Lanthanide-doped upconversion nanoparticles complexed with nano-oxide graphene used for upconversion fluorescence imaging and photothermal therapy

2018 ◽  
Vol 6 (4) ◽  
pp. 877-884 ◽  
Author(s):  
Po Li ◽  
Yue Yan ◽  
Binlong Chen ◽  
Pan Zhang ◽  
Siling Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Fluorescence Imaging ◽  
Photothermal Therapy ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Research Interest ◽  
Upconversion Nanoparticles ◽  
Multifunctional Nanoparticles ◽  
Nano Oxide

In recent years, multifunctional nanoparticles have attracted much research interest in various biomedical applications such as biosensors, diagnosis, and drug delivery systems.

Rediscovering Tocophersolan: a renaissance for nano-based drug delivery and nanotheranostic applications

2020 ◽  
Vol 21 ◽  
Author(s):  
Dickson Pius Wande ◽  
Qin Cui ◽  
Shijie Chen ◽  
Cheng Xu ◽  
Hui Xiong ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
Drug Dissolution ◽  
Glycol Succinate ◽  
Permeation Enhancer ◽  
P Glycoprotein ◽  
Us Fda ◽  
Anticancer Compound

: As a unique and pleiotropic polymer, d-alpha-tocopheryl polyethylene glycol succinate (Tocophersolan) is a polymeric synthetic version of vitamin E. Tocophersolan has attracted enormous attention as a versatile excipient in different biomedical applications including drug delivery systems and nutraceuticals. The multiple inherent properties of Tocophersolan make it play flexible roles in drug delivery system design, including excipients with outstanding biocompatibility, solubilizer with the ability of promoting drug dissolution, drug permeation enhancer, P-glycoprotein inhibitor and anticancer compound. For these reasons, Tocophersolan has been widely used for improving the bioavailability of numerous pharmaceutical active ingredients. Tocophersolan has been approved by stringent regulatory authorities (such as US FDA, EMA, and PMDA) as a safe pharmaceutical excipient. In this review, we systematically curated current advances in nano-based delivery systems consisting of Tocophersolan with possibilities for futuristic applications in drug delivery, gene therapy, and nanotheranostic.

scholarly journals Bioceramics: from bone substitutes to nanoparticles for drug delivery

2019 ◽  
Vol 91 (4) ◽  
pp. 687-706 ◽  
Author(s):  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Bone Repair ◽  
Research Team ◽  
Research Work ◽  
Bone Substitutes ◽  
Delivery Systems ◽  
Smart Drug ◽  
Smart Drug Delivery

Abstract Since the second half of the 20th century, bioceramics are used for bone repair and regeneration. Inspired by bones and teeth, and aimed at mimicking their structure and composition, several artificial bioceramics were developed for biomedical applications. And nowadays, in the 21st century, with the increasing prominence of nanoscience and nanotechnology, certain bioceramics are being used to build smart drug delivery systems, among other applications. This minireview will mainly describe both tendencies through the research work carried out by the research team of María Vallet-Regí.

scholarly journals Comparison of Traditional and Ultrasound-Enhanced Electrospinning in Fabricating Nanofibrous Drug Delivery Systems

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 495 ◽  
Author(s):  
Hakkarainen ◽  
Kõrkjas ◽  
Laidmäe ◽  
Lust ◽  
Semjonov ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Fiber Diameter ◽  
Pulse Repetition Frequency ◽  
Reference Method ◽  
Delivery Systems ◽  
Water Soluble ◽  
Aqueous Acetic Acid ◽  
Promising Alternative

We investigated nozzleless ultrasound-enhanced electrospinning (USES) as means to generate nanofibrous drug delivery systems (DDSs) for pharmaceutical and biomedical applications. Traditional electrospinning (TES) equipped with a conventional spinneret was used as a reference method. High-molecular polyethylene oxide (PEO) and chitosan were used as carrier polymers and theophylline anhydrate as a water-soluble model drug. The nanofibers were electrospun with the diluted mixture (7:3) of aqueous acetic acid (90% v/v) and formic acid solution (90% v/v) (with a total solid content of 3% w/v). The fiber diameter and morphology of the nanofibrous DDSs were modulated by varying ultrasonic parameters in the USES process (i.e., frequency, pulse repetition frequency and cycles per pulse). We found that the USES technology produced nanofibers with higher fiber diameter (402 ± 127 nm) than TES (77 ± 21 nm). An increase of a burst count in USES increased the fiber diameter (555 ± 265 nm) and the variation in fiber size. The slight-to-moderate changes in a solid state (crystallinity) were detected when compared the nanofibers generated by TES and USES. In conclusion, USES provides a promising alternative for aqueous-based fabrication of nanofibrous DDSs for pharmaceutical and biomedical applications.

scholarly journals Intra/Inter-Particle Energy Transfer of Luminescence Nanocrystals for Biomedical Applications

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Ching-Ping Liu ◽  
Shih-Hsun Cheng ◽  
Nai-Tzu Chen ◽  
Leu-Wei Lo
Keyword(s):  
Drug Delivery ◽  
Energy Transfer ◽  
Rare Earth ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Particle Energy ◽  
Upconversion Nanoparticles ◽  
Biological Assays ◽  
Rare Earth Doped ◽  
Luminescent Nanocrystals

Elaborate design of energy transfer systems in luminescent nanocrystals revealed tremendous advantages in nanotechnology, especially in biosensing and drug delivery systems. Recently, upconversion nanoparticles have been discussed as promising probes as labels in biological assays and imaging. This article reviews the works performed in the recent years using quantum dot- and rare-earth doped nanoparticle-based energy transfer systems for biomedical applications.

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