scholarly journals Characterization of Follicular Atresia Responsive to BPA in Zebrafish by Morphometric Analysis of Follicular Stage Progression

2018 ◽  
Vol 2018 ◽  
pp. 1-10 ◽  
Author(s):  
M. Migliaccio ◽  
T. Chioccarelli ◽  
C. Ambrosino ◽  
A. Suglia ◽  
F. Manfrevola ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Morphometric Analysis ◽  
Endocrine Disruptor ◽  
Endocrine System ◽  
Stage Iv ◽  
Follicular Atresia ◽  
Interference Effects ◽  
Qualitative And Quantitative ◽  
Stage Development

Bisphenol A is an industrial chemical compound, pervasively polluting the environment and diet, classified as an endocrine disruptor because of its interference effects on the endocrine system. In zebrafish, BPA exposure induces follicular atresia. To acquire knowledge on this atretic effect, using a qualitative and quantitative histomorphological approach, we studied zebrafish ovarian follicular stage development in response to low BPA concentrations. Results show that BPA interferes with follicular progression by affecting the previtellogenic and vitellogenic phases. In particular, BPA exposure (i) increases follicular recruitment by acting on primary stage follicles, (ii) forces the follicular transition from stage III to stage IV producing enlarged stage IV follicles, and (iii) induces atresia by producing atretic follicles that are peculiarly enlarged (i.e., big atretic follicles). We suggest that BPA induces atresia by the primary effect on recruitment of stage I follicles. This forces follicular progression and produces stage IV follicles that are peculiarly enlarged that undertake the atretic development.

scholarly journals Changes Caused by Low Doses of Bisphenol A (BPA) in the Neuro-Chemistry of Nerves Located in the Porcine Heart

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 780
Author(s):  
Krystyna Makowska ◽  
Slawomir Gonkowski
Keyword(s):  
Bisphenol A ◽  
Endocrine Disruptor ◽  
Sympathetic Innervation ◽  
Daily Intake ◽  
Everyday Objects ◽  
Living Organisms ◽  
The Impact ◽  
Heart Wall ◽  
Cholinergic Structures

Bisphenol A (BPA) contained in plastics used in the production of various everyday objects may leach from these items and contaminate food, water and air. As an endocrine disruptor, BPA negatively affects many internal organs and systems. Exposure to BPA also contributes to heart and cardiovascular system dysfunction, but many aspects connected with this activity remain unknown. Therefore, this study aimed to investigate the impact of BPA in a dose of 0.05 mg/kg body weight/day (in many countries such a dose is regarded as a tolerable daily intake–TDI dose of BPA–completely safe for living organisms) on the neurochemical characterization of nerves located in the heart wall using the immunofluorescence technique. The obtained results indicate that BPA (even in such a relatively low dose) increases the number of nerves immunoreactive to neuropeptide Y, substance P and tyrosine hydroxylase (used here as a marker of sympathetic innervation). However, BPA did not change the number of nerves immunoreactive to vesicular acetylcholine transporter (used here as a marker of cholinergic structures). These observations suggest that changes in the heart innervation may be at the root of BPA-induced circulatory disturbances, as well as arrhythmogenic and/or proinflammatory effects of this endocrine disruptor. Moreover, changes in the neurochemical characterization of nerves in the heart wall may be the first sign of exposure to BPA.

scholarly journals The Role of the Bisphenol A in Diabetes and Obesity

Biomedicines ◽  
2021 ◽  
Vol 9 (6) ◽  
pp. 666
Author(s):  
Marcelino Pérez-Bermejo ◽  
Irene Mas-Pérez ◽  
Maria Teresa Murillo-Llorente
Keyword(s):  
Risk Factor ◽  
Bisphenol A ◽  
Endocrine Disruptor ◽  
Experimental Studies ◽  
Endocrine System ◽  
Epidemiological Studies ◽  
Additional Risk Factor ◽  
Health Campaigns ◽  
Obesity And Diabetes ◽  
Diabetes And Obesity

Bisphenol A is a compound commonly found in products meant for daily use. It was one of the first compounds to be identified as an endocrine disruptor that was capable of disrupting the endocrine system and producing very similar effects to those of metabolic syndrome. It has recently gained popularity in the scientific arena as a risk factor for obesity and diabetes due to its ability to imitate natural oestrogens and bind to their receptors. The aim was to study the possible relationship between the Bisphenol A endocrine disruptor with diabetes and obesity. The analysis of the articles allows us to conclude that Bisphenol A is an additional risk factor to consider in the development of diabetes and obesity, since it is capable of stimulating the hypertrophy of adipocytes and altering the endocrine system by mimicking the effects of the oestrogen molecule, since epidemiological studies carried out have suggested that the same disruptions seen in experimental studies on animals can be found in humans; however, despite many countries having developed policies to limit exposure to this disruptor in their populations, there is a lack of international agreement. Understanding its relationship with obesity and diabetes will help to raise awareness in the population and adopt public health campaigns to prevent exposure—especially among young people—to these substances.

scholarly journals Production, Validation and Morphometric Analysis of a Digital Terrain Model for Lake Trichonis Using Geospatial Technologies and Hydroacoustics

