scholarly journals Bacteremia due toLeuconostoc pseudomesenteroidesin a Patient with Acute Lymphoblastic Leukemia: Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Kazuko Ino ◽  
Kazunori Nakase ◽  
Kei Suzuki ◽  
Akiko Nakamura ◽  
Atsushi Fujieda ◽  
...  
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Hematologic Malignancies ◽  
Blood Cultures ◽  
Immunocompromised Patients ◽  
Causative Pathogen ◽  
Review Of The Literature ◽  
Gram Positive ◽  
Vancomycin Resistant ◽  
Gram Positive Cocci

Leuconostocspecies are vancomycin-resistant Gram-positive cocci. Infections due toLeuconostocspecies have been reported in various immunocompromised patients, but little is known about such infection in patients with hematologic malignancies. We report a case ofLeuconostocinfection in a 44-year-old woman with acute lymphoblastic leukemia. The patient developed a high fever despite antimicrobial therapy with doripenem after induction chemotherapy. After an isolate from blood cultures was identified asL. pseudomesenteroides, we changed the antibiotics to piperacillin-tazobactam and gentamicin, after which the patient recovered from the infection. Physicians should be aware ofLeuconostocspecies as causative pathogen if they encounter Gram-positive cocci bacteremia resistant to standard antibiotics such as vancomycin and teicoplanin, especially in patients with hematologic malignancies.

scholarly journals In Vitro Activity and Killing Effect of Uperin 3.6 against Gram-Positive Cocci Isolated from Immunocompromised Patients

2005 ◽  
Vol 49 (9) ◽  
pp. 3933-3936 ◽  
Author(s):  
Andrea Giacometti ◽  
Oscar Cirioni ◽  
Wojciech Kamysz ◽  
Carmela Silvestri ◽  
Alberto Licci ◽  
...  
Keyword(s):  
Vitro Activity ◽  
Immunocompromised Patients ◽  
In Vitro Activity ◽  
Gram Positive ◽  
Killing Effect ◽  
Methicillin Resistant ◽  
Vancomycin Resistant Enterococci ◽  
Vancomycin Resistant ◽  
Gram Positive Cocci

ABSTRACT The in vitro activity of uperin 3.6, alone or combined with six antibiotics, against gram-positive cocci, including Rhodococcus equi, methicillin-resistant staphylococci, and vancomycin-resistant enterococci, was investigated. All isolates were inhibited at concentrations of 1 to 16 mg/liter. Synergy was demonstrated when uperin 3.6 was combined with clarithromycin and doxycycline.

scholarly journals Fatal Disseminated Mucormycosis in a Hematological Immunocompromised Patient with Extensive Voriconazole Exposure: A Case Report and Review of the Literature

2020 ◽  
Vol 12 (3) ◽  
pp. 168-173 ◽  
Author(s):  
Victoria S. Humphrey ◽  
Xiaoxiao Li ◽  
Sonal Choudhary ◽  
Timothy Patton
Keyword(s):  
Immunocompromised Patient ◽  
Lymphoblastic Leukemia ◽  
Hematologic Malignancies ◽  
Immunocompromised Patients ◽  
Past Medical History ◽  
Review Of The Literature ◽  
History Of ◽  
Cell Acute Lymphoblastic Leukemia ◽  
Cutaneous Mucormycosis ◽  
Disseminated Mucormycosis

Disseminated mucormycosis is a rare, opportunistic, and aggressive infection typically presenting in immunocompromised patients. Herein, we report a 55-year-old male with a past medical history of Philadelphia-negative B-cell acute lymphoblastic leukemia who presented with a 2-month history of non-painful necrotic ulcers on the nose, knuckles, elbow, foot, and scrotum following 3 months of voriconazole (VRC) exposure in the setting of an unrelated fungal pneumonia. Our case reinforces the virulent and often fatal nature of the disease amongst immunocompromised patients, along with extensive VRC exposure as a possible supplementary risk factor. Disseminated cutaneous mucormycosis should be regarded as a differential diagnosis in all immunocompromised patients, especially those with hematologic malignancies or a history of VRC use, who present with cutaneous ulcerations and eschars.

scholarly journals Evaluation of the LightCycler Staphylococcus MGRADE Kits on Positive Blood Cultures That Contained Gram-Positive Cocci in Clusters

2005 ◽  
Vol 43 (12) ◽  
pp. 6144-6146 ◽  
Author(s):  
N. K. Shrestha ◽  
M. J. Tuohy ◽  
R. A. Padmanabhan ◽  
G. S. Hall ◽  
G. W. Procop
Keyword(s):  
Blood Cultures ◽  
Gram Positive ◽  
Gram Positive Cocci

scholarly journals Bacteremia Caused by Kocuria kristinae from Egypt: Are There More? A Case Report and Review of the Literature

