scholarly journals Relationship between Branched-Chain Amino Acids, Metabolic Syndrome, and Cardiovascular Risk Profile in a Chinese Population: A Cross-Sectional Study

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Wen Hu ◽  
Luning Sun ◽  
Yingyun Gong ◽  
Ying Zhou ◽  
Panpan Yang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Amino Acids ◽  
Chinese Population ◽  
Branched Chain Amino Acids ◽  
Risk Profile ◽  
Middle Aged ◽  
Cross Sectional ◽  
Elderly Chinese ◽  
Branched Chain

Objective.This study aimed to evaluate the relationship between branched-chain amino acids (BCAAs), metabolic syndrome (MS), and other cardiovascular (CV) risk factors in middle-aged and elderly Chinese population at high risk for the development of cardiovascular disease (CVD).Methods.1302 subjects were enrolled from the Huai’an Diabetes Prevention Program.Results.BCAAs levels were positively correlated with MS, its components, and CV risk profile. The odds ratio (OR) for MS among subjects in the fourth quartile of BCAAs levels showed a 2.17-fold increase compared with those in the first quartile. BCAAs were independently associated with high Framingham risk score even after adjusting for MS and its components (P<0.0001). Additionally, the OR for high CV risk was 3.20-fold (P<0.0001) in participants in the fourth BCAAs quartile with MS compared with participants in the first BCAAs quartile without MS.Conclusions.Increased BCAAs levels are independent risk factors of MS and CVD in addition to the traditional factors in middle-aged and elderly Chinese population. The development of CVD in MS patients with high level BCAAs is accelerated. Intervention studies are needed to investigate whether the strategy of BCAAs reduction has impacts on endpoints in patients with higher CV risk. This study is registered withChiCTR-TRC-14005029.

scholarly journals Dietary Intakes and Circulating Concentrations of Branched-Chain Amino Acids in Relation to Incident Type 2 Diabetes Risk Among High-Risk Women with a History of Gestational Diabetes Mellitus

2018 ◽  
Vol 64 (8) ◽  
pp. 1203-1210 ◽  
Author(s):  
Deirdre K Tobias ◽  
Clary Clish ◽  
Samia Mora ◽  
Jun Li ◽  
Liming Liang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Amino Acids ◽  
Gestational Diabetes ◽  
Plasma Concentrations ◽  
Branched Chain Amino Acids ◽  
High Risk Women ◽  
History Of ◽  
Branched Chain

Abstract BACKGROUND Circulating branched-chain amino acids (BCAAs; isoleucine, leucine, valine) are consistently associated with increased type 2 diabetes (T2D) risk, but the relationship with dietary intake of BCAAs is less clear. METHODS The longitudinal Nurses' Health Study II cohort conducted a blood collection from 1996 to 1999. We profiled plasma metabolites among 172 incident T2D cases and 175 age-matched controls from women reporting a history of gestational diabetes before blood draw. We estimated dietary energy-adjusted BCAAs from food frequency questionnaires. We used conditional logistic regression models to estimate odds ratios (OR) and 95% CI of T2D risk across quartiles (Q1–Q4) of BCAAs, adjusting for age, body mass index (BMI), physical activity, family history, and other established risk factors. We also assessed joint exposure to below/above medians of diet and plasma concentrations, with lower diet/lower plasma as reference. RESULTS Dietary and plasma BCAA concentrations were positively associated with incident T2D (diet Q4 vs Q1 OR = 4.6, CI = 1.6, 13.4; plasma Q4 vs Q1 OR = 4.4, CI = 1.4, 13.4). Modeling the joint association indicated that higher diet BCAAs were associated with T2D when plasma concentrations were also higher (OR = 6.0, CI = 2.1, 17.2) but not when concentrations were lower (OR = 1.6, CI = 0.61, 4.1). Conversely, higher plasma BCAAs were associated with increased T2D for either lower or higher diet. CONCLUSIONS Independent of BMI and other risk factors, higher diet and plasma BCAA concentrations were associated with an increased incident T2D risk among high-risk women with a history of gestational diabetes, supporting impaired BCAA metabolism as conferring T2D risk.

scholarly journals Prevalence of chronic kidney disease and associated metabolic risk factors in a middle-aged and elderly Taiwanese population: a cross-sectional study

2020 ◽  
Author(s):  
Mei-Chun Lu ◽  
I-Ju Chen ◽  
Wei-Chung Yeh ◽  
Hai-Hua Chuang ◽  
Yu-Chung Tsao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Elderly Population ◽  
Cross Sectional Study ◽  
Metabolic Risk ◽  
Multiple Logistic Regression ◽  
Sectional Study ◽  
Middle Aged ◽  
Cross Sectional

Abstract Background: This study aimed to quantify the prevalence of chronic kidney disease (CKD) and associated metabolic risk factors in a middle-aged and elderly population in Guishan District, Taoyuan City, Taiwan. Methods: This cross-sectional study enrolled residents aged 50-90 years living in one community. All subjects received a standardized personal interview, including a structured questionnaire, anthropometric measurements, and blood samples collected for laboratory testing. CKD was defined as the presence of kidney damage (urine albumin-creatinine ratio ≥30mg/g) or estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m 2 . Multiple logistic regression models were used to evaluate risk factors associated with CKD. Results : A total of 400 subjects were enrolled. The overall prevalence of CKD was 20.3% (95% CI: 16.36–24.24%). The age-specific prevalence of CKD in subjects aged 50-64 years, 65-74 years, and 75 years and over was 17.7%, 18.8%, and 33.9%, respectively, (p value for Cochran-Armitage trend test = 0.022). Multiple logistic regression model revealed that elevated blood pressure (OR = 2.55, 95% CI: 1.30–5.01), hyperglycemia (OR = 2.78, 95% CI: 1.59–4.88), hyperuricemia (OR = 1.36, 95% CI: 1.12–1.65) and metabolic syndrome (OR = 2.48, 95% CI: 1.40–4.40) were statistically and significantly associated with CKD. Conclusions: The prevalence of CKD in our study population is high. Hypertension, hyperglycemia, hyperuricemia and metabolic syndrome are significantly associated with CKD in a middle-aged and elderly population in Taiwan.

scholarly journals Low-Grade Albuminuria Is Associated with Metabolic Syndrome and Its Components in Middle-Aged and Elderly Chinese Population

PLoS ONE ◽  
2013 ◽  
Vol 8 (6) ◽  
pp. e65597 ◽  
Author(s):  
Jie Zhang ◽  
Yuhong Chen ◽  
Yu Xu ◽  
Mian Li ◽  
Tiange Wang ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Chinese Population ◽  
Low Grade ◽  
Middle Aged ◽  
Elderly Chinese
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