scholarly journals Lone Hepatocellular Carcinoma: An Isolated Chest Wall Malignancy

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Joseph Allencherril ◽  
Sebastian Bruera ◽  
Ronan Allencherril ◽  
Richard J. Hamill
Keyword(s):  
Hepatocellular Carcinoma ◽  
Chest Wall ◽  
Liver Lesion ◽  
Medical Intervention ◽  
Pathological Examination ◽  
Primary Malignancy ◽  
Tissue Mass ◽  
Illicit Substance Use ◽  
History Of ◽  
Chest Mass

Herein we describe the case of an elderly diabetic gentleman presenting with a two-week history of dyspnea and nonproductive cough, found to have a large left anterolateral chest wall mass. Further characterization through computed tomography (CT) of the chest revealed a soft tissue mass in the left anterior lower hemithorax found to be hepatocellular carcinoma (HCC). The liver, spleen, and pancreas were unremarkable. Diagnostic labs were unremarkable. The patient had no history of hepatitis, alcohol abuse, or illicit substance use. Pathological examination and immunohistochemical staining of the chest mass biopsy were consistent with metastatic hepatocellular carcinoma (HCC). The patient opted to pursue no further medical intervention and expired two weeks later. To the authors’ knowledge, this is one of very few descriptions of isolated hepatocellular carcinoma found in the absence of a primary liver lesion and classical risk factors for hepatocarcinogenesis. This case highlights that HCC may present independently of liver lesions seen on imaging in a patient without clear signs or symptoms of liver. HCC should be considered in cases of isolated tumors with unclear primaries as ectopic carcinogenesis and occult primary malignancy are possibilities.

scholarly journals Case Report: Synchronous primary malignancy including the breast and endometrium

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1502
Author(s):  
Elham Sadat Banimostafavi ◽  
Sepideh Tayebi ◽  
Maryam Tayebi ◽  
Fatemeh Montazer
Keyword(s):  
Endometrial Cancer ◽  
Rare Event ◽  
Uterine Wall ◽  
Pelvic Cavity ◽  
Primary Malignancy ◽  
Tissue Mass ◽  
Her Family ◽  
History Of ◽  
Abnormal Vaginal Bleeding ◽  
The Right

Breast and endometrial cancer are the most common types of female cancers, but the incidence of both of these malignancies in a single patient is a rare event. Multiple primary malignancy has been increasingly reported over the past decade, and double primary cancer is considered as the most common type.  In this study, we present a 53-year-old woman with synchronous primary malignancy of breast and endometrium. This patient had a history of breast and endometrial cancer in her family. Mammography and chest CT of the patient revealed a mass in the right breast and left supraclavicular region. However, the patient did not want to initiate treatment. Subsequently, the patient returned with a chief complaint of persistent abnormal vaginal bleeding. Abdominopelvic CT scan of the patient revealed a huge soft tissue mass in the pelvic cavity. She underwent hysterectomy, and pathology revealed endometrioid carcinoma, which had invaded the full thickness of uterine wall. Since this type of malignancy is rare and several risk factors are associated with it, it is worth being considered by clinicians when making decisions about screening or strategy for prevention.

Urinary Retention Due to Benign Tumor of the Bladder Neck in a Woman; A Rare Case of Papillary Cystitis

2013 ◽  
Vol 80 (1) ◽  
pp. 83-85 ◽  
Author(s):  
Kostantinos Stamatiou
Keyword(s):  
Urinary Retention ◽  
Bladder Neck ◽  
Transitional Cell ◽  
Pathological Examination ◽  
Tissue Mass ◽  
First Case ◽  
History Of ◽  
Carcinoma Of The Bladder ◽  
Papillary Cystitis ◽  
Polypoid Cystitis

