scholarly journals Multifocal Aeromonas Osteomyelitis in a Child with Leukemia

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Dimitrios Doganis ◽  
Margarita Baka ◽  
Maria Tsolia ◽  
Apostolos Pourtsidis ◽  
Evangelia Lebessi ◽  
...  
Keyword(s):  
Aeromonas Hydrophila ◽  
Severe Pain ◽  
Oral Antibiotics ◽  
Imaging Studies ◽  
Bone Marrow Aplasia ◽  
Left Femur ◽  
Osteolytic Lesions ◽  
Gram Negative ◽  
Soft Tissue Swelling ◽  
Extraintestinal Disease

Aeromonas hydrophilais a Gram negative organism causing both intestinal and extraintestinal disease. The case of a 14-year-old girl with underlying immunodeficiency and leukemia who developed systemicA. hydrophilainfection is described in this report. While in deep bone marrow aplasia she developed fever, severe pain in the lower extremities, and swelling of the left femur. Blood culture showedEscherichia coliandA. hydrophilawhereas pus culture from the soft tissue swelling showed the presence ofA. hydrophila. Imaging studies showed diffuse osteolytic lesions. Patient received 5 months of intravenous and oral antibiotics and she improved clinically whereas the radiology findings persisted.

Silver Oxide–Copper Oxide Nanocomposite Preparation and Antimicrobial Activity as a Source for the Treatment of Fish Diseases

2017 ◽  
pp. 140-151
Author(s):  
Sayed Reza Shaffiey ◽  
Sayedeh Fatemeh Shaffiey
Keyword(s):  
Aeromonas Hydrophila ◽  
Bacterial Infections ◽  
Antimicrobial Activities ◽  
Cuo Nanoparticles ◽  
Negative Bacterium ◽  
Electron Micrograph ◽  
X Ray Diffraction ◽  
Gram Negative ◽  
Transmission Electron ◽  
Scanning Electron

Aeromonas hydrophila is a heterotrophic, gram negative bacterium which is primary or secondary cause of ulcers, fin rot, tail rot, and hemorrhagic septicaemia in fish. The treatments for this infection are only restricted to some antibiotics. So, novel materials are being searched for combating with bacterial infections and the resulting consequences. In this chapter, Ag2O/CuO nanocomposites were synthesized chemically and characterized by X-ray diffraction (XRD), scanning electron micrograph (SEM) and transmission electron microscope (TEM). The antimicrobial activities of Ag2O/CuO nanoparticles (NPs), was checked by both well diffusion and turbidometric (spectrophotometric) method. Synthesized nanoparticles exhibited their antimicrobial efficacy in both the standard inhibitory assays; these results thus provide a scope for further research on the application of Ag2O/CuO nanoparticles as disinfectant and/or antibiotic in the fishery industry.

scholarly journals A Case of Mortality Caused by Aeromonas hydrophila in Wild-Caught Red-Eyed Crocodile Skinks (Tribolonotus gracilis)

2019 ◽  
Vol 7 (1) ◽  
pp. 4 ◽  
Author(s):  
Jun Kwon ◽  
Sang Guen Kim ◽  
Sang Wha Kim ◽  
Saekil Yun ◽  
Hyoun Joong Kim ◽  
...  
Keyword(s):  
Aeromonas Hydrophila ◽  
Opportunistic Infections ◽  
Clinical Symptoms ◽  
Human Medicine ◽  
Aquatic Environments ◽  
Negative Bacterium ◽  
Severe Stress ◽  
Antimicrobial Susceptibility Test ◽  
Gram Negative ◽  
In The Wild

Aeromonas hydrophila, a Gram-negative bacterium commonly found in aquatic environments, is pathogenic to amphibians, reptiles, and mammals. In human medicine, the clinical symptoms of aeromonad infection include not only gastroenteritis but also extraintestinal infections, such as wounds, cellulitis, and septicemia, in immunocompromised and immunocompetent individuals. In this study, ten red-eyed crocodile skinks (Tribolonotus gracilis) that shared the same space were found dead 7 days after being shipped from Indonesia. The necropsy revealed A. hydrophila to be the causative agent, and the isolates were susceptible to most antibiotics, based on an antimicrobial susceptibility test. Seven virulence factors (act, ast, alt, aerA, fla, gcaT, and ahyB) considered to be associated with virulence were detected by PCR. Microscopic examination revealed several necrotic lesions and melano-macrophage centers in the tissue slides. Reptiles caught in the wild for trade experience captivity stress. Furthermore, in the winter, reptiles are easily exposed to the cold atmosphere. These stresses can negatively impact the immunity of these ectotherms, making them vulnerable to A. hydrophila infections. Therefore, to avoid such opportunistic infections and mortality following exposure to severe stress, medical care is recommended. The studies of alternatives, such as bacteriophage and bacteriocin, are needed for a preventive application.

