scholarly journals Growth Rate Analysis of an Untreated Glomus Vagale on MRI

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Jeffrey Tzu-Yu Wang ◽  
Allen Yu-Yu Wang ◽  
Sheila Cheng ◽  
Lavier Gomes ◽  
Melville Da Cruz

Paragangliomas are slow growing, hypervascular neuroendocrine tumors that develop in the extra-adrenal paraganglion tissues. Paraganglioma involving the vagus nerve ganglia is termed glomus vagale. The slow growth of head and neck paragangliomas especially in the absence of symptom may obviate the necessity for any active intervention, in which case, a “wait and scan” policy is implemented involving long-term clinical and radiologic follow-ups. We present a case of a 71-year-old female with an untreated left glomus vagale who underwent a conservative “wait and rescan” plan of management and the tumor was observed with 8 serial MRI scans over a period of 7.4 years. A growth rate analysis was conducted which demonstrated a slow growth. A literature review of radiologic studies examining the natural history of head and neck paragangliomas was also performed.

2016 ◽  
Vol 77 (S 02) ◽  
Author(s):  
Marcello Marchetti ◽  
Valentina Pinzi ◽  
Francesco Prada ◽  
Elena De Martin ◽  
Valeria Cuccarini ◽  
...  

1954 ◽  
Vol 5 (3) ◽  
pp. 353 ◽  
Author(s):  
AM Olsen

The school shark fishery in south-eastern Australian waters has operated on a homogeneous stock which has a low reproductive potential. The species is slow-growing; the smallest mature males (120 cm) are over 8 yr of age and the smallest mature females (135 cm) are at least 2 yr older. The gestation period is approximately 6 months and it is estimated that only about half the female population bear young each year. Each gravid female carries 17-41 young with a mean number of 28. The lengths of the normal full-term embryos range from 280 to 350 mm with a mean for both sexes of 300 mm. The larger females tend to have the longest embryos. Slightly more male than female young (54 : 46) are born. Because the inshore populations of juveniles have been dwindling and the size of the older stock is decreasing, it is believed that this slow-growing species is being overfished. Measures aimed at protecting school sharks in their vulnerable stages have been proposed. Any conservation programme will be long-term as this shark has such a low reproductive capacity.


ORL ro ◽  
2016 ◽  
Vol 3 (1) ◽  
pp. 12-14
Author(s):  
Andreea Nicoleta Costache ◽  
I. Bulescu ◽  
Alexandra Guligă ◽  
A. Panfiloiu ◽  
Mihai Tușaliu ◽  
...  

The paranasal sinus osteoma is a benign tumor characterized by a slow growth rate. Initially, the symptoms are uncharacteristic in most of the cases, afterwards they can cause headaches, nasal obstruction, epiphora etc. The authors present the case of a 45-year-old patient from IFACF - ENT “Prof. Dr. D. Hociota” with a history of frontal headache and retrobulbar pain, which started about 6 months ago. The endoscopic and computer tomographic exam mark the presence of a left frontoethmoidal tumor with bone consistency. The surgical approach was combined, with the complete macroscopic removal of the tumor and ensuring the physiological frontal sinus drainage.


Head & Neck ◽  
2012 ◽  
Vol 35 (6) ◽  
pp. 819-825 ◽  
Author(s):  
Nalin Payakachat ◽  
Songthip Ounpraseuth ◽  
James Y. Suen

1996 ◽  
Vol 115 (5) ◽  
pp. 409-414 ◽  
Author(s):  
Dale P. Sandler

Although there have been many studies of cancer risk associated with a variety of x-ray treatments for benign conditions of the head and neck, little is known about the possible long-term health consequences of nasopharyngeal radium irradiation. This treatment results in minimal radiation exposure to the thyroid gland, which is the focus of much of the research regarding other head and neck irradiation. With nasopharyngeal radiation, on the other hand, exposure to the pituitary gland and the nasopharynx in the area immediately adjacent to the application site may have been substantial. In 1975 a follow-up study was undertaken in Washington County, Maryland, of 2925 persons who were treated at the Health Department's Clinic for the Prevention of Deafness in Children between 1943 and 1960. Of these, 904 persons had been treated with nasopharyngeal radium. After an average of 24 years of follow-up, an excess risk from brain cancer was suggested on the basis of three cases of cancer occurring in the treated group and none occurring in those who were not treated. This finding could have resulted by chance. Other results were consistent with a potential pituitary effect of radiation, but interpretation is limited by the absence of clinical and laboratory data. The history of the study is reported along with an overview of study methods and results.


