scholarly journals Adenosine Receptors as a Biological Pathway for the Anti-Inflammatory and Beneficial Effects of Low Frequency Low Energy Pulsed Electromagnetic Fields

2017 ◽  
Vol 2017 ◽  
pp. 1-11 ◽  
Author(s):  
Katia Varani ◽  
Fabrizio Vincenzi ◽  
Annalisa Ravani ◽  
Silvia Pasquini ◽  
Stefania Merighi ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Adenosine Receptors ◽  
Biological Effects ◽  
Low Frequency ◽  
Low Energy ◽  
Membrane Receptors ◽  
Pulsed Electromagnetic Fields ◽  
Inflammatory Status ◽  
Anti Inflammatory ◽  
Pulsed Electromagnetic

Several studies explored the biological effects of low frequency low energy pulsed electromagnetic fields (PEMFs) on human body reporting different functional changes. Much research activity has focused on the mechanisms of interaction between PEMFs and membrane receptors such as the involvement of adenosine receptors (ARs). In particular, PEMF exposure mediates a significant upregulation ofA2Aand A3ARs expressed in various cells or tissues involving a reduction in most of the proinflammatory cytokines. Of particular interest is the observation that PEMFs, acting as modulators of adenosine, are able to increase the functionality of the endogenous agonist. By reviewing the scientific literature on joint cells, a double role for PEMFs could be hypothesized in vitro by stimulating cell proliferation, colonization of the scaffold, and production of tissue matrix. Another effect could be obtained in vivo after surgical implantation of the construct by favoring the anabolic activities of the implanted cells and surrounding tissues and protecting the construct from the catabolic effects of the inflammatory status. Moreover, a protective involvement of PEMFs on hypoxia damage in neuron-like cells and an anti-inflammatory effect in microglial cells have suggested the hypothesis of a positive impact of this noninvasive biophysical stimulus.

scholarly journals Effects of Low-Frequency Pulsed Electromagnetic Fields on High-Altitude Stress Ulcer Healing in Rats

2019 ◽  
Vol 2019 ◽  
pp. 1-8
Author(s):  
Mingke Jiao ◽  
Hong Yin ◽  
Jie Hu ◽  
Wenjuan Xu ◽  
Xiao Zhang ◽  
...  
Keyword(s):  
High Altitude ◽  
Electromagnetic Fields ◽  
Stress Ulcer ◽  
Biological Effects ◽  
Low Frequency ◽  
Pulsed Electromagnetic Fields ◽  
Sprague Dawley ◽  
Ph Values ◽  
Tissue Healing ◽  
Pulsed Electromagnetic

High-altitude stress ulcer (HSU) has constantly been a formidable clinical challenge for high-altitude and severe hypoxia. Pulsed electromagnetic fields (PEMFs) have been verified to have the ability to penetrate tissues, and the biological effects have been confirmed effective on various tissue restorations. However, the therapeutic effect of PEMFs on HSU has been rarely reported. This study aimed to evaluate the effects of PEMFs on HSU healing systematically. Sprague–Dawley rats were assigned to control, HSU, and HSU+PEMF groups. The HSU models were induced by restraint stress under low-pressure hypoxia. The HSU+PEMF group was subjected to PEMF exposure. During the HSU healing, gastric juice pH values, ulcer index (UI), and histopathologic changes were investigated. Furthermore, tumor necrosis factor-α (TNF-α) was determined to analyze the severity of gastric membrane inflammations. Norepinephrine (NE), which influences gastric acid secretion, was measured. Results indicated the UI of the HSU+PEMF decreased faster than that of the HSU group. Histopathologic observation suggested that the ulcer tissue healing is faster in the HSU+PEMF group than in the HSU group. The TNF-α/total protein results revealed that the inflammation of the HSU+PEMF group is suppressed effectively. The pH values are higher in the HSU+PEMF group than in the HSU, as confirmed by NE examination. The results indicated that low-frequency PEMFs can penetrate stomach tissues to relieve the symptoms of HSU and promote the regeneration of disturbed tissues, thus implying the clinical potential of PEMF therapy for HSU treatment.

