Urethral dysfunction and therapeutic effects of a PDE 5 inhibitor (tadalafil) in a rat model of detrusor underactivity induced by pelvic nerve crush injury

2020 ◽  
Vol 39 (3) ◽  
pp. 916-925
Author(s):  
Ei‐Ichiro Takaoka ◽  
Masahiro Kurobe ◽  
Takahisa Suzuki ◽  
Nobutaka Shimizu ◽  
Joonbeom Kwon ◽  
...  
Keyword(s):  
Rat Model ◽  
Crush Injury ◽  
Therapeutic Effects ◽  
Detrusor Underactivity ◽  
Pelvic Nerve ◽  
Nerve Crush ◽  
Nerve Crush Injury

scholarly journals Functional and molecular characterisation of the bilateral pelvic nerve crush injury rat model for neurogenic detrusor underactivity

2019 ◽  
Vol 123 (5A) ◽  
pp. E86-E96 ◽  
Author(s):  
Karel Dewulf ◽  
Emmanuel Weyne ◽  
Thomas Gevaert ◽  
Yves Deruyver ◽  
Thomas Voets ◽  
...  
Keyword(s):  
Rat Model ◽  
Crush Injury ◽  
Detrusor Underactivity ◽  
Molecular Characterisation ◽  
Pelvic Nerve ◽  
Nerve Crush ◽  
Nerve Crush Injury

Effect of TRPV4 activation in a rat model of detrusor underactivity induced by bilateral pelvic nerve crush injury

2018 ◽  
Vol 37 (8) ◽  
pp. 2527-2534 ◽  
Author(s):  
Ei-ichiro Takaoka ◽  
Masahiro Kurobe ◽  
Hiroki Okada ◽  
Shun Takai ◽  
Takahisa Suzuki ◽  
...  
Keyword(s):  
Rat Model ◽  
Crush Injury ◽  
Detrusor Underactivity ◽  
Pelvic Nerve ◽  
Nerve Crush ◽  
Nerve Crush Injury

scholarly journals PD36-01 HYPOGASTRIC AND PELVIC NERVE CRUSH INJURY IMPAIRS VAGINAL MICROVASCULAR PERFUSION IN A RAT MODEL

2020 ◽  
Vol 203 ◽  
pp. e723
Author(s):  
Samuel Sorkhi* ◽  
Min Chul Cho ◽  
Sung Yong Cho ◽  
Hong Chung ◽  
Christopher Cano Sanchez ◽  
...  
Keyword(s):  
Rat Model ◽  
Microvascular Perfusion ◽  
Crush Injury ◽  
Pelvic Nerve ◽  
Nerve Crush ◽  
Nerve Crush Injury

scholarly journals Canine Adipose-Derived Mesenchymal Stromal Cells Enhance Neuroregeneration in a Rat Model of Sciatic Nerve Crush Injury

2018 ◽  
Vol 28 (1) ◽  
pp. 47-54 ◽  
Author(s):  
Diego Noé Rodríguez Sánchez ◽  
Luiz Antonio de Lima Resende ◽  
Giovana Boff Araujo Pinto ◽  
Ana Lívia de Carvalho Bovolato ◽  
Fábio Sossai Possebon ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Mesenchymal Stromal Cells ◽  
Rat Model ◽  
Stromal Cells ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Muscle Weight ◽  
Nerve Crush ◽  
Nerve Crush Injury

Crush injuries in peripheral nerves are frequent and induce long-term disability with motor and sensory deficits. Due to axonal and myelin sheath disruptions, strategies for optimized axonal regeneration are needed. Multipotent mesenchymal stromal cells (MSC) are promising because of their anti-inflammatory properties and secretion of neurotrophins. The present study investigated the effect of canine adipose tissue MSC (Ad-MSC) transplantation in an experimental sciatic nerve crush injury. Wistar rats were divided into three groups: sham ( n = 8); Crush+PBS ( n = 8); Crush+MSC ( n = 8). Measurements of sciatic nerve functional index (SFI), muscle mass, and electromyography (EMG) were performed. Canine Ad-MSC showed mesodermal characteristics (CD34-, CD45-, CD44+, CD90+ and CD105+) and multipotentiality due to chondrogenic, adipogenic, and osteogenic differentiation. SFI during weeks 3 and 4 was significantly higher in the Crush+MSC group ( p < 0.001). During week 4, the EMG latency in the Crush+MSC groups had better near normality ( p < 0.05). The EMG amplitude showed results close to normality during week 4 in the Crush+MSC group ( p < 0.04). There were no statistical differences in muscle weight between the groups ( p > 0.05), but there was a tendency toward weight gain in the Crush+MSC groups. Better motor functional recovery after crush and perineural canine Ad-MSC transplantation was observed during week 2. This was maintained till week 4. In conclusion, the canine Ad-MSC transplantation showed early pro-regenerative effects between 2–4 weeks in the rat model of sciatic nerve crush injury.

