scholarly journals Bacterial Exopolysaccharides as Reducing and/or Stabilizing Agents during Synthesis of Metal Nanoparticles with Biomedical Applications

2018 ◽  
Vol 2018 ◽  
pp. 1-15 ◽  
Author(s):  
Carlos Enrique Escárcega-González ◽  
Javier A. Garza-Cervantes ◽  
Augusto Vázquez-Rodríguez ◽  
José Rubén Morones-Ramírez
Keyword(s):  
Drug Delivery ◽  
Contrast Agents ◽  
Metal Nanoparticles ◽  
Chemical Sensors ◽  
Extracellular Space ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Cellular Interactions ◽  
Stabilizing Agents ◽  
Bacterial Exopolysaccharides

Bacterial exopolysaccharides (EPSs) are biomolecules secreted in the extracellular space and have diverse biological functionalities, such as environmental protection, surface adherence, and cellular interactions. EPSs have been found to be biocompatible and eco-friendly, therefore making them suitable for applications in many areas of study and various industrial products. Recently, synthesis and stabilization of metal nanoparticles have been of interest because their usefulness for many biomedical applications, such as antimicrobials, anticancer drugs, antioxidants, drug delivery systems, chemical sensors, contrast agents, and as catalysts. In this context, bacterial EPSs have been explored as agents to aid in a greener production of a myriad of metal nanoparticles, since they have the ability to reduce metal ions to form nanoparticles and stabilize them acting as capping agents. In addition, by incorporating EPS to the metal nanoparticles, the EPS confers them biocompatibility. Thus, the present review describes the main bacterial EPS utilized in the synthesis and stabilization of metal nanoparticles, the mechanisms involved in this process, and the different applications of these nanoparticles, emphasizing in their biomedical applications.

scholarly journals A REVIEW ON PROPERTIES, APPLICATIONS AND TOXICITIES OF METAL NANOPARTICLES

2020 ◽  
pp. 58-63
Author(s):  
SANGEETHA G. ◽  
USHA N. ◽  
NANDHINI R. ◽  
KAVIYA P. ◽  
VIDHYA G. ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Nanoparticles ◽  
Metallic Nanoparticles ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Noble Metals ◽  
Novel Technology ◽  
Current Review ◽  
The World ◽  
History Of

Nanotechnology is a broad and novel technology related to all branches of science. However, in the Pharmaceutical industry, it plays an immense role in the drug delivery system. Nanotechnology applied on metal-based drug delivery systems varies; the size ranges from 100 nm or less. Metallic nanoparticles are existing the world from the 4th century. The noble metals, like gold and silver have attracted many researchers in the class of anticancer and anti-microbial. Metallic nanoparticles are not only used in the biomedical applications also have major functions in the domain of textiles, agriculture, photography, etc. Various metals are found in various applications in the biomedical industries. At the same time, the metallic nanoparticles have been evidences of remarkable toxicity in various studies. The rationale behind this topic was that the properties, applications and toxicity of individual metal nanoparticles. As this study have not been compiled and reported. So, in the current review, the gap was filled. The main sources for the preparation of the manuscript are Pubmed, Elsevier and google scholars. Keywords used includes metallic nanoparticles, reported toxicity of metals in drug delivery, applications of metals in drug delivery, history of novel metals in drug delivery, etc. Approximately 400 reviews and academic papers were reviewed to compose the manuscript and sorted by reference to the need for a manuscript.

Rediscovering Tocophersolan: a renaissance for nano-based drug delivery and nanotheranostic applications

2020 ◽  
Vol 21 ◽  
Author(s):  
Dickson Pius Wande ◽  
Qin Cui ◽  
Shijie Chen ◽  
Cheng Xu ◽  
Hui Xiong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Dissolution ◽  
Glycol Succinate ◽  
Permeation Enhancer ◽  
P Glycoprotein ◽  
Us Fda ◽  
Anticancer Compound

: As a unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan) is a polymeric synthetic version of vitamin E. Tocophersolan has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. The multiple inherent properties of Tocophersolan make it play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability of promoting drug dissolution, drug permeation enhancer, P-glycoprotein inhibitor and anticancer compound. For these reasons, Tocophersolan has been widely used for improving the bioavailability of numerous pharmaceutical active ingredients. Tocophersolan has been approved by stringent regulatory authorities (such as US FDA, EMA, and PMDA) as a safe pharmaceutical excipient. In this review, we systematically curated current advances in nano-based delivery systems consisting of Tocophersolan with possibilities for futuristic applications in drug delivery, gene therapy, and nanotheranostic.

Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy

2018 ◽  
Vol 6 (4) ◽  
pp. 877-884 ◽  
Author(s):  
Po Li ◽  
Yue Yan ◽  
Binlong Chen ◽  
Pan Zhang ◽  
Siling Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Research Interest ◽  
Upconversion Nanoparticles ◽  
Multifunctional Nanoparticles ◽  
Nano Oxide

In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems.

scholarly journals Bioceramics: from bone substitutes to nanoparticles for drug delivery

2019 ◽  
Vol 91 (4) ◽  
pp. 687-706 ◽  
Author(s):  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Bone Repair ◽  
Research Team ◽  
Research Work ◽  
Bone Substitutes ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

Abstract Since the second half of the 20th century, bioceramics are used for bone repair and regeneration. Inspired by bones and teeth, and aimed at mimicking their structure and composition, several artificial bioceramics were developed for biomedical applications. And nowadays, in the 21st century, with the increasing prominence of nanoscience and nanotechnology, certain bioceramics are being used to build smart drug delivery systems, among other applications. This minireview will mainly describe both tendencies through the research work carried out by the research team of María Vallet-Regí.

scholarly journals Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug Delivery Systems

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 495 ◽  
Author(s):  
Hakkarainen ◽  
Kõrkjas ◽  
Laidmäe ◽  
Lust ◽  
Semjonov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Fiber Diameter ◽  
Pulse Repetition Frequency ◽  
Reference Method ◽  
Delivery Systems ◽  
Water Soluble ◽  
Aqueous Acetic Acid ◽  
Promising Alternative

We investigated nozzleless ultrasound-enhanced electrospinning (USES) as means to generate nanofibrous drug delivery systems (DDSs) for pharmaceutical and biomedical applications. Traditional electrospinning (TES) equipped with a conventional spinneret was used as a reference method. High-molecular polyethylene oxide (PEO) and chitosan were used as carrier polymers and theophylline anhydrate as a water-soluble model drug. The nanofibers were electrospun with the diluted mixture (7:3) of aqueous acetic acid (90% v/v) and formic acid solution (90% v/v) (with a total solid content of 3% w/v). The fiber diameter and morphology of the nanofibrous DDSs were modulated by varying ultrasonic parameters in the USES process (i.e., frequency, pulse repetition frequency and cycles per pulse). We found that the USES technology produced nanofibers with higher fiber diameter (402 ± 127 nm) than TES (77 ± 21 nm). An increase of a burst count in USES increased the fiber diameter (555 ± 265 nm) and the variation in fiber size. The slight-to-moderate changes in a solid state (crystallinity) were detected when compared the nanofibers generated by TES and USES. In conclusion, USES provides a promising alternative for aqueous-based fabrication of nanofibrous DDSs for pharmaceutical and biomedical applications.

scholarly journals Intra/Inter-Particle Energy Transfer of Luminescence Nanocrystals for Biomedical Applications

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Ching-Ping Liu ◽  
Shih-Hsun Cheng ◽  
Nai-Tzu Chen ◽  
Leu-Wei Lo
Keyword(s):  
Drug Delivery ◽  
Energy Transfer ◽  
Rare Earth ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Particle Energy ◽  
Upconversion Nanoparticles ◽  
Biological Assays ◽  
Rare Earth Doped ◽  
Luminescent Nanocrystals

Elaborate design of energy transfer systems in luminescent nanocrystals revealed tremendous advantages in nanotechnology, especially in biosensing and drug delivery systems. Recently, upconversion nanoparticles have been discussed as promising probes as labels in biological assays and imaging. This article reviews the works performed in the recent years using quantum dot- and rare-earth doped nanoparticle-based energy transfer systems for biomedical applications.

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