scholarly journals Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised ofMorus alba,Scutellaria baicalensis, andAcacia catechu

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Mesfin Yimam ◽  
Teresa Horm ◽  
Laura Wright ◽  
Ping Jiao ◽  
Mei Hong ◽  
...  
Keyword(s):  
Analgesic Activity ◽  
Pain Sensitivity ◽  
Structural Integrity ◽  
Disease Model ◽  
Morus Alba ◽  
Scutellaria Baicalensis ◽  
Botanical Composition ◽  
Model Study ◽  
Associated Symptoms ◽  
Acacia Catechu

Although there have been augmented advances in drug discovery, current OA management is inadequate due to the lack of successful therapies proven to be effective in modifying disease progression. For some, the risk outweighs the benefit. As a result, there is a desperate need for safe and efficacious natural alternatives. Here we evaluated a composition fromMorus alba,Scutellaria baicalensis, andAcacia catechuin maintaining joint structural integrity and alleviating OA associated symptoms in monoiodoacetate- (MIA-) induced rat OA disease model. Study lasted for 6 weeks. 59.6%, 64.6%, 70.7%, 69.9%, and 70.3% reductions in pain sensitivity were observed for rats treated with the composition from week 1 to week 5, respectively. Statistically significant improvements in articular cartilage matrix integrity (maintained at 57.1% versus MIA + vehicle treated rats) were shown from the modified total Mankin score for animals treated with the composition. The composition showed a statistically significant reduction in uCTX-II level (54.1% reductions). The merit of combining these botanicals was also demonstrated in their synergistic analgesic activity. Therefore, the standardized blend ofMorus alba,Scutellaria baicalensis, andAcacia catechucould potentially be considered as an alternative remedy from natural sources for the management of OA and/or its associated symptoms.

scholarly journals UP3005, a Botanical Composition Containing Two Standardized Extracts ofUncaria gambirandMorus alba, Improves Pain Sensitivity and Cartilage Degradations in Monosodium Iodoacetate-Induced Rat OA Disease Model

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Mesfin Yimam ◽  
Young-Chul Lee ◽  
Tae-Woo Kim ◽  
Breanna Moore ◽  
Ping Jiao ◽  
...  
Keyword(s):  
Pain Sensitivity ◽  
Structural Integrity ◽  
Disease Model ◽  
Symptomatic Therapy ◽  
Root Bark ◽  
Mineral Density ◽  
Irreversible Damage ◽  
Limited Mobility ◽  
Associated Symptoms ◽  
Monosodium Iodoacetate

Osteoarthritis (OA) is a multifactorial disease primarily noted by cartilage degradation in association with inflammation that causes significant morbidity, joint pain, stiffness, and limited mobility. Present-day management of OA is inadequate due to the lack of principal therapies proven to be effective in hindering disease progression where symptomatic therapy focused approach masks the actual etiology leading to irreversible damage. Here, we describe the effect of UP3005, a composition containing a proprietary blend of two standardized extracts from the leaf ofUncaria gambirand the root bark ofMorus alba, in maintaining joint structural integrity and alleviating OA associated symptoms in monosodium-iodoacetate- (MIA-) induced rat OA disease model. Pain sensitivity, micro-CT, histopathology, and glycosaminoglycans (GAGs) level analysis were conducted. Diclofenac at 10 mg/kg was used as a reference compound. UP3005 resulted in almost a complete inhibition in proteoglycans degradation, reductions of 16.6% (week 4), 40.5% (week 5), and 22.0% (week 6) in pain sensitivity, statistically significant improvements in articular cartilage matrix integrity, minimal visual subchondral bone damage, and statistically significant increase in bone mineral density when compared to the vehicle control with MIA. Therefore, UP3005 could potentially be considered as an alternative therapy from natural sources for the treatment of OA and/or its associated symptoms.

Repeated dose 28-day oral toxicity study of a botanical composition composed of Morus alba and Acacia catechu in rats

2018 ◽  
Vol 94 ◽  
pp. 115-123 ◽  
Author(s):  
Mesfin Yimam ◽  
Ping Jiao ◽  
Mei Hong ◽  
Lidia Brownell ◽  
Hyun-Jin Kim ◽  
...  
Keyword(s):  
Morus Alba ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Botanical Composition ◽  
Oral Toxicity ◽  
Acacia Catechu

A Botanical Composition Mitigates Cartilage Degradations and Pain Sensitivity in Osteoarthritis Disease Model

2017 ◽  
Vol 20 (6) ◽  
pp. 568-576 ◽  
Author(s):  
Mesfin Yimam ◽  
Young-Chul Lee ◽  
Laura Wright ◽  
Ping Jiao ◽  
Teresa Horm ◽  
...  
Keyword(s):  
Pain Sensitivity ◽  
Disease Model ◽  
Botanical Composition

scholarly journals UP1306: A Composition Containing Standardized Extracts of Acacia catechu and Morus alba for Arthritis Management