Background Urinary retention (UR) is not common in women. There are numerous causes now recognized in women, broadly categorized as infective, pharmacological, neurological, anatomical, myopathic and functional. As opposed to the male, obstructive UR is unusual in women. Methods A 56-year-old woman presented with urinary retention. She reported difficulty in urination for more than 15 days. She had no history of urinary tract infection, bladder surgery and catheterization. Her physical examination revealed a soft tissue mass obstructing the external orifice of the urethra. After its partial removal the patient regained her ability to urinate. Results The patient underwent urological investigation. Ultrasound examination of the urinary system was normal. Cystoscopic examination revealed a papillary lesion with broad base floating along the bladder neck. The patient underwent transurethral resection of the bladder tumor. Discussion Pathological examination diagnosed papillary cystitis. She was scheduled for a regular follow-up with urine cytology, ultrasound and cystoscopy. One year after diagnosis the patient remains free of symptoms and no recurrence was observed. Conclusions Papillary and polypoid cystitis are benign lesions, however under certain circumstances they should be considered in the differential diagnosis of transitional cell carcinoma of the bladder. Lack of the prominent inflammation and edema that characterizes both papillary and polypoid cystitis, and absence of a history of recent bladder catheterization and presence of vesical fistula may facilitate the decision to biopsy the lesion. To our knowledge, this is the first case of papillary cystitis presenting with urinary retention in a woman to be reported in the literature.

scholarly journals Ocular Melanoma Metastasizing to Intra-Abdominal Lymph Nodes

2013 ◽  
Vol 2013 ◽  
pp. 1-4
Author(s):  
David Aranovich ◽  
Karen Meir ◽  
Michal M. Lotem ◽  
Liat Appelbaum ◽  
Hadar Merhav
Keyword(s):  
Lymph Nodes ◽  
Metastatic Melanoma ◽  
Disease Free Survival ◽  
Ocular Melanoma ◽  
Pathological Examination ◽  
Tissue Mass ◽  
Case Presentation ◽  
Free Survival ◽  
History Of ◽  
Disease Free

Background. Visceral metastatic spread of ocular melanoma most commonly occurs via hematogenous route to the liver. Lymphatic spread of ocular melanoma into abdominal lymph nodes has not been reported previously.Case Presentation. A 47-year-old man with a history of ocular melanoma presented with a soft tissue mass on CT scan. The mass encased the portal structures of the hepaticoduodenal ligament. Image-guided biopsy revealed it to be a metastatic melanoma to lymph nodes. The patient underwent surgery with the intent to prolong disease-free survival. On final pathological examination, two lymph nodes were found harboring metastatic melanoma.Conclusion. Extrahepatic lymphatic intra-abdominal spread of ocular melanoma is not impossible. Since this mode of spread is rare, the oncologic significance of surgical resection of isolated intra-abdominal nodal with metastatic ocular melanoma is difficult to determine at the present time.

scholarly journals Case Report: Synchronous primary malignancy including the breast and endometrium

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 1502 ◽  
Author(s):  
Elham Sadat Banimostafavi ◽  
Sepideh Tayebi ◽  
Maryam Tayebi
Keyword(s):  
Endometrial Cancer ◽  
Rare Event ◽  
Uterine Wall ◽  
Pelvic Cavity ◽  
Primary Malignancy ◽  
Tissue Mass ◽  
Her Family ◽  
History Of ◽  
Abnormal Vaginal Bleeding ◽  
The Right

Breast and endometrial cancer are the most common types of female cancers, but the incidence of both of these malignancies in a single patient is a rare event. Multiple primary malignancy has been increasingly reported over the past decade, and double primary cancer is considered as the most common type.  In this study, we present a 53-year-old woman with synchronous primary malignancy of breast and endometrium. This patient had a history of breast and endometrial cancer in her family. Mammography and chest CT of the patient revealed a mass in the right breast and left supraclavicular region. However, the patient did not want to initiate treatment. Subsequently, the patient returned with a chief complaint of persistent abnormal vaginal bleeding. Abdominopelvic CT scan of the patient revealed a huge soft tissue mass in the pelvic cavity. She underwent hysterectomy, and pathology revealed endometrioid carcinoma, which had invaded the full thickness of uterine wall. Since this type of malignancy is rare and several risk factors are associated with it, it is worth being considered by clinicians when making decisions about screening or strategy for prevention.

Progressive course of isolated splenic myeloid sarcoma

Open Medicine ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. 499-502
Author(s):  
Darko Antic ◽  
Maja Perunicic Jovanovic ◽  
Djordje Knezevic ◽  
Slavenko Ostojic ◽  
Ivo Elezovic
Keyword(s):  
Tumor Tissue ◽  
Soft Tissue Mass ◽  
Lactate Dehydrogenase Level ◽  
Myeloid Sarcoma ◽  
Pathological Examination ◽  
Blood Cell Count ◽  
Broad Spectrum Antibiotic ◽  
Tissue Mass ◽  
Superior Part ◽  
History Of

