scholarly journals Intraoperative Local Administration of Platelet-Rich Plasma (PRP) during Neurolysis Surgery for the Treatment of Digital Nerve Crush Injury

2018 ◽  
Vol 2018 ◽  
pp. 1-6 ◽  
Author(s):  
Akira Ikumi ◽  
Yuki Hara ◽  
Eriko Okano ◽  
Sho Kohyama ◽  
Norihito Arai ◽  
...  
Keyword(s):  
Neuropathic Pain ◽  
Case Report ◽  
Peripheral Nerve ◽  
Platelet Rich Plasma ◽  
Crush Injury ◽  
Local Administration ◽  
Therapeutic Effects ◽  
Digital Nerve ◽  
Nerve Crush ◽  
Nerve Crush Injury

The digital nerves are important for normal hand function. In addition to conventional therapies such as neurolysis, direct repair, and auto/allografts, new treatments administering growth factors and cells for promoting nerve regeneration exist. Platelet-rich plasma (PRP), an autologous product with proven therapeutic effects for musculoskeletal disorders, is a new treatment option for peripheral nerve injury. We hypothesized that PRP could stimulate healing of digital nerve injuries. In the current case report, intraoperative local administration of PRP was performed during neurolysis surgery for a healthy 28-year-old woman with digital nerve crush injury. Five weeks postinjury, surgery was performed due to severe uncontrollable neuropathic pain and no sensory nerve action potential derivation of the index finger. Therapeutic effects were assessed by physical examination, visual analog scale for pain, and nerve conduction study. Postoperatively, early neuropathic pain relief and good functional recovery were obtained with no PRP-related adverse events. This case report demonstrates the therapeutic potential of intraoperative PRP to enhance the healing process of nerve crush injury in the acute phase and to decrease the neuropathic pain, thus enhancing healing of peripheral nerve crush injury.

scholarly journals Ultrasound-guided platelet-rich plasma injection and multimodality ultrasound examination of peripheral nerve crush injury

2020 ◽  
Vol 5 (1) ◽  
Author(s):  
Yaqiong Zhu ◽  
Zhuang Jin ◽  
Jing Wang ◽  
Siming Chen ◽  
Yongqiang Hu ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Platelet Rich Plasma ◽  
Blood Platelets ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Maximal Effect ◽  
Ultrasound Guided ◽  
Nerve Crush ◽  
Nerve Crush Injury

AbstractUltrasound-guided platelet-rich plasma (PRP) injection is able to make up for the limitations of applying a single growth factor. The goal of this study was to investigate the effects of serial ultrasound-guided PRP injections of the appropriate concentration on the treatment of sciatic nerve crush injury, and explore the value of multimodality ultrasound techniques in evaluating the prognosis of crushed peripheral nerve. In vitro, optimal concentration of PRP (from 150%, 250%, 450%, and 650%) was screened due for its maximal effect on proliferation and neurotrophic function of Schwann cells (SCs). In vivo, ninety rabbits were equally and randomly divided into normal control, model, PRP-2.5×, PRP-4.5×, and PRP-6.5× groups. The neurological function and electrophysiological recovery evaluation, and the comparison of the multimodality ultrasound evaluation with the histological results of sciatic nerve crush injury were performed to investigate the regenerative effects of PRP at different concentrations on the sciatic nerve crush injury. Our results showed that the PRP with a 4.5-fold concentration of whole blood platelets could significantly stimulate the proliferation and secretion of SCs and nerve repair. The changes in stiffness and blood perfusion were positively correlated with the collagen area percentage and VEGF expression in the injured nerve, respectively. Thus, serial ultrasound-guided PRP injections at an appropriate concentration accelerates the recovery of axonal function. Multimodality ultrasound techniques provide a clinical reference for prognosis by allowing the stiffness and microcirculation perfusion of crush-injured peripheral nerves to be quantitatively evaluated.

scholarly journals Platelet-rich plasma can release nutrient factors to promote facial nerve crush injury recovery in rats

