scholarly journals Eosinophilic vasculitis: A Rare Presentation of Whipple’s Disease

2007 ◽  
Vol 21 (3) ◽  
pp. 189-191 ◽  
Author(s):  
Waleed Al-hamoudi ◽  
Fadi Habbab ◽  
Carmine Nudo ◽  
Ayoub Nahal ◽  
Kenneth Flegel
Keyword(s):  
Lymph Node ◽  
Lymph Node Involvement ◽  
Lymph Node Biopsy ◽  
Whipple’S Disease ◽  
Whipple's Disease ◽  
Rare Presentation ◽  
Negative Results ◽  
Mild Anemia ◽  
Node Involvement ◽  
Foamy Macrophages

Whipple’s disease is a multisystem infectious disease caused by the bacteriumTropheryma whippelii. A case with an unusual presentation is reported. A 66-year-old man presented with a febrile vasculitic rash on his forearms. An extensive rheumatological, hematological and infectious workup gave negative results, apart from mild anemia and eosinophilia. An abdominal computed tomography revealed a retroperitoneal lymphadenopathy, and a skin biopsy revealed an eosinophilic vasculitis. This diverted the work toward ruling out a lymphoma or a vasculitic process. A lymph node biopsy was then performed and showed a diffuse neutrophilic inflammation with abundant foamy macrophages, fat necrosis and lipogranuloma formation. These findings were considered to be nonspecific and no further pathological investigation was carried out. After a course of corticosteroids, diarrhea and weight loss predominated and subsequently a diagnosis of Whipple’s disease was confirmed on a small-bowel biopsy. Lymph node involvement was then confirmed on re-evaluation using the appropriate stains.

Lymphography in Sarcoidosis.

1974 ◽  
Vol 60 (4) ◽  
pp. 317-323 ◽  
Author(s):  
Renato Musumeci ◽  
Carlo Uslenghi
Keyword(s):  
Lymph Node ◽  
Lymph Nodes ◽  
Pulmonary Involvement ◽  
Lymph Node Involvement ◽  
Lymph Node Biopsy ◽  
Pathological Findings ◽  
Node Biopsy ◽  
Node Involvement ◽  
Extensive Lymph Node

Abdominal lymphography was performed in 30 patients, 12 males and 18 females, with sarcoidosis. The diagnosis of disease was in every case histological, after mediastinal biopsy in 16 cases and after biopsy of lymph nodes in various sites in 14 cases. Mediastino-pulmonary involvement of varying degree was present in 23 patients. Lymphography revealed involvement of the inguinoretroperitoneal lymph nodes in 18 cases, bilateral in 15 of them. Lymphographic diagnosis of sarcoidosis is fairly arduous because the pattern elicited is very similar to that of lymphomas. The pathological findings were graded into 4 groups. No correlation between lymphographic pattern and duration and extent of the disease was demonstrated. In 5 patients with pathological lymphography lymph node biopsy confirmed the diagnosis. The routine use of lymphography in patients with sarcoidosis is not to be racommended because the demonstration of extensive lymph node involvement does not affect the treatment in any way.

scholarly journals Sentinel Lymph Node Biopsy in Breast Cancer: Predictors of Axillary and Non-Sentinel Lymph Node Involvement

2013 ◽  
Vol 30 (4) ◽  
pp. 415-421 ◽  
Author(s):  
Hakan Postacı ◽  
Baha Zengel ◽  
Ulkem Yararbas ◽  
Adam Uslu ◽  
Nukhet Eliyatkin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Sentinel Lymph Node ◽  
Sentinel Lymph Node Biopsy ◽  
Lymph Node Involvement ◽  
Lymph Node Biopsy ◽  
Node Biopsy ◽  
Node Involvement

scholarly journals Tuberculosis in patients with chronic renal failure

1987 ◽  
Vol 29 (3) ◽  
pp. 127-130 ◽  
Author(s):  
Flávio Jota de Paula ◽  
Luiz Sérgio Fonseca de Azevedo ◽  
Luiz Estevam Ianhez ◽  
João Egidio Romão Júnior ◽  
Pedro Renato Chocair ◽  
...  
Keyword(s):  
Lymph Node ◽  
Pulmonary Involvement ◽  
Lymph Node Involvement ◽  
Immunosuppressive Drugs ◽  
Lymph Node Biopsy ◽  
The Other ◽  
Pleural Biopsy ◽  
Node Biopsy ◽  
Node Involvement ◽  
Cervical Lymph Node Biopsy