AbstractA previously healthy 40-year-old male presented with a 2-week history of fever and abdominal discomfort that was resistant to empirical broad-spectrum antibiotic treatment. The patient’s blood cell count and complete biochemical panel was normal, except for an increased lactate dehydrogenase level. Ultrasonography and computed tomography of the abdomen showed a large, soft tissue mass had infiltrated superior part of the spleen. Splenectomy with total tumor mass removal were performed. The pathological examination of the tumor tissue confirmed diagnosis of isolated myeloid sarcoma with monoblastic differentiation. Despite intensive antileukemic therapy, patient died four months after diagnosis was established.

scholarly journals A case report of an angiomyxoma in the liver

2018 ◽  
Vol 100 (4) ◽  
pp. e81-e84 ◽  
Author(s):  
AK Malik ◽  
R Filobbos ◽  
A Manoharan ◽  
N Harvey ◽  
DA O’Reilly ◽  
...  
Keyword(s):  
Liver Parenchyma ◽  
Liver Lesion ◽  
Pathological Examination ◽  
Resected Specimen ◽  
Curative Intent ◽  
Right Hemihepatectomy ◽  
History Of ◽  
Size And Morphology ◽  
Disseminated Disease

Angiomyxomas are uncommon myxoid tumours arising most commonly from the pelvis. A 46-year-old woman with a history of polycystic kidney disease presented asymptomatically for surveillance ultrasonography; changes were noted in the size and morphology of her liver cysts. Subsequent radiological assessment displayed features suspicious of malignancy and a right hemihepatectomy was performed with curative intent. Pathological examination of the resected specimen found histology consistent with an angiomyxoma arising primarily from the liver parenchyma. Follow-up review of the patient has been uneventful with annual imaging showing no evidence of recurrence. Angiomyxomas do not characteristically invade other tissues. However, any liver lesion displaying suspicious features of malignancy should be resected in the absence of disseminated disease.

scholarly journals Case Report: Synchronous primary malignancy including the breast and endometrium

F1000Research ◽  
2018 ◽  
Vol 6 ◽  
pp. 1502
Author(s):  
Elham Sadat Banimostafavi ◽  
Sepideh Tayebi ◽  
Maryam Tayebi ◽  
Fatemeh Montazer
Keyword(s):  
Endometrial Cancer ◽  
Rare Event ◽  
Uterine Wall ◽  
Pelvic Cavity ◽  
Primary Malignancy ◽  
Tissue Mass ◽  
Her Family ◽  
History Of ◽  
Abnormal Vaginal Bleeding ◽  
The Right

Breast and endometrial cancer are the most common types of female cancers, but the incidence of both of these malignancies in a single patient is a rare event. Multiple primary malignancy has been increasingly reported over the past decade, and double primary cancer is considered as the most common type.  In this study, we present a 53-year-old woman with synchronous primary malignancy of breast and endometrium. This patient had a history of breast and endometrial cancer in her family. Mammography and chest CT of the patient revealed a mass in the right breast and left supraclavicular region. However, the patient did not want to initiate treatment. Subsequently, the patient returned with a chief complaint of persistent abnormal vaginal bleeding. Abdominopelvic CT scan of the patient revealed a huge soft tissue mass in the pelvic cavity. She underwent hysterectomy, and pathology revealed endometrioid carcinoma, which had invaded the full thickness of uterine wall. Since this type of malignancy is rare and several risk factors are associated with it, it is worth being considered by clinicians when making decisions about screening or strategy for prevention.

Vaccination: A Public Health Intervention That Changed History & Is Changing with History

2011 ◽  
Vol 73 (9) ◽  
pp. 513-519
Author(s):  
Richard A. Stein
Keyword(s):  
Public Health ◽  
Hepatocellular Carcinoma ◽  
Public Health Intervention ◽  
Medical Intervention ◽  
Vaccination Programs ◽  
History Of Public Health ◽  
Interdisciplinary Field ◽  
Ethical Misconduct ◽  
History Of ◽  
National Programs

