scholarly journals Are the Symptoms of an NSAID-Induced Ulcer Truly Milder Than Those of an Ordinary Ulcer?

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Toshihiko Tomita ◽  
Sumire Mori ◽  
Katsuyuki Tozawa ◽  
Eitatsu Arai ◽  
Nobuo Tano ◽  
...  
Keyword(s):  
Peptic Ulcer ◽  
Gastroduodenal Ulcer ◽  
Gastrointestinal Symptoms ◽  
Acute Stage ◽  
Abdominal Symptoms ◽  
Low Dose Aspirin ◽  
Upper Gastrointestinal Symptoms ◽  
Inflammatory Drugs ◽  
Upper Abdominal Symptoms ◽  
Upper Abdominal

Objective. The percentage of patients with nonsteroidal anti-inflammatory drugs (NSAIDs) and low-dose aspirin- (LDA-) induced ulcers who complain of gastrointestinal symptoms has generally been considered to be low. The aim of this study was to examine and compare the symptoms and quality of life (QOL) at peptic ulcer onset. Methods. This study involved 200 patients who were confirmed by endoscopy to be in the acute stage of gastroduodenal ulcer (A1-H1). Patients completed a self-administered questionnaire (Global Overall Symptom score and SF-8) at ulcer onset, and data were compared between NSAIDs/LDA ulcers and non-NSAIDs/LDA ulcers. Results. The upper gastrointestinal symptoms score was significantly lower for patients using LDA only (20.5 ± 9.4 in the nonusing group, 19.6 ± 8.6 in the NSAIDs-only group, 16.7 ± 11.6 in the LDA-only group, and 18.5 ± 7.2 in the NSAIDs/LDA group, P<0.05). The QOL score (physical summary) was significantly lower in the NSAID group (42.1 ± 9.9) than in the nonusing group (47.6 ± 7.6) (P<0.05). Patients’ characteristics showed no significant differences among the groups, with the exception of age. Conclusion. The severity of upper abdominal symptoms at peptic ulcer onset was similar between NSAID users and nonusers.

scholarly journals A New Strategy Using Rikkunshito to Treat Anorexia and Gastrointestinal Dysfunction

2015 ◽  
Vol 2015 ◽  
pp. 1-10 ◽  
Author(s):  
Yayoi Saegusa ◽  
Tomohisa Hattori ◽  
Miwa Nahata ◽  
Chihiro Yamada ◽  
Hiroshi Takeda
Keyword(s):  
Gastric Motility ◽  
Epigastric Pain ◽  
Gastrointestinal Symptoms ◽  
Herbal Medicines ◽  
Gastrointestinal Dysfunction ◽  
Ghrelin Receptor ◽  
Postprandial Fullness ◽  
Upper Gastrointestinal Symptoms ◽  
Upper Abdominal ◽  
Upper Gastrointestinal

Because the clinical condition of gastrointestinal dysfunction, including functional dyspepsia, involves tangled combinations of pathologies, there are some cases of insufficient curative efficacy. Thus, traditional herbal medicines (Kampo medicines) uniquely developed in Japan are thought to contribute to medical treatment for upper gastrointestinal symptoms. Rikkunshito is a Kampo medicine often used to treat dyspeptic symptoms. Over the past few years, several studies have investigated the efficacy of rikkunshito for dysmotility, for example, upper abdominal complaints, in animals and humans. Rikkunshito ameliorated the decrease in gastric motility and anorexia in cisplatin-treated rats, stress-loaded mice, and selective serotonin reuptake inhibitor-treated rats by enhancing plasma ghrelin levels via serotonin2B/2Creceptor antagonism. In addition, rikkunshito ameliorated the decrease in food intake in aged mice and stress-loaded decreased gastric motility via enhanced ghrelin receptor signaling. Several clinical studies revealed that rikkunshito was effective in ameliorating upper gastrointestinal symptoms, including dyspepsia, epigastric pain, and postprandial fullness. In this review, we discuss these studies and propose additional evidence-based research that may promote the clinical use of Kampo medicines, particularly rikkunshito, for treating anorexia and gastrointestinal dysfunction.

Comparison of the effects of omeprazole and famotidine in treatment of upper abdominal symptoms in patients with reflux esophagitis

2009 ◽  
Vol 44 (4) ◽  
pp. 261-270 ◽  
Author(s):  
Hiroaki Kusunoki ◽  
Masayasu Kusaka ◽  
Soichiro Kido ◽  
Ryo Yamauchi ◽  
Yoshinori Fujimura ◽  
...  
Keyword(s):  
Reflux Esophagitis ◽  
Abdominal Symptoms ◽  
Upper Abdominal Symptoms ◽  
Upper Abdominal

Upper abdominal symptoms in patients with Type 1 diabetes: unrelated to impairment in gastric emptying caused by autonomic neuropathy

2008 ◽  
Vol 25 (5) ◽  
pp. 570-577 ◽  
Author(s):  
J. Punkkinen ◽  
M. Färkkilä ◽  
S. Mätzke ◽  
T. Korppi-Tommola ◽  
T. Sane ◽  
...  
Keyword(s):  
Type 1 Diabetes ◽  
Gastric Emptying ◽  
Autonomic Neuropathy ◽  
Abdominal Symptoms ◽  
Upper Abdominal Symptoms ◽  
Upper Abdominal

scholarly journals Gastroparesis as a significant gastrointestinal adverse event during intensive chemotherapy for solid cancer

2021 ◽  
Author(s):  
Tomohiro Nakayama ◽  
Koji Haratani ◽  
Takashi Kurosaki ◽  
Kaoru Tanaka ◽  
Kazuhiko Nakagawa
Keyword(s):  
Delayed Gastric Emptying ◽  
Late Onset ◽  
Solid Cancer ◽  
Gastrointestinal Adverse Event ◽  
Abdominal Symptoms ◽  
Solid Malignancies ◽  
Platinum Based Chemotherapy ◽  
Anticancer Treatment ◽  
Upper Abdominal Symptoms ◽  
Upper Abdominal

Abstract Proper management of chemotherapy-related gastrointestinal toxicities is essential to maximize therapeutic outcome for malignancies. Gastroparesis is characterized by delayed gastric emptying without gastrointestinal obstruction. Although it has not been well recognized as a complication of chemotherapy for solid malignancies, we here report a case of gastroparesis apparently due to neurotoxicity of high-intensity taxane- and platinum-based chemotherapy for a solid tumor. The patient experienced late-onset gastric dysmotility as evidenced by an abnormally dilated stomach even after cessation of feeding for several days. The gastroparesis was successfully controlled with a 5-HT4 receptor agonist, resulting in recovery of gastric motility and allowing completion of curative anticancer treatment. Despite its rarity in patients with solid cancers, gastroparesis should be recognized as a potential cause of persistent upper abdominal symptoms during neurotoxic chemotherapy in such individuals, given that a delay in its management may be detrimental to survival outcome.

Is peptic ulcer a common cause of upper gastrointestinal symptoms?

2001 ◽  
Vol 160 (8) ◽  
pp. 497-500 ◽  
Author(s):  
Eleftheria Roma ◽  
Yota Kafritsa ◽  
Joanna Panayiotou ◽  
Roula Liakou ◽  
Andreas Constantopoulos
Keyword(s):  
Peptic Ulcer ◽  
Gastrointestinal Symptoms ◽  
Common Cause ◽  
Upper Gastrointestinal Symptoms ◽  
Upper Gastrointestinal
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