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 272 ◽  
Author(s):  
Mesfin Yimam ◽  
Teresa Horm ◽  
Laura Wright ◽  
Ping Jiao ◽  
Mei Hong ◽  
...  
Keyword(s):  
Treatment Options ◽  
Cartilage Degradation ◽  
Morus Alba ◽  
Root Bark ◽  
Botanical Composition ◽  
Collagen Induced Arthritis ◽  
Arthritis Severity ◽  
Tnf Α ◽  
Acacia Catechu ◽  
Factor Α

Osteoarthritis (OA) is characterized by progressive articular cartilage degradation. Although there have been significant advances in OA management, to date, there are no effective treatment options to modify progression of the disease. We believe these unmet needs could be bridged by nutrients from natural products. Collagen induced arthritis in rats was developed and utilized to evaluate anti-inflammatory and cartilage protection activity of orally administered botanical composition, UP1306 (50 mg/kg) and Methotrexate (75 µg/kg) daily for three weeks. Objective arthritis severity markers, urine, synovial lavage, and serum were collected. At necropsy, the hock joint from each rat was collected for histopathology analysis. Urinary cartilage degradation marker (CTX-II), pro-inflammatory cytokines (tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β), and IL-6), and proteases (Matrix Metallopeptidase 3 (MMP3) and 13) were measured. Rats treated with UP1306 showed statistically significant improvements in arthritis severity markers, including uCTX-II (91.4% vs. collagen-induced arthritis (CIA)), serum IL-1β, TNF-α, and IL-6 levels as well as synovial MMP-13. The histopathology data were also well aligned with the severity score of arthritis for both UP1306 and Methotrexate. UP1306, a botanical composition that contains a standardized blend of extracts from the heartwood of Acacia catechu and the root bark of Morus alba, could potentially be considered as a dietary supplement product for the management of arthritis.

scholarly journals Therapeutic targeting PLK1 by ON-01910.Na is effective in local treatment of retinoblastoma

2021 ◽  
Author(s):  
Huan Ma ◽  
Cong Nie ◽  
Ying Chen ◽  
Jinmiao Li ◽  
Yanjie Xie ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Cell Death ◽  
Cell Cycle Arrest ◽  
Cell Cycle Progression ◽  
Structural Integrity ◽  
Apoptotic Cell ◽  
Disease Model ◽  
Local Treatment ◽  
Three Dimensional ◽  
Cycle Arrest

Cell cycle deregulation is involved in pathogenesis of many cancers, and often associated with protein kinase aberrations, including the polo-like kinase 1 (PLK1). Wehereby used retinoblastoma, an intraocular malignancy that lacks targeted therapy, as a disease model and set out to reveal targetability of PLK1 with a small molecularinhibitor ON-01910.Na. First, transcriptomic analysis on patient retinoblastoma tissues suggested that cell cycle progression was deregulated and confirmed that PLK1pathway was upregulated. Next, antitumor activity of ON-01910.Na was investigated inboth cellular and animal levels. Cytotoxicity induced by ON-01910.Na was tumor-specific and dose-dependent in retinoblastoma cells, whilst non-tumor cells wereminimally affected. In three-dimensional culture, ON-01910.Na demonstrated efficient drug-penetrability with multilayer cell death. Post-treatment transcriptomic findingsrevealed that cell cycle arrest and MAPK cascade activation were induced following PLK1 inhibition, and eventually result in apoptotic cell death. In Balb/c nude mice, a safe threshold of 0.8 nmol intravitreal dosage of ON-01910.Na was established for intraocular safety, which was demonstrated by structural integrity and functional preservation. Furthermore, intraocular and subcutaneous xenograft were significantlyreduced with ON-01910.Na treatments. For the first time, we demonstrated targetability of PLK1 in retinoblastoma by efficiently causing cell cycle arrest and apoptosis. Ourstudy is supportive that local treatment of ON-01910.Na may be a novel, effectivemodality benefiting patients with PLK1-aberrant tumors.

scholarly journals UP1304, a botanical composition containing two standardized extracts of Curcuma longa and Morus alba, mitigates pain and inflammation in Adjuvant-induced arthritic rats

2016 ◽  
Vol 8 (2) ◽  
pp. 112 ◽  
Author(s):  
Mesfin Yimam ◽  
Young-Chul Lee ◽  
Breanna Moore ◽  
Ping Jiao ◽  
Mei Hong ◽  
...  
Keyword(s):  
Curcuma Longa ◽  
Morus Alba ◽  
Botanical Composition
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