scholarly journals Correlation ofA2bARandKLF4/KLF15with Obesity-Dyslipidemia Induced Inflammation in Uygur Population

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Cuizhe Wang ◽  
Xiaodan Ha ◽  
Wei Li ◽  
Peng Xu ◽  
Yajuan Gu ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Normal Control Group ◽  
Expression Level ◽  
Control Group ◽  
Mrna Expression Level ◽  
Key Genes ◽  
Visceral Adipose ◽  
Lower Expression ◽  
Uygur Population

In this paper, the researchers collected visceral adipose tissue from the Uygur population, which were divided into two groups: the normal control group (NC,n=50, 18.0 kg/m2≤ BMI ≤ 23.9 kg/m2) and the obese group (OB,n=45, BMI ≥ 28 kg/m2), and then use real-time PCR to detect the mRNA expression level of key genes involved in inflammation signaling pathway. The findings suggest that, in obese status, the lower expression level ofA2bAR,KLF4, andKLF15of visceral adipose tissue may correlate with obese-dyslipidemia induced inflammation in Uygur population.

P4462Atorvastatin and fenofibrate exert opposite effects on the vascularization and characteristics of visceral adipose tissue

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
O Perez-Mendez ◽  
M Luna-Luna ◽  
A Mondragon-Garcia ◽  
A Aranda-Fraustro
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
New Zealand ◽  
High Risk ◽  
Visceral Adipose Tissue ◽  
Control Group ◽  
Increased Risk ◽  
Tnf Α ◽  
New Zealand White Rabbits ◽  
Visceral Adipose

Abstract Background Statins may precipitate the onset of type 2 diabetes (T2D) in high-risk patients. In contrast, only the subset of individuals with insulin resistance (IR) and/or diabetes receives cardiovascular benefits with fibrates. The mechanism responsible of such effects may be related with visceral adipose tissue (VAT). In this context, previous observations have suggested that atorvastatin induced an increase of VAT whereas fenofibrate had the opposite effects in rabbits. Purpose To determine the mass, morphology and vascularization of VAT in New Zealand white rabbits that received of atorvastatin or fenofibrate during two months. Methods New Zealand white rabbits (n=6 per group) received by oral gavage during 2 months, 0.33 mg/kg of atorvastatin or 2.6 mg/kg fenofibrate. The control group received 0.5 mL of vehicle. Plasma lipids were monitored. The visceral adipose tissue (VAT) was dissected and quantified. The expression of genes related with vascularization, VEGF-A and TGF-β, FGF2 as well as TNF-α were determined by qPCR in VAT. Histological slices were stained by hematoxilin and eosin to determine the size of adipocytes. The marker of angiogenesis, PECAM-1, was determined by immunohistochemistry. Results As expected, the cholesterol from atorvastatin was lower after treatment while triglycerides decreased in fenofibrate group. The mass of VAT from fenofibrate group was 46% lower compared with the controls meanwhile atorvastatin was associated with a larger diameter of adipocytes (+65%) than that of the control and fenofibrate groups. FGF2 gene expression was lower in fenofibrate than in control group (−54%). By contrast, VEGF-A gene expression in fenofibrate-treated rabbits was 110% higher than in control group. TGF-β and TNF-α remained comparable among groups. In agreement with the gene expression, the marker of angiogenesis PECAM-1 was slightly but significantly higher (+10%) in rabbits treated with fenofibrate than in controls, as determined by immunohistochemistry. Conclusion Fenofibrate enhanced the VEGF-A gene expression, PCAM-1 in VAT whereas decreased its total mass. In contrast, atorvastatin increased the adipocyte size without any effect on vascularization markers. These results suggest that fenofibrate is associated with a favorable remodeling of VAT, in contrast with atorvastatin, which induced a non-favorable remodeling of VAT. These results may be related with the cardiovascular benefits of fenofibrate and the increased risk of T2D in high-risk subjects induced by atorvastatin.

scholarly journals Hypoxia is associated with a lower expression of genes involved in lipogenesis in visceral adipose tissue

2015 ◽  
Vol 13 (1) ◽  
Author(s):  
Eduardo García-Fuentes ◽  
Concepción Santiago-Fernández ◽  
Carolina Gutiérrez-Repiso ◽  
María D. Mayas ◽  
Wilfredo Oliva-Olivera ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Expression Of Genes ◽  
Visceral Adipose ◽  
Lower Expression

scholarly journals Preferential reductions in intermuscular and visceral adipose tissue with exercise-induced weight loss compared with calorie restriction

2012 ◽  
Vol 112 (1) ◽  
pp. 79-85 ◽  
Author(s):  
Joan C. Murphy ◽  
Jennifer L. McDaniel ◽  
Katherine Mora ◽  
Dennis T. Villareal ◽  
Luigi Fontana ◽  
...  
Keyword(s):  
Weight Loss ◽  
Adipose Tissue ◽  
Calorie Restriction ◽  
Visceral Adipose Tissue ◽  
Control Group ◽  
Oral Glucose ◽  
Sensitivity Index ◽  
Fat Depots ◽  
Exercise Induced ◽  
Visceral Adipose