DNA Repair after γ Irradiation in Lymphocytes Exposed to Low-Frequency Pulsed Electromagnetic Fields

1989 ◽  
Vol 118 (1) ◽  
pp. 161 ◽  
Author(s):  
A. Cossarizza ◽  
D. Monti ◽  
P. Sola ◽  
G. Moschini ◽  
R. Cadossi ◽  
...  
Keyword(s):  
Dna Repair ◽  
Electromagnetic Fields ◽  
Low Frequency ◽  
Pulsed Electromagnetic Fields ◽  
Γ Irradiation ◽  
Pulsed Electromagnetic

scholarly journals Translational Insights into Extremely Low Frequency Pulsed Electromagnetic Fields (ELF-PEMFs) for Bone Regeneration after Trauma and Orthopedic Surgery

2019 ◽  
Vol 8 (12) ◽  
pp. 2028 ◽  
Author(s):  
Sabrina Ehnert ◽  
Steffen Schröter ◽  
Romina H. Aspera-Werz ◽  
Wiebke Eisler ◽  
Karsten Falldorf ◽  
...  
Keyword(s):  
Treatment Regimen ◽  
Electromagnetic Fields ◽  
Electrical Potential ◽  
Low Frequency ◽  
Treatment Modalities ◽  
Pulsed Electromagnetic Fields ◽  
Osteochondral Defects ◽  
Extremely Low Frequency ◽  
Pulsed Electromagnetic ◽  
Pemf Treatment

The finding that alterations in electrical potential play an important role in the mechanical stimulation of the bone provoked hype that noninvasive extremely low frequency pulsed electromagnetic fields (ELF-PEMF) can be used to support healing of bone and osteochondral defects. This resulted in the development of many ELF-PEMF devices for clinical use. Due to the resulting diversity of the ELF-PEMF characteristics regarding treatment regimen, and reported results, exposure to ELF-PEMFs is generally not among the guidelines to treat bone and osteochondral defects. Notwithstanding, here we show that there is strong evidence for ELF-PEMF treatment. We give a short, confined overview of in vitro studies investigating effects of ELF-PEMF treatment on bone cells, highlighting likely mechanisms. Subsequently, we summarize prospective and blinded studies, investigating the effect of ELF-PEMF treatment on acute bone fractures and bone fracture non-unions, osteotomies, spinal fusion, osteoporosis, and osteoarthritis. Although these studies favor the use of ELF-PEMF treatment, they likewise demonstrate the need for more defined and better controlled/monitored treatment modalities. However, to establish indication-oriented treatment regimen, profound knowledge of the underlying mechanisms in the sense of cellular pathways/events triggered is required, highlighting the need for more systematic studies to unravel optimal treatment conditions.

Development of a Therapeutic Device for Osteoporosis

2013 ◽  
Vol 302 ◽  
pp. 603-606
Author(s):  
Tian Yue ◽  
Lei Tao
Keyword(s):  
Magnetic Field ◽  
Electromagnetic Fields ◽  
Biological Effects ◽  
Homogeneous Magnetic Field ◽  
Pulsed Electromagnetic Fields ◽  
Treatment Of Osteoporosis ◽  
Non Invasive ◽  
Helmholtz Coils ◽  
Prevention And Treatment ◽  
Pulsed Electromagnetic

Pulsed electromagnetic fields (PEMF) have been reported as a non-invasive way in the prevention and treatment of osteoporosis. A new PEMF generator was designed to produce more homogeneous magnetic field than normal Helmholtz coils. The intensity and distribution of magnetic field y were calculated theoretically. The results showed that magnetic field generated by improved Helmholtz coils (three identical coils) is more intensive and homogeneous than normal Helmholtz coils (two identical coils). Moreover, this apparatus might play a significant role in the study of biological effects of PEMF on osteoporosis.

Effects of extremely low-frequency pulsed electromagnetic fields (ELF-PEMFs) on glioblastoma cells (U87)

2016 ◽  
Vol 36 (3) ◽  
pp. 238-247 ◽  
Author(s):  
Zeinab Akbarnejad ◽  
Hossein Eskandary ◽  
Cristian Vergallo ◽  
Seyed Noureddin Nematollahi-Mahani ◽  
Luciana Dini ◽  
...  
Keyword(s):  
Electromagnetic Fields ◽  
Low Frequency ◽  
Pulsed Electromagnetic Fields ◽  
Glioblastoma Cells ◽  
Extremely Low Frequency ◽  
Pulsed Electromagnetic
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