Pyrogens fail to produce fever in a cordylid lizard

1981 ◽  
Vol 241 (3) ◽  
pp. R198-R202 ◽  
Author(s):  
H. P. Laburn ◽  
D. Mitchell ◽  
E. Kenedi ◽  
G. N. Louw
Keyword(s):  
Body Temperature ◽  
Ambient Temperature ◽  
Aeromonas Hydrophila ◽  
Thermal Gradient ◽  
Negative Bacterium ◽  
Gram Negative ◽  
Sterile Saline ◽  
Rabbit Blood ◽  
Preferred Body Temperature

We investigated the effects on body temperature of the lizard Cordylus cataphractus of intracardiac injections of leucocyte pyrogen (LP) synthesized from rabbit blood and of killed Aeromonas hydrophila, a gram-negative bacterium reputed to be pathogenic in lizards. Lizards were placed in a photothermal gradient that allowed them to select a preferred body temperature following the injections. Neither injection of 0.5 ml rabbit LP nor of 4 X 10(9) organisms of A. hydrophila in 0.2 ml sterile saline caused body temperature of lizards to differ from that of control lizards injected with sterile saline. Following injection of these solutions in the lizards placed in a thermal gradient where ambient temperature ranged from 20-88 degrees C, body temperature was maintained between 32 and 34 degrees C. Pyrogens failed to elevate body temperature even when body temperature was elevated artificially to 36 degrees C before injection. We conclude that C. cataphractus does not respond with fever to either rabbit LP or A. hydrophila. Fever may not be ubiquitous even among lizards.

Resistance to oral antibiotics in 4569 Gram-negative rods isolated from urinary tract infection in children

2016 ◽  
Vol 175 (9) ◽  
pp. 1219-1225 ◽  
Author(s):  
Anna Calzi ◽  
Sara Grignolo ◽  
Ilaria Caviglia ◽  
Maria Grazia Calevo ◽  
Giuseppe Losurdo ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Oral Antibiotics ◽  
Gram Negative

scholarly journals IgD (kappa) "nonsecretory" multiple myeloma: report of a case

Blood ◽  
1980 ◽  
Vol 56 (5) ◽  
pp. 898-901
Author(s):  
C Bartoloni ◽  
G Flamini ◽  
C Logroscino ◽  
L Guidi ◽  
F Scuderi ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Plasma Cells ◽  
Protein Electrophoresis ◽  
Lytic Lesion ◽  
Normal Amount ◽  
Left Femur ◽  
Osteolytic Lesions ◽  
Normal Bone ◽  
Single Clone ◽  
Scintigraphic Study

A case of IgD “nonsecretory” multiple myeloma in a 46-yr-old woman is reported. Despite the presence of disseminated osteolytic lesions, both serum protein electrophoresis and serum and urine immunoelectrophoresis were normal. In addition, bone scintigraphic study was normal. Bone marrow biopsy and aspirate obtained from the left femur lytic lesion showed only myelomatous proplasmocytes; when examined by immunofluorescence with monospecifc antisera, the cytoplasm showed only the presence of delta and kappa chains, suggesting that the neoplastic plasma cells might belong to a single clone. Lymphocyte studies indicated the presence of a normal amount of both B and T cells.

scholarly journals 159. Comparing Clinical Cure and Patient Outcomes Between Intravenous Therapy and Intravenous (IV)-to-Oral (PO) Step-down Therapy for Treatment of Gram-Negative Bloodstream Infections

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S105-S105
Author(s):  
Kelsey Williams ◽  
Riane Ghamrawi ◽  
Sheila Takieddine ◽  
Peter Grubbs ◽  
Maggie Powers-Fletcher ◽  
...  
Keyword(s):  
Clinical Cure ◽  
Medical Center ◽  
Univariate Analysis ◽  
Bloodstream Infections ◽  
Hospital Length Of Stay ◽  
Oral Antibiotic ◽  
Oral Antibiotics ◽  
Gram Negative ◽  
Step Down ◽  
Cure Rates

