scholarly journals Gastrocolic Fistula: A Rare Presentation of Colon Cancer

2018 ◽  
Vol 2018 ◽  
pp. 1-3
Author(s):  
Chukwunonso Chime ◽  
Madhavi Ravi ◽  
Myrta Daniel ◽  
Harish Patel ◽  
Bhavna Balar
Keyword(s):  
Colon Cancer ◽  
Late Complication ◽  
Survival Rates ◽  
Standard Of Care ◽  
Lymph Node Involvement ◽  
En Bloc ◽  
Rare Presentation ◽  
Additional Advantage ◽  
Node Involvement

Gastrocolic fistulae have been described for benign conditions including penetrating peptic ulcer and complicated pancreatitis. Malignant etiology can arise from gastric or colon cancer and is a rare and late complication with an incidence of 0.3-0.4%. Usual presentation is the classic triad of weight loss, diarrhea, and feculent vomiting. Barium enema has been shown to have the highest diagnostic accuracy but endoscopy offers additional advantage of biopsy to aid in diagnosis of malignant etiology; the role of computed tomography (CT) scan is controversial. Treatment by one-stage en bloc surgical approach is the current acceptable standard of care with variable recurrence and survival rates. Adjuvant chemotherapy would be based on lymph node involvement and patient discussion.

scholarly journals Eosinophilic vasculitis: A Rare Presentation of Whipple’s Disease

2007 ◽  
Vol 21 (3) ◽  
pp. 189-191 ◽  
Author(s):  
Waleed Al-hamoudi ◽  
Fadi Habbab ◽  
Carmine Nudo ◽  
Ayoub Nahal ◽  
Kenneth Flegel
Keyword(s):  
Lymph Node ◽  
Lymph Node Involvement ◽  
Lymph Node Biopsy ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
Rare Presentation ◽  
Negative Results ◽  
Mild Anemia ◽  
Node Involvement ◽  
Foamy Macrophages

Whipple’s disease is a multisystem infectious disease caused by the bacteriumTropheryma whippelii. A case with an unusual presentation is reported. A 66-year-old man presented with a febrile vasculitic rash on his forearms. An extensive rheumatological, hematological and infectious workup gave negative results, apart from mild anemia and eosinophilia. An abdominal computed tomography revealed a retroperitoneal lymphadenopathy, and a skin biopsy revealed an eosinophilic vasculitis. This diverted the work toward ruling out a lymphoma or a vasculitic process. A lymph node biopsy was then performed and showed a diffuse neutrophilic inflammation with abundant foamy macrophages, fat necrosis and lipogranuloma formation. These findings were considered to be nonspecific and no further pathological investigation was carried out. After a course of corticosteroids, diarrhea and weight loss predominated and subsequently a diagnosis of Whipple’s disease was confirmed on a small-bowel biopsy. Lymph node involvement was then confirmed on re-evaluation using the appropriate stains.

scholarly journals Surgical management of urachal tumors: Can the umbilicus be sparred in localized disease?

Rare Tumors ◽  
2019 ◽  
Vol 11 ◽  
pp. 203636131984728
Author(s):  
Cristian Pavelescu ◽  
Alexandra Pavelescu ◽  
Cristian Surcel ◽  
Cristian Mirvald ◽  
Mario Alvarez-Maestro ◽  
...  
Keyword(s):  
Lymph Node ◽  
Surgical Treatment ◽  
Local Recurrence ◽  
Distant Metastasis ◽  
Lymph Node Involvement ◽  
Partial Cystectomy ◽  
En Bloc ◽  
Node Involvement ◽  
Urachal Adenocarcinoma