One of the most successful prophylactic interventions in the history of public health, vaccination helped control some of the deadliest and most debilitating infectious diseases. As a result of vaccination programs, smallpox was eradicated worldwide, poliomyelitis was nearly eradicated and emerges as the next eradication target, and national programs helped reduce the incidence of tuberculosis in many countries. Other, more recent vaccines have already achieved a visible impact, as revealed by the ability of the hepatitis B vaccine to decrease the number of new hepatitis infections and the incidence of hepatocellular carcinoma. While vaccination, like any other medical intervention, may have adverse effects, significant controversies gravitated, in recent years, around its supposed link to autism. One of the articles that provided substantial support for this link was recently retracted amid evidence of ample scientific and ethical misconduct. As studies from several countries found that the incidence of autism was increasing even after the removal of thimerosal from vaccines, it appears that, in all likelihood, this trend was not caused by the mercury- containing preservative, and potential causes have to be pursued somewhere else. Although many early vaccines were prepared empirically from live attenuated or inactivated pathogens, recent years have witnessed a shift toward a more rational strategy, in which concepts from disciplines including molecular biology, genomics, proteomics, and bioinformatics are increasingly incorporated into vaccine design, transforming vaccinology into a dynamic and vibrant interdisciplinary field.

scholarly journals Atypical deep somatic soft-tissue leiomyoma of extrathoracic chest wall: first case of the literature

2018 ◽  
Vol 11 (1) ◽  
pp. e226668 ◽  
Author(s):  
Guntug Batihan ◽  
Ozan Usluer ◽  
Seyda Ors Kaya ◽  
Zekiye Aydogdu
Keyword(s):  
Soft Tissue ◽  
Chest Wall ◽  
Smooth Muscles ◽  
Pathological Finding ◽  
Pathological Examination ◽  
X Ray ◽  
First Case ◽  
History Of ◽  
Chest X Ray

Leiomyomas are benign soft-tissue tumours which take origin from the smooth muscles. Pleura and chest wall are uncommon location for such tumours. Here, we report a case of a 26-year-old female patient presented with 3 months history of chest pain. Chest X-ray and CT showed a calcified mass of 6×12 cm in size in the left lateral of the chest wall. After resection of the mass, pathological examination diagnosed it as atypical deep somatic soft-tissue leiomyoma of extrathoracic chest wall. No pathological finding was detected during follow-up.

The Diagnostic Value of Pericardial Fluid and Pericardial Biopsy: Single Center Experiences

2016 ◽  
Vol 19 (1) ◽  
pp. 023 ◽  
Author(s):  
Mehmet Yildirim ◽  
Recep Ustaalioglu ◽  
Murat Erkan ◽  
Bala Basak Oven Ustaalioglu ◽  
Hatice Demirbag ◽  
...  
Keyword(s):  
Pericardial Effusion ◽  
Thoracoscopic Surgery ◽  
Pericardial Tamponade ◽  
Pericardial Fluid ◽  
Pathological Examination ◽  
Common Disease ◽  
Pericardial Window ◽  
Surgical Interventions ◽  
History Of ◽  
Recurrent Pericardial Effusion

<strong>Background:</strong> Patients with recurrent pericardial effusion and pericardial tamponade are usually treated in thoracic surgery clinics by VATS (video-assisted thoracoscopic surgery) or open pericardial window operation. The diagnostic importance of pathological evaluation of the pericardial fluid and tissue in the same patients has been reported in few studies. We reviewed pathological examination of the pericardial tissue and fluid specimens and the effect on the clinical treatment in our clinic, and compared the results with the literature. <br /><strong>Methods:</strong> We retrospectively analyzed 174 patients who underwent pericardial window operation due to pericardial tamponade or recurrent pericardial effusion. For all patients both the results of the pericardial fluid and pericardial biopsy specimen were evaluated. Clinicopathological factors were analyzed by using descriptive analysis. <br /><strong>Results:</strong> Median age was 61 (range, 20-94 years). The most common benign diagnosis was chronic inflammation (94 patients) by pericardial biopsy. History of malignancy was present in 28 patients (16.1%) and the most common disease was lung cancer (14 patients). A total of 24 patients (13.8%) could be diagnosed as having malignancy by pericardial fluid or pericardial biopsy examination. The malignancy was recognized for 12 patients who had a history of cancer; 9 of 12 with pericardial biopsy, 7 diagnosed by pericardial fluid. Twelve of 156 patients were recognized as having underlying malignancy by pericardial biopsy (n = 9) or fluid examination (n = 10), without known malignancy previously. <br /><strong>Conclusion:</strong> Recurrent pericardial effusion/pericardial tamponade are entities frequently diagnosed, and surgical interventions may be needed either for diagnosis and/or treatment, but specific etiology can rarely be obtained in spite of pathological examination of either pericardial tissue or fluid. For increasing the probability of a specific diagnosis both the pericardial fluid and the pericardial tissues have to be sent for pathologic examination.

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