scholarly journals Add-on Pegylated Interferon Alpha-2a Therapy in Chronic Hepatitis B Japanese Patients Treated with Entecavir

2017 ◽  
Vol 2017 ◽  
pp. 1-7
Author(s):  
Hideyuki Tamai ◽  
Yoshiyuki Ida ◽  
Naoki Shingaki ◽  
Ryo Shimizu ◽  
Kazuhiro Fukatsu ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Seroconversion Rate ◽  
Univariate Analysis ◽  
Area Under The Curve ◽  
Complete Response ◽  
Japanese Patients ◽  
Pegylated Interferon ◽  
Hbs Ag

Entecavir requires long-term administration. Pegylated interferon (PEG-IFN) therapy leads to significant reduction of hepatitis B surface antigen (HBs Ag) levels. This study aimed to assess the safety and efficacy of adding PEG-IFN-α-2a to entecavir toward cessation of entecavir. A total of 23 patients treated with entecavir underwent add-on PEG-IFN-α-2a therapy (90 μg per week) for 48 weeks. Viral response (VR) was defined as more than 50% reduction of baseline hepatitis B surface antigen (HBs Ag) level at 72 weeks from the start of therapy. Complete response (CR) was defined as the decline of HBs Ag levels <100 IU/mL. Hepatitis B e antigen (HBe Ag) seroconversion rate was 25% (2/8), and VR rate was 52% (12/23). CR was observed in four patients (17%). However, CR rate in baseline HBs Ag level <2000 IU/mL and HBe Ag negative patients was 50% (4/8). Univariate analysis showed that the percentage of HBs Ag level reduction at week 12 was significantly associated with VR. The area under the curve value was 0.848. Adding PEG-IFN-α-2a to entecavir has limited efficacy. The percentage reduction of HBs Ag level at week 12 may be a useful predictor for VR.

478 KINETICS OF SERUM HEPATITIS B SURFACE ANTIGEN LEVEL IN GENOTYPE C HBS AG SEROCLEARED CARRIERS

2012 ◽  
Vol 56 ◽  
pp. S188
Author(s):  
S. Nagaoka ◽  
H. Yatsuhashi ◽  
Y. Kugiytama ◽  
K. Ogihara ◽  
S. Bekki ◽  
...  
Keyword(s):  
Hepatitis B ◽  
Surface Antigen ◽  
Hepatitis B Surface Antigen ◽  
Antigen Level ◽  
Serum Hepatitis ◽  
Genotype C ◽  
Hbs Ag ◽  
Kinetics Of

scholarly journals Coexistence of Hepatitis B Surface Antigen (HBs Ag) and Anti-HBs Antibodies in Chronic Hepatitis B Virus Carriers: Influence of “a” Determinant Variants

2006 ◽  
Vol 80 (6) ◽  
pp. 2968-2975 ◽  
Author(s):  
Olivier Lada ◽  
Yves Benhamou ◽  
Thierry Poynard ◽  
Vincent Thibault
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Surface Antigen ◽  
Immune Escape ◽  
Hepatitis B Surface Antigen ◽  
Group I ◽  
Group Ii ◽  
Hbs Ag ◽  
Selection Of

ABSTRACT In chronic hepatitis B (CHB), the persistence of hepatitis B surface antigen (HBs Ag) is sometimes associated with antibodies (Ab) to HBs (anti-HBs). To assess the hypothesis of the selection of HBs Ag immune escape variants in CHB patients, the variability of the HBV S gene was determined for patients persistently carrying both HBs Ag and anti-HBs antibodies and patients solely positive for HBs Ag. We selected 14 patients who presented both markers (group I) in several consecutive samples and 12 patients positive for HBs Ag only (group II). The HBs Ag-encoding gene was amplified and cloned, and at least 15 clones per patient were sequenced and analyzed. The number of residue changes within the S protein was 2.7 times more frequent for group I than for group II patients and occurred mostly in the “a” determinant of the major hydrophilic region (MHR), with 9.52 versus 2.43 changes per 100 residues (P = 0.009), respectively. Ten patients (71%) from group I, but only three (25%) from group II, presented at least two residue changes in the MHR. The most frequent changes in group I patients were located at positions s145, s129, s126, s144, and s123, as described for immune escape variants. In CHB patients, the coexistence of HBs Ag and anti-HBs Ab is associated with an increase of “a” determinant variability, suggesting a selection of HBV immune escape mutants during chronic carriage. The consequences of this selection process with regard to vaccine efficacy, diagnosis, and clinical evolution remain partially unknown.

scholarly journals Localization on the viral genome and nucleotide sequence of the gene coding for the two major polypeptides of the Hepatitis B surface antigen (HBs Ag)

1979 ◽  
Vol 7 (2) ◽  
pp. 335-346 ◽  
Author(s):  
Patrick Charnay ◽  
Elisabeth Mandart ◽  
Annie Hampe ◽  
Françoise Fitoussi ◽  
Pierre Tiollais ◽  
...  
Keyword(s):  
Nucleotide Sequence ◽  
Hepatitis B ◽  
Surface Antigen ◽  
Viral Genome ◽  
Hepatitis B Surface Antigen ◽  
Gene Coding ◽  
Hbs Ag
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