Urachal adenocarcinoma represents the third most common histological type of non-urotelial bladder cancer. A very low incidence of this disease and the lack of prospective studies have led to a rich and heterogeneous treatment history. Currently, the standard of care for these patients is represented by partial cystectomy en bloc with resection of the urachal ligament and total omphalectomy. The aim of this article is to present our experience and results in the management of patients with urachal adenocarcinoma. Between 2005 and 2015, 16 patients have undergone surgical treatment for urachal adenocarcinoma in “Fundeni” Clinical Institute and Madrid University Hospital “Infanta Sofia.” Partial cystectomy was performed in 11 (68.76%) patients, while radical cystectomy en bloc with omphalectomy was performed in 5 (31.25%) patients, which were not amendable to a limited resection. The Sheldon classification was used, as it provides appropriate disease staging and is the most commonly utilized. Postoperative pathological results showed that 7 (43.75%) patients had localized tumors, and more than one-third (37.5%) of the patients had locally advanced Sheldon III disease, while 3 patients had distant metastasis at the time of surgery. Lymph node involvement was present in 3 patients (18.75%). Mean follow-up time was 2.5 years, ranging from 4 months to 7.6 years. Three patients (18.75%) were lost to follow-up, without any documented signs of local or systemic recurrence and were cancer free at the time of the last evaluation. In cases with lymph node involvement, local recurrence or distant metastasis, patients underwent cisplatin- or 5-fluorouracil-based salvage chemotherapy. Surgical treatment represents the gold standard, while adjuvant chemotherapy has a limited impact on overall survival. The utility of navel resection is questionable due to the rarity of direct invasion or local recurrence.

The effect of chemotherapy on overall survival of stage II colon cancer.

2011 ◽  
Vol 29 (4_suppl) ◽  
pp. 625-625
Author(s):  
M. Omaira ◽  
M. Mozayen ◽  
K. Katato
Keyword(s):  
Colon Cancer ◽  
Overall Survival ◽  
Survival Rate ◽  
Survival Rates ◽  
Stage Ii ◽  
Disease Stage ◽  
Overall Survival Rate ◽  
Significant Difference ◽  
Stage Ii Colon Cancer

625 Background: Surgical resection of local colon cancer is the only curative treatment, at the same time adjuvant chemotherapy is clearly shown to be beneficial as the standard of care for node positive disease (stage III) colon cancer. However the role of chemotherapy for stage II colon cancer treatment is still conflicting. We aim to compare the overall survival rate of stage II colon cancer patient's with and without chemotherapy. Methods: A retrospective observational study was conducted from 1990-2006. Patients with stage II colon cancer were included. Patient's characteristics including age, gender, common site of involvement, histology patterns, overall survival rate and treatment with chemotherapy were recorded. Results: A total of 138 consecutive patients were identified from 1990-2006. The median age was 68 (21-91) year, males (44%), African Americans (47.6%). The most common sites of the primary tumor were sigmoid and cecum (22.4%) each. Adenocarcinoma being the most common pathology. Majority of the patients (86.2%) were found to have T 3 tumors. Of the patients that received chemotherapy (29/44) 66% had an overall survival rate of three years or more, whereas (53/94) 57% of the patients who did not receive chemotherapy had a survival rate of three years or more. The difference of survival rates between the two groups of patients was not statistically significant. Conclusions: The role of chemotherapy in stage II colon ancer is still controversial. There was no significant difference in overall survival between the two groups who did and did not receive chemotherapy; thus more studies are warranted to explore the factors that predict the survival of stage II colon cancer. No significant financial relationships to disclose.

Clinicopathologic characteristics of pure papillary breast carcinoma.

2013 ◽  
Vol 31 (15_suppl) ◽  
pp. e12521-e12521
Author(s):  
Fatma P. Turkoz ◽  
Mustafa Solak ◽  
Özge Keskin ◽  
Zafer Arik ◽  
Cagatay Arslan ◽  
...  
Keyword(s):  
Breast Carcinoma ◽  
Ductal Carcinoma ◽  
Menopausal Status ◽  
Survival Rates ◽  
Disease Free Survival ◽  
Lymph Node Involvement ◽  
Low Grade ◽  
Breast Cancer Patients ◽  
Clinicopathologic Characteristics ◽  
Node Involvement