BMC Surgery ◽  
2020 ◽  
Vol 20 (1) ◽  
Author(s):  
An Sung ◽  
Ka-Wo Lee

Abstract Background Head and neck surgeries can perturb normal structures of neck muscles and nerve innervations, which are supposed to function in harmony to allow complicated process like swallowing. It is still likely that cricopharyngal dysfunction emerges years after the head and neck surgeries. Case presentation We report a case with history of left unilateral vocal cord immobility and development of dysphagia and aspiration 2 years after radical thyroidectomy with neck lymph nodes dissection and medialization thyroplasty. Cricopharyngeal dysfunction was impressed and was confirmed with visualization of cricopharyngeal narrowing segment in radiographic contrast swallow examination. The patient was treated successfully by cricopharyngeal myotomy, achieving long-term relief in our 4 years of follow up. Conclusions Our case of delayed cricopharyngal dysfunction after radical thyroidectomy and medialization thyroplasty shows that it is important to follow up swallowing functions after patients with UVCI undergo medialization thyroplasty. In the event of delayed manifestation of cricopharyngeal function, it can still be treated successfully by cricoharyngeal myotomy, achieving long term relief of dysphagia.


2016 ◽  
Vol 48 (2) ◽  
pp. 151-174 ◽  
Author(s):  
Stephen Carradini

Indie rock musicians are a group of extra-institutional individuals who play an often-vibrant role in urban economic development. The organizational structure that guides their professional activities has yet to be investigated. Interviews with 18 indie rock musicians provided a way to investigate organizational structure. They reported a build structure featuring the principles of audience development, slow growth, and unevenness. The constraints of the musician’s professional situation require long-term promotion of aesthetic products to a slowly growing audience in a saturated market that produces unevenness through power imbalances. This slow-growing structure contrasts with organizational structures that provide immediate benefits.


2019 ◽  
Vol 131 (5) ◽  
pp. 1405-1412 ◽  
Author(s):  
Patrick P. J. H. Langenhuizen ◽  
Svitlana Zinger ◽  
Patrick E. J. Hanssens ◽  
Henricus P. M. Kunst ◽  
Jef J. S. Mulder ◽  
...  

OBJECTIVEThe aim of this study was to gain insight into the influence of the pretreatment growth rate on the volumetric tumor response and tumor control rates after Gamma Knife radiosurgery (GKRS) for incidental vestibular schwannoma (VS).METHODSAll patients treated with GKRS at the Gamma Knife Center, ETZ Hospital, who exhibited a confirmed radiological progression of their VS after an initial observation period were included. Pre- and posttreatment MRI scans were volumetrically evaluated, and the volume doubling times (VDTs) prior to treatment were calculated. Posttreatment volumes were used to create an objective mathematical failure definition: 2 consecutive significant increases in tumor volume among 3 consecutive follow-up MRI scans. Spearman correlation, Kaplan-Meier survival analysis, and Cox proportional hazards regression analysis were used to determine the influence of the VDT on the volumetric treatment response.RESULTSThe resulting patient cohort contained 311 patients in whom the VDT was calculated. This cohort had a median follow-up time of 60 months after GKRS. Of these 311 patients, 35 experienced loss of tumor control after GKRS. The pretreatment growth rate and the relative volume changes, calculated at 6 months and 1, 2, and 3 years following treatment, showed no statistically significant correlation. Kaplan-Meier analysis revealed that slow-growing tumors, with a VDT equal to or longer than the median VDT of 15 months, had calculated 5- and 10-year control rates of 97.3% and 86.0%, respectively, whereas fast-growing tumors, with a VDT less than the median growth rate, had control rates of 85.5% and 67.6%, respectively (log-rank, p = 0.001). The influence of the VDT on tumor control was also determined by employing the Cox regression analysis. The resulting model presented a significant (p = 0.045) effect of the VDT on the hazard rates of loss of tumor control.CONCLUSIONSBy employing a unique, large database with long follow-up times, the authors were able to accurately investigate the influence of the pretreatment VS growth rate on the volumetric GKRS treatment response. The authors have found a predictive model that illustrates the negative influence of the pretreatment VS growth rate on the efficacy of radiosurgery treatment. The resulting tumor control rates confirm the high efficacy of GKRS for slow-growing VS. However, fast-growing tumors showed significantly lower control rates. For these cases, different treatment strategies may be considered.


2021 ◽  
Vol 10 (23) ◽  
pp. 5704
Author(s):  
Ko Miura ◽  
Tadayuki Oshima ◽  
Akio Tamura ◽  
Ken Hara ◽  
Takuya Okugawa ◽  
...  

Early detection of gastric cancer is important. However, rapid growth of gastric cancers that cannot be resected endoscopically occurs even with periodic check-ups. Accordingly, we assessed factors associated with the speed of gastric cancer growth by examining historical endoscopic images. A total of 1996 gastric cancer cases were screened, and characteristics of lesions with slow and rapid growth were assessed. A total of 114 lesions from 114 patients were included in the assessment. Sixty slow-growing and fifty-four rapidly growing gastric cancers were compared. Female sex and incidence of lesions in the lower part of the stomach were significantly less frequent in the rapid-growth group than in the slow-growth group. History of endoscopic treatment tended to be more frequent in the rapid-growth group. Age, body mass index, histology, Helicobacter pylori status, and medications did not differ significantly between groups. Xanthoma was significantly related to rapid growth of gastric cancer, and map-like redness tended to be more frequent in the rapid-growth group in univariate analysis. Xanthoma was significantly related to rapid growth of gastric cancer on multivariate analysis. Further studies are warranted to clarify the pathophysiological mechanisms involved in the speed of gastric cancer growth.


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