scholarly journals A Novel Green Synthesis of Thalidomide and Analogs

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Ellis Benjamin ◽  
Yousef M. Hijji
Keyword(s):  
Microwave Irradiation ◽  
Glutamic Acid ◽  
Green Synthesis ◽  
Ammonium Chloride ◽  
Synthesis Method ◽  
Multicomponent Synthesis ◽  
Synthesis System ◽  
One Pot ◽  
Anticancer Properties ◽  
Related Compounds

Thalidomide and its derivatives are currently under investigation for their antiangiogenic, immunomodulative, and anticancer properties. Current methods used to synthesize these compounds involve multiple steps and extensive workup procedures. Described herein is an efficient microwave irradiation green synthesis method that allows preparation of thalidomide and its analogs in a one-pot multicomponent synthesis system. The multicomponent synthesis system developed involves an array of cyclic anhydrides, glutamic acid, and ammonium chloride in the presence of catalytic amounts of 4-N,N-dimethylaminopyridine (DMAP) to produce thalidomide and structurally related compounds within minutes in good isolated yields.

One-pot multicomponent synthesis of novel thiazol-2-imines via microwave irradiation and their antifungal evaluation

2018 ◽  
Vol 48 (16) ◽  
pp. 2061-2073 ◽  
Author(s):  
Saba Kauser Jaweed Shaikh ◽  
Ravindra Ramappa Kamble ◽  
Shilpa M. Somagond ◽  
Atulkumar A. Kamble ◽  
Mahadev N. Kumbar
Keyword(s):  
Microwave Irradiation ◽  
Multicomponent Synthesis ◽  
One Pot

Silica-supported NiO nanocomposites prepared via a sol–gel technique and their excellent catalytic performance for one-pot multicomponent synthesis of benzodiazepine derivatives under microwave irradiation

2017 ◽  
Vol 41 (13) ◽  
pp. 5893-5903 ◽  
Author(s):  
Zeba Nasir ◽  
Abad Ali ◽  
Mohammad Shakir ◽  
Rizwan Wahab ◽  
Shamsuzzaman Shamsuzzaman ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Sol Gel ◽  
Catalytic Performance ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Benzodiazepine Derivatives ◽  
Gel Technique ◽  
The One ◽  
Excellent Catalytic Performance

Heterogeneous and versatile NiO–SiO2 NCs were synthesized by a sol–gel technique and used as a catalyst for the one-pot multicomponent synthesis of benzodiazepines.

ChemInform Abstract: Facile One-Pot, Multicomponent Synthesis of Pyridines under Microwave Irradiation.

ChemInform ◽  
2009 ◽  
Vol 40 (38) ◽  
Author(s):  
Jian-Feng Zhou ◽  
Yuan-Zhi Song ◽  
Jin-Shun Lv ◽  
Gui-Xia Gong ◽  
Shujiang Tu
Keyword(s):  
Microwave Irradiation ◽  
Multicomponent Synthesis ◽  
One Pot

Fast and Green One-Pot Multicomponent Synthesis of a Library of Pyrrolo[1,2-c] Pyrimidines Under Microwave Irradiation

2013 ◽  
Vol 16 (10) ◽  
pp. 851-857 ◽  
Author(s):  
Emilian Georgescu ◽  
Florentina Georgescu ◽  
Constantin Draghici ◽  
Liliana Cristian ◽  
Marcel Popa ◽  
...  
Keyword(s):  
Microwave Irradiation ◽  
Multicomponent Synthesis ◽  
One Pot

scholarly journals Ecofriendly and Facile One-Pot Multicomponent Synthesis of Thiopyrimidines under Microwave Irradiation

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Biswa Mohan Sahoo ◽  
B. V. V. Ravi Kumar ◽  
Jnyanaranjan Panda ◽  
S. C. Dinda
Keyword(s):  
Reaction Time ◽  
Microwave Irradiation ◽  
Spectral Data ◽  
Multicomponent Reaction ◽  
Multicomponent Reactions ◽  
Multicomponent Synthesis ◽  
One Pot ◽  
Heating Method ◽  
Green Protocol ◽  
Drug Molecules

A rapid, improved, and ecofriendly synthesis of thiopyrimidines is carried out via one-pot multicomponent reaction of ethylcyanoacetate, substituted benzaldehydes, and thiourea in presence of ethanolic K2CO3 using microwave irradiation heating method. Excellent yields, shorter reaction time, and easy workup are the major advantageous features of this green protocol. So the application of multicomponent reactions involves the combination of multiple starting materials with different functional groups leading to the highly efficient and environmentally friendly construction of multifunctional drug molecules. The structures of the newly synthesized products were assigned on the basis of IR and 1HNMR spectral data.

scholarly journals One-pot multicomponent synthesis of substituted 5,7-dihydro-1,6-naphthyridines and 5,6,7,8-tetrahydroquinolines

2008 ◽  
Vol 6 (2) ◽  
pp. 188-198 ◽  
Author(s):  
Chao-Guo Yan ◽  
Qi-Fang Wang ◽  
Xi-Mei Cai ◽  
Jing Sun
Keyword(s):  
Microwave Irradiation ◽  
Nitrogen Source ◽  
Aromatic Aldehydes ◽  
Tandem Reaction ◽  
Cyclic Ketones ◽  
Multicomponent Synthesis ◽  
One Pot

AbstractAn one-pot approach was developed for the synthesis of substituted 5,7-dihydro-1,6-naphthyridines and 5,6,7,8-tetrahydroquinolines with moderate to good yields. This pathway is a modified two-step synthesis of Kröhnke pyridine and involves a four-component tandem reaction of N-phenacylpyridinium bromide, aromatic aldehydes, substituted or nitrogen-containing cyclic ketones and a nitrogen source. This multi-component reaction is performed using microwave irradiation heating of the reaction substrates under an environment of NH4OAc/HOAc.

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