A powerful combination of quadruple isotope dilution strategy with dispersive magnetic solid phase extraction for the accurate and precise multi-analyte determination of tadalafil, sildenafil, avanafil and vardenafil in human plasma and urine samples using LC-ESI-Tandem MS

2020 ◽  
Vol 152 ◽  
pp. 104302 ◽  
Author(s):  
Elif Öztürk Er ◽  
Erhan Akkaya ◽  
Belma Özbek ◽  
Sezgin Bakırdere
Keyword(s):  
Solid Phase Extraction ◽  
Human Plasma ◽  
Isotope Dilution ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Tandem Ms ◽  
Phase Extraction ◽  
Plasma And Urine Samples ◽  
Magnetic Solid

Magnetic solid-phase extraction based on a trimethylstearylammonium bromide coated Fe3O4/SiO2 composite for determination of adriamycin hydrochloride in human plasma and urine by HPLC-FLD

2014 ◽  
Vol 6 (17) ◽  
pp. 6736-6744 ◽  
Author(s):  
Nengxuan Ma ◽  
Lin Zhang ◽  
Ruijin Li ◽  
Yehong Zhou ◽  
Zongwei Cai ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Human Plasma ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Phase Extraction ◽  
Human Plasma And Urine ◽  
Magnetic Solid

A novel TSAB coated Fe3O4/SiO2 MNP was fabricated and used as the adsorbent for magnetic solid-phase extraction of ADR with HPLC-FLD.

scholarly journals Magnetic Solid-Phase Extraction Using Fe3O4@SiO2 Magnetic Nanoparticles Followed by UV-Vis Spectrometry for Determination of Paraquat in Plasma and Urine Samples

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Ou Sha ◽  
Yu Wang ◽  
Xin Yin ◽  
Xiaobing Chen ◽  
Li Chen ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Solid Phase ◽  
Magnetic Solid Phase Extraction ◽  
Urine Samples ◽  
Phase Extraction ◽  
Simple Method ◽  
Relative Standard ◽  
Plasma And Urine Samples ◽  
Magnetic Solid

A rapid and simple method was optimized and validated for the separation and quantification of paraquat, a frequently used herbicide and a leading cause of fatal poisoning worldwide, at trace levels with UV-Vis spectrophotometry in plasma and urine samples by direct magnetic solid-phase extraction. Fe3O4@SiO2 nanoparticles (NPs) were used as the magnetic solid-phase extraction agents and the paraquat absorbed on NPs was eluted using NaOH and ascorbic acid. Upon optimization, paraquat could be extracted and concentrated from various samples by 35-fold. The linear range, limit of detection (LOD), correlation coefficient (R), and relative standard deviation (RSD) could reach 15.0–400.0 μg/L, 12.2 μg/L, 0.9987, and 0.65% (n=5, c = 40.0 μg/L), respectively. The Fe3O4@SiO2 NPs could be reused up to five times. The method was successfully applied to the determination of paraquat in urine and plasma at different hemoperfusion numbers in a local hospital for the patient of paraquat poisoning. The experiment result could not only enable immediate medical intervention but also benefit patients’ survival.

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