scholarly journals Carapa guianensis Aublet (Andiroba) Seed Oil: Chemical Composition and Antileishmanial Activity of Limonoid-Rich Fractions

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
Iara dos Santos da Silva Oliveira ◽  
Carla Junqueira Moragas Tellis ◽  
Maria do Socorro dos Santos Chagas ◽  
Maria Dutra Behrens ◽  
Kátia da Silva Calabrese ◽  
...  
Keyword(s):  
Seed Oil ◽  
Chemical Study ◽  
Peritoneal Macrophages ◽  
Antileishmanial Activity ◽  
Ionization Mass ◽  
Chemical Analyses ◽  
Carapa Guianensis ◽  
Intracellular Amastigotes ◽  
The World ◽  
Traditional Communities

Leishmaniasis is a complex of diseases caused by protozoa of the genus Leishmania and affects millions of people around the world. Several species of plants are used by traditional communities for the treatment of this disease, among which is Carapa guianensis Aubl. (Meliaceae), popularly known as andiroba. The objective of the present work was to conduct a chemical study of C. guianensis seed oil and its limonoid-rich fractions, with the aim of identifying its secondary metabolites, particularly the limonoids, in addition to investigating its anti-Leishmania potential. The chemical analyses of the C. guianensis seed oil and fractions were obtained by electrospray ionization mass spectrometry (ESI-MS). The cytotoxic activity was tested against peritoneal macrophages, and antileishmanial activity was evaluated against promastigotes and intracellular amastigotes of Leishmania amazonensis. All the C. guianensis seed oil samples analyzed exhibited the same pattern of fatty acids, while the limonoids 7-deacetoxy-7-hydroxygedunin, deacetyldihydrogedunin, deoxygedunin, andirobin, gedunin, 11β-hydroxygedunin, 17-glycolyldeoxygedunin, 6α-acetoxygedunin, and 6α,11β-diacetoxygedunin were identified in the limonoid-rich fractions of the oil. The C. guianensis seed oil did not exhibit antileishmanial activity, and cytotoxicity was higher than 1000 μg/mL. Three limonoid-rich oil fractions demonstrated activity against promastigotes (IC50 of 10.53±0.050, 25.3±0.057, and 56.9±0.043μg/mL) and intracellular amastigotes (IC50 of 27.31±0.091, 78.42±0.086, and 352.2±0.145 μg/mL) of L. amazonensis, as well as cytotoxicity against peritoneal macrophages (CC50 of 78.55±1.406, 139.0±1.523, and 607.7±1.217 μg/mL). The anti-Leishmania activity of the limonoid-rich fractions of C. guianensis can be attributed to the limonoids 11β-hydroxygedunin and 6α,11β-diacetoxygedunin detected in the chemical analysis.

Chemical analyses in the World Coal Quality Inventory

2010 ◽  
Author(s):  
Susan J. Tewalt ◽  
Harvey E. Belkin ◽  
John R. SanFilipo ◽  
Matthew D. Merrill ◽  
Curtis A. Palmer ◽  
...  
Keyword(s):  
Chemical Analyses ◽  
Coal Quality ◽  
The World

ANTI-CANCER COMPOUNDS ISOLATED FROM SOFT CORAL SINULARIA CRUCIATA - ALCYONIIDAE

2012 ◽  
pp. 84-89
Author(s):  
Quoc Hung Vo ◽  
Nguyen Phuong Nhi Doan ◽  
Dinh Quynh Phu Nguyen ◽  
Thi Dieu Tram Ho ◽  
Thi Hoai Nguyen
Keyword(s):  
Mass Spectrometry ◽  
Soft Coral ◽  
Normal Phase ◽  
Ionization Mass ◽  
Medical Field ◽  
Bioactive Substances ◽  
Anti Cancer ◽  
The World ◽  
Pure Compounds ◽  
Layer Chromatography

