scholarly journals Sociodemographic and Lifestyle Determinants of Plasma Oxidative Stress Markers 8-OHdG and F2-Isoprostanes and Associations with Metabolic Syndrome

2016 ◽  
Vol 2016 ◽  
pp. 1-10 ◽  
Author(s):  
Catherine N. Black ◽  
Mariska Bot ◽  
Peter G. Scheffer ◽  
Brenda W. J. H. Penninx
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Future Research ◽  
Depression And Anxiety ◽  
Sample Storage ◽  
Weak Correlation ◽  
Stress Markers ◽  
Multivariable Regression ◽  
Alcohol Users ◽  
A Current

Background.Oxidative stress is increasingly important in health research. Therefore, it is necessary to understand which factors determine basal oxidative stress. This study examines the associations of various determinants with markers of oxidative DNA and lipid damage: 8-hydroxy-2′-deoxyguanosine (8-OHdG) and F2-isoprostanes.Methods.Data are from the Netherlands Study of Depression and Anxiety; 1117 subjects (18–65 years) without a current psychiatric diagnosis. Multivariable regression analyses were conducted with plasma levels of 8-OHdG and F2-isoprostanes (measured by LC/MS-MS) including sociodemographic, lifestyle, and sampling variables. Associations with metabolic syndrome (MetS) and chronic disease were examined.Results.8-OHdG and F2-isoprostanes were weakly correlated (r= 0.06,p= 0.045). Both were positively associated with age and cotinine (cigarette exposure); 8-OHdG was lower in females and after longer sample storage. F2-isoprostanes were higher in females, alcohol users, and in samples collected in spring and lower in supplement users and those with more education. Both markers were lower in fasting subjects. F2-isoprostanes, not 8-OHdG, were positively associated with MetS.Conclusion.The weak correlation between 8-OHdG and F2-isoprostanes suggests they reflect specific aspects of oxidative stress. Both markers are associated with a range of sociodemographic, lifestyle, and sampling determinants which should be considered in future research. F2-isoprostanes are associated with MetS.

scholarly journals Natural Antioxidant Anthocyanins—A Hidden Therapeutic Candidate in Metabolic Disorders with Major Focus in Neurodegeneration

Nutrients ◽  
2019 ◽  
Vol 11 (6) ◽  
pp. 1195 ◽  
Author(s):  
Rahat Ullah ◽  
Mehtab Khan ◽  
Shahid Ali Shah ◽  
Kamran Saeed ◽  
Myeong Ok Kim
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Neurodegenerative Diseases ◽  
Metabolic Disorders ◽  
Antioxidant Defense System ◽  
Vital Role ◽  
Therapeutic Interventions ◽  
Substantial Contribution ◽  
Future Research ◽  
Commercial Sources

All over the world, metabolic syndrome constitutes severe health problems. Multiple factors have been reported in the pathogenesis of metabolic syndrome. Metabolic disorders result in reactive oxygen species (ROS) induced oxidative stress, playing a vital role in the development and pathogenesis of major health issues, including neurological disorders Alzheimer’s disease (AD) Parkinson’s disease (PD). Considerable increasing evidence indicates the substantial contribution of ROS-induced oxidative stress in neurodegenerative diseases. An imbalanced metabolism results in a defective antioxidant defense system, free radicals causing inflammation, cellular apoptosis, and tissue damage. Due to the annual increase in financial and social burdens, in addition to the adverse effects associated with available synthetic agents, treatment diversion from synthetic to natural approaches has occurred. Antioxidants are now being considered as convincing therapeutic agents against various neurodegenerative disorders. Therefore, medicinal herbs and fruits currently receive substantially more attention as commercial sources of antioxidants. In this review, we argue that ROS-targeted therapeutic interventions with naturally occurring antioxidant flavonoid, anthocyanin, and anthocyanin-loaded nanoparticles might be the ultimate treatment against devastating illnesses. Furthermore, we elucidate the hidden potential of the neuroprotective role of anthocyanins and anthocyanin-loaded nanoparticles in AD and PD neuropathies, which lack sufficient attention compared with other polyphenols, despite their strong antioxidant potential. Moreover, we address the need for future research studies of native anthocyanins and nano-based-anthocyanins, which will be helpful in developing anthocyanin treatments as therapeutic mitochondrial antioxidant drug-like regimens to delay or prevent the progression of neurodegenerative diseases, such as AD and PD.

Preventive Effect of Different Wild Pistachio Oils on Oxidative Stress Markers, Liver Enzymes, and Histopathological Findings in a Metabolic Syndrome Model

2019 ◽  
Vol 8 ◽  
pp. 1238
Author(s):  
Sanaz Jamshidi ◽  
Najmeh Hejazi ◽  
Mohammad-Taghi Golmakani ◽  
Nader Tanideh ◽  
Mina Heidari Esfahani
Keyword(s):  
Oxidative Stress ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Normal Saline ◽  
Liver Enzymes ◽  
Therapeutic Effects ◽  
Oxidative Stress Markers ◽  
Histopathological Findings ◽  
Kernel Oil ◽  
Stress Markers

