scholarly journals Corrigendum to “Clinical and Preclinical Cognitive Function Improvement after Oral Treatment of a Botanical Composition Composed of Extracts from Scutellaria baicalensis and Acacia catechu”

2017 ◽  
Vol 2017 ◽  
pp. 1-1 ◽  
Author(s):  
Mesfin Yimam ◽  
Bruce P. Burnett ◽  
Lidia Brownell ◽  
Qi Jia
Keyword(s):  
Cognitive Function ◽  
Oral Treatment ◽  
Scutellaria Baicalensis ◽  
Botanical Composition ◽  
Acacia Catechu

scholarly journals Cartilage Protection and Analgesic Activity of a Botanical Composition Comprised ofMorus alba,Scutellaria baicalensis, andAcacia catechu

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Mesfin Yimam ◽  
Teresa Horm ◽  
Laura Wright ◽  
Ping Jiao ◽  
Mei Hong ◽  
...  
Keyword(s):  
Analgesic Activity ◽  
Pain Sensitivity ◽  
Structural Integrity ◽  
Disease Model ◽  
Morus Alba ◽  
Scutellaria Baicalensis ◽  
Botanical Composition ◽  
Model Study ◽  
Associated Symptoms ◽  
Acacia Catechu

Although there have been augmented advances in drug discovery, current OA management is inadequate due to the lack of successful therapies proven to be effective in modifying disease progression. For some, the risk outweighs the benefit. As a result, there is a desperate need for safe and efficacious natural alternatives. Here we evaluated a composition fromMorus alba,Scutellaria baicalensis, andAcacia catechuin maintaining joint structural integrity and alleviating OA associated symptoms in monoiodoacetate- (MIA-) induced rat OA disease model. Study lasted for 6 weeks. 59.6%, 64.6%, 70.7%, 69.9%, and 70.3% reductions in pain sensitivity were observed for rats treated with the composition from week 1 to week 5, respectively. Statistically significant improvements in articular cartilage matrix integrity (maintained at 57.1% versus MIA + vehicle treated rats) were shown from the modified total Mankin score for animals treated with the composition. The composition showed a statistically significant reduction in uCTX-II level (54.1% reductions). The merit of combining these botanicals was also demonstrated in their synergistic analgesic activity. Therefore, the standardized blend ofMorus alba,Scutellaria baicalensis, andAcacia catechucould potentially be considered as an alternative remedy from natural sources for the management of OA and/or its associated symptoms.

Repeated dose 28-day oral toxicity study of a botanical composition composed of Morus alba and Acacia catechu in rats

2018 ◽  
Vol 94 ◽  
pp. 115-123 ◽  
Author(s):  
Mesfin Yimam ◽  
Ping Jiao ◽  
Mei Hong ◽  
Lidia Brownell ◽  
Hyun-Jin Kim ◽  
...  
Keyword(s):  
Morus Alba ◽  
Toxicity Study ◽  
Repeated Dose ◽  
Botanical Composition ◽  
Oral Toxicity ◽  
Acacia Catechu

Preferences of adults with cancer for systemic cancer treatment: do preferences differ based on age?

2021 ◽  
Author(s):  
Prajwal Dhakal ◽  
Christopher S Wichman ◽  
Bunny Pozehl ◽  
Meaghann Weaver ◽  
Alfred L Fisher ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cognitive Function ◽  
Cancer Treatment ◽  
Hospital Stay ◽  
Functional Ability ◽  
Older Patients ◽  
Oral Treatment ◽  
Treatment Preferences ◽  
Exact Test

Background: We used the Therapy Preference Scale, a 30-item questionnaire, to determine cancer treatment preferences of adults with cancer. Methods: We used Wilcoxon’s rank sum test and Fisher’s exact test to compare the preferences of younger (<60 years) versus older adults (≥60 years). Results: While 56% of patients would accept treatment offering increased life expectancy at an expense of short-term side effects, 75% preferred maintenance of cognition, functional ability and quality of life to quantity of days. Oral instead of intravenous treatment (p = 0.003), shorter hospital stay (p = 0.03), preservation of cognitive function (p = 0.01) and avoidance of pain (p = 0.02) were more important to older patients compared with younger patients. Conclusion: Many patients prioritized maintenance of cognition, functional ability and quality of life; older patients valued oral treatment, shorter hospital stay, preservation of cognitive function and avoidance of pain.

SAFETY EVALUATION OF A COMBINATION, DEFINED EXTRACT OF SCUTELLARIA BAICALENSIS AND ACACIA CATECHU

2007 ◽  
Vol 31 (6) ◽  
pp. 797-825 ◽  
Author(s):  
BRUCE P. BURNETT ◽  
STACIA SILVA ◽  
MICHAEL H. MESCHES ◽  
STEVEN WILSON ◽  
QI JIA
Keyword(s):  
Safety Evaluation ◽  
Scutellaria Baicalensis ◽  
Acacia Catechu
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