Objectives: Nowadays, bioactive substances isolated from marine organisms which are abundant and varied in Vietnamese sea attracted more and more the attention of scientists in the world and Vietnam as well. We have studied on soft coral Sinularia cruciata – Alcyoniidae, which has never been studied in Vietnam before, to find substances which are useful in medical field, especially in anti-cancer therapy. Materials and method: Specimens of soft coral Sinularia cruciata were collected from Con Co, Quang Tri province in May 2011. Pure compounds were isolated by using Thin Layer Chromatography; Column Chromatography normal phase and inverse phase; Shephadex LH 20. Structures of them were determined by spectral data of Nuclear Magnetic Resonance (NMR), Electrospray Ionization Mass Spectrometry (ESI-MS). Results & Conclusion: Structures of 4 compounds were identified: (1) 5.8-epidioxycholest-6-en-3-ol (2) Cholesterol (3) 1-O-hexadecyl-glycerol (Chimyl alcohol) (4) Glycerol 1-O-octadecyl ether (Batyl alcohol). The substance (1) was demonstrated to have strong anti-cancer effects in previous study. Key words Sinularia cruciata, Alcyoniidae, 5,8-epidioxycholest-6-en-3-ol, soft coral, cancer.

Antileishmanial activity of verbascoside: Selective arginase inhibition of intracellular amastigotes of Leishmania (Leishmania) amazonensis with resistance induced by LPS plus IFN-γ

2017 ◽  
Vol 127 ◽  
pp. 28-33 ◽  
Author(s):  
Claudia do Carmo Maquiaveli ◽  
Arina Lázaro Rochetti ◽  
Heidge Fukumasu ◽  
Paulo Cezar Vieira ◽  
Edson Roberto da Silva
Keyword(s):  
Leishmania Amazonensis ◽  
Antileishmanial Activity ◽  
Intracellular Amastigotes ◽  
Ifn Γ

‘We must send you a sample’—a Persian–European dialogue: insights into late nineteenth-century ceramic technology based on chemical analysis of tiles from the Ettehadieh house complex, Tehran, Iran

2020 ◽  
Author(s):  
Moujan Matin ◽  
Mohammad Gholamnejad ◽  
Ali Nemati Abkenar
Keyword(s):  
Nineteenth Century ◽  
Chemical Analysis ◽  
Production Technology ◽  
Chemical Study ◽  
Ceramic Technology ◽  
Late Nineteenth Century ◽  
Chemical Analyses ◽  
Technological Information ◽  
Late Nineteenth ◽  
First Time

This paper focuses on the production technology of late nineteenth-century tiles from the Ettehadieh House Complex in Tehran, Iran. It makes use of the opportunity to provide for the first time the results of chemical and microstructural analyses of late nineteenth-century tiles selected directly from context and with known provenance. The paper integrates the results of chemical study of the Ettehadieh tiles with other available technological information on nineteenth-century Persian tiles, including chemical analyses of signed tiles and samples of pigments, as well as the study of the treatise of a certain Persian potter, ‘Ali Mohammad Isfahani, to suggest processes of materials procurement and manufacture. These processes are used as evidence to discuss trade and technological interactions between Iran and Europe in the nineteenth century.

Lipidomic profiles from seed oil of Carapa guianensis Aubl. and Carapa vasquezii Kenfack and implications for the control of phytopathogenic fungi

2019 ◽  
Vol 129 ◽  
pp. 67-73 ◽  
Author(s):  
Gleisson O. Nascimento ◽  
Diego P. Souza ◽  
Alberdan S. Santos ◽  
Josimar F. Batista ◽  
Bala Rathinasabapathi ◽  
...  
Keyword(s):  
Seed Oil ◽  
Phytopathogenic Fungi ◽  
Carapa Guianensis

scholarly journals In Vitro Schistosomicidal Activity of the Alkaloid-Rich Fraction from Ruta graveolens L. (Rutaceae) and Its Characterization by UPLC-QTOF-MS

2019 ◽  
Vol 2019 ◽  
pp. 1-8 ◽  
Author(s):  
Lara Soares Aleixo de Carvalho ◽  
Lucas Sales Queiroz ◽  
Ismael José Alves Junior ◽  
Ayla das Chagas Almeida ◽  
Elaine Soares Coimbra ◽  
...  
Keyword(s):  
Folk Medicine ◽  
Peritoneal Macrophages ◽  
Antileishmanial Activity ◽  
Parasitic Infections ◽  
Leishmania Braziliensis ◽  
Ruta Graveolens ◽  
Active Fraction ◽  
Ms Analysis ◽  
First Time

