Association between hyperhomocysteinemia and metabolic syndrome with early carotid artery atherosclerosis: A cross-sectional study in middle-aged Chinese population

Nutrition ◽  
2018 ◽  
Vol 53 ◽  
pp. 115-119 ◽  
Author(s):  
Chengguo Liu ◽  
Xiaohui Sun ◽  
Hanli Lin ◽  
Ruizhi Zheng ◽  
Liansheng Ruan ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Carotid Artery ◽  
Chinese Population ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Middle Aged ◽  
Cross Sectional ◽  
Carotid Artery Atherosclerosis

scholarly journals Relation of serum uric acid to asymptomatic proximal extracranial artery stenosis in a middle-aged Chinese population: a community-based cross-sectional study

BMJ Open ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. e020681 ◽  
Author(s):  
Xiaolei Yang ◽  
Haichen Lv ◽  
Tesfaldet Habtemariam Hidru ◽  
Jing Wu ◽  
Henghui Liu ◽  
...  
Keyword(s):  
Uric Acid ◽  
Carotid Artery ◽  
Serum Uric Acid ◽  
Chinese Population ◽  
Cross Sectional Study ◽  
Artery Stenosis ◽  
Arterial Stenosis ◽  
Sectional Study ◽  
Community Based ◽  
Cross Sectional

ObjectiveSerum uric acid (SUA) has been associated with cardiovascular diseases, including atherosclerosis and carotid artery stenosis. However, data on the relationship between SUA level and proximal extracranial artery stenosis (PEAS) are limited. Therefore, this study investigates the association between SUA levels and the risk of PEAS in asymptomatic Chinese population.SettingThis community-based cross-sectional study was conducted in Jidong Community Hospital, Tangshan, Hebei, China between July 2013 and August 2014.ParticipantsThe study examined 3325 asymptomatic participants (40–60 years) to evaluate the risk of PEAS.ResultsFor the participants stratified into quartiles based on gender-specific SUA levels, the prevalence of PEAS increased from Q1 to Q4 from 12.3% to 29.8% in the vertebral artery (VA), and from 2.8% to 5.8% in the common carotid artery. The proportion of PEAS relative to the detected number of arterial stenosis was lower in Q1 than in Q2–Q4. The multivariable ORs and 95% CI of PEAS in the second through fourth compared with the lowest quartiles for arterial stenosis were 1.278 (0.980 to 1.665), 1.117 (0.851 to 1.468) and 1.375 (1.033 to 1.830) (ptrend=0.0399); and for VA stenosis, 1.285 (0.966 to 1.709), 1.085 (0.808 to 1.457) and 1.439 (1.061 to 1.952) (ptrend=0.0235).ConclusionElevated SUA concentration is significantly associated with PEAS in an asymptomatic middle-aged Chinese population, and vertebral arteries appeared to be the most vulnerable vessels.

scholarly journals Prevalence of chronic kidney disease and associated metabolic risk factors in a middle-aged and elderly Taiwanese population: a cross-sectional study

2020 ◽  
Author(s):  
Mei-Chun Lu ◽  
I-Ju Chen ◽  
Wei-Chung Yeh ◽  
Hai-Hua Chuang ◽  
Yu-Chung Tsao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Metabolic Syndrome ◽  
Chronic Kidney Disease ◽  
Elderly Population ◽  
Cross Sectional Study ◽  
Metabolic Risk ◽  
Multiple Logistic Regression ◽  
Sectional Study ◽  
Middle Aged ◽  
Cross Sectional

Abstract Background: This study aimed to quantify the prevalence of chronic kidney disease (CKD) and associated metabolic risk factors in a middle-aged and elderly population in Guishan District, Taoyuan City, Taiwan. Methods: This cross-sectional study enrolled residents aged 50-90 years living in one community. All subjects received a standardized personal interview, including a structured questionnaire, anthropometric measurements, and blood samples collected for laboratory testing. CKD was defined as the presence of kidney damage (urine albumin-creatinine ratio ≥30mg/g) or estimated glomerular filtration rate (eGFR) <60 mL/min/1.73m 2 . Multiple logistic regression models were used to evaluate risk factors associated with CKD. Results : A total of 400 subjects were enrolled. The overall prevalence of CKD was 20.3% (95% CI: 16.36–24.24%). The age-specific prevalence of CKD in subjects aged 50-64 years, 65-74 years, and 75 years and over was 17.7%, 18.8%, and 33.9%, respectively, (p value for Cochran-Armitage trend test = 0.022). Multiple logistic regression model revealed that elevated blood pressure (OR = 2.55, 95% CI: 1.30–5.01), hyperglycemia (OR = 2.78, 95% CI: 1.59–4.88), hyperuricemia (OR = 1.36, 95% CI: 1.12–1.65) and metabolic syndrome (OR = 2.48, 95% CI: 1.40–4.40) were statistically and significantly associated with CKD. Conclusions: The prevalence of CKD in our study population is high. Hypertension, hyperglycemia, hyperuricemia and metabolic syndrome are significantly associated with CKD in a middle-aged and elderly population in Taiwan.

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