scholarly journals Quality Assessment of Artemether-Lumefantrine Samples and Artemether Injections Sold in the Cape Coast Metropolis

2016 ◽  
Vol 2016 ◽  
pp. 1-6 ◽  
Author(s):  
James Prah ◽  
Elvis Ofori Ameyaw ◽  
Richmond Afoakwah ◽  
Patrick Fiawoyife ◽  
Ernest Oppong-Danquah ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Side Effects ◽  
Quality Assessment ◽  
Uncomplicated Malaria ◽  
High Performance ◽  
Cape Coast ◽  
Regulatory Bodies ◽  
Wavelength Detector

Most prescribers and patients in Ghana now opt for the relatively expensive artemether/lumefantrine rather than artesunate-amodiaquine due to undesirable side effects in the treatment of uncomplicated malaria. The study sought to determine the existence of substandard and/or counterfeit artemether-lumefantrine tablets and suspension as well as artemether injection on the market in Cape Coast. Six brands of artemether-lumefantrine tablets, two brands of artemether-lumefantrine suspensions, and two brands of artemether injections were purchased from pharmacies in Cape Coast for the study. The mechanical properties of the tablets were evaluated. The samples were then analyzed for the content of active ingredients using High Performance Liquid Chromatography with a variable wavelength detector. None of the samples was found to be counterfeit. However, the artemether content of the samples was variable (93.22%−104.70% of stated content by manufacturer). The lumefantrine content of the artemether/lumefantrine samples was also variable (98.70%–111.87%). Seven of the artemether-lumefantrine brands passed whilst one failed the International Pharmacopoeia content requirements. All brands of artemether injections sampled met the International Pharmacopoeia content requirement. The presence of a substandard artemether-lumefantrine suspension in the market should alert regulatory bodies to be more vigilant and totally flush out counterfeit and substandard drugs from the Ghanaian market.

EFFECT OF ZINC DITHIOCARBAMATES AND THIAZOLE-BASED ACCELERATORS ON THE VULCANIZATION OF NATURAL RUBBER

2012 ◽  
Vol 85 (1) ◽  
pp. 120-131 ◽  
Author(s):  
Md. Najib Alam ◽  
Swapan Kumar Mandal ◽  
Subhas Chandra Debnath
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Reaction Mechanism ◽  
Natural Rubber ◽  
High Performance ◽  
Binary Systems ◽  
Synergistic Activity ◽  
Tetramethylthiuram Disulfide

Abstract Several zinc dithiocarbamates (ZDCs) as accelerator derived from safe amine has been exclusively studied in the presence of thiazole-based accelerators to introduce safe dithiocarbamate in the vulcanization of natural rubber. Comparison has been made between conventional unsafe zinc dimethyldithiocarbamate (ZDMC) with safe novel ZDC combined with thizole-based accelerators in the light of mechanical properties. The study reveals that thiuram disulfide and 2-mercaptobenzothiazole (MBT) are always formed from the reaction either between ZDC and dibenzothiazyledisulfide (MBTS) or between ZDC and N-cyclohexyl-2-benzothiazole sulfenamide (CBS). It has been conclusively proved that MBT generated from MBTS or CBS reacts with ZDC and produces tetramethylthiuram disulfide. The observed synergistic activity has been discussed based on the cure and physical data and explained through the results based on high-performance liquid chromatography and a reaction mechanism. Synergistic activity is observed in all binary systems studied. The highest tensile strength is observed in the zinc (N-benzyl piperazino) dithiocarbamate-accelerated system at 3:6 mM ratios. In respect of tensile strength and modulus value, unsafe ZDMC can be successfully replaced by safe ZDCs in combination with thiazole group containing accelerator.