scholarly journals Hypoglossal-facial ‘side’-to-side neurorrhaphy combined with electrical myostimulation for facial palsy in rats

2018 ◽  
Vol 9 (1) ◽  
pp. 167-174
Author(s):  
Binbin Wang ◽  
Shiwei Wang ◽  
Song Liu ◽  
Shaodong Zhang ◽  
Dezhi Li ◽  
...  
Keyword(s):  
Facial Nerve ◽  
Motor Neurons ◽  
Functional Recovery ◽  
Rat Model ◽  
Facial Palsy ◽  
Crush Injury ◽  
Nerve Crush ◽  
Retrograde Labeling ◽  
Electrophysiological Examination ◽  
Nerve Crush Injury

Abstract Introduction This study investigated the effect of combining hypoglossal-facial nerve “side”-to-side neurorrhaphy and electrical myostimulation in a rat model of facial palsy. Methods Rats with facial nerve crush injury were subjected to control condition, monotherapy of either neurorrhaphy or electrical myostimulation, or bitherapy of the two treatments. After 1, 3, and 6 months, rats were performed the facial symmetry evaluation, electrophysiological examination and the retrograde labeling of motor neurons. Results As early as 3 months after injury, face symmetry significantly improved in rats of the bitherapy group. At 3 or 6 months after injury, either the parameters of electrophysiological examination or the number of labeled motor neurons were significantly increased in the bitherapy group than in any other group. Discussion The combination of neurorrhaphy and electrical myostimulation effectively promoted the functional recovery after facial nerve crush injury.

Electromagnetic Field Treatment of Nerve Crush Injury in a Rat Model: Effect of Signal Configuration on Functional Recovery

2007 ◽  
Vol 28 (4) ◽  
pp. 256-263 ◽  
Author(s):  
Janet L. Walker ◽  
Richard Kryscio ◽  
Jennifer Smith ◽  
Arthur Pilla ◽  
Betty F. Sisken
Keyword(s):  
Electromagnetic Field ◽  
Functional Recovery ◽  
Rat Model ◽  
Crush Injury ◽  
Nerve Crush ◽  
Nerve Crush Injury

scholarly journals Expression of VEGF and neural repair after alprostadil treatment in a rat model of sciatic nerve crush injury

2009 ◽  
Vol 57 (4) ◽  
pp. 387 ◽  
Author(s):  
Xinsheng Ding ◽  
Jinrong Tang ◽  
Ye Hua ◽  
Jianhua Su ◽  
Ping Zhang ◽  
...  
Keyword(s):  
Sciatic Nerve ◽  
Rat Model ◽  
Crush Injury ◽  
Sciatic Nerve Crush ◽  
Nerve Crush ◽  
Neural Repair ◽  
Nerve Crush Injury

MP43-18 EARLY REGULAR TREATMENT WITH A CANNABINOID 2 RECEPTOR AGONIST PROTECTED ERECTILE FUNCTION IN A RAT MODEL OF CAVERNOUS NERVE CRUSH INJURY

2014 ◽  
Vol 191 (4S) ◽  
Author(s):  
Ettore Di Trapani ◽  
Colicchia Michele ◽  
Alberto Briganti ◽  
Manuela Tutolo ◽  
Niccolò Maria Passoni ◽  
...  
Keyword(s):  
Rat Model ◽  
Erectile Function ◽  
Receptor Agonist ◽  
Crush Injury ◽  
Nerve Crush ◽  
Cavernous Nerve ◽  
Regular Treatment ◽  
Nerve Crush Injury
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