scholarly journals How Intraday Index Changes Influence Periodontal Assessment: A Preliminary Study

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Carlo Bertoldi ◽  
Andrea Forabosco ◽  
Michele Lalla ◽  
Luigi Generali ◽  
Davide Zaffe ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Clinical Severity ◽  
Daily Fluctuation ◽  
Plaque Score ◽  
Severe Periodontal Disease ◽  
Index Changes ◽  
Preliminary Study ◽  
Bleeding Score ◽  
Periodontal Risk ◽  
Periodontal Indices

It is reputed that periodontal indices remain unchanged over a 24-hour period, with great clinical significance. This preliminary study analyzes daily index changes. In 56 selected patients, full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), periodontal screening and recording (PSR) indices, and periodontal risk assessment (PRA) were recorded at baseline and three times per day (check-I: 08.30, check-II: 11.30, and check-III: 14.30), after appropriate cause-related therapy. Correlation between variables was statistically analyzed by Stata. All periodontal indices improved at the examination phase. Statistical differences were detected for FMPS comparing all thrice daily checks. Statistical differences were detected for FMBS and PRA comparing check-III with check-I and check-II. PSR showed no significant changes. The worst baseline indices produced the widest daily fluctuation at the examination phase. Significant variation of indices is directly related to clinical severity of periodontal conditions at baseline. Patients affected by severe periodontal disease may show significantly greater index changes. As indices are routinely recorded only once per day, the index daily variation has clinical significance. This greatly affects therapeutic strategy as correct periodontal assessment requires multiple evaluations at standardized times, particularly when baseline conditions are severe.

A Detailed Comparison of the Performance of the Standard versus the Nijmegen Modification of the Bethesda Assay in Detecting Factor VIII:C Inhibitors in the Haemophilia A Population of Canada

1998 ◽  
Vol 79 (04) ◽  
pp. 872-875 ◽  
Author(s):  
Bert Verbruggen ◽  
Georges Rivard ◽  
Jerome Teitel ◽  
Irwin Walker ◽  
Alan Giles ◽  
...  
Keyword(s):  
Factor Viii ◽  
Clinical Significance ◽  
Protein Concentration ◽  
Detailed Comparison ◽  
Recombinant Factor Viii ◽  
Surveillance Program ◽  
Haemophilia A ◽  
Laboratory Findings ◽  
Preliminary Study ◽  
Normal Pool Plasma

SummaryThe Bethesda assay is widely used to monitor the development and progress of Factor VIII:C inhibitors. Factor VIII stability in the substrate plasma (normal pool) is compromised by pH shift and reduction in protein concentration. Preliminary study, by Verbruggen and colleagues (8), suggested a reduction in spuriously positive assay results may result from buffering the normal pool plasma substrate with imidazole to pH 7.4 and substituting Factor VIII deficient plasma for imidazole buffer in the control incubation mix. These laboratory findings have now been confirmed by the performance of both the standard and the modified Bethesda assays in parallel on 877 patient samples screened during the Factor VIII:C Inhibitor Surveillance Program instituted following the conversion of all Canadian haemophilia A patients to recombinant Factor VIII. Although this study does not address the question of the clinical significance of spurious positive assays, these laboratory findings do support the conclusions of Verbruggen and the modified assay has recently been endorsed by the Factor VIII/IX Subcommittee of the SSC.

scholarly journals Predictive Periodontitis: The Most Promising Salivary Biomarkers for Early Diagnosis of Periodontitis

2021 ◽  
Vol 10 (7) ◽  
pp. 1488
Author(s):  
Carlo Cafiero ◽  
Gianrico Spagnuolo ◽  
Gaetano Marenzi ◽  
Ranieri Martuscelli ◽  
Michele Colamaio ◽  
...  
Keyword(s):  
Immune Response ◽  
Early Diagnosis ◽  
Interleukin 1 ◽  
Periodontal Health ◽  
Plaque Score ◽  
Poor Countries ◽  
Whole Saliva ◽  
Bleeding Score ◽  
And Migration ◽  
Meta Analyses

The primary cause of tooth loss in the industrialized world is periodontitis, a bacterial anaerobic infection whose pathogenesis is characterized by composite immune response. At present, the diagnose of periodontitis is made by a complete status check of the patient’s periodontal health; full-mouth plaque score, full-mouth bleeding score, probing depth, clinical attachment level, bleeding on probing, recessions, mobility, and migration are evaluated in order to provides a clear picture of the periodontal conditions of a single patient. Chair-side diagnostic tests based on whole saliva could be routinely used by periodontists for a very early diagnosis of periodontitis, monitoring, prognosis, and management of periodontal patients by biomarker detection, whose diagnostic validity is related to sensitivity and specificity. Recent paper reviews and meta-analyses have focused on five promising host derived biomarkers as candidate for early diagnosis of periodontitis: MMP-8 (Metalloproteinase-8), MIP-1α (Macrophage inflammatory protein-1 alpha), IL-1 β (Interleukin-1 beta), IL-6 (Interleukin-6), and HB (Hemoglobin), and their combinations. Chair-side Lab-on-a-chip (LOC) technology may soon become an important part of efforts to detect such biomarkers in saliva medium to improve worldwide periodontal health in developed nations as well as in underserved communities and poor countries. Their applications in preventive and predictive medicine is now fundamental, and is aimed at the early detection of risk factors or the presence or evolution of the disease, and in personalized medicine, which aims to identify tailor-made treatments for individual patients. The aim of the present paper is to be informative about host derived periodontal biomarkers and, in particular, we intend to report information about the most important immune response derived biomarkers and Hemoglobin as candidates to be routinely utilized in order to obtain a chair-side early diagnosis of periodontal disease.