Nine cases of tuberculosis (TB) were diagnosed among 800 uremic patients, followed-up during 11 years, a prevalence of 1125%, 2.5 times higher than that in the general population. Six patients (66.7%) had lymph node involvement (4 cervical and 2 mediastinal). Three patients (33.3%) had pulmonary involvement (2 pleuro-pulmonary and 1 bilateral apical pulmonary). Eight patients were undergoing dialysis and 1 was pre-dialytic. The duration of dialysis ranged from 1 to 60 months. Three patients had previously received immunosuppressive drugs for unsuccessful renal transplantation. Daily fever was present in all but one patient; he was asymptomatic and TB was suspected after routine chest radiography. Biopsy was the diagnostic procedure in 7 patients (77.8%), four by direct cervical lymph node biopsy, 2 by mediastinal, performed by mediastinoscopy and 1 by pleural biopsy. In 2 other patients TB was confirmed by the presence of tubercle bacilli; in sputum (1 patient) and in a bronchial flushing specimen (the other patient). Triple therapy was used in all patients (isoniazid and ethambutol in all), plus rifampicin in 8 and streptomycin in 1. One patient had jaundice and another had optical neuritis. Five patients were cured. The other four died during treatment of causes unrelated to TB or its treatment.

scholarly journals IgG4-Related Lymphadenopathy

2012 ◽  
Vol 2012 ◽  
pp. 1-8 ◽  
Author(s):  
Yasuharu Sato ◽  
Tadashi Yoshino
Keyword(s):  
Lymph Node ◽  
Plasma Cells ◽  
Elevated Serum ◽  
Serum Levels ◽  
Lymph Node Involvement ◽  
Lymph Node Biopsy ◽  
Immunoglobulin G4 ◽  
Reactive Protein ◽  
Serum Igg4 ◽  
Node Involvement

Lymphadenopathy is frequently observed in patients with immunoglobulin G4-related disease (IgG4-RD) and sometimes appears as the first manifestation of the disease. The diagnosis of IgG4-related lymphadenopathy is complicated owing to a great histological diversity, with at least 5 histological subtypes. Indeed, lymph node biopsy may be performed under the suspicion that the lymphadenopathy is a malignant lymphoma or other lymphoproliferative disorder. The diagnosis of IgG4-RD is characterized by both elevated serum IgG4 (>135?mg/dL) and histopathological features, including a dense lymphoplasmacytic infiltrate rich in IgG4+plasma cells (IgG4+/IgG+plasma cell ratio >40%). However, patients with hyper-interleukin (IL-) 6 syndromes such as multicentric Castleman’s disease, rheumatoid arthritis, and other immune-mediated conditions frequently show lymph node involvement and often fulfill the diagnostic criteria for IgG4-RD. Owing to these factors, IgG4-RD cannot be differentiated from hyper-IL-6 syndromes on the basis of histological findings alone. Laboratory analyses are crucial to differentiate between the 2 diseases. Hyper-IL-6 syndromes are characterized by elevated serum levels of IgG, IgA, IgM, and C-reactive protein (CRP); thrombocytosis; anemia; hypoalbuminemia; hypocholesterolemia. In contrast, IgG4-RD does not share any of these characteristics. Therefore, the diagnosis of IgG4-RD requires not only pathological findings but also clinical and laboratory analyses.

Whipple's disease: an unexpected finding in a peripheral lymph node biopsy

The Lancet ◽  
2014 ◽  
Vol 383 (9936) ◽  
pp. 2268 ◽  
Author(s):  
Sarah Walters ◽  
Talal Valliani ◽  
Robert Przemioslo ◽  
Nicholas Rooney
Keyword(s):  
Lymph Node ◽  
Lymph Node Biopsy ◽  
Unexpected Finding ◽  
Whipple’S Disease ◽  
Peripheral Lymph Node ◽  
Whipple's Disease ◽  
Node Biopsy ◽  
Peripheral Lymph
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