scholarly journals Feasibility of Using a Novel 2.45 GHz Double Short Distance Slot Coaxial Antenna for Minimally Invasive Cancer Breast Microwave Ablation Therapy: Computational Model, Phantom, and In Vivo Swine Experimentation

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
R. Ortega-Palacios ◽  
C. J. Trujillo-Romero ◽  
M. F. J. Cepeda Rubio ◽  
A. Vera ◽  
L. Leija ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Minimally Invasive ◽  
Computational Model ◽  
Short Distance ◽  
Microwave Ablation ◽  
Slot Antenna ◽  
Invasive Treatment ◽  
Promising Alternative ◽  
Ablation Therapy

Microwave ablation (MWA) by using coaxial antennas is a promising alternative for breast cancer treatment. A double short distance slot coaxial antenna as a newly optimized applicator for minimally invasive treatment of breast cancer is proposed. To validate and to analyze the feasibility of using this method in clinical treatment, a computational model, phantom, and breast swine in vivo experimentation were carried out, by using four microwave powers (50 W, 30 W, 20 W, and 10 W). The finite element method (FEM) was used to develop the computational model. Phantom experimentation was carried out in breast phantom. The in vivo experimentation was carried out in a 90 kg swine sow. Tissue damage was estimated by comparing control and treated micrographs of the porcine mammary gland samples. The coaxial slot antenna was inserted in swine breast glands by using image-guided ultrasound. In all cases, modeling, in vivo and phantom experimentation, and ablation temperatures (above 60°C) were reached. The in vivo experiments suggest that this new MWA applicator could be successfully used to eliminate precise and small areas of tissue (around 20–30 mm2). By modulating the power and time applied, it may be possible to increase/decrease the ablation area.

scholarly journals Computational FEM Model and Phantom Validation of Microwave Ablation for Segmental Microcalcifications in Breasts Using a Coaxial Double-Slot Antenna

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Kristian Segura Félix ◽  
Geshel D. Guerrero López ◽  
Mario F. J. Cepeda Rubio ◽  
José I. Hernández Jacquez ◽  
Francisco G. Flores García ◽  
...  
Keyword(s):  
Computational Model ◽  
Microwave Ablation ◽  
Computational Models ◽  
Blood Perfusion ◽  
Premalignant Lesions ◽  
Slot Antenna ◽  
Treatment Modalities ◽  
Surgical Removal ◽  
Ablation Therapy ◽  
Breast Phantom

Introduction. Cancer is the second leading cause of death worldwide. Breast cancer is the second most common cause of cancer-related mortality, accounting for 11.6% of the total number of deaths. The main treatments for this disease are surgical removal of the tumor, radiotherapy, and chemotherapy. Recently, different minimally invasive technologies have been applied (e.g., emission of electromagnetic waves, thermal and chemical means) to overcome the important side effects of these treatment modalities. The objective of this study was to develop and evaluate a predictive computational model of microwave ablation. Materials and Methods. The predictive computational model of microwave ablation was constructed by means of a dual-slot coaxial antenna. The model was compared with an experiment performed using a breast phantom, which emulates the dielectric properties of breast tissue with segmental microcalcifications. The standing wave ratio (SWR) was obtained for both methods to make a comparison and determine the feasibility of applying electromagnetic ablation to premalignant lesions in breasts. Specifically, for the analysis of segmental microcalcifications, a breast phantom with segmental microcalcifications was developed and two computational models were performed under the same conditions (except for blood perfusion, which was excluded in one of the models). Results. The SWR was obtained by triplicate experiments in the phantom, and the measurements had a difference of 0.191 between the minimum and maximum SWR values, implying a change of power reflection of 0.8%. The average of the three measurements was compared with the simulation that did not consider blood perfusion. The comparison yielded a change of 0.104, representing a 0.2% change in power reflection. Discussion. Both experimentation in phantom and simulations demonstrated that ablation therapy can be performed using this antenna. However, an additional optimization procedure is warranted to increase the efficiency of the antenna.

110 O - Magnetic resonance imaging guided minimally invasive treatment of breast cancer

1996 ◽  
Vol 32 ◽  
pp. S22
Author(s):  
H. Mumtaz ◽  
M.W. Kissin ◽  
M.A. Hall-Craggs ◽  
T. Davidson ◽  
I. Taylor ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Minimally Invasive ◽  
Minimally Invasive Treatment ◽  
Resonance Imaging ◽  
Invasive Treatment

scholarly journals CRYOGENIC TECHNOLOGY IN MINIMALLY INVASIVE TREATMENT OF BREAST CANCER. LITERATURE REVIEW

2020 ◽  
Vol 66 (2) ◽  
pp. 103-108
Author(s):  
Aleksey Belyaev ◽  
Georgiy Prokhorov ◽  
Viktoriya Zakharova
Keyword(s):  
Breast Cancer ◽  
Literature Review ◽  
Minimally Invasive ◽  
Standard Treatment ◽  
Invasive Treatment ◽  
Scientific Validity ◽  
Control Material ◽  
Cryogenic Technology ◽  
Navigation And Control ◽  
And Control