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
Reem M. Hassan ◽  
Dina M. Bassiouny ◽  
Yomna Matar
Keyword(s):  
Case Report ◽  
Review Of The Literature ◽  
Normal Flora ◽  
Gram Positive ◽  
Clinical Specimens ◽  
First Report ◽  
The Family ◽  
Gram Positive Cocci ◽  
Kocuria Kristinae

Kocuria kristinae is opportunistic Gram-positive cocci from the family Micrococcaceae. It is usually considered part of the normal flora that rarely is isolated from clinical specimens. Here, we report a case of Kocuria kristinae bacteremia; to the best of our knowledge, this is the first report from Egypt.

scholarly journals Evaluation of MRSASelect™Chromogenic Medium for the Early Detection of Methicillin-ResistantStaphylococcus aureusfrom Blood Cultures

2013 ◽  
Vol 24 (4) ◽  
pp. e113-e116 ◽  
Author(s):  
Kanchana Manickam ◽  
Andrew Walkty ◽  
Philippe RS Lagacé-Wiens ◽  
Heather Adam ◽  
Barbara Swan ◽  
...  
Keyword(s):  
Early Detection ◽  
Antimicrobial Therapy ◽  
Predictive Value ◽  
Turnaround Time ◽  
Blood Cultures ◽  
Gram Stain ◽  
Chromogenic Medium ◽  
Gram Positive ◽  
Microbiological Methods ◽  
Gram Positive Cocci

INTRODUCTION:Staphylococcus aureusbacteremia is associated with considerable morbidity and mortality. In theory, reducing the turnaround time in reporting of methicillin-resistantS aureus(MRSA) among patients with bactermia could assist with the rapid optimization of antimicrobial therapy.OBJECTIVE: To evaluate the sensitivity and specificity of MRSASelect(Bio-Rad Laboratories, USA), a chromogenic medium, in the early detection of MRSA from blood cultures growing Gram-positive cocci in clusters, and to confirm that routine use of this medium would, in fact, reduce turnaround time for MRSA identification.METHODS: The present study was conducted at three microbiology laboratories in Manitoba. Between April 2010 and May 2011, positive blood cultures with Gram-positive cocci in clusters visualized on Gram stain were subcultured to both MRSASelectand routine media. MRSA isolates were identified using conventional microbiological methods from routine media and using growth with the typical colony morphology (pink colony) on MRSASelectmedium.RESULTS: A total of 490 blood cultures demonstrating Gram-positive cocci in clusters on Gram stain were evaluated.S aureuswas recovered from 274 blood cultures, with 51S aureusisolates (51 of 274 [18.6%]) identified as MRSA. MRSASelectmedium had a sensitivity of 98%, a specificity of 100%, a positive predictive value of 100% and a negative predictive value of 99.8% for the recovery and identification of MRSA directly from positive blood culture bottles. In addition, use of MRSASelectmedium was found to improve turnaround time in the detection of MRSA by almost 24 h relative to conventional methods.DISCUSSION: These data support the utility of MRSASelectmedium for the rapid identification of MRSA from positive blood cultures. Further clinical studies are warranted to determine whether the improvement in turnaround time will result in a measurable reduction in suboptimal antimicrobial therapy and/or improvement in patient outcome.

scholarly journals Nosocomial blood stream infections in Imam Khomeini Hospital, Urmia, Islamic Republic of Iran, 1999-2001

2005 ◽  
Vol 11 (3) ◽  
pp. 478-484
Author(s):  
M. Rahbar
Keyword(s):  
Blood Stream ◽  
Blood Cultures ◽  
Microbiology Laboratory ◽  
Islamic Republic ◽  
Coagulase Negative Staphylococci ◽  
Gram Positive ◽  
Blood Stream Infections ◽  
Skin Contamination ◽  
Islamic Republic Of Iran ◽  
Gram Positive Cocci

Ina 2-year retrospective study, the database of the microbiology laboratory of the Imam Khomeini Hospital was reviewed to identify patients who had nosocomial bacteraemia between 1 May 1999 and 31 May 2001 and identify the pathogen responsible and its resisitance to antibiotics. Of 6492 patients in various wards, 593 [9.1%] had positive blood cultures; 85 of those [14.3%] had signs of potential skin contamination. Gram-positive cocci, including coagulase-negative staphylococci, Staphylococcus aureus, Streptococcus pneumoniae and other Gram-positive cocci, accounted for 42.3% of isolates. Gram-negative bacilli were responsible for another 42.3% of isolates; Pseudomonas aeruginosa was the predominant isolate. Patterns of drug resistance varied according to species of bacteria but were generally quite high

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