scholarly journals Comparison of Esophageal Function Tests in Chinese Patients with Functional Heartburn and Reflux Hypersensitivity

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Feng Gao ◽  
Yan Gao ◽  
Xue Chen ◽  
Jie Qian ◽  
Jie Zhang
Keyword(s):  
Chinese Patients ◽  
Multichannel Intraluminal Impedance ◽  
Esophageal Function ◽  
Functional Heartburn ◽  
High Resolution Manometry ◽  
Ineffective Esophageal Motility ◽  
Function Tests ◽  
Intraluminal Impedance ◽  
Total Reflux ◽  
Associated Symptoms

Objective. To investigate the differences in the results of esophageal function tests for functional heartburn (FH) and reflux hypersensitivity (RH). Methods. Patients with FH and RH and healthy volunteers (HVs) from the Department of Gastroenterology, Beijing Anzhen Hospital and Beijing Chao-Yang hospital, who underwent high-resolution manometry and impedance (HRIM), and 24-hour multichannel intraluminal impedance and pH recording (MII/pH) between 2014 and 2016, were enrolled in this study. Results. 36 HV, 147 FH patients, and 91 RH patients were enrolled. The postreflux swallow-induced peristaltic wave index (PSPW index) and mean nocturnal baseline impedance (MNBI) values were significantly lower in RH than in FH and HV. The ineffective esophageal motility (IEM), fragmented peristalsis rates, total bolus exposure, proximal total reflux events, and distal total reflux events were significantly greater in RH than in FH and HV. Conclusions. Compared to HV and FH patients, RH patients exhibited greater IEM and fragmented peristalsis rates, a greater total bolus exposure, more proximal total and distal total reflux events, and reduced chemical clearance and mucosal integrity. By using the above described parameters, HRIM and MII/pH assays could be used to correctly classify RH and FH and hence allow physicians to provide adequate relief from associated symptoms.

scholarly journals Examination of the Effects of Vardenafil on Esophageal Function Using Multichannel Intraluminal Impedance and Manometry

2012 ◽  
Vol 18 (4) ◽  
pp. 399-405
Author(s):  
Tae Hee Lee ◽  
Joon Seong Lee ◽  
Su Jin Hong ◽  
Seong Ran Jeon ◽  
Wan Jung Kim ◽  
...  
Keyword(s):  
Multichannel Intraluminal Impedance ◽  
Esophageal Function ◽  
Intraluminal Impedance

scholarly journals Critical Analysis of Esophageal Multichannel Intraluminal Impedance Monitoring 20 Years Later

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Fernando A. M. Herbella
Keyword(s):  
Critical Analysis ◽  
Acid Reflux ◽  
Clinical Applications ◽  
Multichannel Intraluminal Impedance ◽  
Esophageal Diseases ◽  
Esophageal Function ◽  
Bolus Transit ◽  
Intraluminal Impedance ◽  
Esophageal Physiology ◽  
Impedance Monitoring

Multichannel intraluminal impedance (MII) for the evaluation of esophageal diseases was created in 1991 trying to solve previous limitations of esophageal function test. MII-pH is able to determine the physical characteristics of the refluxate (liquid, gas, or mixed) and nonacidic GER. MII-manometry can determine the presence of bolus and its relation with peristalsis. This paper makes a critical analysis of the clinical applications of MII 20 years after its creation. Literature review shows that MII made great contributions for the understanding of esophageal physiology; however, direct clinical applications are few. MII-pH was expected to identify patients with normal acid reflux and abnormal nonacidic reflux. These patients are rarely found off therapy, that is, nonacidic reflux parallels acid reflux. Furthermore, the significance of isolated nonacidic reflux is unclear. Contradictory MII-manometry and conventional manometry findings lack better understanding and clinical implication as well as the real significance of bolus transit.

Impact of ineffective esophageal motility on chemical clearance in patients with gastroesophageal reflux symptoms

2020 ◽  
Vol 33 (9) ◽  
Author(s):  
Hang Viet Dao ◽  
Tomoaki Matsumura ◽  
Tatsuya Kaneko ◽  
Satsuki Takahashi ◽  
Mamoru Tokunaga ◽  
...  
Keyword(s):  
Gastroesophageal Reflux ◽  
Esophageal Motility ◽  
Erosive Esophagitis ◽  
High Resolution Manometry ◽  
Ineffective Esophageal Motility ◽  
Intraluminal Impedance ◽  
Significant Difference ◽  
Multichannel Intraluminal Impedance Ph ◽  
The Impact ◽  
The Relationship

Summary Ineffective esophageal motility (IEM) is the most common manometric abnormality in gastroesophageal reflux disease (GERD). However, the impact of IEM on esophageal chemical clearance has not been fully investigated. This study aimed to determine the impact of IEM on esophageal chemical clearance in patients with GERD. A total of 369 patients with GERD symptoms who underwent upper endoscopy and high-resolution manometry (HRM) test were retrospectively analyzed. The relationship between IEM and erosive esophagitis was examined. In addition, the impact of IEM on chemical clearance was examined in patients who underwent an additional combined multichannel intraluminal impedance–pH (MII–pH) test. Esophageal chemical clearance capability was evaluated via postreflux swallow-induced peristaltic wave (PSPW) index and acid clearance time (ACT). Of 369 patients, 181 (49.1%) had esophageal motility disorders, of which 78 (21.1%) had IEM. The proportion of IEM patients in those with erosive esophagitis and those without were 16.2% and 21.7%, respectively, and no significant difference was observed (P = 0.53). After excluding patients other than those with IEM and normal esophageal motility, 64 subsequently underwent MII–pH test. The median values of the PSPW index in the IEM and normal esophageal motility group were 11.1% (4.2%–20.0%) and 17.1% (9.8%–30.6%), respectively. The PSPW index was significantly lower in the IEM group than in the normal esophageal motility group (P < 0.05). The median ACT values in the IEM group and normal esophageal motility group were 125.5 (54.0–183.5) seconds and 60.0 (27.2–105.7) seconds, respectively. The ACT was significantly longer in the IEM group than in the normal esophageal motility group (P < 0.05). In conclusion, IEM was found to be associated with chemical clearance dysfunction as measured against the PSPW index and ACT. As this condition could be a risk factor for GERD, future treatments should be developed with a focus on chemical clearance.

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