Schistosomiasis is a neglected tropical disease that affects million people worldwide, mostly in developing countries. Ruta graveolens (Rutaceae) is a plant used in folk medicine to treat several diseases, including parasitic infections. In this study, we reported the in vitro schistosomicidal activity of the R. graveolens extract (Rg) and its active fraction (Rg-FAE). Also, the characterization of Rg-FAE by UPLC-ESI-QTOF-MS analysis and its in vitro antileishmanial activity against Leishmania braziliensis were also performed. In vitro schistosomicidal assays were assessed against adult worms of S. mansoni, while cell viability against peritoneal macrophages was measured by MTT assay. Rg (100 μg/mL) exhibited noticeable schistosomicidal activity, causing 100% mortality and decreasing motor activity of all adult male and female schistosomes, but with low activity against L. braziliensis. After chromatographic fractionation of Rg, fraction Rg-FAE was obtained, showing high activity against adult schistosomes. UPLC-ESI-QTOF-MS analysis of Rg-FAE revealed the presence of eleven alkaloids and one furanocoumarin. No significant antileishmanial activity was found for Rg, while Rg-FAE exhibited activity against L. braziliensis promastigotes. We demonstrated, for the first time, that the R. graveolens extract (Rg) and its alkaloid-rich fraction (Rg-FAE) are active against adult worms of S. mansoni, with no significant cytotoxicity on macrophages. Our findings open the route to further antiparasitic studies with the active fraction of R. graveolens and its identified compounds, especially alkaloids.

Chemical Characterization of Jatropha curcas L. Seed Oil and Its Biodiesel by Ambient Desorption/Ionization Mass Spectrometry

2015 ◽  
Vol 29 (5) ◽  
pp. 3096-3103 ◽  
Author(s):  
Anna Maria A. P. Fernandes ◽  
Soraya El-Khatib ◽  
Ildenize B. S. Cunha ◽  
Andréia M. Porcari ◽  
Marcos N. Eberlin ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Jatropha Curcas ◽  
Seed Oil ◽  
Chemical Characterization ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Jatropha Curcas L ◽  
Desorption Ionization

scholarly journals Globalisation as a facilitator of terroris

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
MA. Genc Mekaj
Keyword(s):  
Rule Of Law ◽  
Terrorist Attacks ◽  
Gradual Change ◽  
The Rule Of Law ◽  
Cultural Boundaries ◽  
The World ◽  
Terrorist Groups ◽  
Economic Boom ◽  
Traditional Communities ◽  
Over Time

Terrorism is a phenomenon that develops over time, always bringing about gradual change of form and activity. Terrorist groups organize terrorist attacks based on ideologies. Terrorism is one of the biggest problems facing the world today. Terrorists are always at odds with the rule of law, with the norms and ideals of civilization itself. Terrorism is the use of fear or violence to overthrow a government and society in accepting a radical political or social change. It is geographically widespread and ideologically selected.The process of globalization, which includes the technological, economic boom, cultural boundaries between countries around the world has fostered a culture corrupt market in traditional communities. Many places consider this as a threat to their country. Globalization has somewhat helped terrorism, moreover has brought the involvement of the latest and latest technologies

scholarly journals Physics-chemical study of hydration process of three calcium aluminate phase and Metakaolin

2014 ◽  
Vol 12 ◽  
pp. 107-112
Author(s):  
Ts Erdenebat ◽  
R Sanjaasuren
Keyword(s):  
Calcium Aluminate ◽  
Early Stage ◽  
Chemical Study ◽  
Hydration Process ◽  
Phase Content ◽  
Chemical Analyses ◽  
X Ray Diffraction ◽  
X Ray

This research based on X-Ray Diffraction, SEM and chemical analyses were revealed that decreasing of Ca(OH)2 phase content and increasing of C3AH6 and trisulfate aluminate calcium-3 as the stable phases for the hydration period of first 30 to 60 minutes when comparing K-crent doping to the phase to without any doping. Also results have been proposed in case of doping metakaoline to draw structural analogies as formation of stable hydrated phases and the decrease of new formed unstable crystalline metaphases in the early stage of 3CAO·Al2O3 hydration process.DOI: http://dx.doi.org/10.5564/mjc.v12i0.183 Mongolian Journal of Chemistry Vol.12 2011: 107-112 

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