The survey of literature includes period from the first attempts of palliative cryodestruction to modern miniinvasive technologies with the use of different methods of navigation and control. Material, that shows scientific validity, efficiency, positive technologic and clinical evolution of method, is collected sufficiently. But despite of general positive and optimistic assessment of cryogenic technologies’ opportunity, there are no results of randomized studies comparing distant results of cryogenic and existing standard treatment of breast cancer. In conclusion authors indicate the objective difficulties in problem’s studying and offer possible resolutions.

scholarly journals Bronchoscopically delivered microwave ablation in an in vivo porcine lung model

2020 ◽  
Vol 6 (4) ◽  
pp. 00146-2020
Author(s):  
Jan Sebek ◽  
Steve Kramer ◽  
Rob Rocha ◽  
Kun-Chang Yu ◽  
Radoslav Bortel ◽  
...  
Keyword(s):  
Microwave Ablation ◽  
Early Stage ◽  
Lung Parenchyma ◽  
Lung Model ◽  
Guidance System ◽  
Lung Tumour ◽  
Virtual Bronchoscopy ◽  
Invasive Treatment ◽  
Technical Feasibility

BackgroundPercutaneous microwave ablation is clinically used for inoperable lung tumour treatment. Delivery of microwave ablation applicators to tumour sites within lung parenchyma under virtual bronchoscopy guidance may enable ablation with reduced risk of pneumothorax, providing a minimally invasive treatment of early-stage tumours, which are increasingly detected with computed tomography (CT) screening. The objective of this study was to integrate a custom microwave ablation platform, incorporating a flexible applicator, with a clinically established virtual bronchoscopy guidance system, and to assess technical feasibility for safely creating localised thermal ablations in porcine lungs in vivo.MethodsPre-ablation CTs of normal pigs were acquired to create a virtual model of the lungs, including airways and significant blood vessels. Virtual bronchoscopy-guided microwave ablation procedures were performed with 24–32 W power (at the applicator distal tip) delivered for 5–10 mins. A total of eight ablations were performed in three pigs. Post-treatment CT images were acquired to assess the extent of damage and ablation zones were further evaluated with viability stains and histopathologic analysis.ResultsThe flexible microwave applicators were delivered to ablation sites within lung parenchyma 5–24 mm from the airway wall via a tunnel created under virtual bronchoscopy guidance. No pneumothorax or significant airway bleeding was observed. The ablation short axis observed on gross pathology ranged 16.5–23.5 mm and 14–26 mm on CT imaging.ConclusionWe have demonstrated the technical feasibility for safely delivering microwave ablation in the lung parenchyma under virtual bronchoscopic guidance in an in vivo porcine lung model.

Harlequin syndrome following microwave ablation in a child with a symptomatic paraspinal mass

2020 ◽  
Vol 13 (8) ◽  
pp. e232700
Author(s):  
Lauren Schultz ◽  
Amelia Mackarey ◽  
Caleb Oh ◽  
Paul Kent
Keyword(s):  
Minimally Invasive ◽  
Microwave Ablation ◽  
Paediatric Population ◽  
Invasive Technique ◽  
Specific Mechanism ◽  
Ct Guided ◽  
Ablation Therapy ◽  
Inherent Risk ◽  
Harlequin Syndrome ◽  
The Face

Our goal is to describe a case of Harlequin syndrome associated with microwave ablation in the treatment of a symptomatic paraspinal mass in a child, along with a summary of the literature. Our patient is the only known case of persistent Harlequin syndrome associated with microwave ablation treatment of a symptomatic paraspinal mass. Harlequin syndrome is a rare neurological condition characterised by unilateral sweating and flushing of the face, neck and/or upper chest. The specific mechanism is unclear, but the majority of cases are believed to be a result of contralateral lesions along the sympathetic chain. CT-guided microwave ablation therapy is a minimally invasive technique used as an alternative to surgery in this case due to the risk and morbidity associated with excision of the mass. There is limited literature assessing the use and inherent risk of developing complications following microwave ablation to the paraspinal region in the paediatric population.

scholarly journals Minimally-invasive treatment of early stage breast cancer: A feasibility study using radiofrequency ablation under local anesthesia

The Breast ◽  
2014 ◽  
Vol 23 (2) ◽  
pp. 152-158 ◽  
Author(s):  
Kai-Uwe Schässburger ◽  
Lars Löfgren ◽  
Ulla Lagerstedt ◽  
Karin Leifland ◽  
Karin Thorneman ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radiofrequency Ablation ◽  
Minimally Invasive ◽  
Local Anesthesia ◽  
Feasibility Study ◽  
Early Stage ◽  
Early Stage Breast Cancer ◽  
Minimally Invasive Treatment ◽  
Invasive Treatment
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