scholarly journals Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Seahyoung Lee ◽  
Hyang-Hee Seo ◽  
Chang Youn Lee ◽  
Jiyun Lee ◽  
Sunhye Shin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Noncoding Rna ◽  
Molecular Mechanisms ◽  
Stem Cell Differentiation ◽  
Therapeutic Modality ◽  
Key Factors ◽  
Rna Regulation ◽  
Near Future ◽  
Pluripotency Maintenance

Because of their capability of differentiation into lineage-specific cells, stem cells are an attractive therapeutic modality in regenerative medicine. To develop an effective stem cell-based therapeutic strategy with predictable results, deeper understanding of the underlying molecular mechanisms of stem cell differentiation and/or pluripotency maintenance is required. Thus, reviewing the key factors involved in the transcriptional and epigenetic regulation of stem cell differentiation and maintenance is important. Accumulating data indicate that long noncoding RNAs (lncRNAs) mediate numerous biological processes, including stem cell differentiation and maintenance. Here, we review recent findings on the human lncRNA regulation of stem cell potency and differentiation. Although the clinical implication of these lncRNAs is only beginning to be elucidated, it is anticipated that lncRNAs will become important therapeutic targets in the near future.

scholarly journals Iannis Aifantis: An accidental scientist

2020 ◽  
Vol 217 (2) ◽  
Author(s):  
Stephanie Houston
Keyword(s):  
Clinical Trials ◽  
Stem Cell ◽  
Cell Differentiation ◽  
Molecular Mechanisms ◽  
Medical Center ◽  
Basic Research ◽  
Stem Cell Differentiation ◽  
Normal Stem Cell ◽  
Hematopoietic Stem ◽  
Hematopoietic Stem Cell Differentiation

Iannis Aifantis is a principal investigator at NYU Langone Medical Center, and his laboratory works on the molecular mechanisms that drive normal stem cell differentiation and malignant transformation. Specifically, they’re interested in the genomic, epigenetic, and proteomic regulation of hematopoietic stem cell differentiation and the induction of leukemia and lymphoma; some of their basic research has led to clinical trials in leukemia and myelodysplastic syndromes. I chatted with Iannis to find out about his career in science so far.

scholarly journals Physicochemical Control of Adult Stem Cell Differentiation: Shedding Light on Potential Molecular Mechanisms

2010 ◽  
Vol 2010 ◽  
pp. 1-14 ◽  
Author(s):  
Igor Titushkin ◽  
Shan Sun ◽  
Jennifer Shin ◽  
Michael Cho
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Molecular Mechanisms ◽  
Adult Stem Cell ◽  
Stem Cell Differentiation ◽  
Cell Behavior ◽  
Soluble Factors ◽  
Multiple Differentiation ◽  
Exciting Potential ◽  
Physical Forces

Realization of the exciting potential for stem-cell-based biomedical and therapeutic applications, including tissue engineering, requires an understanding of the cell-cell and cell-environment interactions. To this end, recent efforts have been focused on the manipulation of adult stem cell differentiation using inductive soluble factors, designing suitable mechanical environments, and applying noninvasive physical forces. Although each of these different approaches has been successfully applied to regulate stem cell differentiation, it would be of great interest and importance to integrate and optimally combine a few or all of the physicochemical differentiation cues to induce synergistic stem cell differentiation. Furthermore, elucidation of molecular mechanisms that mediate the effects of multiple differentiation cues will enable the researcher to better manipulate stem cell behavior and response.

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