scholarly journals A 36-Year-Old Renal Transplant Recipient Female with Leg Ulcer: A Case Report and Brief Review

2018 ◽  
Vol 2018 ◽  
pp. 1-6
Author(s):  
Ali Monfared ◽  
Eftekhari Hojat ◽  
Seyed Alireza Mesbah ◽  
Abbas Darjani ◽  
Seyyede Zeinab Azimi
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Opportunistic Infections ◽  
Rare Complication ◽  
Organ Transplant ◽  
Transplant Recipients ◽  
Cutaneous Lesions ◽  
Case Presentation ◽  
High Clinical Suspicion

Background. Opportunistic infections are common in organ transplant recipients. After 6 months of transplantation, patients have the highest risk of opportunistic infections such as cryptococcosis. Case Presentation. The report presents the case of a 36-year-old female renal transplant recipient, with complaints of few subcutaneous painful and warm nodules and large, warm, erythematous, nontender plaques on the mildly edematous right leg and ankle. Incisional biopsy of the subcutaneous nodule over the leg showed panniculitis with small- to medium-sized vasculitis associated with round yeast forms, and culture of the fragments revealed C. neoformans var. grubii. Conclusions. This article also reviews in brief the treatment of this rare complication. Reviewing the literature showed that since the cryptococcal cutaneous lesions are often nonspecific, the clinical picture solely is not enough to construct a definite diagnosis and there must be a high clinical suspicion.

scholarly journals Gastropulmonary Fistula in a Renal Transplanted Patient! Who Knew?

2021 ◽  
Vol 5 (1) ◽  
Author(s):  
Ahad Qayyum ◽  
Marium Tahir ◽  
Fahad Mehmood ◽  
Ahmad Raza
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Immunosuppressive Therapy ◽  
Renal Transplant Recipient ◽  
Cause Of Death ◽  
Organ Transplant ◽  
Klebsiella Pneumonia ◽  
Transplant Recipients ◽  
Life Threatening ◽  
Life Threatening Complication

Patients requiring immunosuppressive therapy after transplantation are susceptible to infection by a variety of common and uncommon pathogens, and infection has been the major cause of death in organ transplant recipients. Here we present one of a kind case where klebsiella pneumonia led to a fatal and life threatening complication i.e. gastro pulmonary fistula in a renal transplant recipient.

Successful treatment of high-grade vulval intra-epithelial neoplasia with imiquimod 5% in a renal transplant recipient

2018 ◽  
Vol 30 (2) ◽  
pp. 198-200
Author(s):  
Azra Khatun ◽  
Helen Lotery ◽  
Sangeetha Sundaram
Keyword(s):  
Human Papillomavirus ◽  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Successful Treatment ◽  
Organ Transplant ◽  
High Grade ◽  
Transplant Recipients ◽  
Topical Imiquimod ◽  
Associated Lesions

Organ transplant recipients are at a higher risk of pre-malignant human papillomavirus-associated lesions due to immunosuppression. The efficacy of immunomodulants such as imiquimod 5% is not yet fully evaluated in this population. We describe a case of vulval intra-epithelial neoplasia in a renal transplant recipient which was successfully treated with topical imiquimod.

scholarly journals Pacemaker-related Candida parapsilosis fungaemia in an immunosuppressed renal transplant recipient

2021 ◽  
Vol 14 (7) ◽  
pp. e242917
Author(s):  
Josephine Hebert ◽  
Ellen Barr ◽  
Colm Magee
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Candida Parapsilosis ◽  
Opportunistic Infections ◽  
Blood Cultures ◽  
Renal Transplant Recipients ◽  
Pulmonary Emboli ◽  
Transplant Recipients ◽  
Pacemaker Leads

Renal transplant recipients are at risk for opportunistic infections due to their immunosuppressed state. We describe the case of a 59-year-old renal transplant recipient who presented with sepsis and bilateral pulmonary emboli due to Candida parapsilosis. She was treated with intravenous caspofungin and had a transoesophageal echocardiogram, which revealed vegetations on her pacemaker leads. She then underwent surgery to replace her pacemaker; however, her blood cultures remained positive for C. parapsilosis postoperatively. Her antifungal was switched to liposomal amphotericin B and flucytosine for 6 weeks, which yielded sterile blood cultures, and she was then initiated on lifelong fluconazole. Her recovery was complicated by tacrolimus toxicity 1 month after discharge due to fluconazole-induced CYP3A inhibition.

scholarly journals Opportunistic infections in a renal transplant recipient

2012 ◽  
Vol 4 (1) ◽  
pp. 8 ◽  
Author(s):  
Vijaya V. Mysorekar ◽  
Mahesh Eshwarappa ◽  
Umesh Lingaraj
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Organ Transplantation ◽  
Opportunistic Infections ◽  
Intestinal Tuberculosis ◽  
Transplant Recipients ◽  
Allograft Survival ◽  
Treatment Of Infection ◽  
Transplantation Procedures

With the present progress in transplantation procedures, there is an improvement in patient and allograft survival. However, the immunosuppression necessary to sustain the allograft predisposes these transplant recipients to infection, which is now a significant cause of morbidity and mortality. We describe a case of a 30-year-old renal transplant recipient with two opportunistic infections, namely, primary cutaneous aspergillosis and intestinal tuberculosis, with terminal enterococcal pleuritis and peritonitis. Control of the degree of immunosuppression, and prompt recognition and treatment of infection are vital for successful organ transplantation.