e12521 Background: Pure papillary breast carcinoma (PPBC) is a very rare entity which usually occurs in older women with a favorable prognosis. The aim of this cohort study was to evaluate the demographic, clinicopathologic characteristics and survival rates of PPBC compared to invasive ductal carcinoma (IDC). Methods: A total of 2451 invasive breast cancer patients from a single center were analyzed retrospectively. Of these, 24 patients were PPBC (1%) and 1785 (73%) patients were pure IDC. Results: PPBC were significantly different from IDC with respect to the age at diagnosis, menopausal status, tumor size, grade and lymph node involvement (p<0.05) (Table 1). The median follow-up period was 26,5 months (4-400 months). Only one patient with PPBC had lung and bone metastasis, others were alive with no evidence of disease. PPBC was associated with a better 5-year overall survival (100 vs. 84%) and disease-free survival (75 vs. 54%) compared to IDC. Conclusions: Compared to IDC, PPBC is a small, low-grade tumor and less likely to involve the lymph nodes. Cases are usually older, postmenopausal women and have a better prognosis. [Table: see text]

Role of prostate dose escalation in patients with greater than 15% risk of pelvic lymph node involvement

2005 ◽  
Vol 61 (3) ◽  
pp. 695-701 ◽  
Author(s):  
Rojymon Jacob ◽  
Alexandra L. Hanlon ◽  
Eric M. Horwitz ◽  
Benjamin Movsas ◽  
Robert G. Uzzo ◽  
...  
Keyword(s):  
Lymph Node ◽  
Dose Escalation ◽  
Lymph Node Involvement ◽  
Pelvic Lymph Node ◽  
Node Involvement ◽  
Pelvic Lymph Node Involvement

scholarly journals PANCREATODUODENECTOMY FOR RETROPANCREATIC HEAD LYMPH NODE INVOLVEMENT FROM LIVER METASTASIS OF COLON CANCER-REPORT OF A CASE-

2000 ◽  
Vol 61 (7) ◽  
pp. 1857-1861
Author(s):  
Yasuhiko NAGANO ◽  
Kaoru NAGAHORI ◽  
Kuniya TANAKA ◽  
Hideyuki IKE ◽  
Shinji TOGO ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Liver Metastasis ◽  
Lymph Node Involvement ◽  
Node Involvement

Evaluating the prognostic significance of lymphovascular invasion in stage II and III colon cancer.

2019 ◽  
Vol 37 (4_suppl) ◽  
pp. 685-685 ◽  
Author(s):  
Dorotea Mutabdzic ◽  
Shalana BL O'Brien ◽  
Elizabeth A. Handorf ◽  
Karthik Devarajan ◽  
Sanjay S. Reddy ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Overall Survival ◽  
Lymph Node ◽  
High Risk ◽  
Adjuvant Chemotherapy ◽  
Lymphovascular Invasion ◽  
Lymph Node Involvement ◽  
Stage Ii ◽  
Stage Iii ◽  
Node Involvement

