Traditional Chinese medicine in prevention and treatment of liver cancer: function, status and existed problems

Background: Nonalcoholic fatty liver disease (NAFLD) is a kind of metabolic stress-induced liver injury closely related to insulin resistance and genetic susceptibility, and there is no specific drug for its clinical treatment currently. In recent years, a large amount of literature has reported that many natural compounds extracted from traditional Chinese medicine (TCM) can improve NAFLD through various mechanisms. According to the latest reports, some emerging natural compounds have shown great potential to improve NAFLD but are seldom used clinically due to the lacking special research. Purpose: This paper aims to summarize the molecular mechanisms of the potential natural compounds on improving NAFLD, thus providing a direction and basis for further research on the pathogenesis of NAFLD and the development of effective drugs for the prevention and treatment of NAFLD. Methods: By searching various online databases, such as Web of Science, SciFinder, PubMed, and CNKI, NAFLD and these natural compounds were used as the keywords for detailed literature retrieval. Results: The pathogenesis of NAFLD and the molecular mechanisms of the potential natural compounds on improving NAFLD have been reviewed. Conclusion: Many natural compounds from traditional Chinese medicine have a good prospect in the treatment of NAFLD, which can serve as a direction for the development of anti-NAFLD drugs in the future.

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Prevention and Treatment of Diabetic Nephropathy Using Traditional Chinese Medicine

Journal of Integrative Nephrology and Andrology ◽

10.4103/2225-1243.143374 ◽

2014 ◽

Vol 1 (2) ◽

pp. 53 ◽

Cited By ~ 1

Author(s):

Xuemei Zhang ◽

Wen Peng ◽

Peihao Yin ◽

Xia Chen ◽

Aili Cao ◽

...

Keyword(s):

Diabetic Nephropathy ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Prevention And Treatment

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Application of Traditional Chinese Medicine injection in treatment of primary liver cancer: a review

Journal of Traditional Chinese Medicine ◽

10.1016/s0254-6272(13)60029-1 ◽

2012 ◽

Vol 32 (3) ◽

pp. 299-307 ◽

Cited By ~ 21

Author(s):

Mouduo Li ◽

Cuixia Qiao ◽

Liping Qin ◽

Junyong Zhang ◽

Changquan Ling

Keyword(s):

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Liver Cancer ◽

Primary Liver Cancer

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Use of Chlorogenic Acid against Diabetes Mellitus and Its Complications

Journal of Immunology Research ◽

10.1155/2020/9680508 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Yongwang Yan ◽

Xu Zhou ◽

Kangxiao Guo ◽

Feng Zhou ◽

Hongqi Yang

Keyword(s):

Diabetes Mellitus ◽

Diabetic Retinopathy ◽

Diabetic Nephropathy ◽

Peripheral Neuropathy ◽

Chinese Medicine ◽

Traditional Chinese Medicine ◽

Chlorogenic Acid ◽

Pharmacological Properties ◽

Prevention And Treatment ◽

Main Component

Chlorogenic acid (CA) is a phenolic compound commonly found in human plant-based diets. CA is the main component of many traditional Chinese medicine preparations, and in recent years, it has been found to have hypoglycemic, hypolipidemic, anti-inflammatory, antioxidant, and other pharmacological properties. Specifically, CA relieves the effects of, and prevents, diabetes mellitus (DM). In addition, CA is also beneficial against complications arising from DM, such as diabetic nephropathy (DN), diabetic retinopathy (DR), and diabetic peripheral neuropathy (DPN). Herein, we review the use of CA in the prevention and treatment of DM and its complications, providing a background for further research and medical uses.

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