scholarly journals The Ethanol Supernatant Extracts of Liushenwan Could Alleviate Nanodiethylnitrosamine-Induced Liver Cancer in Mice

2018 ◽  
Vol 2018 ◽  
pp. 1-11 ◽  
Author(s):  
Xi-Zhen Chen ◽  
Wei Kevin Zhang ◽  
He-Bin Tang ◽  
Xiao-Jun Li ◽  
Gui-Hua Tian ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chinese Medicine ◽  
Liver Cancer ◽  
Liver Tumor ◽  
Supernatant Fraction ◽  
Ethanol Extraction ◽  
Prevention And Treatment ◽  
Ultrasound Assisted ◽  
Cox 2 ◽  
Intragastric Gavage

Liver cancer is one of the leading causes of cancerous deaths worldwide. At present, the treatment of hepatocellular carcinoma (HCC) remains to be a problem globally. Liushenwan (LSW), an ancient Chinese medicine previously used to treat localized infections, was recently reported to possess anticancer activity. Here in this study, we aim to examine the effect of LSW-ET (LSW-ET is the supernatant fraction of LSW from ultrasound assisted ethanol extraction) in prevention and treatment on nanodiethylnitrosamine- (nanoDEN-) induced HCC in mice. In nanoDEN-induced HCC mice treated with LSW-ET by oral (po) or intragastric gavage (ig), we observed an alleviation of serum ALT and AST levels, amelioration in histopathological stainings, and an inhibition in liver tumor growth. In addition, compared with the nanoDEN group, downregulation of multiple pivotal factors (COX-2,β-catenin, PCNA, and HMGB-1) was observed in LSW-ET-po and LSW-ET-ig groups. Taken together, the delivery of LSW-ET by oral could be a potential prevention and treatment of liver cancer.

scholarly journals Fluorescence imaging of hepatocellular carcinoma with a specific probe of COX-2

RSC Advances ◽  
2018 ◽  
Vol 8 (2) ◽  
pp. 994-1000
Author(s):  
Haibo Wang ◽  
Chengyong Dong ◽  
Keqiu Jiang ◽  
Shuangzhe Zhang ◽  
Fei Long ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Fluorescence Imaging ◽  
Primary Liver Cancer ◽  
Specific Probe ◽  
Cox 2

Hepatocellular carcinoma (HCC) is the major subtype of primary liver cancer.

scholarly journals Dietary Agents and Phytochemicals in the Prevention and Treatment of Hepatocellular Carcinoma: Review Article

Med Phoenix ◽  
2017 ◽  
Vol 2 (1) ◽  
pp. 52-62
Author(s):  
Mohammad Ahmad ◽  
Anuradha Mishra ◽  
Afreen Usmani ◽  
Md. Parwez Ahmad
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Cancer ◽  
Epigallocatechin Gallate ◽  
Cancer Chemoprevention ◽  
Scientific Data ◽  
Anticancer Properties ◽  
Treatment And Prevention ◽  
Liver Cancers ◽  
Prevention And Treatment ◽  
Dietary Agents

Amongst all types of primary liver cancers, hepatocellular carcinoma (HCC) is the commonest form of liver cancer in the world. Cancer chemoprevention using dietary supplements and phytochemicals has attracted increasing attention in recent years. Numerous study reports suggest the role of phytochemicals and dietary compounds in the prevention and treatment of liver cancer. Certain dietary agents and related phytochemicals present in grapes, pomegranate, vegetables, beans, turmeric, soy, rice bran, and fish oils are reported to have chemopreventive potentials against hepatocellular carcinoma. Phytochemicals such as Carotenoids, Epigallocatechin gallate (EGCG), Curcumin, Resveratrol, Rutoside, Quercetin, Chrysin and Silibinin have possible therapeutic importance in tumor suppression during the initial phases of carcinogenesis. Many phytochemicals which are still under investigation lack the scientific data in support of anticancer properties of these compounds rather than anti-oxidant mechanism. So, emphasis should be given on the investigation of plausible molecular mechanism behind anticancer activity. This review summarizes the use of these dietary agents and phytochemicals in the treatment and prevention of HCC and also highlights the mechanisms responsible for their effects.Med Phoenix Vol.2(1) July 2017, 52-62

Molecular Mechanism of Bushen Jianpi Inhibition of Postoperative Recurrence and Metastasis of Hepatocellular Carcinoma

