (e.g. occupational asthma or mesothelioma), while others are defined by their specific etiology (e.g. silicosis, farmer’s lung). Most fall into one of three categories. The first is airways disease, including occupational asthma (induced by a workplace agent), work-exacerbated asthma (preexisting asthma provoked by one or more agents at work), and irritant-induced asthma (initiated by a single, toxic exposure to a respiratory irritant); COPD and obliterative bronchiolitis may arise from workplace exposures, and around 10% of lung cancers have an occupational etiology. The second is parenchymal diseases, incorporating the many types of pneumoconiosis, differentiated by the dust that caused them, and the many types of extrinsic allergic alveolitis (or hypersensitivity pneumonia) categorized by the occupations in which they arise. The third is pleural diseases comprising pleural plaques, diffuse pleural thickening, and mesothelioma.

Asbestos-related pleural diseases: Dimensional criteria are not appropriate to differentiate diffuse pleural thickening from pleural plaques

2004 ◽  
Vol 45 (3) ◽  
pp. 289-296 ◽  
Author(s):  
Jacques Ameille ◽  
Mireille Matrat ◽  
Christophe Paris ◽  
Nathalie Joly ◽  
Claude Raffaelli ◽  
...  
Keyword(s):  
Pleural Diseases ◽  
Pleural Thickening ◽  
Pleural Plaques ◽  
Diffuse Pleural Thickening

scholarly journals Occupational exposure for asbestos-related disease groups: geomapping of the last 5 years in Italy

2020 ◽  
Vol 30 (Supplement_5) ◽  
Author(s):  
A Vinci ◽  
F Ingravalle ◽  
M D'Ercole ◽  
S Mancinelli ◽  
F Lucaroni ◽  
...  
Keyword(s):  
Public Health ◽  
World War Ii ◽  
Incidence Rate ◽  
Asbestos Exposure ◽  
Common Disease ◽  
Study Objective ◽  
Gradient Distribution ◽  
Pleural Plaques ◽  
Asbestos Related Disease ◽  
Incident Cases

Abstract Background Asbestos-related diseases are a public health challenge in Italy: the country has been a major producer and user of asbestos since World War II until complete ban in 1992. Several contaminated sites and structures across the country have never been decontaminated: incidence peak of asbestos-related diseases is expected somewhen between 2015 and 2020. Study objective is to investigate incidence of asbestos-related diseases in Italy in the last 5 years, from both a chronological and geographical perspective. Methods Ascertained diagnoses of asbestos-related diseases among workers were collected from the INAIL public registry from 2014 to 2018. Yearly incidence rate was estimated per province (incident cases per million workers) and mapped by year. Global incidence quota by working sector and sub-sector was also calculated. Results 8.620 cases have been reported. Incidence rate rapidly increased from 2014, peaking at 7,2 new cases per 100.000 workers in 2015. Afterwards, the number of ascertained cases decreased. There is a clear gradient distribution between northern and southern Italian provinces, with the highest rates in Northern Italy (especially in year 2014) and declining over time. Mesothelioma (all variants) was the most common disease, (2.995 cases, 35% of total), followed by pleural plaques (2.955 cases, 34%), pneumoconiosis (1.327 cases, 15%) and cancer of lungs/respiratory tract (1.298 cases, 14%). Most affected category was that of metal workers, but construction, transportation and electricity workers were also affected. Conclusions Detailed surveillance with mapping support is an effective tool for public health servants to locally manage prevention programs targeted on occupational risk. This is especially true for areas with active industries in the most affected sectors. Key messages Asbestos does not mean mesothelioma, but also other diseases that impact on workforce health status. Pneumoconiosis and other oral and respiratory cancers are also associated with asbestos exposure. Risk management should be tailored for a wider array of worker types than usually considered, since such exposure happens in sectors that are not traditionally related to asbestos exposure.

Respiratory symptoms and quality of life in asbestos-related diffuse pleural thickening and pleural plaques

2015 ◽  
Author(s):  
Silvie Prazakova ◽  
Alessandra Sandrini ◽  
Susan Miles ◽  
Paul Thomas ◽  
Anthony Johnson ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Respiratory Symptoms ◽  
Pleural Thickening ◽  
Pleural Plaques ◽  
Diffuse Pleural Thickening

scholarly journals The role of polymorphisms in glutathione-related genes in asbestos-related diseases

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Alenka Franko ◽  
Katja Goricar ◽  
Metoda Dodic Fikfak ◽  
Viljem Kovac ◽  
Vita Dolzan
Keyword(s):  
Logistic Regression ◽  
Asbestos Exposure ◽  
Positive Association ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional ◽  
Related Disease ◽  
Pleural Plaques ◽  
Asbestos Related Disease

Abstract Background The study investigated the influence of GCLC, GCLM, GSTM1, GSTT1 and GSTP1 polymorphisms, as well as the influence of interactions between polymorphism and interactions between polymorphisms and asbestos exposure, on the risk of developing pleural plaques, asbestosis and malignant mesothelioma (MM). Subjects and methods The cross sectional study included 940 asbestos-exposed subjects, among them 390 subjects with pleural plaques, 147 subjects with asbestosis, 225 subjects with MM and 178 subjects with no asbestos-related disease. GCLC rs17883901, GCLM rs41303970, GSTM1 null, GSTT1 null, GSTP1 rs1695 and GSTP1 rs1138272 genotypes were determined using PCR based methods. In statistical analysis, logistic regression was used. Results GSTT1 null genotype was associated with the decreased risk for pleural plaques (OR = 0.63; 95% CI = 0.40–0.98; p = 0.026) and asbestosis (OR = 0.51; 95% CI = 0.28–0.93; p = 0.028), but not for MM. A positive association was found between GSTP1 rs1695 AG + GG vs. AA genotypes for MM when compared to pleural plaques (OR = 1.39; 95% CI = 1.00–1.94; p = 0.049). The interactions between different polymorphisms showed no significant influence on the risk of investigated asbestos-related diseases. The interaction between GSTT1 null polymorphism and asbestos exposure decreased the MM risk (OR = 0.17; 95% CI = 0.03–0.85; p = 0.031). Conclusions Our findings suggest that GSTT1 null genotype may be associated with a decreased risk for pleural plaques and asbestosis, may modify the association between asbestos exposure and MM and may consequently act protectively on MM risk. This study also revealed a protective effect of the interaction between GSTP1 rs1695 polymorphism and asbestos exposure on MM risk.

Sign in / Sign up

Export Citation Format

Share Document