scholarly journals Development of Cytomegalovirus-Mediated Sensorineural Hearing Loss in a Guinea Pig Model

2010 ◽  
Vol 136 (1) ◽  
pp. 48 ◽  
Author(s):  
Albert H. Park ◽  
Thomas Gifford ◽  
Mark R. Schleiss ◽  
Lisa Dahlstrom ◽  
Shane Chase ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Sensorineural Hearing Loss ◽  
Sensorineural Hearing ◽  
Pig Model ◽  
Guinea Pig Model

Harderian gland-derived stem cells as a cytotherapy in a guinea pig model of carboplatin-induced hearing loss

2019 ◽  
Vol 98 ◽  
pp. 139-152
Author(s):  
Hoda H. Hussein Abd El Raouf ◽  
Rania A. Galhom ◽  
Mona H. Mohammed Ali ◽  
Wael Amin Nasr El-Din
Keyword(s):  
Stem Cells ◽  
Hearing Loss ◽  
Guinea Pig ◽  
Harderian Gland ◽  
Pig Model ◽  
Guinea Pig Model

scholarly journals Mechanisms of Hearing Loss in a Guinea Pig Model of Superior Semicircular Canal Dehiscence

2018 ◽  
Vol 2018 ◽  
pp. 1-10
Author(s):  
Bu-Sheng Tong ◽  
Zi-Yu He ◽  
Chen-Ru Ding ◽  
Juan-Mei Yang ◽  
Jing Wang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Semicircular Canal ◽  
Pig Model ◽  
Auditory Brainstem Responses ◽  
Round Window Membrane ◽  
Superior Semicircular Canal ◽  
Energy Leakage ◽  
Guinea Pig Model ◽  
Canal Dehiscence

Defective acoustic transmission in the cochlea is closely related with various auditory and vestibular symptoms. Among them, semicircular canal dehiscence (SCD) with a defective semicircular bone is typical. Currently, the pathogenesis of SCD is usually explained by the third window hypothesis; however, this hypothesis fails to explain the variability in the symptoms and signs experienced by superior SCD (SSCD) patients. We evaluated the mechanism of hearing loss in a guinea pig model of bony dehiscence with various sizes and locations along the superior semicircular canal. Auditory brainstem responses (ABRs) and laser Doppler velocimetry were used to measure hearing loss and vibration changes before and after fenestration, as well as after restorative patching. ABR thresholds at low frequencies (e.g., 1000 Hz) increased after fenestration and decreased back to the normal range after we repaired the defect. Energy leakage from the surgically introduced third window was detected in the range of 300–1500 Hz, accompanied by increased vibration at the umbo, stapes head, and the dehiscence site, while decreased vibration was observed at the round window membrane in the same frequency range. After the patching procedure, the deviant vibrations were recovered. The degree of postfenestration energy leakage was proportional to the size of fenestration and the proximity of the fenestration site to the oval window. These results suggest that the bony fenestration of the superior semicircular canal mimics the hearing loss pattern of patients with SSCD. The decrease in perilymph wave impedance likely accounts for the auditory changes.

scholarly journals Factors associated with hearing loss in a normal-hearing guinea pig model of hybrid cochlear implants

2014 ◽  
Vol 316 ◽  
pp. 82-93 ◽  
Author(s):  
Chiemi Tanaka ◽  
Anh Nguyen-Huynh ◽  
Katherine Loera ◽  
Gemaine Stark ◽  
Lina Reiss
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Cochlear Implants ◽  
Normal Hearing ◽  
Pig Model ◽  
Factors Associated ◽  
Guinea Pig Model

Water-soluble Coenzyme Q10 formulation (Q-ter) promotes outer hair cell survival in a guinea pig model of noise induced hearing loss (NIHL)

2009 ◽  
Vol 1257 ◽  
pp. 108-116 ◽  
Author(s):  
Anna Rita Fetoni ◽  
Roberto Piacentini ◽  
Antonella Fiorita ◽  
Gaetano Paludetti ◽  
Diana Troiani
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Hair Cell ◽  
Cell Survival ◽  
Coenzyme Q10 ◽  
Outer Hair Cell ◽  
Water Soluble ◽  
Pig Model ◽  
Noise Induced Hearing Loss ◽  
Guinea Pig Model

Prevention of cisplatin-induced hearing loss by administration of a thiosulfate-containing gel to the middle ear in a guinea pig model

2011 ◽  
Vol 68 (6) ◽  
pp. 1547-1556 ◽  
Author(s):  
Cecilia Engmér Berglin ◽  
Pernilla Videhult Pierre ◽  
Tobias Bramer ◽  
Katarina Edsman ◽  
Hans Ehrsson ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Middle Ear ◽  
Pig Model ◽  
Guinea Pig Model

scholarly journals Morphological correlates of hearing loss after cochlear implantation and electro-acoustic stimulation in a hearing-impaired Guinea pig model

2015 ◽  
Vol 327 ◽  
pp. 163-174 ◽  
Author(s):  
Lina A.J. Reiss ◽  
Gemaine Stark ◽  
Anh T. Nguyen-Huynh ◽  
Kayce A. Spear ◽  
Hongzheng Zhang ◽  
...  
Keyword(s):  
Hearing Loss ◽  
Guinea Pig ◽  
Cochlear Implantation ◽  
Acoustic Stimulation ◽  
Hearing Impaired ◽  
Pig Model ◽  
Guinea Pig Model
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