Abstract Background There is a paucity of evidence surrounding optimal prescribing practices for the treatment of Gram-negative bloodstream infections (GNBSI). This study aimed to assess the appropriateness of IV-to-PO step-down therapy in the treatment of GNBSI. Methods A retrospective cohort study was conducted at the University of Cincinnati Medical Center and West Chest Hospital and included subject’s ≥18 years of age with GNBSI caused by Enterobacteriaceae spp. or Pseudomonas aeruginosa. The primary objective was to compare clinical cure rates between IV-only and IV-to-PO therapy, and to further assess differences in clinical cure rates amongst oral antibiotics of high, moderate, and low bioavailability. The study also aimed to identify factors associated with clinical cure, hospital length of stay, and emergence of multi-drug-resistant organisms (MDRO). Results Amongst 215 subjects screened, 99 subjects were included and 64 subjects met criteria for clinical cure. In the univariate analysis, the IV-to-PO group had a higher percentage of clinical cure than IV only therapy (82% vs. 48%, P = 0.001). Of note, the two study groups were significantly different in regards to intensive care status, Pitt bacteremia score, and primary site of infection. Upon further analysis, data from the multivariate logistic regression revealed that critical illness was the only significant factor that negatively impacted clinical cure (OR = 0.208; 95% CI 0.04–0.99; P = 0.049). A total of 49 subjects received oral antibiotics. Majority of patients (82%) in the IV-to-PO group received a moderately bioavailable oral antibiotic. No difference in respect to clinical cure rate was found between the three PO antibiotic bioavailability groups (P = 0.346). The median duration of hospital stay was shorter in the IV-to-PO compared with IV alone group (4 days vs. 9.5 days, respectively, P ≤ 0.001). There was a trend in emergence of MDROs with IV therapy compared with IV-to-PO therapy (10% vs. 2%, P = 0.204). Conclusion IV-to-PO stepdown therapy compared with IV therapy alone was noninferior in clinical cure rates in the treatment of GNBSI and may result in fewer hospital days and less emergence of multidrug-resistant organisms. These conclusions are limited by significant differences in severity of illness between groups in this study. Disclosures All authors: No reported disclosures.

scholarly journals Unusual Multiple Brain Abscesses Caused by Aeromonas hydrophila in a Preterm Neonate: Case Report

2018 ◽  
Vol 08 (01) ◽  
pp. e55-e57
Author(s):  
Elham Bukhari
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Brain Abscess ◽  
Aeromonas Hydrophila ◽  
Preterm Neonate ◽  
Preterm Newborn ◽  
Neonatal Brain ◽  
Gram Negative ◽  
Facultative Anaerobic ◽  
Brain Abscesses ◽  
Citrobacter Diversus

AbstractNeonatal brain abscess is rare. The most common etiologic microorganisms that are responsible for this condition are Citrobacter diversus, Proteus mirabilis, Pseudomonas aeruginosa, Serratia marcescens, and other Enterobacteriaceae. Aeromonas hydrophila is a halophilic, gram-negative, facultative anaerobic bacillus.It has been reported to cause intestinal and extraintestinal infections and has rarely been reported to cause meningitis at neonatal age. A. hydrophila has not been reported previously to cause brain abscess in neonates. In this report, we describe a case of severe multiple brain abscesses and ventriculitis as complications in meningitis caused by A. hydrophila in a preterm newborn.

Effectiveness of oral antibiotics for definitive therapy of Gram-negative bloodstream infections

2016 ◽  
Vol 48 (5) ◽  
pp. 498-503 ◽  
Author(s):  
Leila F. Kutob ◽  
Julie Ann Justo ◽  
P. Brandon Bookstaver ◽  
Joseph Kohn ◽  
Helmut Albrecht ◽  
...  
Keyword(s):  
Bloodstream Infections ◽  
Oral Antibiotics ◽  
Gram Negative ◽  
Definitive Therapy

scholarly journals Susceptibility of Multidrug-Resistant Gram-Negative Urine Isolates to Oral Antibiotics

2016 ◽  
Vol 60 (5) ◽  
pp. 3138-3140 ◽  
Author(s):  
Elizabeth B. Hirsch ◽  
Paola C. Zucchi ◽  
Alice Chen ◽  
Brian R. Raux ◽  
James E. Kirby ◽  
...  
Keyword(s):  
Emergency Department ◽  
Treatment Options ◽  
Multidrug Resistant ◽  
Hospitalized Patients ◽  
Oral Antibiotics ◽  
Gram Negative ◽  
Susceptibility Data ◽  
Oral Agents ◽  
High Prevalence

ABSTRACTIncreasing resistance among Gram-negative uropathogens limits treatment options, and susceptibility data for multidrug-resistant isolates are limited. We assessed the activity of five oral agents against 91 multidrug-resistant Gram-negative urine isolates that were collected from emergency department/hospitalized patients. Fosfomycin and nitrofurantoin were most active (>75% susceptibility). Susceptibilities to sulfamethoxazole-trimethoprim, ciprofloxacin, and ampicillin were ≤40%; empirical use of these agents likely provides inadequate coverage in areas with a high prevalence of multidrug-resistant uropathogens.

Sign in / Sign up

Export Citation Format

Share Document