Intermuscular adipose tissue (IMAT) and visceral adipose tissue (VAT) are associated with insulin resistance. We sought to determine whether exercise-induced weight loss (EX) results in greater reductions in IMAT and VAT compared with similar weight loss induced by calorie restriction (CR) and whether these changes are associated with improvements in glucoregulation. Sedentary men and women (50–60 yr; body mass index of 23.5–29.9 kg/m2) were randomized to 1 yr of CR ( n = 17), EX ( n = 16), or a control group (CON; n = 6). Bilateral thigh IMAT and VAT volumes were quantified using multi-slice magnetic resonance imaging. Insulin sensitivity index (ISI) was determined from oral glucose tolerance test glucose and insulin levels. Weight loss was comparable ( P = 0.25) in the CR (−10.8 ± 1.4%) and EX groups (−8.3 ± 1.5%) and greater than in the control group (−2.0 ± 2.4%; P < 0.05). IMAT and VAT reductions were larger in the CR and EX groups than in the CON group ( P ≤ 0.05). After controlling for differences in total fat mass change between the CR and EX groups, IMAT and VAT reductions were nearly twofold greater ( P ≤ 0.05) in the EX group than in the CR group (IMAT: −45 ±5 vs. −25 ± 5 ml; VAT: −490 ± 64 vs. −267 ± 61 ml). In the EX group, the reductions in IMAT were correlated with increases in ISI ( r = −0.71; P = 0.003), whereas in the CR group, VAT reductions were correlated with increases in ISI ( r = −0.64; P = 0.006). In conclusion, calorie restriction and exercise-induced weight loss both decrease IMAT and VAT volumes. However, exercise appears to result in preferential reductions in these fat depots.

Lower expression of adiponectin mRNA in visceral adipose tissue in lean and obese subjects

2004 ◽  
Vol 219 (1-2) ◽  
pp. 9-15 ◽  
Author(s):  
Aina S Lihn ◽  
Jens M Bruun ◽  
Gengsheng He ◽  
Steen B Pedersen ◽  
Peter F Jensen ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Adiponectin Mrna ◽  
Obese Subjects ◽  
Visceral Adipose ◽  
Lower Expression

Atorvastatin and Fenofibrate Exert Opposite Effects on the Vascularization and Characteristics of Visceral Adipose Tissue in New Zealand White Rabbits

2019 ◽  
Vol 24 (6) ◽  
pp. 559-566 ◽  
Author(s):  
Andrea Mondragón-García ◽  
María Luna-Luna ◽  
Cristobal Flores-Castillo ◽  
Alberto Aranda-Fraustro ◽  
Elizabeth Carreón-Torres ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
New Zealand ◽  
Growth Factor ◽  
High Risk ◽  
Visceral Adipose Tissue ◽  
Control Group ◽  
New Zealand White Rabbits ◽  
Risk Patients ◽  
Visceral Adipose

Statins may precipitate the onset of type 2 diabetes (T2D) in high-risk patients. In contrast, only the subset of individuals with insulin resistance and/or diabetes receives cardiovascular benefits with fibrates. In this context, previous observations from our laboratory suggested that atorvastatin induced an increase in visceral adipose tissue (VAT), whereas fenofibrate had the opposite effects in rabbits. Therefore, we determined the mass, morphology, and vascularization of VAT in New Zealand white rabbits (n = 6/group) that received 0.33 or 2.6 mg/kg/d of atorvastatin or fenofibrate, respectively, during 2 months. As expected, the cholesterol from the atorvastatin group was lower after treatment, while triglycerides decreased in the fenofibrate group. The mass of VAT from the fenofibrate group was 46% lower compared to the controls, meanwhile atorvastatin was associated with a larger diameter of adipocytes (+65%) than that of the control and fenofibrate groups. Fibroblast growth factor 2 ( FGF2) gene expression was lower in the fenofibrate group than in the control group (−54%). By contrast, vascular endothelial growth factor A (VEGF-A) gene expression in fenofibrate-treated rabbits was 110% higher than in the control group. In agreement with the gene expression, the marker of angiogenesis platelet endothelial cell adhesion molecule 1 was slightly but significantly higher (+10%) in rabbits treated with fenofibrate than in controls, as determined by immunohistochemistry. These results suggest that fenofibrate is associated with a favorable remodeling of VAT, that is, reduced mass and increased vascularization in normolipemic rabbits; in contrast, atorvastatin induced a nonfavorable remodeling of VAT. These results may be related to the cardiovascular benefits of fenofibrate and the increased risk of T2D in high-risk patients induced by atorvastatin.

scholarly journals The Effect of Vitamin D Administration on Leptin, Adiponectin and mRNA MCP-1 Levels in Adipose Tissue of Obese Female Wistar Rats

