scholarly journals A theoretical model for p53 dynamics: Identifying optimal therapeutic strategy for its activation and stabilization

Cell Cycle ◽  
2009 ◽  
Vol 8 (22) ◽  
pp. 3707-3716 ◽  
Author(s):  
Do-Hyun Kim ◽  
Kyoohyoung Rho ◽  
Sunghoon Kim
Keyword(s):  
Theoretical Model ◽  
Therapeutic Strategy ◽  
Optimal Therapeutic Strategy

scholarly journals Case Report: Convalescent Plasma, a Targeted Therapy for Patients with CVID and Severe COVID-19

2020 ◽  
Vol 11 ◽  
Author(s):  
Karel F. A. Van Damme ◽  
Simon Tavernier ◽  
Nele Van Roy ◽  
Elisabeth De Leeuw ◽  
Jozefien Declercq ◽  
...  
Keyword(s):  
Case Report ◽  
Targeted Therapy ◽  
Therapeutic Strategy ◽  
Clinical Course ◽  
Disease Course ◽  
Viral Shedding ◽  
Clinical Recovery ◽  
Immunodeficiency Disorder ◽  
Optimal Therapeutic Strategy ◽  
Common Variable

The disease course of COVID-19 in patients with immunodeficiencies is unclear, as well as the optimal therapeutic strategy. We report a case of a 37-year old male with common variable immunodeficiency disorder and a severe SARS-CoV-2 infection. After administration of convalescent plasma, the patient’s condition improved rapidly. Despite clinical recovery, viral RNA remained detectable up to 60 days after onset of symptoms. We propose that convalescent plasma might be considered as a treatment option in patients with CVID and severe COVID-19. In addition, in patients with immunodeficiencies, a different clinical course is possible, with prolonged viral shedding.

scholarly journals CD13: A Key Player in Multidrug Resistance in Cancer Chemotherapy

2020 ◽  
Vol 28 (5) ◽  
pp. 533-540
Author(s):  
Qie Guo ◽  
Xiao Li ◽  
Meng-Na Cui ◽  
Jia-Lin Sun ◽  
Hong-Yan Ji ◽  
...  
Keyword(s):  
Multidrug Resistance ◽  
Cell Surface ◽  
Tumor Cells ◽  
Systemic Chemotherapy ◽  
Therapeutic Strategy ◽  
Great Difficulty ◽  
Current Evidence ◽  
Outer Cell ◽  
Optimal Therapeutic Strategy

Cancer is one of the most serious diseases that are harmful to human health. Systemic chemotherapy is an optimal therapeutic strategy for the treatment of cancer, but great difficulty has been encountered in its administration in the form of multidrug resistance (MDR). As an enzyme on the outer cell surface, CD13 is documented to be involved in the MDR development of tumor cells. In this review, we will focus on the role of CD13 in MDR generation based on the current evidence.

scholarly journals Standardizing and Optimizing Acupuncture Therapy for Irritable Bowel Syndrome: A Delphi Expert Consensus Study

2020 ◽  
Author(s):  
Xin-Tong Su ◽  
Li-Qiong Wang ◽  
Na Zhang ◽  
Jin-Ling Li ◽  
Ling-Yu Qi ◽  
...  
Keyword(s):  
Irritable Bowel Syndrome ◽  
Therapeutic Strategy ◽  
Conclusive Evidence ◽  
Expert Consensus ◽  
Therapeutic Effects ◽  
Clinical Issue ◽  
Therapeutic Principles ◽  
Irritable Bowel ◽  
Optimal Therapeutic Strategy ◽  
Level Of Agreement

Abstract Background: Acupuncture has been regarded as a potential physical approach for irritable bowel syndrome (IBS). However, there is still no adequate conclusive evidence on its efficacy and optimal therapeutic strategy of acupuncture for IBS. The purpose of this expert consensus study was to put forward some viable recommendations for clinical acupuncture practitioners in treating IBS.Methods: A panel composed of 74 acupuncturists, was convened to participate in a 2-round clinical issue investigation. Subsequently, systematic reviews on acupuncture for IBS were screened using 3 databases. An initial consensus voting list was generated from the results of clinical issue investigation and literature review. Finally, a multi-round Delphi vote was conducted to develop an expert consensus on these specific issues. 30 authoritative experts were required to respond with agreement, neutrality, or disagreement for the items on the consensus voting list. Consensus achievement was identified as the level of agreement on a given item > 80%.Results: Following a 2-round Delphi vote, there were 19 items achieving consensus; of which 5 items (26.32%) achieved complete consensus, and more than 80% expert agreement was reached for the other 14 items. These items can be roughly categorized into 3 major domains of acupuncture for IBS: (1) therapeutic effects, (2) therapeutic principles and protocols, (3) possible adverse events.Conclusions: Without any ready-made guidelines, this preliminary expert consensus could be helpful for acupuncturists in daily clinical practice and patients with IBS to acquire appropriate and standardized acupuncture treatment. In addition, it also points out the clinical issues which need to be further explored in future studies.

scholarly journals Novel GLDC Compound Heterozygous Variant Leading to Nonketotic Hyperglycinemia: Case Report and Literature Review

