scholarly journals Endothelial-Mesenchymal Transition in Regenerative Medicine

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Damian Medici
Keyword(s):  
Stem Cell ◽  
Degenerative Diseases ◽  
Connective Tissues ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Mesenchymal Transition ◽  
Signaling Mechanisms ◽  
Recent Developments ◽  
Endothelial Mesenchymal Transition

Endothelial-mesenchymal transition (EndMT) is a fundamental cellular mechanism that regulates embryonic development and diseases such as cancer and fibrosis. Recent developments in biomedical research have shown remarkable potential to harness the EndMT process for tissue engineering and regeneration. As an alternative to traditional or artificial stem cell therapies, EndMT may represent a safe method for engineering new tissues to treat degenerative diseases by mimicking a process that occurs in nature. This review discusses the signaling mechanisms and therapeutic inhibitors of EndMT, as well as the role of EndMT in development, disease, acquiring stem cell properties and generating connective tissues, and its potential as a novel mechanism for tissue regeneration.

Endometrial Regeneration in Asherman's Syndrome: Clinical and Translational evidence of Stem Cell Therapies

2019 ◽  
Vol 14 (6) ◽  
pp. 454-459
Author(s):  
Xuejing Hou ◽  
Ying Liu ◽  
Isabelle Streuli ◽  
Patrick Dällenbach ◽  
Jean Dubuisson ◽  
...  
Keyword(s):  
Stem Cell ◽  
Molecular Mechanisms ◽  
Uterine Cavity ◽  
Stem Cell Therapies ◽  
Intrauterine Adhesions ◽  
Asherman’S Syndrome ◽  
Cell Therapies ◽  
Fibrotic Process ◽  
Physical Barriers

Asherman’s Syndrome or Intrauterine adhesions is an acquired uterine condition where fibrous scarring forms within the uterine cavity, resulting in reduced menstrual flow, pelvic pain and infertility. Until recently, the molecular mechanisms leading to the formation of fibrosis were poorly understood, and the treatment of Asherman’s syndrome has largely focused on hysteroscopic resection of adhesions, hormonal therapy, and physical barriers. Numerous studies have begun exploring the molecular mechanisms behind the fibrotic process underlying Asherman’s Syndrome as well as the role of stem cells in the regeneration of the endometrium as a treatment modality. The present review offers a summary of available stem cell-based regeneration studies, as well as highlighting current gaps in research.

scholarly journals The Kynurenine Pathway in Stem Cell Biology

2013 ◽  
Vol 6 ◽  
pp. IJTR.S12626 ◽  
Author(s):  
Simon P. Jones ◽  
Gilles J. Guillemin ◽  
Bruce J. Brew
Keyword(s):  
Stem Cell ◽  
Cell Biology ◽  
Critical Role ◽  
Kynurenine Pathway ◽  
Stem Cell Biology ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Functional Behavior ◽  
Lateral Sclerosis

The kynurenine pathway (KP) is the main catabolic pathway of the essential amino acid tryptophan. The KP has been identified to play a critical role in regulating immune responses in a variety of experimental settings. It is also known to be involved in several neuroinflammatory diseases including Huntington's disease, amyotrophic lateral sclerosis, and Alzheimer's disease. This review considers the current understanding of the role of the KP in stem cell biology. Both of these fundamental areas of cell biology have independently been the focus of a burgeoning research interest in recent years. A systematic review of how the two interact has not yet been conducted. Several inflammatory and infectious diseases in which the KP has been implicated include those for which stem cell therapies are being actively explored at a clinical level. Therefore, it is highly relevant to consider the evidence showing that the KP influences stem cell biology and impacts the functional behavior of progenitor cells.

scholarly journals Role of stem cell therapies in treating chronic wounds: A systematic review

2020 ◽  
Vol 12 (7) ◽  
pp. 659-675
Author(s):  
Anjali C Raghuram ◽  
Roy P Yu ◽  
Andrea Y Lo ◽  
Cynthia J Sung ◽  
Melissa Bircan ◽  
...  
Keyword(s):  
Systematic Review ◽  
Stem Cell ◽  
Chronic Wounds ◽  
Stem Cell Therapies ◽  
Cell Therapies

The role of stem cell therapies in degenerative lumbar spine disease: a review

2015 ◽  
Vol 38 (3) ◽  
pp. 429-445 ◽  
Author(s):  
David Oehme ◽  
Tony Goldschlager ◽  
Jeffrey V. Rosenfeld ◽  
Peter Ghosh ◽  
Graham Jenkin
Keyword(s):  
Stem Cell ◽  
Lumbar Spine ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Degenerative Lumbar Spine ◽  
Spine Disease

scholarly journals Lung Stem Cell Update: Promise and Controversy

2016 ◽  
Vol 65 (1) ◽  
Author(s):  
I.P. Neuringer ◽  
S.H. Randell
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cell Biology ◽  
Lung Parenchyma ◽  
Stem Cell Therapies ◽  
Cell Therapies ◽  
Circulating Cells ◽  
New Information ◽  
Injury And Repair

Currently, there is great enthusiasm about potential stem cell therapies for intractable diseases. We previously reviewed the topic of stem cells in lung injury and repair, including the role of endogenous, tissue (somatic) stem cells and the contribution of circulating cells to the lung parenchyma. Our purpose here is to provide a concise update in this fast-moving field. New information and ongoing debate focus attention on basic issues in lung stem cell biology and highlight the need for additional studies to establish the feasibility of cell therapies to prevent or treat lung diseases.

scholarly journals The Role of Nonhuman Primate Animal Models in the Clinical Development of Pluripotent Stem Cell Therapies

2016 ◽  
Vol 24 (7) ◽  
pp. 1165-1169 ◽  
Author(s):  
So Gun Hong ◽  
Yongshun Lin ◽  
Cynthia E Dunbar ◽  
Jizhong Zou
Keyword(s):  
Stem Cell ◽  
Animal Models ◽  
Nonhuman Primate ◽  
Pluripotent Stem Cell ◽  
Clinical Development ◽  
Stem Cell Therapies ◽  
Cell Therapies
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