scholarly journals Hyperechogenicity of the Substantia Nigra in Parkinson’s Disease: Insights from Two Brothers with Markedly Different Disease Durations

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Julie M. Hall ◽  
Matthew J. Georgiades ◽  
Deborah A. Hammond ◽  
Xiaoting Feng ◽  
Ahmed A. Moustafa ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Clinical Features ◽  
Disease Duration ◽  
Clinical Symptoms ◽  
The Other ◽  
Transcranial Ultrasound ◽  
Large Area ◽  
Substantia Nigra Echogenicity

We present clinical features and substantia nigra morphology for two brothers with Parkinson’s disease (PD) aged 60 and 59 years. The brothers were diagnosed at 41 and 50 years of age, respectively. Both patients exhibited an abnormally large area of substantia nigra echogenicity bilaterally when viewed with transcranial ultrasound. The abnormality was similar in both brothers despite one having a much longer disease duration than the other. These findings further highlight that transcranial ultrasound is not associated with severity of clinical symptoms, but it might assist in the diagnosis of PD provided that it is combined with other variables known to precede PD.

Substantia nigra echogenicity correlated with clinical features of Parkinson's disease

2016 ◽  
Vol 24 ◽  
pp. 28-33 ◽  
Author(s):  
Hai-Yan Zhou ◽  
Qian Sun ◽  
Yu-Yan Tan ◽  
Yun-Yun Hu ◽  
Wei-Wei Zhan ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Clinical Features ◽  
Substantia Nigra Echogenicity

Substantia nigra echogenicity in Parkinson’s disease: relation to serum iron and C-reactive protein

2011 ◽  
Vol 119 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Uwe Walter ◽  
Rike Witt ◽  
Alexander Wolters ◽  
Matthias Wittstock ◽  
Reiner Benecke
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Serum Iron ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Substantia Nigra Echogenicity

Substantia nigra echogenicity and imaging of striatal dopamine transporters in Parkinson's disease: A cross-sectional study

2014 ◽  
Vol 20 (5) ◽  
pp. 477-481 ◽  
Author(s):  
Edson Bor-Seng-Shu ◽  
Jose Luiz Pedroso ◽  
Andre C. Felicio ◽  
Daniel Ciampi de Andrade ◽  
Manoel Jacobsen Teixeira ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Cross Sectional Study ◽  
Striatal Dopamine ◽  
Sectional Study ◽  
Dopamine Transporters ◽  
Cross Sectional ◽  
Substantia Nigra Echogenicity

Substantia nigra echogenicity: A structural correlate of functional impairment of the dopaminergic striatal projection in Parkinson's disease

2009 ◽  
Vol 24 (11) ◽  
pp. 1669-1675 ◽  
Author(s):  
David Weise ◽  
Reinhard Lorenz ◽  
Mira Schliesser ◽  
Andreas Schirbel ◽  
Karlheinz Reiners ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Functional Impairment ◽  
Structural Correlate ◽  
Substantia Nigra Echogenicity

scholarly journals [18F]-AV-1451 binding in the substantia nigra as a marker of neuromelanin in lewy body diseases

2021 ◽  
Author(s):  
Elijah Mak ◽  
Antonina Kouli ◽  
Negin Holland ◽  
Nicolas Nicastro ◽  
George Savulich ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Lewy Body ◽  
Dementia With Lewy Bodies ◽  
Disease Duration ◽  
Rating Scale ◽  
Surrogate Marker ◽  
Lewy Bodies ◽  
Lewy Body Diseases

Abstract While [18F]-AV-1451 was developed as a positron emission tomography (PET) radiotracer with high affinity for hyperphosphorylated tau, it has been proposed that loss of “off-target” [18F]-AV-1451 binding to neuromelanin in the substantia nigra could be a surrogate marker of Lewy body diseases. [18F]-AV-1451 binding was measured in the substantia nigra of patients with Parkinson’s disease (n = 35), dementia with Lewy bodies (n = 10) and separate control groups (n = 37; n = 14). Associations with motor symptoms, cognition, and disease duration were evaluated using linear regression models. The dementia with Lewy bodies group had significantly reduced substantia nigra [18F]-AV-1451 binding compared to controls after adjusting for age (p < 0.05). However, there were no significant differences in substantia nigra [18F]-AV-1451 binding between Parkinson’s disease and controls. Substantia nigra [18F]-AV-1451 binding was not associated with age, disease duration, Movement Disorders Society—Unified Parkinson’s Disease Rating Scale and cognitive scores in dementia with Lewy bodies and Parkinson’s disease groups. Despite the reduction of substantia nigra [18F]-AV-1451 binding in dementia with Lewy bodies, these findings suggest that substantia nigra [18F]-AV-1451 binding has no value as a diagnostic marker in early Parkinson’s disease. Further investigations in longitudinal cohorts are warranted.

scholarly journals Tau Knockout and α-Synuclein A53T Synergy Modulated Parvalbumin-Positive Neurons Degeneration Staging in Substantia Nigra Pars Reticulata of Parkinson’s Disease-Liked Model

2022 ◽  
Vol 13 ◽  
Author(s):  
Meige Zheng ◽  
Yanchang Liu ◽  
Zhaoming Xiao ◽  
Luyan Jiao ◽  
Xian Lin
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Substantia Nigra ◽  
Transgenic Mice ◽  
Molecular Mechanism ◽  
The Other ◽  
Substantia Nigra Pars Reticulata ◽  
Transitional Stage ◽  
Mice Model ◽  
End Stage

The loss of parvalbumin-positive (PV+) neurons in the substantia nigra pars reticulata (SNR) was observed in patients with end-stage Parkinson’s disease (PD) and our previously constructed old-aged Pitx3-A53Tα-Syn × Tau–/– triple transgenic mice model of PD. The aim of this study was to examine the progress of PV+ neurons loss. We demonstrated that, as compared with non-transgenic (nTg) mice, the accumulation of α-synuclein in the SNR of aged Pitx3-A53Tα-Syn × Tau–/– mice was increased obviously, which was accompanied by the considerable degeneration of PV+ neurons and the massive generation of apoptotic NeuN+TUNEL+ co-staining neurons. Interestingly, PV was not costained with TUNEL, a marker of apoptosis. PV+ neurons in the SNR may undergo a transitional stage from decreased expression of PV to increased expression of NeuN and then to TUNEL expression. In addition, the degeneration of PV+ neurons and the expression of NeuN were rarely observed in the SNR of nTg and the other triple transgenic mice. Hence, we propose that Tau knockout and α-syn A53T synergy modulate PV+ neurons degeneration staging in the SNR of aged PD-liked mice model, and NeuN may be suited for an indicator that suggests degeneration of SNR PV+ neurons. However, the molecular mechanism needs to be further investigated.

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