scholarly journals A Neonatal Case of Glial Choristoma of the Tongue Causing Airway Obstruction

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Hajime Machi ◽  
Hiroki Karata ◽  
Yusuke Yamane ◽  
Junya Fukuoka ◽  
Yasutomo Funakoshi ◽  
...  
Keyword(s):  
Respiratory Distress ◽  
Airway Obstruction ◽  
Therapeutic Strategy ◽  
Age At Onset ◽  
Subtotal Resection ◽  
Soft Mass ◽  
Central Nervous Tissue ◽  
Dorsal Tongue ◽  
Male Neonate ◽  
Optimal Therapeutic Strategy

Glial choristoma is considered to be a type of brain heterotopia consisting of ectopic central nervous tissue. We herein report a neonate with glial choristoma of the tongue who developed respiratory distress due to airway obstruction. A male neonate presented with respiratory distress due to a soft mass on the midline region of the dorsal tongue base at birth. He was intubated using a flexible fiberoptic nasopharyngoscope. MRI showed a well-circumscribed mass measuring 25 × 23 × 27 mm in size in the same region. A histologic examination confirmed a pathological diagnosis of glial choristoma. He underwent tracheotomy at 22 days of age, and a subtotal resection of the tumor was performed at five months of age. The clinical behavior of oral glial choristoma varies depending on the age at onset as well as the location and size of the mass. The small size of the organ and the narrow operating field hamper the surgical approach in neonates. The optimal therapeutic strategy for neonatal cases of glial choristoma should thus be determined based on the condition of each individual patient.

scholarly journals Giant intracranial congenital hemangiopericytoma/solitary fibrous tumor: A case report and literature review

2019 ◽  
Vol 10 ◽  
pp. 75 ◽  
Author(s):  
Dimitrios Giakoumettis ◽  
Ioannis Nikas ◽  
Kalliopi Stefanaki ◽  
Antonis Kattamis ◽  
George Sfakianos ◽  
...  
Keyword(s):  
Solitary Fibrous Tumor ◽  
Therapeutic Strategy ◽  
Good Prognosis ◽  
Subtotal Resection ◽  
Neurosurgical Department ◽  
Adult Type ◽  
Therapeutic Algorithm ◽  
Fibrous Tumor ◽  
The Right ◽  
Optimal Therapeutic Strategy

Background: Hemangiopericytoma and solitary fibrous tumor (HPC/SFT) are considered to be one category according to the WHO 2016 classification of central nervous system tumors. HPC/SFT are subdivided into infantile (congenital) and adult type. Both are extremely rare entities, with little knowledge about etiology, prognosis, and optimal therapeutic strategy. Case Description: A 10-day-old girl was referred to our neurosurgical department due to hypotonia, palsy of the right oculomotor nerve, and prominent frontal fontanel. Imaging studies revealed a large occupying mass in the right middle cerebral fossa and the suprasellar cisterns. Only a subtotal resection of the tumor was possible, and postoperatively, she underwent chemotherapy (CHx). After a 3-year follow-up, the girl has minimum neurologic signs and receives no medications, and she can walk when she is supported. Conclusion: Congenital HPC/SFT is considered to have a benign behavior with a good prognosis. Treatment with gross total resection, when it is feasible, is the key to a good prognosis and low rates of recurrence. However, there is no consensus on the therapeutic strategy of a HPC/SFT, which is difficult to be completely resected. Literature lacks a therapeutic algorithm for these tumors, and thus, more clinical studies are needed to reach a consensus.

Respiratory distress in patients with central airway obstruction

2010 ◽  
Vol 26 (2) ◽  
pp. 151-156
Author(s):  
Mohamed Abdel Hamied Regal ◽  
Yasser Ahmed El Ghoneimy ◽  
Yasser Maher Aljehani
Keyword(s):  
Respiratory Distress ◽  
Airway Obstruction ◽  
Central Airway Obstruction ◽  
Central Airway

scholarly journals Sub-glottic cysts causing upper airway obstruction

2020 ◽  
Vol 6 (6) ◽  
pp. 1203
Author(s):  
Swathi Chigicherla ◽  
Shruti Tewari ◽  
Rahul Deo Sharma ◽  
Rajesh Nathani
Keyword(s):  
Respiratory Distress ◽  
Airway Obstruction ◽  
Direct Laryngoscopy ◽  
Upper Airway ◽  
Upper Airway Obstruction ◽  
First Case