685 Background: Presence of lymphovascular invasion (LVI) is known to be a predictor of lymph node involvement in colon adenocarcinoma (CA). Lymph node involvement is associated with poorer prognosis necessitating adjuvant therapy. While some studies have suggested that LVI is a predictor of worse overall survival in early stage colon cancer, the significance of LVI on prognosis has not been tested in a comprehensive North American data set. Methods: Patients with stage II and III CA with LVI data available and those who received predefined standard of care treatment were identified from the National Cancer Data Base (NCDB) from 2011 to 2015. The relationship between LVI and overall survival was tested using Kaplan-Meier survival curves and Cox proportional hazards regression analysis after adjusting for relevant clinical and demographic variables. Hazard ratios and 95% confidence intervals are reported along with median overall survival (OS) where available. Results: The dataset included 93,070 patients with stage II and 66,701 patients with stage III CA. The proportion of patients with LVI was 13% in stage II and 47% in stage III CA. After adjusting for age, sex, gender, race, comorbidities, socioeconomic status, T, and N stage, LVI was associated with worse OS in stage II, HR 1.2 (1.15-1.25, p < 0.001), and in stage III, HR 1.25 (1.21-1.30, p < 0.001), CA. Median OS was 6.51 years with LVI versus. 6.85 years without LVI in stage II compared with 6.57 years with LVI versus not reached without LVI in stage III CA. Of the stage II patients with LVI, 20% received adjuvant chemotherapy (CT) and median OS was 6.91 years for those who did versus 6.07 years for those who did not receive CT. Conclusions: Our data suggest that LVI is an important predictor of OS in stage II and III CA. There is evidence that adjuvant chemotherapy improves OS in advanced CA but there remains uncertainty as to the benefit in stage II. Despite this uncertainty, guidelines suggest consideration of adjuvant CT in patients with high-risk stage II disease. Our data support the recommendation that LVI be considered a high-risk feature in stage II disease. Further studies are necessary to examine whether the type or duration of CT should differ for patients with CA and LVI.

Stroma-High Lymph Node Involvement Predicts Poor Survival More Accurately for Patients with Stage III Colon Cancer

2016 ◽  
Vol 01 (02) ◽  
Author(s):  
Gabi W van Pelt ◽  
Torben F Hansen ◽  
Esther Bastiaannet ◽  
Sanne Kjær Frifeldt ◽  
J Han JM van Krieken ◽  
...  
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Lymph Node Involvement ◽  
Stage Iii ◽  
Poor Survival ◽  
Stage Iii Colon Cancer ◽  
Node Involvement ◽  
High Lymph Node

scholarly journals Association Between Chemotherapy and Survival in T1 Colon Cancer With Lymph Node Metastasis: A Propensity-Score Matched Analysis

2021 ◽  
Vol 11 ◽  
Author(s):  
Wangxin Yan ◽  
Huizhen Zhou ◽  
Si Shi ◽  
Jixu Lin ◽  
Qiangkang Lin
Keyword(s):  
Colon Cancer ◽  
Lymph Node ◽  
Propensity Score ◽  
Lymph Nodes ◽  
Tumor Grade ◽  
Female Gender ◽  
Lymph Node Involvement ◽  
Black Race ◽  
Node Involvement ◽  
Cancer Specific Mortality

This study aimed to comprehensively examine the efficacy of chemotherapy in T1 colon cancer patients with lymph node metastasis.MethodsThe differences in categorical variables in colon cancer patients according to lymph node status were evaluated by Pearson’s chi-square test. The Kaplan-Meier method was used to assess Cancer-specific survival (CSS) and overall survival (OS) with the log-rank test. Cox proportional hazards models were built, multivariate Cox regression analyses were performed with the hazard ratio (HR) and 95% confidence interval (CI) to identify the potential independent prognostic factors. Propensity score matching was also undertaken to adjust for treatment bias due to measured confounders.ResultsYounger age (52.2% VS. 43.0% for ≤ 65 years old, p &lt; 0.001), female gender (50.3% VS. 46.8% for female, p &lt; 0.001), more lymph nodes harvested (68.1% VS. 46.6% for ≥12 lymph nodes harvested, p &lt; 0.001), Black race (13.6% VS. 12.0% for the Black race, p &lt; 0.001), and higher tumor grade (14.2% VS. 5.6% for grade III/IV, p &lt; 0.001) were more prone to be diagnosed with lymph node involvement. The receipt of adjuvant chemotherapy following radical surgery significantly reduced the risk of colon cancer-specific mortality by 33.9% after propensity-score matching (HR = 0.661, 95%CI = 0.476-0.917, p = 0.013).ConclusionsYounger age, female gender, more lymph nodes harvested, Black race, and higher tumor grade were more prone to be diagnosed with lymph node involvement. The receipt of adjuvant chemotherapy following radical surgery also significantly decreased the risk of colon cancer-specific mortality by 33.9% in T1 colon cancer with lymph node involvement.

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