2019 ◽  
Vol 40 (12) ◽  
pp. 1209-1217 ◽  
Author(s):  
Liheng Li ◽  
Jing Cai ◽  
Yang Yuan ◽  
Yanyan Mao ◽  
Lei Xu ◽  
...  
Keyword(s):  
Facial Nerve ◽  
Platelet Rich Plasma ◽  
Crush Injury ◽  
Nerve Crush ◽  
Injury Recovery ◽  
Nerve Crush Injury

Urethral dysfunction and therapeutic effects of a PDE 5 inhibitor (tadalafil) in a rat model of detrusor underactivity induced by pelvic nerve crush injury

2020 ◽  
Vol 39 (3) ◽  
pp. 916-925
Author(s):  
Ei‐Ichiro Takaoka ◽  
Masahiro Kurobe ◽  
Takahisa Suzuki ◽  
Nobutaka Shimizu ◽  
Joonbeom Kwon ◽  
...  
Keyword(s):  
Rat Model ◽  
Crush Injury ◽  
Therapeutic Effects ◽  
Detrusor Underactivity ◽  
Pelvic Nerve ◽  
Nerve Crush ◽  
Nerve Crush Injury

The promotion of peripheral nerve regeneration by chitooligosaccharides in the rat nerve crush injury model

2009 ◽  
Vol 454 (3) ◽  
pp. 239-243 ◽  
Author(s):  
Maorong Jiang ◽  
Xiaoming Zhuge ◽  
Yumin Yang ◽  
Xiaosong Gu ◽  
Fei Ding
Keyword(s):  
Peripheral Nerve ◽  
Nerve Regeneration ◽  
Peripheral Nerve Regeneration ◽  
Crush Injury ◽  
Nerve Crush ◽  
Injury Model ◽  
Rat Nerve ◽  
Nerve Crush Injury

scholarly journals Reduced Renshaw Recurrent Inhibition after Neonatal Sciatic Nerve Crush in Rats

2014 ◽  
Vol 2014 ◽  
pp. 1-11
Author(s):  
Liang Shu ◽  
Jingjing Su ◽  
Lingyan Jing ◽  
Ying Huang ◽  
Yu Di ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Sciatic Nerve ◽  
Peripheral Nerve ◽  
Nerve Injury ◽  
Peripheral Nerve Injury ◽  
Recurrent Inhibition ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Nerve Crush Injury

Renshaw recurrent inhibition (RI) plays an important gated role in spinal motion circuit. Peripheral nerve injury is a common disease in clinic. Our current research was designed to investigate the change of the recurrent inhibitory function in the spinal cord after the peripheral nerve crush injury in neonatal rat. Sciatic nerve crush was performed on 5-day-old rat puppies and the recurrent inhibition between lateral gastrocnemius-soleus (LG-S) and medial gastrocnemius (MG) motor pools was assessed by conditioning monosynaptic reflexes (MSR) elicited from the sectioned dorsal roots and recorded either from the LG-S and MG nerves by antidromic stimulation of the synergist muscle nerve. Our results demonstrated that the MSR recorded from both LG-S or MG nerves had larger amplitude and longer latency after neonatal sciatic nerve crush. The RI in both LG-S and MG motoneuron pools was significantly reduced to virtual loss (15–20% of the normal RI size) even after a long recovery period upto 30 weeks after nerve crush. Further, the degree of the RI reduction after tibial nerve crush was much less than that after sciatic nerve crush indicatig that the neuron-muscle disconnection time is vital to the recovery of the spinal neuronal circuit function during reinnervation. In addition, sciatic nerve crush injury did not cause any spinal motor neuron loss but severally damaged peripheral muscle structure and function. In conclusion, our results suggest that peripheral nerve injury during neonatal early development period would cause a more sever spinal cord inhibitory circuit damage, particularly to the Renshaw recurrent inhibition pathway, which might be the target of neuroregeneration therapy.

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