2021 ◽  
Vol 10 (2) ◽  
pp. 91
Author(s):  
Triantafyllia-Maria Perivolioti ◽  
Antonios Mouratidis ◽  
Dimitrios Terzopoulos ◽  
Panagiotis Kalaitzis ◽  
Dimitrios Ampatzidis ◽  
...  
Keyword(s):  
Morphometric Analysis ◽  
Ad Hoc ◽  
Regional Scale ◽  
Digital Terrain Model ◽  
Relevant Information ◽  
Relative Difference ◽  
Systematic Observation ◽  
Qualitative And Quantitative ◽  
Terrain Model ◽  
Digital Terrain

Covering an area of approximately 97 km2 and with a maximum depth of 58 m, Lake Trichonis is the largest and one of the deepest natural lakes in Greece. As such, it constitutes an important ecosystem and freshwater reserve at the regional scale, whose qualitative and quantitative properties ought to be monitored. Depth is a crucial parameter, as it is involved in both qualitative and quantitative monitoring aspects. Thus, the availability of a bathymetric model and a reliable DTM (Digital Terrain Model) of such an inland water body is imperative for almost any systematic observation scenario or ad hoc measurement endeavor. In this context, the purpose of this study is to produce a DTM from the only official cartographic source of relevant information available (dating back approximately 70 years) and evaluate its performance against new, independent, high-accuracy hydroacoustic recordings. The validation procedure involves the use of echosoundings coupled with GPS, and is followed by the production of a bathymetric model for the assessment of the discrepancies between the DTM and the measurements, along with the relevant morphometric analysis. Both the production and validation of the DTM are conducted in a GIS environment. The results indicate substantial discrepancies between the old DTM and contemporary acoustic data. A significant overall deviation of 3.39 ± 5.26 m in absolute bottom elevation differences and 0.00 ± 7.26 m in relative difference residuals (0.00 ± 2.11 m after 2nd polynomial model corrector surface fit) of the 2019 bathymetric dataset with respect to the ~1950 lake DTM and overall morphometry appear to be associated with a combination of tectonics, subsidence and karstic phenomena in the area. These observations could prove useful for the tectonics, geodynamics and seismicity with respect to the broader Corinth Rift region, as well as for environmental management and technical interventions in and around the lake. This dictates the necessity for new, extensive bathymetric measurements in order to produce an updated DTM of Lake Trichonis, reflecting current conditions and tailored to contemporary accuracy standards and state-of-the-art research in various disciplines in and around the lake.

scholarly journals Graphene, an Interesting Nanocarbon Allotrope for Biosensing Applications: Advances, Insights, and Prospects

2021 ◽  
Vol 12 ◽  
pp. 117959722098382
Author(s):  
Farid Menaa ◽  
Yazdian Fatemeh ◽  
Sandeep K Vashist ◽  
Haroon Iqbal ◽  
Olga N Sharts ◽  
...  
Keyword(s):  
Cost Effective ◽  
Genetic Alterations ◽  
Multiplex Detection ◽  
Quantitative Characterization ◽  
Disease Biomarkers ◽  
Qualitative And Quantitative ◽  
Sensing Systems ◽  
Doped Graphene ◽  
Bioanalytical Applications

Graphene, a relatively new two-dimensional (2D) nanomaterial, possesses unique structure (e.g. lighter, harder, and more flexible than steel) and tunable physicochemical (e.g. electronical, optical) properties with potentially wide eco-friendly and cost-effective usage in biosensing. Furthermore, graphene-related nanomaterials (e.g. graphene oxide, doped graphene, carbon nanotubes) have inculcated tremendous interest among scientists and industrials for the development of innovative biosensing platforms, such as arrays, sequencers and other nanooptical/biophotonic sensing systems (e.g. FET, FRET, CRET, GERS). Indeed, combinatorial functionalization approaches are constantly improving the overall properties of graphene, such as its sensitivity, stability, specificity, selectivity, and response for potential bioanalytical applications. These include real-time multiplex detection, tracking, qualitative, and quantitative characterization of molecules (i.e. analytes [H2O2, urea, nitrite, ATP or NADH]; ions [Hg2+, Pb2+, or Cu2+]; biomolecules (DNA, iRNA, peptides, proteins, vitamins or glucose; disease biomarkers such as genetic alterations in BRCA1, p53) and cells (cancer cells, stem cells, bacteria, or viruses). However, there is still a paucity of comparative reports that critically evaluate the relative toxicity of carbon nanoallotropes in humans. This manuscript comprehensively reviews the biosensing applications of graphene and its derivatives (i.e. GO and rGO). Prospects and challenges are also introduced.

Effective adsorption of the endocrine disruptor compound bisphenol a from water on surface-modified carbon materials

2021 ◽  
Vol 552 ◽  
pp. 149513
Author(s):  
A.B. Hernández-Abreu ◽  
S. Álvarez-Torrellas ◽  
R.P. Rocha ◽  
M.F.R. Pereira ◽  
V.I. Águeda ◽  
...  
Keyword(s):  
Bisphenol A ◽  
Endocrine Disruptor ◽  
Carbon Materials ◽  
Surface Modified

scholarly journals Characterization of Copoly(p-hydroxybenzoate/bisphenol A terephthalate) by NMR Spectroscopy

1996 ◽  
Vol 28 (10) ◽  
pp. 896-900 ◽  
Author(s):  
Yong Wang ◽  
Dacheng Wu ◽  
Xingguang Xie ◽  
Ruixia Li
Keyword(s):  
Nmr Spectroscopy ◽  
Bisphenol A
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