scholarly journals Comparison of US Strain Elastography and Entero-MRI to Typify the Mesenteric and Bowel Wall Changes during Crohn’s Disease: A Pilot Study

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Giuseppe Lo Re ◽  
Dario Picone ◽  
Federica Vernuccio ◽  
Laura Scopelliti ◽  
Ambra Di Piazza ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Signal Intensity ◽  
Bowel Wall ◽  
Color Pattern ◽  
Statistical Correlation ◽  
Blue Color ◽  
Strain Elastography ◽  
Color Scale ◽  
Bowel Segments

Purpose. To evaluate and compare the mesenteric and bowel wall changes during Crohn’s disease (CD) on ultrasonography (US) Strain Elastography (SE) and Enterography Magnetic Resonance Imaging (E-MRI). Methods. From July 2014 to September 2016, 35 patients with ileocolonoscopy diagnosis of CD were prospectively examined with E-MRI and in the same time with US and SE. Results. A total of 41 affected bowel segments and 35 unaffected bowel segments in 35 patients were evaluated. US-SE color-scale coding showed a blue color pattern in the fibrotic mesentery and bowel wall in 15 patients and a green color pattern in the edematous ones in 20 patients. The signal of the bowel wall and mesenteric fat was iso/hypointense on T2-weighted sequence in the fibrotic pattern (23/35 and 12/35 patients) and hyperintense in the edematous pattern (12/35 and 23/35 patients). Mean ADC values were, respectively, 2,58±0,33 × 10−3 for the fibrotic mesentery and 2,14±0,28 × 10−3 for edematous one. There was a statistical correlation between US-SE color-scale and T2 signal intensity and between the US-SE color-scale and ADC maps. Conclusions. US-SE, ADC, and signal intensity on T2-weighted sequences on MR prove to be useful tools for the evaluation of CD pattern.

scholarly journals Comparison of noncontrast MRI magnetization transfer andT2-Weighted signal intensity ratios for detection of bowel wall fibrosis in a Crohn's disease animal model

2014 ◽  
Vol 42 (3) ◽  
pp. 801-810 ◽  
Author(s):  
Jonathan R. Dillman ◽  
Scott D. Swanson ◽  
Laura A. Johnson ◽  
David S. Moons ◽  
Jeremy Adler ◽  
...  
Keyword(s):  
Animal Model ◽  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Signal Intensity ◽  
Bowel Wall ◽  
Magnetization Transfer ◽  
Intensity Ratios

scholarly journals Quantification of inflammatory activity in patients with Crohn’s disease using diffusion weighted imaging (DWI) in MR enteroclysis and MR enterography

2016 ◽  
Vol 58 (3) ◽  
pp. 264-271 ◽  
Author(s):  
Nora Stanescu-Siegmund ◽  
Yessica Nimsch ◽  
Arthur P Wunderlich ◽  
Martin Wagner ◽  
Reinhard Meier ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bowel Wall ◽  
Mr Enterography ◽  
Normal Bowel ◽  
Apparent Diffusion Coefficients ◽  
Diffusion Weighted ◽  
Mr Enteroclysis ◽  
Adc Values ◽  
Bowel Segments

Background Individual studies have demonstrated the potential of diffusion-weighted magnetic resonance imaging (DWI-MRI) for identifying inflamed bowel segments. However, these studies were conducted with rather small patient cohorts and in most cases by means of MR enterography only. Purpose To demonstrate the feasibility of detecting inflamed bowel segments in a large collective of patients with Crohn’s disease using DWI in MR enteroclysis and MR enterography and to compare the results of both techniques, also considering clinical parameters by means of the Harvey-Bradshaw Index (HBI). Material and Methods Ninety-six patients underwent MRI enteroclysis and 35 patients MR enterography, both with additional DWI. The HBI as well as apparent diffusion coefficients (ADC) in areas of inflamed and normal bowel wall were determined. Thus resulting in 208 bowel segments that were visualized and subsequently statistically analyzed. Results There were no significant differences in ADC values in MR enteroclysis and MR enterography ( P = 0.383 in inflammation, P = 0.223 in normal wall). Areas of inflammation showed statistically highly significant lower ADC values than areas of normal bowel wall ( P < 0.001). An ADC threshold of 1.56 × 10–3 mm2/s can distinguish between normal and inflamed bowel segments with a sensitivity of 97.4% and a specificity of 99.2%. A highly significant correlation could be shown between ADC and HBI values ( P = 0.001). Conclusion DWI-MRI facilitates recognition of inflamed bowel segments in patients with Crohn’s disease and the ADC values show an excellent correlation to the HBI. There were no significant differences in ADC values in MR enteroclysis and MR enterography. An ADC threshold of 1.56 × 10–3 mm2/s differentiates between normal and inflamed bowel wall.

