scholarly journals RETRACTED: The Noncoding RNA Mistral Activates Hoxa6 and Hoxa7 Expression and Stem Cell Differentiation by Recruiting MLL1 to Chromatin

2011 ◽  
Vol 43 (6) ◽  
pp. 1040-1046 ◽  
Author(s):  
Stéphane Bertani ◽  
Silvia Sauer ◽  
Eugene Bolotin ◽  
Frank Sauer
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Noncoding Rna ◽  
Stem Cell Differentiation

scholarly journals Human Long Noncoding RNA Regulation of Stem Cell Potency and Differentiation

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Seahyoung Lee ◽  
Hyang-Hee Seo ◽  
Chang Youn Lee ◽  
Jiyun Lee ◽  
Sunhye Shin ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Differentiation ◽  
Noncoding Rna ◽  
Molecular Mechanisms ◽  
Stem Cell Differentiation ◽  
Therapeutic Modality ◽  
Key Factors ◽  
Rna Regulation ◽  
Near Future ◽  
Pluripotency Maintenance

Because of their capability of differentiation into lineage-specific cells, stem cells are an attractive therapeutic modality in regenerative medicine. To develop an effective stem cell-based therapeutic strategy with predictable results, deeper understanding of the underlying molecular mechanisms of stem cell differentiation and/or pluripotency maintenance is required. Thus, reviewing the key factors involved in the transcriptional and epigenetic regulation of stem cell differentiation and maintenance is important. Accumulating data indicate that long noncoding RNAs (lncRNAs) mediate numerous biological processes, including stem cell differentiation and maintenance. Here, we review recent findings on the human lncRNA regulation of stem cell potency and differentiation. Although the clinical implication of these lncRNAs is only beginning to be elucidated, it is anticipated that lncRNAs will become important therapeutic targets in the near future.

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