2020 ◽  
pp. 541-549
Author(s):  
Luh Putu Ratna Sundari ◽  
Made Bakta ◽  
Nyoman Mantik Astawa ◽  
Putu Gede Adiatmika ◽  
Gusti Kamasan Nyoman Arijana ◽  
...  
Keyword(s):  
Vitamin D ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Wistar Rats ◽  
Control Group ◽  
Group Design ◽  
Obese Female ◽  
Female Wistar Rats ◽  
Group A ◽  
Visceral Adipose

In obesity, there is an accumulation of adipocytes which produces adipokine that are pro-inflammatory substance, such as leptin and MCP-1 and anti-inflammatory substance, such as adiponectin, while the bioavailability of vitamin D is decreased. This research aimed to study the effect of vitamin D administration on leptin, MCP-1, and adiponectin levels in adipose tissue rats with obesity. Vitamin D was administered to the obese model of 6-9 months old female Wistar rats. This experiment was a randomized control group design with a post-test group design only. Twenty-seven (27) female obese Wistar rats were included in this study. The animals were divided randomly into 3 groups: 9 rats were given 2400 IU vitamin D (group A), 9 rats were given 800 IU vitamin D (group B) and 9 rats were given a placebo as control (group C). The administration of Vitamin D was given once daily for 8 weeks. The visceral adipose tissue was taken to measure the level of leptin, adiponectin and mRNA MCP-1. Data among groups was analyzed by using one-way ANOVA and followed by LSD test, at a significance level of p <0.05. The lowest level of leptin (1059.15+135.20 pg/ml) and mRNA MCP-1 (2.36 + 0.75 fg/ml) and the highest adiponectin level (3.43 + 0.47 ng/ml) were found in group A. In conclusion, oral administration of vitamin D (2400 IU) decreased pro-inflammatory substances, such as leptin and mRNA MCP-1 and increased anti-inflammatory substances, such as adiponectin, in visceral adipose tissue of obese female Wistar rats.

scholarly journals Increased visceral adipose tissue in clear cell renal cell carcinoma with and without peritumoral collateral vessels

2020 ◽  
Vol 93 (1112) ◽  
pp. 20200334
Author(s):  
Federico Greco ◽  
Luigi Giuseppe Quarta ◽  
Rosario Francesco Grasso ◽  
Bruno Beomonte Zobel ◽  
Carlo Augusto Mallio
Keyword(s):  
Renal Cell Carcinoma ◽  
Adipose Tissue ◽  
Visceral Adipose Tissue ◽  
Renal Cell ◽  
Clear Cell ◽  
Control Group ◽  
Cell Renal Cell Carcinoma ◽  
Collateral Vessels ◽  
Visceral Adipose ◽  
And Control

Objective: The excessive amount of adipose tissue, mainly visceral, determines adiposopathy. With respect to oncogenesis, visceral adipose tissue (VAT) releases secretes adipokines, proinflammatory citokines and growth factors, considered mediating molecules in the development of obesity-related tumors. In this study, we quantify VAT in male patients with clear cell renal cell carcinoma (ccRCC) subgrouped according to the presence or absence of peritumoral collateral vessels. Methods: in this retrospective study, we enrolled 141 male caucasian patients divided into 2 groups: the ccRCC group (n = 106) composed of patients with ccRCC and control group (n = 35). The ccRCC group was further divided into two subgroups: the ccRCCa subgroup which showed absence of collateral vessels (n = 48) and ccRCCp subgroup with collateral vessels (n = 58). Total adipose tissue (TAT) area, VAT area and subcutaneous adipose tissue (SAT) area were measured in the groups and subgroups. VAT/SAT ratio was calculated for each subject. Results: Statistically significant differences were obtained between ccRCC group and control group for TAT area (p < 0.005), VAT area (p < 0.005) and SAT area (p = 0.01). Between ccRCCa subgroup and control group for TAT area (p < 0.001), VAT area (p = 0.005) and SAT area (p = 0.001). Between ccRCCp subgroup and control group for TAT area (p = 0.01) and VAT area (p = 0.01). Conclusion: This study confirms the increase of abdominal, especially visceral, adipose tissue in ccRCC patients and demonstrates a significant VAT accumulation in both categories of patients with and without peritumoral collateral vessels. Advances in knowledge: Visceral adiposity is present in patients with ccRCC regardless the presence of peritumoral collateral vessels, with surprisingly stronger results in the ccRCCa subgroup.

Lack of association between colorectal adenoma recurrence and visceral adipose tissue

2001 ◽  
Vol 120 (5) ◽  
pp. A254-A254
Author(s):  
D SASS ◽  
R SCHOEN ◽  
J WEISSFELD ◽  
L KULLER ◽  
F THAETE ◽  
...  
Keyword(s):  
Adipose Tissue ◽  
Colorectal Adenoma ◽  
Visceral Adipose Tissue ◽  
Adenoma Recurrence ◽  
Colorectal Adenoma Recurrence ◽  
Visceral Adipose
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