scholarly journals Magnetic Solid-Phase Extraction Using Fe3O4@SiO2 Magnetic Nanoparticles Followed by UV-Vis Spectrometry for Determination of Paraquat in Plasma and Urine Samples

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Ou Sha ◽  
Yu Wang ◽  
Xin Yin ◽  
Xiaobing Chen ◽  
Li Chen ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Urine Samples ◽  
Phase Extraction ◽  
Simple Method ◽  
Relative Standard ◽  
Plasma And Urine Samples ◽  
Magnetic Solid

A rapid and simple method was optimized and validated for the separation and quantification of paraquat, a frequently used herbicide and a leading cause of fatal poisoning worldwide, at trace levels with UV-Vis spectrophotometry in plasma and urine samples by direct magnetic solid-phase extraction. Fe3O4@SiO2 nanoparticles (NPs) were used as the magnetic solid-phase extraction agents and the paraquat absorbed on NPs was eluted using NaOH and ascorbic acid. Upon optimization, paraquat could be extracted and concentrated from various samples by 35-fold. The linear range, limit of detection (LOD), correlation coefficient (R), and relative standard deviation (RSD) could reach 15.0–400.0 μg/L, 12.2 μg/L, 0.9987, and 0.65% (n=5, c = 40.0 μg/L), respectively. The Fe3O4@SiO2 NPs could be reused up to five times. The method was successfully applied to the determination of paraquat in urine and plasma at different hemoperfusion numbers in a local hospital for the patient of paraquat poisoning. The experiment result could not only enable immediate medical intervention but also benefit patients’ survival.

Magnetic solid-phase extraction coupled with UHPLC–MS/MS for four antidepressants and one metabolite in clinical plasma and urine samples

Bioanalysis ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 35-52
Author(s):  
Peishan Cai ◽  
Xiang Xiong ◽  
Dan Li ◽  
Yu Zhou ◽  
Chaomei Xiong
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Solid Phase Extraction ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Urine Samples ◽  
Therapeutic Drug ◽  
Phase Extraction ◽  
Plasma And Urine Samples ◽  
Magnetic Solid ◽  
Routine Therapeutic Drug Monitoring

Aim: Routine therapeutic drug monitoring is highly recommended since common antidepressant combinations increase the risk of drug–drug interactions or overlapping toxicity. Materials & methods: A magnetic solid-phase extraction by using C18-functionalized magnetic silica nanoparticles (C18-Fe3O4@SiO2 NPs) as sorbent was proposed for rapid extraction of venlafaxine, paroxetine, fluoxetine, norfluoxetine and sertraline from clinical plasma and urine samples followed by ultra-HPLC–MS/MS assay. Results: The synthesized C18-Fe3O4@SiO2 NPs showed high magnetization and efficient extraction for the analytes. After cleanup by magnetic solid-phase extraction, no matrix effects were found in plasma and urine matrices. The analytes showed LODs among 0.15–0.75 ng ml-1, appropriate linearity (R ≥ 0.9990) from 2.5 to 1000 ng ml-1, acceptable accuracies 89.1–110.9% with precisions ≤11.0%. The protocol was successfully applied for the analysis of patients’ plasma and urine samples. Conclusion: It shows high potential in routine therapeutic drug monitoring of clinical biological samples.

scholarly journals Magnetic Solid-Phase Extraction Based onβ-Cyclodextrins/Acrylic Acid Modified Magnetic Gelatin for Determination of Moxidectin in Milk Samples

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
Yinzhu Shang ◽  
Jing Luo ◽  
Peng Wang ◽  
Xiaoya Zhao ◽  
Cheng Ye ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Solid Phase Extraction ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Phase Extraction ◽  
Milk Samples ◽  
Relative Standard ◽  
Magnetic Solid ◽  
Target Molecules

β-Cyclodextrins/acrylic acid modified magnetic gelatin was prepared and then employed as the magnetic solid-phase extraction (MSPE) sorbent for extraction of moxidectin in milk samples. Due to the rigidity of hydrophobic cavity ofβ-cyclodextrins and carboxyl groups of acrylic acid, magnetic composites are prepared to form a complex with target molecules through various kinds of chemical reactions and then showed excellent extraction performance. This method exhibits the advantages of simplicity of implementation, short extraction time (5 min), low solvent consumption, and high extraction efficiency. A rapid, simple, and effective method for the analysis of moxidectin in milk samples was established by MSPE coupled with liquid chromatography-fluorescence detection. The limit of detection was 0.1 ng·mL−1and the recoveries from milk samples were in the range of 93.8%–112.5%. The relative standard deviation was not higher than 6.4%. In conclusion, magnetic solid-phase extraction is a simple and robust preconcentration technique that can be coupled to other analytical methods for the quantitative determination of target molecules in complex samples.

Determination of losartan potassium in the presence of hydrochlorothiazide via a combination of magnetic solid phase extraction and fluorometry techniques in urine samples

RSC Advances ◽  
2015 ◽  
Vol 5 (124) ◽  
pp. 102895-102903 ◽  
Author(s):  
Amir Farnoudian-Habibi ◽  
Sahar Kangari ◽  
Bakhshali Massoumi ◽  
Mehdi Jaymand
Keyword(s):  
Solid Phase Extraction ◽  
Efficient Method ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Urine Samples ◽  
Losartan Potassium ◽  
Phase Extraction ◽  
Highly Efficient ◽  
Magnetic Solid

A sensitive and highly efficient method for the determination of losartan potassium (LOS) in the presence of hydrochlorothiazide (HCTZ) via a combination of magnetic solid phase extraction (MSPE) and fluorometry techniques is suggested.

A chitosan–polypyrrole@Fe3O4nanocomposite for magnetic solid-phase extraction of macrolides from swine urine samples

2015 ◽  
Vol 7 (6) ◽  
pp. 2806-2812 ◽  
Author(s):  
Qie Gen Liao ◽  
Li Fang Hu ◽  
Lin Guang Luo
Keyword(s):  
Solid Phase Extraction ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Urine Samples ◽  
Phase Extraction ◽  
Swine Urine ◽  
Magnetic Solid

An effective MSPE procedure with the CS–PPy@Fe3O4nanocomposite has been developed for extraction of four macrolides. An effective MSPE-LC-MS/MS method for determination of macrolides in swine urine samples has been developed.

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