scholarly journals Heavy Cigarette Smokers in a Chinese Population Display a Compromised Permeability Barrier

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Shujun Xin ◽  
Li Ye ◽  
George Man ◽  
Chengzhi Lv ◽  
Peter M. Elias ◽  
...  
Keyword(s):  
Cigarette Smoking ◽  
Skin Surface ◽  
Transepidermal Water Loss ◽  
Permeability Barrier ◽  
Biophysical Parameters ◽  
Cigarette Smokers ◽  
Recovery Rates ◽  
Surface Ph ◽  
Epidermal Permeability Barrier ◽  
Skin Surface Ph

Cigarette smoking is associated with various cutaneous disorders with defective permeability. Yet, whether cigarette smoking influences epidermal permeability barrier function is largely unknown. Here, we measured skin biophysical properties, including permeability barrier homeostasis, stratum corneum (SC) integrity, SC hydration, skin surface pH, and skin melanin/erythema index, in cigarette smokers. A total of 99 male volunteers were enrolled in this study. Smokers were categorized as light-to-moderate (<20 cigarettes/day) or heavy smokers (≥20 cigarettes/day). An MPA5 was used to measure SC hydration and skin melanin/erythema index on the dorsal hand, forehead, and cheek. Basal transepidermal water loss (TEWL) and barrier recovery rates were assessed on the forearm. A Skin-pH-Meter pH900 was used to measure skin surface pH. Our results showed that heavy cigarette smokers exhibited delayed barrier recovery after acute abrogation (1.02%±13.06versus16.48%±6.07), and barrier recovery rates correlated negatively with the number of daily cigarettes consumption (p=0.0087). Changes in biophysical parameters in cigarette smokers varied with body sites. In conclusion, heavy cigarette smokers display compromised permeability barrier homeostasis, which could contribute, in part, to the increased prevalence of certain cutaneous disorders characterized by defective permeability. Thus, improving epidermal permeability barrier should be considered for heavy cigarette smokers.

Topical Applications of a Heparinoid-Containing Product Attenuate Glucocorticoid-Induced Alterations in Epidermal Permeability Barrier in Mice

2021 ◽  
Vol 34 (2) ◽  
pp. 86-93
Author(s):  
Si Wen ◽  
Jiangmei Wu ◽  
Li Ye ◽  
Bin Yang ◽  
Lizhi Hu ◽  
...  
Keyword(s):  
Stratum Corneum ◽  
Skin Surface ◽  
Clobetasol Propionate ◽  
Permeability Barrier ◽  
Surface Ph ◽  
Expression Levels ◽  
Stratum Corneum Hydration ◽  
Epidermal Permeability Barrier ◽  
Skin Surface Ph ◽  
Topical Applications

Introduction: Either systemic or topical glucocorticoids (GCs) can cause significant adverse effects on cutaneous structure and function. Although some products and ingredients can improve GC-induced abnormalities in epidermal permeability barrier, the efficacy is moderate. Prior studies in normal mice showed that topical applications of a heparinoid-containing product, Hirudoid® cream, improve epidermal barrier function by upregulation of epidermal proliferation, expression of mRNA for epidermal differentiation, and lipid production. Objective: The objective of this study was to assess whether topical applications of this product could prevent GC-induced changes in epidermal function in murine skin. Materials and Methods: One group of C57BL/6J mice was treated topically with 0.05% clobetasol propionate twice daily for 6 days, while another group was treated topically with Hirudoid® cream 30 min after each application of clobetasol propionate. Untreated mice served as normal controls. Transepidermal water loss (TEWL) rates, stratum corneum hydration, and skin surface pH were measured using respective probes connected to an MPA5 physiology monitor. qPCR was used to measure the expression levels of mRNA for keratinocyte differentiation-related proteins and lipid synthetic enzymes. Results: Co-applications of Hirudoid® cream with GC minimally, but significantly, increased skin thickness in comparison to GC treatment alone (p < 0.05), in parallel with increased expression levels of mRNA for PCNA in both the dermis and the epidermis. Moreover, Hirudoid® cream largely prevented GC-induced elevation in basal TEWL (p < 0.001) and delay in barrier recovery (p < 0.05), accompanied by upregulation in the expression levels of mRNA for epidermal involucrin, HMGCoA, and SPT1. However, both stratum corneum hydration and skin surface pH were comparable in the skin treated with GC alone versus GC + Hirudoid® cream. Conclusion: Topical heparinoid-containing product can partially prevent GC-induced alterations in some epidermal functions.

scholarly journals Modern emollients impact on the damaged skin barrier at children with atopic dermatitis

2013 ◽  
Vol 10 (4) ◽  
pp. 65-68
Author(s):  
E T Kindeeva ◽  
A N Pampura
Keyword(s):  
Atopic Dermatitis ◽  
Combined Therapy ◽  
Skin Barrier ◽  
Skin Surface ◽  
Skin Lesions ◽  
Transepidermal Water Loss ◽  
Surface Ph ◽  
Before And After ◽  
Skin Surface Ph ◽  
Group 1

Introduction. Damaged skin barrier has significant role in the pathogenesis of atopic dermatitis (AD). Use of emollients is reasonable for skin care of AD patients. Background. To compare the clinical efficacy of Kserodian plus with traditional moisturizer (cream Unna) at children with atopic dermatitis. Materials and methods. The study included 31 children with AD. Children were divided into 2 groups: patients in group 1 (n=8) used Kserodian plus 2 times daily for skin lesions and limbs in the complex therapy, patients in the 2nd group (n=13) received combined therapy incorporating traditional dampening agent on the basis of lanolin (cream Unna) 3 times daily. All patients underwent measurement of transepidermal water loss (TEWL) (Tewameter TM 300, Multi Probe Adapter MPA 5/9, Courage + Khazaka) and the pH of the skin (SkinpHMeter, Multi Probe Adapter MPA 5/9, Courage + Khazaka) before and after 2 weeks of therapy. Results. Kserodian plus decreased erythema, dryness of the skin, itching, square of leasons in all the patients. Statistically significant decrease in the values of TEWL and skin surface pH (p

Involvement of skin surface pH on development of atopic dermatitis

2016 ◽  
Vol 84 (1) ◽  
pp. e40
Author(s):  
Hyosun Jang ◽  
Akira Matsuda ◽  
Yosuke Amagai ◽  
Hiroshi Matsuda ◽  
Akane Tanaka
Keyword(s):  
Atopic Dermatitis ◽  
Skin Surface ◽  
Surface Ph ◽  
Skin Surface Ph
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