<p class="abstract">Wigger and Tang reported the first case of a sub-glottic cyst (SGC) in 1968. SGC are rare but potentially reversible causes of upper airway obstruction, in previously intubated children. These children present with respiratory distress and stridor, and the diagnosis is confirmed by direct laryngoscopy. The management depends on the size of the cysts and the severity of the symptoms. We are presenting two cases of SGCs who were born prematurely and were intubated for a prolonged period. They presented with stridor and were diagnosed to have sub-glottic cysts at bronchoscopy.</p>

scholarly journals Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19

2020 ◽  
Vol 11 ◽  
Author(s):  
Karel F. A. Van Damme ◽  
Simon Tavernier ◽  
Nele Van Roy ◽  
Elisabeth De Leeuw ◽  
Jozefien Declercq ◽  
...  
Keyword(s):  
Case Report ◽  
Targeted Therapy ◽  
Therapeutic Strategy ◽  
Clinical Course ◽  
Disease Course ◽  
Viral Shedding ◽  
Clinical Recovery ◽  
Immunodeficiency Disorder ◽  
Optimal Therapeutic Strategy ◽  
Common Variable

The disease course of COVID-19 in patients with immunodeficiencies is unclear, as well as the optimal therapeutic strategy. We report a case of a 37-year old male with common variable immunodeficiency disorder and a severe SARS-CoV-2 infection. After administration of convalescent plasma, the patient’s condition improved rapidly. Despite clinical recovery, viral RNA remained detectable up to 60 days after onset of symptoms. We propose that convalescent plasma might be considered as a treatment option in patients with CVID and severe COVID-19. In addition, in patients with immunodeficiencies, a different clinical course is possible, with prolonged viral shedding.

Congenital Bony Nasal Cavity Deformities

1998 ◽  
Vol 12 (2) ◽  
pp. 81-86 ◽  
Author(s):  
Jacqueline E. Jones ◽  
Eytan Young ◽  
Linda Heier
Keyword(s):  
Soft Tissue ◽  
Respiratory Distress ◽  
Airway Obstruction ◽  
Nasal Cavity ◽  
Congenital Anomalies ◽  
Clinical Management ◽  
Choanal Atresia ◽  
Anatomical Features ◽  
Tissue Edema ◽  
Pyriform Aperture

Although the most common form of nasal obstruction in neonates is soft tissue edema, congenital bony nasal deformities are being recognized as an important cause of newborn airway obstruction. In addition to the well described choanal atresia, CT imaging of the newborn in respiratory distress reveals two other forms of bony nasal cavity deformities: nasal pyriform aperture stenosis and nasal cavity stenosis. All of the three types of bony nasal cavity deformities have characteristic anatomical features, are associated with distinctive congenital anomalies, and are postulated to have differing embryological causes. Five patients with congenital bony nasal cavity deformities are presented. These cases illustrate the clinical and radiological presentation of varied types of congenital nasal cavity obstruction as well as the criteria used to guide clinical management.

scholarly journals CD13: A Key Player in Multidrug Resistance in Cancer Chemotherapy

2020 ◽  
Vol 28 (5) ◽  
pp. 533-540
Author(s):  
Qie Guo ◽  
Xiao Li ◽  
Meng-Na Cui ◽  
Jia-Lin Sun ◽  
Hong-Yan Ji ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cell Surface ◽  
Tumor Cells ◽  
Systemic Chemotherapy ◽  
Therapeutic Strategy ◽  
Great Difficulty ◽  
Current Evidence ◽  
Outer Cell ◽  
Optimal Therapeutic Strategy

Cancer is one of the most serious diseases that are harmful to human health. Systemic chemotherapy is an optimal therapeutic strategy for the treatment of cancer, but great difficulty has been encountered in its administration in the form of multidrug resistance (MDR). As an enzyme on the outer cell surface, CD13 is documented to be involved in the MDR development of tumor cells. In this review, we will focus on the role of CD13 in MDR generation based on the current evidence.

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