scholarly journals Preliminary study on the clinical significance of kinesin Kif18a in nonsmall cell lung cancer

Medicine ◽  
2020 ◽  
Vol 99 (4) ◽  
pp. e19011
Author(s):  
Weifeng Guo ◽  
Huiqing Zeng ◽  
Jinyang Zheng ◽  
Yueming He ◽  
Xibin Zhuang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Clinical Significance ◽  
Cell Lung Cancer ◽  
Nonsmall Cell Lung Cancer ◽  
Preliminary Study

Clinical significance of intraoral strain elastography for diagnosing early stage tongue carcinoma: a preliminary study

2016 ◽  
Vol 33 (3) ◽  
pp. 204-211 ◽  
Author(s):  
Motoki Shingaki ◽  
Yutaka Nikkuni ◽  
Kouji Katsura ◽  
Nobuyuki Ikeda ◽  
Satoshi Maruyama ◽  
...  
Keyword(s):  
Clinical Significance ◽  
Early Stage ◽  
Tongue Carcinoma ◽  
Strain Elastography ◽  
Preliminary Study

scholarly journals Influence of Tooth-Brushing on Early Healing after Access Flap Surgery: A Randomized Controlled Preliminary Study

Materials ◽  
2021 ◽  
Vol 14 (11) ◽  
pp. 2933
Author(s):  
Carlo Bertoldi ◽  
Luigi Generali ◽  
Pierpaolo Cortellini ◽  
Michele Lalla ◽  
Sofia Luppi ◽  
...  
Keyword(s):  
Clinical Results ◽  
Periodontal Pocket ◽  
Pocket Depth ◽  
Clinical Attachment Level ◽  
Plaque Score ◽  
Probing Pocket Depth ◽  
Plaque Control ◽  
Bleeding Score ◽  
Early Healing ◽  
Attachment Level

In the present study, the clinical outcomes obtained using three different protocols of post-operative plaque control for the 4 weeks after surgery were compared. Thirty healthy subjects, presenting at least one periodontal pocket requiring resective surgery, were selected and randomly distributed to three different groups corresponding to respective post-surgical protocols: (A) toothbrushes + chlorhexidine + anti-discoloration system (ADS + CHX); (B) toothbrushes + chlorhexidine (CHX); (C) only toothbrushes. The full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), probing pocket depth (PPD), recession depth (REC), clinical attachment level (CAL), and bleeding on probing (BoP) were measured in six aspects per tooth (mesio-buccal (MB), buccal (B), disto-buccal (DB), disto-lingual (DL), lingual (L), and mesio-lingual (ML)) at baseline, 3 months, and 6 months after surgery. FMPS and FMBS did not significantly change (p > 0.05), whereas PPD and CAL significantly decreased, and REC significantly increased in all groups during the study (p < 0.05). Clinical results were satisfactory in all cases, with no significant differences between groups 3 months after surgery. Six months after surgery, only PPD-MB was significantly different in the three groups (p < 0.05). Nevertheless, this value was not clinically relevant because the value of PPD-B (about 2 mm) in group C was physiologic. The mechanical plaque control was proven to be fundamental and sufficient in all the six aspects per tooth to guarantee an excellent clinical outcome without the need of chemical plaque control.

scholarly journals A single intra-articular dose of vitamin D analog calcipotriol alleviates synovitis without adverse effects in rats

PLoS ONE ◽  
2021 ◽  
Vol 16 (4) ◽  
pp. e0250352
Author(s):  
Johanna A. Huhtakangas ◽  
Jere Huovinen ◽  
Sakari Laaksonen ◽  
Hanna-Marja Voipio ◽  
Olli Vuolteenaho ◽  
...  
Keyword(s):  
Vitamin D ◽  
Histological Grade ◽  
Clinical Severity ◽  
Control Group ◽  
Sprague Dawley ◽  
Glucose Levels ◽  
Vitamin D Analog ◽  
Significant Difference ◽  
Preliminary Study ◽  
Loss Of Appetite

1,25-dihydroxyvitamin-D3 and its derivatives have shown anti-arthritic and chondroprotective effects in experimental animal models with prophylactic dosing. The purpose of this preliminary study was to test the efficacy and safety of calcipotriol, vitamin D analog, as a treatment for a fully-developed knee arthritis in Zymosan-induced arthritis (ZIA) model. Forty 5-month-old male Sprague-Dawley rats were randomized into three arthritis groups and a non-arthritic control group with no injections (10 rats/group). A day after Zymosan (0.1 mg) had been administrated into the right knee joints, the same knees were injected with calcipotriol (0.1 mg/kg), dexamethasone (0.1 mg/kg) or vehicle in a 100 μl volume. The left control knees were injected with saline (PBS) on two consecutive days. All injections, blood sampling and measurements were performed under general anesthesia on days 0, 1, 3 and 8. Internal organs and knees were harvested on day 8 and the histology of the whole knees was assessed blinded. Joints treated with calcipotriol showed a milder histological synovitis than those treated with vehicle (p = 0.041), but there was no statistically significant difference between the dexamethasone and vehicle groups. The clinical severity of arthritis did not differ between the arthritis groups measured by body temperature, swelling of the knee, thermal imaging, clinical scoring or cytokine levels on days 1, 3 and 8. Weight loss was bigger in rats treated with dexamethasone, propably due to loss of appetite,compared to other arthritis groups on days 2–3 (p<0.05). Study drugs did not influence serum calcium ion and glucose levels. Taken together, this preliminary study shows that a single intra-articular injection of calcipotriol reduces histological grade of synovitis a week after the local injection, but dexamethasone did not differ from the vehicle. Calcipotriol may have an early disease-modifying effect in the rat ZIA model without obvious side effects.

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