scholarly journals Crohn’s disease: prevalence, MR features, and clinical significance of enteric and colonic sinus tracts

2020 ◽  
Vol 30 (10) ◽  
pp. 5358-5366
Author(s):  
Martina Scharitzer ◽  
Bernd Koizar ◽  
Harald Vogelsang ◽  
Michael Bergmann ◽  
Christian Primas ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Wall Thickness ◽  
Bowel Wall ◽  
Sinus Tract ◽  
Mr Enterography ◽  
Bowel Distension ◽  
Bowel Wall Thickness ◽  
Bowel Segments ◽  
Mr Visible

Abstract Objectives Enteric and colonic sinus tracts are inflammatory complications that precede intestinal fistulas in patients with Crohn’s disease (CD). The aim of this study was to retrospectively determine the prevalence, morphologic features, and outcome of sinus tracts using MR imaging. Methods A consecutive cohort of 642 patients with known CD, referred for MR enterography or MR enteroclysis (study period 01/2014–09/2019), was evaluated retrospectively for the presence of sinus tracts, their locations, presence and length of coexisting strictures, bowel wall thickness, CDMI score, upstream dilation, and bowel distension. Clinical outcome was assessed using medical records. For metric data, means and standard deviation, as well as one-way ANOVA and Pearson’s correlation coefficient, were calculated. Results In 36/642 patients with CD undergoing MRE, 49 sinus tracts (forty in small intestine, nine in left-sided colon) were detected with a prevalence of 6.9% in patients with MR-visible signs of CD (n = 519, overall prevalence of 5.6%). Mean segmental bowel wall thickness was 8.9 mm, and mean CDMI score was 9.3. All sinus tracts were located within a stenotic segment, showing mesenteric orientation within the small bowel and upstream dilation in 13 patients. Of 36 patients, 19 underwent immediate surgery and seven developed clinical progression within the segment containing the sinus tract. Conclusions Sinus tracts occur in 6.9% of patients with visible signs of CD. They are located within stenotic, severely thickened bowel segments with high MR inflammation scores. Their detection is clinically important, because they indicate a more aggressive phenotype and, if left untreated, may show severe progression. Key Points • Sinus tracts occur in 6.9% of patients with MR-visible signs of Crohn’s disease. • Sinus tracts are a radiological indicator of early penetrating Crohn’s disease, with a high risk of progression, and require dedicated treatment. • Sinus tracts can be recognized by characteristic findings and typically occur in stenotic, severely thickened bowel segments with high MR inflammation scores.

MRI of small bowel Crohn’s disease: determining the reproducibility of bowel wall gadolinium enhancement measurements

2009 ◽  
Vol 19 (8) ◽  
pp. 1960-1967 ◽  
Author(s):  
A. Sharman ◽  
I. A. Zealley ◽  
R. Greenhalgh ◽  
P. Bassett ◽  
S. A. Taylor
Keyword(s):  
Crohn’S Disease ◽  
Small Bowel ◽  
Crohn's Disease ◽  
Bowel Wall ◽  
Gadolinium Enhancement

Normalization of bowel wall after strictureplasty and miniresection for complicated Crohn's disease

2000 ◽  
Vol 32 ◽  
pp. A34
Author(s):  
G.M. Sampietro ◽  
M. Cristaldi ◽  
G. Maconi ◽  
S. Bollani ◽  
P.G. Danelli ◽  
...  
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Bowel Wall
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