2021 ◽  
Vol 9 ◽  
Author(s):  
Yanyan Cao ◽  
Lingzhi Meng ◽  
Yudong Zhang ◽  
Jiancheng Jiao ◽  
Weicong Pu ◽  
...  
Keyword(s):  
Clinical Outcome ◽  
Therapeutic Strategy ◽  
Compound Heterozygous ◽  
Genetic Characteristics ◽  
Whole Exome ◽  
Heterozygous Variant ◽  
Glycine Metabolism ◽  
Metabolic Investigation ◽  
Nonketotic Hyperglycinemia ◽  
Optimal Therapeutic Strategy

Nonketotic hyperglycinemia (NKH) is a lethal autosomal recessive disease resulting from alterations in glycine metabolism, commonly caused by mutations in glycine decarboxylase (GLDC). The symptoms of NKH usually manifest in the neonatal period, and can be categorized into severe NKH and attenuated NKH based on the clinical outcome. To date, only a few NKH cases have been reported in China. We here report a case of a neonate with severe NKH carrying a novel compound heterozygous variant in GLDC. The patient was a 68-h-old girl who had progressive lethargy, no crying, and poor sucking ability from birth, and was therefore transferred to our department. On admission, the patient was supported by intubation and ventilation and presented with profound coma. Metabolic investigation indicated a markedly increased glycine concentration both in the plasma and cerebrospinal fluid (CSF). Symptomatic treatments were administered, but the patient's condition did not improve substantially. Whole-exome sequencing identified compound heterozygous mutations (c.1261G>C, p.G421R and c.450 C>G, p.N150K) in GLDC, which were inherited from the mother and the father, respectively. The patient was hospitalized for 8 days in our department and died 2 days after discharge. We further summarize the clinical features, genetic characteristics, administered treatment, and prognosis of previously reported Chinese NKH patients for context. Our results highlight that due to the non-specific clinical phenotypes of NKH and difficulty in obtaining CSF samples, genetic testing is a crucial tool, not only for a diagnosis but also for predicting the clinical outcome and can potentially help to determine the optimal therapeutic strategy.

scholarly journals Theoretical analysis predicts an optimal therapeutic strategy in distinct parkinsonian landscapes of the striatum

2020 ◽  
Author(s):  
Mathias L. Heltberg ◽  
Hussein N. Awada ◽  
Alessandra Lucchetti ◽  
Mogens H. Jensen ◽  
Jakob K. Dreyer ◽  
...  
Keyword(s):  
Theoretical Analysis ◽  
Conceptual Framework ◽  
Dopaminergic Neurons ◽  
Therapeutic Strategy ◽  
Disease Onset ◽  
Complex Relationship ◽  
Striatal Neurons ◽  
Clinical Variability ◽  
Dopamine Signaling ◽  
Optimal Therapeutic Strategy

SummaryParkinson’s disease (PD) results from a loss of dopaminergic neurons. The age of disease onset, its progression and symptoms vary significantly between patients, pointing to a complex relationship between neuron loss and PD etiology. Yet, our understanding of the clinical variability remains incomplete. Here, we use biophysical modelling to investigate the dopaminergic landscape in the healthy and denervated striatum. Based on currently proposed mechanisms causing PD, we model three distinct denervation patterns, and show notable differences in the dopaminergic network as denervation progresses. We find local and global differences in the activity of two types of striatal neurons as a function of the denervation pattern. Finally, we identify the optimal cellular strategy for maintaining normal dopamine signaling when neurons degenerate within our model. Our results derive a conceptual framework in which the clinical variability of PD is rooted in distinct denervation patterns and forms testable predictions for future PD research.

scholarly journals Next-generation sequencing revealed synchronous double primary lung squamous carcinoma: a case report

2021 ◽  
Vol 49 (5) ◽  
pp. 030006052110185
Author(s):  
De-Song Yang ◽  
Kai Huang ◽  
Min Su ◽  
Ting-Ting Wang ◽  
Si-Si Liu ◽  
...  
Keyword(s):  
Rare Case ◽  
Therapeutic Strategy ◽  
Primary Lung Cancer ◽  
Squamous Carcinoma ◽  
Driver Mutations ◽  
Genetic Profiling ◽  
Multiple Primary ◽  
Lung Squamous Carcinoma ◽  
Optimal Therapeutic Strategy ◽  
Generation Sequencing

Synchronous double primary lung squamous carcinoma (sDPLSCC) is rare and difficult to distinguish from metastatic disease, histopathologically. Owing to the heterogeneity of cancer, it is also difficult to select the optimal therapeutic strategy for patients with multiple primary lung cancer (MPLC). The present study reports a rare case of a 61-year-old male patient with sDPLSCC diagnosed using histology and genetic profiling. LSCC-related driver mutations were detected in this patient, and we reported the TP53 c.475G>C mutation, which has been detected in both breast cancer and hepatocellular carcinoma, but not previously in lung squamous carcinoma. Our findings provide further evidence supporting the necessity of genetic testing for primary tumor diagnosis.

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