scholarly journals Severe hypogammaglobulinaemia and opportunistic infections after rituximab therapy in a renal transplant recipient

2009 ◽  
Vol 3 (2) ◽  
pp. 165-167
Author(s):  
A. Kahveci ◽  
E. Asicioglu ◽  
E. Ari ◽  
H. Arikan ◽  
S. Tuglular ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Opportunistic Infections

scholarly journals Refractory Thrombocytopenia Associated to Disseminated Histoplasmosis in a Living-Related Renal Transplant Recipient: A Case Report and Review of the Literature

2021 ◽  
Vol 8 (6) ◽  
Author(s):  
Rosario MD ◽  
◽  
Alfredo G-G ◽  
De Jesus AOA ◽  
Jorge AS ◽  
...  
Keyword(s):  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Clinical Characteristics ◽  
Clinical Presentation ◽  
Opportunistic Infections ◽  
Review Of The Literature ◽  
Disseminated Histoplasmosis ◽  
First Case ◽  
Living Related

Opportunistic infections are frequent complications after renal transplantation because of the use of immunosuppressants. Disseminated Histoplasmosis (DH) is one such opportunistic infection, and its clinical presentation varies, which makes its diagnosis a challenge. There is no information regarding DH as a cause of refractory thrombocytopenia in renal transplant recipient (RTR); therefore, we consider this an atypical case, and, because of its clinical characteristics, we have classified it as an Immune Thrombocytopenic Purpura (ITP) induced by histoplasmosis. This is the first case reported in our milieu, and it opens up the possibility for use of intravenous immunoglobulin as a strategic therapy for thrombocytopenia induced by HP in immunosuppressed RTRs.

Detection of Toxoplasma Gondii Antibodies and DNA Among Renal Transplant Recipient and blood donor in Khartoum State, Sudan

2021 ◽  
pp. 135-141
Author(s):  
Elghazali Mohammed ◽  
Mustafa Yassin ◽  
Khalid Anan ◽  
Dina N Abdelrahman ◽  
Abdelrahim M. ElHussein ◽  
...  
Keyword(s):  
Toxoplasma Gondii ◽  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Blood Donor ◽  
Blood Donors ◽  
Solid Organ ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Toxoplasma Gondii Infection

Background and Aim: Toxoplasma gondii infection arises in transplant recipient groups, but at varying frequencies. Reactivation of latent T. gondii infection in transplant patients is uncommon, but does occur. The incidence of reactivation is greater in patient groups receiving more aggressive immunosuppressive therapy. Early diagnosis and treatment should be considered in T. gondii-antibody-positive patients subjected to solid organ transplantation. The aim of this study was to estimate the seroprevalence of Toxoplasma gondii infection in renal transplant recipients in Khartoum, Sudan, using serological and molecular methods. Methods: This was a descriptive cross sectional, hospital based study, blood sample were collected from 108 participants; out of them 58 renal transplant recipient individuals and 50 healthy Blood donor attending Sudanese Kidney Association Hospital and Sudan Heart Center Blood Bank. Demographic data were collected by structured questionnaire. All samples were tested for anti-Toxoplasma IgG and IgM antibodies using ELISA, and PCR for detection of Toxoplasma DNA was performed. Results: The seropositivity of IgG anti-T. gondii antibodies was higher in renal transplant recipients than in blood donors (36.2% vs 32.0%). Anti-toxoplasma IgM was positive in one renal transplant recipient individual (1.70%), and no samples exhibit reactive IgM antibody for blood donors. None of the samples exhibited positivity to T.gondii DNA. Conclusion: the study showed a relatively high seroprevalence of T.gondii antibodies in renal transplant recipients and blood donor volunteers, on the other hand, the prevalence was much higher in the study conducted in pregnant woman in Sudan. Our study highlighted that asymptomatic blood donors, may constitute a significant risk of transmitting toxoplasmosis to susceptible recipients.

scholarly journals Severe hyperparathyroidism associated with prolonged hungry bone syndrome in a renal transplant recipient.

1997 ◽  
Vol 8 (10) ◽  
pp. 1626-1631
Author(s):  
A M Miles ◽  
M S Markell ◽  
N Sumrani ◽  
J Hong ◽  
E A Friedman
Keyword(s):  
Renal Transplantation ◽  
Renal Transplant ◽  
Transplant Recipient ◽  
Renal Transplant Recipient ◽  
Pathological Fracture ◽  
Renal Transplant Recipients ◽  
Transplant Recipients ◽  
Hungry Bone Syndrome ◽  
Persistent Hyperparathyroidism ◽  
Hungry Bone

Although widely believed to resolve within 6 to 12 months of successful renal transplantation, hyperparathyroidism may persist or develop after renal transplantation and eventually require parathyroidectomy. Avid calcium retention by demineralized bones (hungry bone syndrome) is well-recognized after parathyroidectomy and usually resolves after a few weeks. This report documents the case of a renal transplant recipient with persistent hyperparathyroidism who developed a pathological fracture of the pelvis and required parathyroidectomy 1 year after transplant and then manifested severe and prolonged hungry bone syndrome lasting for more than 20 months postoperatively. The clinical features and treatment of hyperparathyroidism in renal transplant recipients are discussed, as are diagnosis, pathogenesis, and management of hungry bone syndrome. Recognition of renal transplant recipients at greater risk for severe hungry bone syndrome should permit earlier and more aggressive management of this sometimes protracted complication of parathyroid surgery.

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