The Effects of Heat Treatment on the Chemical Alterations of Oak Wood

2016 ◽  
Vol 688 ◽  
pp. 44-49 ◽  
Author(s):  
Iveta Čabalová ◽  
František Kačík ◽  
Tereza Tribulová
Keyword(s):  
Mechanical Properties ◽  
Heat Treatment ◽  
High Performance Liquid Chromatography ◽  
Renewable Energy ◽  
Liquid Chromatography ◽  
Thermal Treatment ◽  
High Performance ◽  
Treated Wood ◽  
National Renewable Energy Laboratory ◽  
Oak Wood

Samples prepared from oak (Quercusrobur L.) wood were exposed to heat treatment at temperatures of 160, 180, 200 and 220 oC for 3, 6, 9 and 12 hours. In both untreated and thermally treated wood there were determined extractives and lignin by National Renewable Energy Laboratory (NREL) procedures, cellulose by Seifert's method, holocellulose according to Wise, hemicelluloses as difference between holocellulose and cellulose. Monosaccharides were determined by high performance liquid chromatography (NREL).The results show that hemicelluloses are less stable at thermal treatment than cellulose. The amounts of lignin and extractives rose by increasing both temperature and time of the treatment while the amounts of hemicelluloses decreased. Thermal treatment also resulted in significant decreases of the yields of non-glucosic saccharides. Degradation of carbohydrates can cause the deterioration of mechanical properties of wood.

Metabolic Profiling Assisted Quality Assessment ofRhodiola roseaExtracts by High-Performance Liquid Chromatography

Planta Medica ◽  
2012 ◽  
Vol 78 (07) ◽  
pp. 740-746 ◽  
Author(s):  
Zhanguo Wang ◽  
Huiling Hu ◽  
Fang Chen ◽  
Liang Zou ◽  
Mingfu Yang ◽  
...  
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Quality Assessment ◽  
Metabolic Profiling ◽  
High Performance

Quality Assessment of Granule of Danshen Extract by High Performance Liquid Chromatography

2010 ◽  
Vol 7 (5) ◽  
pp. 368-375 ◽  
Author(s):  
Jing-Zheng SONG ◽  
Chun-Feng QIAO ◽  
Song-Lin LI ◽  
Quan-Bin HAN ◽  
Hong-Xi XU
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Quality Assessment ◽  
High Performance

scholarly journals PHYTOCHEMICAL ANALYSIS AND IN-VITRO EVALUATION OF ANTIMICROBIAL PROPERTIES OF Moringa oleifera LEAF EXTRACT AGAINST FOOD BORNE PATHOGENS

2020 ◽  
pp. 217-221
Author(s):  
Asma Shaukat ◽  
M. Shahid Mahmood
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Side Effects ◽  
High Performance ◽  
Moringa Oleifera ◽  
Diffusion Method ◽  
Phytochemical Analysis ◽  
Zone Of Inhibition ◽  
Food Borne Pathogens ◽  
Food Borne

Foodborne pathogens not only spoil food commodity but also cause health issues. Microbes contaminated food and water causes gastroenteritis and inflammation of the stomach and intestinal lining. Allopathic medicines have been used to treat various diseases caused by food borne pathogens, although these medicines are beneficial, but have their own side effects. To overcome these side effects, Moringa oleifera leaves are used worldwide since ancient times. It is used for various medicinal purposes and look for remedies and health approaches for the side effects caused by synthetic chemicals In this study, the antimicrobial components of M. oleifera was quantified by high performance liquid chromatography (HPLC) and their antibacterial effects were investigated against food borne pathogens, Staphylococcus aureus, Escherichia coli, Salmonella typhi, Shigella dysenteriae, Bacillus cereus and Psedomonase aeruginosa by disc diffusion method. Methanolic extract showed zone of inhibition against S. aureus and P. aeruginosa of 9 mm and 8 mm ZOI, respectively. The ethanol extract showed results against S. aureus and P. aeruginosa 12 mm and 9 mm ZOI, respectively. The aqueous extract of plant showed zone of inhibition was E. coli 12mm while S. dysenteriae 9mm. High performance liquid chromatography was used to quantify the antimicrobial components of M. oleifera and the results showed that it contain flavonoids and phenolic compounds

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