Background: Wild pistachio (Pistacia Atlantica mutica) species with wide distribution in Iran have different nutrition properties and may have therapeutic effects in metabolic syndrome. Metabolic syndrome, as a prevalent health problem, is a main risk factor for different chronic diseases such as diabetes, fatty liver and cardiovascular diseases. The present study aimed to evaluate the preventive effects of mixture, kernel, and hull oil of wild pistachio (WP) on oxidative stress markers, liver function and histopathological findings in metabolic syndrome induced rats. Materials and Methods: After oil extraction by cold press method and chemical analysis, rats were divided into 6 groups. Group 1 received normal saline;  group 2 received 2cc fructose solution and 0.5cc normal saline; and groups 3, 4, 5 and 6 received 2 cc fructose solution and 0.5 cc sunflower oil, mixture, hull and kernel oils of WP for 10 weeks, respectively. Then, glycemic indices, oxidative stress, liver enzymes and histopathological examination were determined using standard laboratory tests. Results: WP Kernel and mixture oils notably decreased the fasting blood sugar and insulin resistance compared with the fructose group. Insulin level was significantly increased in the kernel oil group (P<0.05). There was no significant difference in oxidative stress, liver enzymes and histopathology parameters among the groups. Conclusion: Kernel oil of WP improved hyperglycemia, insulin resistance and insulin secretion, but the changes in oxidative stress markers, liver enzymes and histopathologic results were not significant among the groups. [GMJ.2019;In press:e1238]

Oxidative Stress Markers Diagnostic Value in Metabolic Syndrome Dermal Manifestations: a Prospective Clinical Trial

2018 ◽  
Author(s):  
Julija Voicehovska ◽  
Mila Vlaskovska ◽  
Jana Janovska ◽  
Sergejs Babikovs ◽  
Vladimirs Voicehovskis ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Clinical Trial ◽  
Diagnostic Value ◽  
Prospective Clinical Trial ◽  
Oxidative Stress Markers ◽  
Stress Markers

scholarly journals Oxidative Stress Induced by Excess of Adiposity Is Related to a Downregulation of Hepatic SIRT6 Expression in Obese Individuals

2018 ◽  
Vol 2018 ◽  
pp. 1-7 ◽  
Author(s):  
Marcos C. Carreira ◽  
Andrea G. Izquierdo ◽  
Maria Amil ◽  
Felipe F. Casanueva ◽  
Ana B. Crujeiras
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Energy Restriction ◽  
Zucker Rats ◽  
In Vivo Model ◽  
Potential Therapeutic Target ◽  
Stress Markers ◽  
Treatment Of Obesity ◽  
The Relationship

Sirt6 is a member of the sirtuin family involved in physiological and pathological processes including aging, cancer, obesity, diabetes, and energy metabolism. This study is aimed at evaluating the relationship between liver SIRT6 gene expression and the oxidative stress network depending on adiposity levels in Zucker rats, an animal model of metabolic syndrome. We observed that liver-specific SIRT6 expression is reduced in an in vivo model of spontaneous obesity and metabolic syndrome. We also observed that SIRT6 expression in the liver is positively associated with SIRT1 and GST-M2 expressions, two proteins involved in antioxidant protection pathways and inversely related to body weight and plasmatic oxidative status. Interestingly, the SIRT6 expression is upregulated after energy restriction-induced weight loss concomitantly with an improvement in oxidative stress markers. These results suggest that SIRT6 may be a potential therapeutic target for the treatment of obesity and associated metabolic disorders, such as liver disease.

scholarly journals The Impact of Rapid Weight Loss on Oxidative Stress Markers and the Expression of the Metabolic Syndrome in Obese Individuals

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Eva Tumova ◽  
Wensheng Sun ◽  
Peter H. Jones ◽  
Michal Vrablik ◽  
Christie M. Ballantyne ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Metabolic Syndrome ◽  
Weight Loss ◽  
Oxidative Stress Marker ◽  
Rapid Weight Loss ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
The Metabolic Syndrome ◽  
Obese Subjects ◽  
The Impact

Objective. Obesity is linked with a state of increased oxidative stress, which plays an important role in the etiology of atherosclerosis and type 2 diabetes mellitus. The aim of our study was to evaluate the effect of rapid weight loss on oxidative stress markers in obese individuals with metabolic syndrome (MetS).Design and Methods. We measured oxidative stress markers in 40 obese subjects with metabolic syndrome (MetS+), 40 obese subjects without metabolic syndrome (MetS−), and 20 lean controls (LC) at baseline and after three months of very low caloric diet.Results. Oxidized low density lipoprotein (ox-LDL) levels decreased by 12% in MetS+ subjects, associated with a reduction in total cholesterol (TC), even after adjustment for age and sex. Lipoprotein associated phospholipase A2(Lp-PLA2) activity decreased by 4.7% in MetS+ subjects, associated with a drop in LDL-cholesterol (LDL-C), TC, and insulin levels. Multivariate logistic regression analysis showed that a model including ox-LDL, LpPLA2activity, and myeloperoxidase (MPO) improved prediction of MetS status among obese individuals compared to each oxidative stress marker alone.Conclusions. Oxidative stress markers were predictive of MetS in obese subjects, suggesting a higher oxidative stress. Rapid weight loss resulted in a decline in oxidative stress markers, especially in MetS+ patients.

The association of oxidative stress markers with conventional risk factors in the metabolic syndrome

Metabolism ◽  
2013 ◽  
Vol 62 (6) ◽  
pp. 828-835 ◽  
Author(s):  
Gulcan G. Korkmaz ◽  
Esma Altınoglu ◽  
Sabiha Civelek ◽  
Volkan Sozer ◽  
Füsun Erdenen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Metabolic Syndrome ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
The Metabolic Syndrome ◽  
Conventional Risk Factors
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