2021 ◽  
Vol 17 (1) ◽  
pp. 53-63
Author(s):  
Zhangjie Zhou ◽  
Shujuan Fu ◽  
Yun Li ◽  
Zujun Que ◽  
Xinhua Liu ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Bile Acid ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Liver Cancer ◽  
Immune Cell ◽  
Cancer Recurrence ◽  
Bile Acid Metabolism

Compared with western medicine, traditional Chinese medicine can better regulate the internal environment and inhibit liver cancer recurrence and metastasis. Bushen Jianpi Recipe (BSJPR) is a traditional Chinese medicine for tonifying the kidney and invigorating the spleen. It has also been used to treat tumors and other related diseases. Here we explore the efficacy of BSJPR inhibition of hepatocellular carcinoma (HCC) in vivo and in vitro . We hypothesize that BSJPR reduces intrahepatic cholestasis and inflammation and increases expression of the bile acid receptor and downstream targets. This study aims to test this hypothesis and determine whether the inhibitory effect of BSJPR on liver cancer recurrence and metastasis is related to bile acid metabolism. We also observed changes in immune cell expression, suggesting that regulation of the immune microenvironment could inhibit the recurrence and metastasis of HCC. These findings provide a basis for the treatment of HCC and new ideas for follow-up studies of BSJPR.

Anti-tumorigenic efficacy of Tangeretin in Liver Cancer – An in-silico approach

2020 ◽  
Vol 16 ◽  
Author(s):  
Sangavi P ◽  
Langeswaran K
Keyword(s):  
Hepatocellular Carcinoma ◽  
Molecular Dynamics ◽  
Molecular Docking ◽  
Molecular Dynamics Simulation ◽  
Liver Cancer ◽  
Primary Liver Cancer ◽  
Dynamics Simulation ◽  
Ligand Complex ◽  
Cox 2 ◽  
Liver Hepatocellular Carcinoma

Background: Liver cancer is otherwise known as Hepatic cancer which originated from the liver. Hepatocellular carcinoma (HCC) is the common primary Liver cancer and is one of the emerging problems worldwide. Very few treatments are available to treat HCC, because the molecular mechanism and other HCC mechanisms are still unclear. Cyclooxygenase 2 (COX-2), one of the most promising targets for Hepatocellular Carcinoma and it is one of the dimeric enzymes which convert Arachidonic acid into Prostaglandin H2 in the step of Prostaglandin biosynthesis. Several, natural bioactive compounds involved in the treatment of various types of cancer. Tangeretin, one of the natural polymethoxyflavone which is present in the peel of citrus fruits and it also acts as an Anti-oxidant modulator and Anti-cancerous. Methods: Computational approaches like Molecular docking and Molecular dynamics was performed to identify the potential inhibitor for Hepatocellular Carcinoma. Objectives: The main objective of this study is to find a suitable inhibitor for Hepatocellular Carcinoma. Results: In this study, COX-2 considered as the potential target for Hepatocellular Carcinoma which was examined with Tangeretin. Conclusion: Tangeretin was screened against C0X-2 which includes Molecular Docking, DFT analysis, ADMET prediction, and Molecular Dynamics simulation. Tangeretin had good docking scores, fulfill the pharmacological properties through ADMET prediction, and the Protein-Ligand complex had good stability in Molecular Dynamics simulation.

scholarly journals Herbal Medicine and Hepatocellular Carcinoma: Applications and Challenges

2011 ◽  
Vol 2011 ◽  
pp. 1-14 ◽  
Author(s):  
Yan Li ◽  
Robert C. G. Martin
Keyword(s):  
Hepatocellular Carcinoma ◽  
Herbal Medicine ◽  
Liver Cancer ◽  
Active Compounds ◽  
The Past ◽  
Significant Distinction ◽  
Prevention And Treatment

Use of herbal medicine in the treatment of liver cancer has a long tradition. The compounds derived from the herb and herbal composites are of considerable interest among oncologists. In the past, certain herbal compounds and herbal composite formulas have been studied throughin vitroandin vivoas an anti-hepatocellular carcinoma (HCC) agent, enhancing our knowledge about their biologic functions and targets. However there is a significant distinction between the herbal medicine and the herbal production even though both are the plant-based remedies used in the practice. In this article, for the sake of clarity, the effective herbal compounds and herbal composite formulas against HCC are discussed, with emphasizing the basic conceptions of herbal medicine in order to have a better understanding of the prevention and treatment of HCC by herbal active compounds and herbal composite formulas.

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